LOCUS       c00048_JAKVLL0..       10033 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAKVLL010000048.1 MAG: Lacticaseibacillus paracasei isolate
            UW_TS_LACCAS1_13 Ga0496082_00300, whole genome shotgun sequence.
ACCESSION   JAKVLL010000048
VERSION     JAKVLL010000048
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-19 23:09:55
            Original ID  :: JAKVLL010000048.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 6198
            Orig. end    :: 16231
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10033
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[11198:11716]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..5518
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10033
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10033
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             82..1458
                     /locus_tag="ctg48_5"
                     /transl_table=11
                     /translation="MSKYRTETDTLGPVEIPANALWGPQTERSRHNFQAGPLMPMPVIR
                     ALLQLKKAAARANVAADVLPAPKGQLITRAVDALLALPDEKLQKDFPLHVYQTGSGTQT
                     NMNVNEVISHQAAKLNPDLPILPNDDVNHSQSSNDTFPTVMNITSAIAVNQLLHAVNQL
                     CSVLYSKAVTYARVVKIGRTHLQDATPLTFGQEISGWVAMMEHDQIALKRLQPNLFYLA
                     IGGTAVGTGLNADPNFGKIVAGRLSDVYQLPLSAKTNKFAALAAHSEISVVHGAIKTLA
                     ADLLKIANDIRFLASGPRAGYGELRIPANEPGSSIMPGKVNPTQAEALTMAAVRVMGND
                     TTITVAASQGNFELNVYKPVIISTFLESADLLTKTVTSFTEKLAAGLTIHAPHMRALVD
                     HSLMLVTALAPHIGYEKSAAIAQLAEQENLDLKAAAIKSGDVTAAQFDKWVDPLKMTRA
                     "
     CDS             complement(1720..2883)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217:NADH:flavin oxidoreductase/NADH oxidase (Score:
                     289.8; E-value: 4.6e-88)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg48_6"
                     /transl_table=11
                     /translation="MSGYHFLKPFTFKHQTITLKNRIVIPPMTTRLSFEDGTVTRDEIR
                     YYQQRAGGVGMFITGTANVNALGKGFEGELSVADDRFIPGLSKLAAAMKTGGTKAILQI
                     FSAGRMSNSKILRGEQPVSASAVAAPRAGYETPRALTPAEIEATIHDFGQAVRRAILAG
                     FDGIELHGANTYLIQQFYSPNSNRRTDEWGGDRDKRMRFPLAVVHEAEKMIATIADRPF
                     LLGYRISPEELEQPGITLDDTLALIAALKQTKIDYLHVSQSDVWRTSLRNPEDTAIMNE
                     QIRNHVAGAFPVIVVGGIKTPADAEKAAESFDLVAIGHEMIREPHWVQKVLDHDEKAIR
                     FQIAPADLEELGIAPTFLDFIESISGGAKGVPLTTAQSVTSSNVTQD"
     CDS             complement(2909..3643)
                     /NRPS_PKS="Domain: PKS_KR (6-169). E-value: 3.6e-12. Score:
                     38.3. Matches aSDomain: nrpspksdomains_ctg48_7_PKS_KR.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     192.9; E-value: 1.1e-58)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg48_7"
                     /sec_met_domain="adh_short (E-value: 3.6e-35, bitscore:
                     111.6, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LTVKDKVVVITGASSGIGAATVQVLAEAGAKLVIGARRTERLAEL
                     AASFTDGQVLYQQTDVTDQQQVKALIDLALDKFGHVDVLYNNAGLMPLSEMAELKVNEW
                     ERMIDVNIKGVLYGIAAVLPPMIAQHSGQIITTDSVAGHIVHPGTAVYSGTKWAIQAIM
                     DGLRQEQAANHIKTTMISPGAVNTELFSTITDPKRREAVEADEKNNGLSASDVAKAVLY
                     AIDQPANVAINEVLLRPVTQER"
     aSDomain        complement(3137..3625)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg48_7_PKS_KR.1"
                     /evalue="3.60E-12"
                     /label="ctg48_7_PKS_KR.1"
                     /locus_tag="ctg48_7"
                     /protein_end="169"
                     /protein_start="6"
                     /score="38.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVVITGASSGIGAATVQVLAEAGAKLVIGARRTERLAELAASFTD
                     GQVLYQQTDVTDQQQVKALIDLALDKFGHVDVLYNNAGLMPLSEMAELKVNEWERMIDV
                     NIKGVLYGIAAVLPPMIAQHSGQIITTDSVAGHIVHPGTAVYSGTKWAIQAIMDGLRQE
                     "
     aSModule        3137..3625
                     /domains="nrpspksdomains_ctg48_7_PKS_KR.1"
                     /incomplete
                     /locus_tags="ctg48_7"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       complement(3542..3622)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg48_7_0001"
                     /evalue="1.90E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg48_7"
                     /protein_end="34"
                     /protein_start="7"
                     /score="14.1"
                     /tool="antismash"
                     /translation="VVITGASSGIGAATVQVLAEAGAKLVI"
     CDS             3848..4801
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039:aldo/keto reductase family oxidoreductase (Score:
                     221.6; E-value: 2.1e-67)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg48_8"
                     /transl_table=11
                     /translation="MKQVRLGGSNWQASSVALGIMRMNVLAPDKAANVLDSAYNDGINF
                     IDSADIYGQGKSEEVFGEALKQASVSRDQLFIQSKVGIVVDPKRSHGSLVFGKRYDFSK
                     DHLLSAVDHILKRLQVDYLDSVLLHRPDPLMEVDDVAAAFDALEQSGKVRHFGVSNFNP
                     EQIALLESGIRQPLLIDQVQFSVAHTGMVNAGMHTNMADAASVDHDGSLLPYLQRKHMT
                     LQAWSPFQYGMFEGTFIDSPKFKALNDELQKVADHYHTNKNAIAVAWLLRHPVGVQVIL
                     GSMNPEHIKESAEGADSTLTRQEWYDIYFAAGNDLP"
     CDS             5001..5306
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_9"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 4.3e-15,
                     bitscore: 46.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYVKDSKVDLTQNNLLPFEEKRKIMSYNYRQLDDFQLSGVSGGKK
                     KFDCAATFVTGITAGIGSGTITGLAGGPFGIIGGAVVGGNLGAVGSAIKCLGDGMQ"
     CDS             5303..5518
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg48_10"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 7.7e-10,
                     bitscore: 29.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISKEVGITLKQHDLVLIQGGAKRRNKPSGCIVSTIGGAVAGAAG
                     LNPFTTVAGAAIGLSLCLSTNYIHPA"
     CDS             5654..5962
                     /locus_tag="ctg48_11"
                     /transl_table=11
                     /translation="MDKIISIIIVILILLATIAFYLAPFVGGLWQGAARSKVIAKILLL
                     NRDLKLSSKGLSRLINPQNPYIVLTTLDGRLDFTFISMSNLKKLKSELMSLEIKSMD"
     CDS             6233..6829
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Mac"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 109.3;
                     E-value: 3.3e-33)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg48_12"
                     /sec_met_domain="Mac (E-value: 3.5e-11, bitscore: 33.4,
                     seeds: 568, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLEEKFAFMATGKPYDDMDPLLLAVRDEATAKTDALNNEHDPAK
                     RNALFRELVGQTGVKPFVNPNFHCEFGRNIRVGDHFYANYDCTILDGAPVTIGDHVLFG
                     PKVGLYTSNHLFDPLERQLGGCIAKPIVVGDGCWLAANVTVLPGVTIGAGTIIGAGSVV
                     THDIPARVIAAGNPCEVLREITAADKTGFAGHDMI"
     CDS             6948..7283
                     /locus_tag="ctg48_13"
                     /transl_table=11
                     /translation="MTDKRETLMSMLSKAYANPTIKAEPALRALIETNAKKVDEGDDEK
                     AYVTAVTQLSHDISKYYLIHHAVPEELVAVFNYIKKDVPAADIDAARYRAQALAAGLVA
                     IPIVWGH"
     CDS             7608..7793
                     /locus_tag="ctg48_14"
                     /transl_table=11
                     /translation="MTLNKAIHYLLLIGISGVFLFTLAAAMGWVNQGDFALPLLLLAAG
                     LTLLRETDAGYEKARH"
     CDS             8045..8377
                     /locus_tag="ctg48_15"
                     /transl_table=11
                     /translation="MNMIQRNKVYFIMTGLNESFQKTATVSVMNTDAQEVIDDALHILE
                     KENVLQNRAIDYALARLYSRFVRLIGLQGMKLSPEADQWWQQLKNFMENDIHEELSQVG
                     GPHFIT"
     CDS             8890..9747
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg48_16"
                     /sec_met_domain="Abi (E-value: 8e-13, bitscore: 38.8,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEKAGFVNLDEGDGMEKKRQRLFTPGLRVLYIFILDEFIEAFVF
                     TPFLSFLQLDFWADIVLYKVLSLVIILGLNLLLLRQKIIFRTSFGWPSWQKFVFWDIVG
                     CLVAWQIFTNRNFLDILQASVIGTIAAVPEEYLYRGVIFGGLLRAFYLANRGGTKRNFL
                     YCMLLSSLAFSLAHLSNLPSQGAVATVGQMIQVSGMGMLLAALYVRYGTLLMPIFVHFM
                     IDCLVTLIHGPYPSKLNGVSDEATLITVSLIWATIYLAISMWVLWHCHDEEGFMARLAG
                     QAIK"
ORIGIN
        1 cgtgggcgaa ttcgtgtaaa ataggtctat gcaaataggc atgttggttg aatttttctg
       61 atggtgatga cggaggtaaa catgagcaaa tatcgaacag aaacggacac attaggacca
      121 gttgaaattc cggcaaacgc tttgtgggga ccgcaaacag agcgcagccg ccataatttt
      181 caggctggtc cattgatgcc gatgccagtg attagggcct tgctgcaact caaaaaagcg
      241 gcagcgcgag caaatgtggc cgctgatgtt ttaccggcac caaaaggcca attaatcacg
      301 cgagcagtcg atgccttgtt ggccttgcca gacgaaaaac tgcaaaaaga ttttccactg
      361 catgtctatc aaaccgggtc tggcacacaa acaaatatga atgtgaacga agtcattagc
      421 caccaagctg caaaactcaa ccccgacttg ccgatcttac cgaatgatga tgtgaatcac
      481 agtcaaagct ccaatgatac ttttccaact gtgatgaata ttacgtcggc tattgcagtg
      541 aatcagttgc tgcacgctgt caaccaactg tgcagtgttt tatattcaaa agccgtcact
      601 tacgctcgtg ttgttaaaat cggtcgaact catttacagg atgcaacgcc gctaacgttt
      661 ggccaagaaa tcagcggatg ggtggccatg atggaacatg atcagattgc tttaaagcgg
      721 cttcagccca atctttttta cttagccatt ggcggaacag cagtcggaac ggggcttaac
      781 gctgacccta actttggcaa gattgtggcg ggccgattga gcgatgttta tcaattacca
      841 ctttcggcga aaaccaataa gtttgctgct ttagcggctc actcagaaat tagcgttgtt
      901 catggtgcca ttaaaacgct agcggctgat ctgcttaaaa tcgccaatga cattcgcttc
      961 cttgccagtg gtccacgtgc tggatacggc gagttgcgca ttccggccaa tgagcctggt
     1021 agttccatca tgccgggcaa agtgaatccc acacaggccg aagcgctaac catggccgct
     1081 gttcgagtca tgggcaacga tacgacgatc acggtggccg cttcacaagg caattttgaa
     1141 ttgaacgtct acaagccggt tatcatcagt acctttttag agtcagctga tctactaacc
     1201 aaaacagtca cgagtttcac tgaaaaatta gctgccggct tgaccatcca cgcaccgcat
     1261 atgagagcac tcgttgatca ttcgctcatg ctggtcaccg ccctcgcacc ccacatcggc
     1321 tacgaaaaaa gtgccgccat cgcgcaattg gctgagcaag aaaacctcga tctaaaagca
     1381 gccgccatca aaagcggcga cgtcacagca gcgcagtttg ataaatgggt cgacccgtta
     1441 aaaatgacaa gagcgtgaac tggcgcggtt agctcggcgt agcgaagtgg cagtgacaca
     1501 gatggtctgg gctttggacc atctgtgtca ctgttcttcg catagccgag ctgcgctggt
     1561 gaacgcgttt aaatcagagc gtgagcaggt gatgatcaca ccttgattta aaacttataa
     1621 atcactggta gcttcaggca ccatcgcgta agttgaagac ggcaagaaaa aaggcgagct
     1681 ttttacagct cgactcgcac gatgatttga aatgctagat taatcttgag tcacgttgct
     1741 tgatgtcaca gactgcgcag ttgttaacgg gacacctttt gccccaccgg aaatactttc
     1801 gataaaatca aggaaggtcg gcgcaatgcc aagttcttca agatcagcag gggcgatctg
     1861 gaaacggatc gccttttcgt catggtctaa gaccttctga acccagtgcg gctcgcgaat
     1921 catttcgtga ccaatcgcga ccaaatcaaa ggattctgcc gctttctcag catcggcggg
     1981 ggttttaatg ccaccgacca caatcactgg aaaagcaccg gcgacgtggt tacgaatttg
     2041 ttcattcatg atggctgtgt cctcggggtt gcgcaatgag gttcgccaaa cgtcactttg
     2101 ggagacgtgc aggtaatcaa tcttggtttg tttcaaagcg gcgattaagg ccaaggtatc
     2161 atccaaggta atgccaggct gttccaactc ttccggcgaa atgcggtagc ctaacaaaaa
     2221 tggccggtca gcaattgtgg caatcatttt ttctgcttca tgaacgactg ccaacggaaa
     2281 acgcatccgc ttatcgcggt caccgcccca ttcatcggtt cggcgattag agtttggcga
     2341 atagaattgc tgtatcagat atgtgttggc accatgcagt tcgatgccat caaaaccagc
     2401 aaggatggcg cggcgcacgg cctgaccaaa atcgtgaata gtggcctcaa tttctgccgg
     2461 tgtcaatgcg cgcggtgttt cgtaacccgc ccgtggcgca gcaaccgcac tggcactgac
     2521 tggctgctca ccgcgcagaa tcttgctatt gctcatgcgg ccagcactga agatttgcaa
     2581 aatagccttg gtgccgcctg ttttcatcgc agcggcgagt ttgctcaaac cggggatgaa
     2641 tcgatcatca gcgacactta gctcaccttc gaatcctttg ccaagcgcat tgacattggc
     2701 ggtaccggta ataaacatgc cgacgccacc ggcccgttgc tggtaatacc tgatttcgtc
     2761 ccgcgtcaca gtgccgtctt caaacgacag gcgcgttgtc atcggcggaa tgacaatgcg
     2821 atttttcaac gtgatggttt ggtgcttgaa ggtgaacggt tttaaaaaat gataacccga
     2881 catgcaatca cactccttta gacgaaaatt aacgttcttg cgtgactggc cgtaagagca
     2941 cttcattgat ggcaacattg gccggttgat caatggcata caaaactgcc ttggcaacat
     3001 ccgaggcgct gaggccattg tttttttcat cggcttcaac agcttcacgg cgcttaggat
     3061 cggtaattgt gctgaaaagc tcagtattca cggcaccggg cgagatcatg gtcgttttaa
     3121 tatgattagc cgcttgttct tgtcgcaggc cgtccatgat cgcctggata gcccacttgg
     3181 taccagagta aacggcggtt ccagggtgaa caatgtgacc ggcgaccgag tctgttgtga
     3241 taatttggcc actgtgttgg gcaatcatag gcggtaaaac cgcggcgatc ccatacaaga
     3301 cgcctttaat gttgacgtca atcatccgct cccattcgtt gactttgagt tcggccattt
     3361 cagaaagtgg catcaggcca gcgttgttat acaaaacatc cacatgacca aacttatcca
     3421 acgccaaatc aatcagcgct ttcacttgct gctggtcggt cacatcggtt tgttgataca
     3481 gcacctgacc gtccgtaaag ctggccgcca attcagccaa ccgttctgtg cgccgcgcac
     3541 cgatgactag ttttgcacca gcctcggcca acacttgtac cgttgccgcg ccaatcccgc
     3601 tcgatgcacc tgtgattaca accactttat ctttaactgt caaaatcacg gcctccttta
     3661 tgggcttatc ctgctaagaa aaaataagta acaaacacag tttaacctac cgcgcagctc
     3721 agcaccatgc aagctgtttt attgaaattc taatattggc ttgacctcaa gtggacttta
     3781 ggggctacac ttaacttatc gtcagtaaca taatttgaaa tgacgtatcg aagggagttt
     3841 tgtgtttatg aaacaagttc gattaggcgg atccaattgg caggcgtcaa gtgtggcctt
     3901 gggcatcatg cggatgaatg tgctggcccc cgacaaagcg gccaatgtgc tggatagtgc
     3961 gtacaatgac ggcatcaact ttatcgactc ggccgacatt tatggccaag gcaaatccga
     4021 agaagttttt ggtgaagcct tgaagcaagc cagcgtttcc cgcgatcagt tattcattca
     4081 atcgaaagtc gggatcgtcg ttgatccaaa acgctctcat ggcagtttgg tattcggcaa
     4141 acggtacgac ttttcaaaag atcacttact gtcagcggtt gatcacattt tgaaacggtt
     4201 gcaggttgat taccttgatt cggtcttgct gcatcggcca gatccgttaa tggaagtcga
     4261 tgacgttgcg gcggcctttg atgcattgga acaaagtggc aaggttcggc attttggcgt
     4321 ctccaacttt aaccctgaac aaattgcgtt gcttgaaagc ggcattcggc agcctttgct
     4381 gattgaccaa gttcaattct ccgttgccca tactggcatg gtcaatgcgg ggatgcacac
     4441 caacatggcc gacgctgcct cggtcgatca tgatggcagc ctattaccat acttacaacg
     4501 caaacacatg accttacaag catggtcacc attccaatac ggcatgtttg aaggcacctt
     4561 tatcgatagc ccgaagttta aggcgttgaa tgatgaactg cagaaagtcg ctgaccacta
     4621 ccacaccaat aaaaatgcaa tcgcagtcgc ttggctatta cgccatccag ttggtgtgca
     4681 ggtgattctc ggctctatga atcctgaaca tatcaaggaa agtgcggaag gcgcggacag
     4741 cacgttgacc cgacaagaat ggtatgacat ttactttgcg gcggggaatg atttgccgta
     4801 agttgatgat atgaaaaaat tgtctcaaat tgctgagacg attttttttg caaaaaattg
     4861 aagtttttac caagcaagga gatttaaacg ttaagaattt ttgactttta aagcgcaact
     4921 gaacaataaa agtgtaaaga cgacgttaaa ctggaaattt cctacgttta aaaaattttg
     4981 gcattttaca caaataatta atgtatgtta aagacagtaa agtcgacctt acacaaaata
     5041 acttgttgcc ttttgaagaa aaaaggaaaa ttatgtctta taattatcgc cagctcgacg
     5101 attttcagtt gtcaggggtt tcaggtggga aaaagaaatt tgattgtgct gctacatttg
     5161 ttactggcat cacggcaggt attggatcag gaacgattac tggcctagct ggtggtcctt
     5221 ttgggataat cggcggcgcc gtagttggtg gaaacttagg agcggttggg tcagctatta
     5281 aatgcttagg agatgggatg caatgataag taaagaagtg ggcattactt taaaacagca
     5341 tgatttggtc ttaatccaag gaggagccaa gcgacgcaat aaacctagtg ggtgtattgt
     5401 gtccacgatc gggggagcgg tagcaggggc agctggatta aatccattta caactgttgc
     5461 aggcgctgca ataggattat ccttgtgtct cagcactaat tacattcacc cagcctaata
     5521 ttggacaaag acggttagct cctatcgcaa ctgttcaata taactaacac cttggtagtg
     5581 ctcacttttt cttgtcttag tcaaagatcg atttcaaatt agtctatttg tgcaaaagga
     5641 agaggaaata caaatggata agataataag tatcatcata gttatcttga ttttactggc
     5701 gacgatcgct ttttatctag caccatttgt tggaggactt tggcaagggg cagcaagaag
     5761 caaagtcatt gccaagatac ttttgttaaa tcgagatttg aaactatcta gtaaggggct
     5821 gagtaggtta atcaatcccc agaaccctta tatagttctc actactctag atggaagact
     5881 tgactttaca tttatctcta tgtcaaattt aaaaaagcta aaatctgagt taatgtcact
     5941 tgagattaag tctatggatt aagctgataa agtccgagga agtagctgaa atttcctaac
     6001 gccagaattt tgtgacgatg aagactgtaa ctgtatgttt ctgtttgtaa caaaacaggc
     6061 gtggttctgt gtgcagacgc gatgtcattg ttttcaagcc accatttctt caagaagtgg
     6121 tggctttttg tagacttcat gcgtaccgat aagcacacct taacatattg gcaattatca
     6181 acgcagtgcg caaatgtctg gtaaacttga gccaagaaag aggggtggcg caatgaatct
     6241 agaagaaaaa tttgctttca tggcaactgg taagccatac gacgacatgg accctttgtt
     6301 actggctgtg cgggatgaag caactgccaa aactgatgcg cttaacaatg aacacgatcc
     6361 agccaaacgc aatgccttgt ttagggaatt ggtaggccaa actggcgtca aaccgtttgt
     6421 gaatccaaac tttcattgtg agtttggccg gaatatccgc gtaggtgatc atttttatgc
     6481 caattatgac tgtaccattt tggacggggc gccggtgacc attggcgatc acgttttgtt
     6541 tggcccgaaa gtcggtttgt acaccagcaa ccaccttttt gatccacttg aacgacaact
     6601 tggtggctgc attgctaaac cgattgtagt cggggatggc tgttggctcg ctgccaatgt
     6661 gacggtgcta cccggcgtca cgattggtgc ggggacgatt atcggggcag gtagtgttgt
     6721 cacccacgac atcccagcgc gcgtgattgc ggcgggtaat ccttgcgaag tgctgcgcga
     6781 gatcacggct gctgataaaa cagggtttgc agggcatgac atgatctaaa cgccaaatcg
     6841 atacttgaaa ttaacaatcg acaagcgcat cctaacaata ttcacaaaga ctaaggtgct
     6901 ccgagtgagc atgaattgcc aagttaatca tcgaaaggaa gtgcaggatg acagacaaac
     6961 gtgaaacttt aatgtcgatg ctaagcaagg catacgctaa tccaacgatc aaagcagagc
     7021 cggcattacg ggcgcttatc gaaaccaacg ccaaaaaggt tgatgaaggt gatgacgaaa
     7081 aggcttatgt gacggctgtc actcagttgt cccacgacat ttccaaatac tatctgattc
     7141 atcacgccgt accagaagag ctggtggccg tcttcaatta catcaaaaaa gatgtacctg
     7201 ctgccgatat tgatgcagca cgttatcgcg cgcaagcctt ggccgctggc ttagttgcca
     7261 ttcccattgt ttgggggcat tagccgatgt acaactgtga attttaaacg gtgaggctaa
     7321 agttgatgat caagcaatca gttatcattt gcaaaaaaac gtcgcagact aagatctgcg
     7381 gctatttttt tgccatgaaa cttgttgaca ccagttaaga aaaaccgagt agcagatcga
     7441 taaagagaaa atttggtcga tatttgacaa aaaagcgacg ttaatcgggc aaaaccctac
     7501 gtttaaaaaa agtttgcgct gttgtgtgaa ctatccagta tagtgtgcgt aaaagcatcc
     7561 gcgagaaaaa gtcgaagttc atctggacgg ggggatacaa gttggcgatg acgttgaata
     7621 aagcaattca ttatctttta ctgataggca tcagtggtgt ctttcttttt acgctggctg
     7681 ccgccatggg ctgggtcaac caaggtgact ttgcgctgcc actactgctt ttggcggcag
     7741 gactcacgtt gttgcgggaa actgatgccg gatatgaaaa agcgaggcat tgaattgggt
     7801 ctgcttagaa ggcagaaaaa cgtgaagccg aatttctgta cacaaggaca aactgatttt
     7861 aaaatgtaat cggttacgat gactcatatc taaaagagtt cagatacaag acggtatcaa
     7921 gatccatcag tcaggctata aagccattgt tttccggtgc tttgcctaaa agccatagca
     7981 tcgatacttt tcaaacattt ctatagaaaa attgtcacga catcaaaagg aatggtgaca
     8041 tattatgaac atgattcagc gaaataaagt ctattttatt atgacagggc tcaacgaaag
     8101 ctttcaaaaa actgcaaccg tcagtgtcat gaataccgat gcacaagagg tcattgatga
     8161 tgcgctacat attttggaaa aagaaaatgt gcttcaaaat agagccattg attacgcatt
     8221 agcgcgcctg tattctcggt tcgttcgctt aattggccta caggggatga aattatcccc
     8281 agaagctgat cagtggtggc aacaactgaa aaattttatg gagaatgata ttcatgaaga
     8341 gctgagtcag gttggcggac cgcacttcat tacttgatcg gtttgttccc aatattggca
     8401 catgcaaatg cgaagtcgga agtcgagtgt tacgctgttt atactgtgac ttaccacttg
     8461 atttagactg gttggggaag gagcacgatg agatgcatcg aataaagaat gatgatttgc
     8521 aacaaatgat tgacgggatg acctgacgta aattcctgac aatgctgatt ttaggattga
     8581 ttgcgataga tgcttggtca cacactgacc aaattattgc ggggttttta aagggatggc
     8641 agggcatgta ggtgtttgtg accggtgaag aattgcgcca attgcaagct ccgcgacttt
     8701 ttcaacactg cagcgtcact tcttcttggc ttagcgtagc gtcgtttgcc gagtgaagtg
     8761 gctttttttg tcaataaatg atcgctagcg aatttttgac ggatgatcgt caacgttaaa
     8821 tggcgaaaac acgacgttta aaattagttg actaaaagcc attcattaac cggtatattg
     8881 ttcatagcaa tgtcggaaaa agccggcttt gtcaacttgg atgaaggtga cggaatggaa
     8941 aagaaacggc aacggttgtt cacgcctgga ttacgggttt tatacatttt tatcttggat
     9001 gaatttatag aagcatttgt gttcacccca tttttaagtt ttctacagct ggatttttgg
     9061 gcagacattg tgctctataa agtacttagt ttagttatca ttctggggct caatctgttg
     9121 ctgttaagac aaaagattat ctttaggacg tcatttggct ggccaagctg gcagaaattt
     9181 gtgttctggg atattgtggg ctgccttgta gcttggcaaa tctttaccaa ccgaaacttc
     9241 ctagatattt tacaagcaag tgtcattggt accatcgccg ctgttcctga agagtacctg
     9301 tatcgcgggg ttattttcgg tggattgctc cgcgcctttt accttgctaa ccgtggtggt
     9361 accaaacgta actttctcta ttgcatgtta ctaagcagtc tggcgttttc gcttgcacac
     9421 ttgagtaatc tgccaagcca aggtgctgtt gcaactgtgg gtcagatgat tcaagtcagc
     9481 gggatgggta tgctgctggc tgctctctac gttcgttatg gcacattact gatgccgatt
     9541 tttgttcatt tcatgatcga ctgcttggta acgctgattc acggccctta tcctagcaaa
     9601 ttaaatgggg taagtgacga agcgacgctc ataactgttt cgttgatctg ggctacgatt
     9661 tacttggcca tttccatgtg ggtcctatgg cactgtcatg acgaagaagg gttcatggca
     9721 aggttagcag gccaagcaat caaataagtt tatagtatct tggacacatt cactcgcaat
     9781 tgcggaaaac tttattactg gatatgataa tcgcttattt aattatagga agatccaaaa
     9841 aagaggagct gaatcaagtg accaaatcta aaaaaagtca aagaatgatt atgatccttg
     9901 ctttgtcagc aatacaggta atgataccct agattgcata attaaagtta ccacccagaa
     9961 aatgtgaaaa aagacctgtc cgttcttgct aaaatggtgt ttgcataaca taccatctag
    10021 agagaaggac agg
//
