LOCUS       c00056_JAKVLH0..       10052 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAKVLH010000056.1 MAG: Lacticaseibacillus paracasei isolate
            UW_TS_LACCAS1_18 Ga0496083_0331, whole genome shotgun sequence.
ACCESSION   JAKVLH010000056
VERSION     JAKVLH010000056
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-19 23:12:00
            Original ID  :: JAKVLH010000056.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 10052
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..10052
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[4534:5052]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      4535..5052
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..10052
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..10052
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             complement(306..1163)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abi"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg56_1"
                     /sec_met_domain="Abi (E-value: 8e-13, bitscore: 38.8,
                     seeds: 823, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSEKAGFVNLDEGDGMEKKRQRLFTPGLRVLYIFILDEFIEAFVF
                     TPFLSFLQLDFWADIVLYKVLSLVIILGLNLLLLRQKIIFRTSFGWPSWQKFVFWDIVG
                     CLVAWQIFTNRNFLDILQASVIGTIAAVPEEYLYRGVIFGGLLRAFYLANRGGTKRNFL
                     YCMLLSSLAFSLAHLSNLPSQGAVATVGQMIQVSGMGMLLAALYVRYGTLLMPIFVHFM
                     IDCLVTLIHGPYPSKLNGVSDEATLITVSLIWATIYLAISMWVLWHCHDEEGFMARLAG
                     QAIK"
     CDS             complement(1676..2008)
                     /locus_tag="ctg56_2"
                     /transl_table=11
                     /translation="MNMIQRNKVYFIMTGLNESFQKTATVSVMNTDAQEVIDDALHILE
                     KENVLQNRAIDYALARLYSRFVRLIGLQGMKLSPEADQWWQQLKNFMENDIHEELSQVG
                     GPHFIT"
     CDS             complement(2260..2445)
                     /locus_tag="ctg56_3"
                     /transl_table=11
                     /translation="MTLNKAIHYLLLIGISGVFLFTLAAAMGWVNQGDFALPLLLLAAG
                     LTLLRETDAGYEKARH"
     CDS             complement(2770..3105)
                     /locus_tag="ctg56_4"
                     /transl_table=11
                     /translation="MTDKRETLMSMLSKAYANPTIKAEPALRALIETNAKKVDEGDDEK
                     AYVTAVTQLSHDISKYYLIHHAVPEELVAVFNYIKKDVPAADIDAARYRAQALAAGLVA
                     IPIVWGH"
     CDS             complement(3224..3820)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Mac"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1156:Chloramphenicol acetyltransferase (Score: 109.3;
                     E-value: 3.3e-33)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg56_5"
                     /sec_met_domain="Mac (E-value: 3.5e-11, bitscore: 33.4,
                     seeds: 568, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNLEEKFAFMATGKPYDDMDPLLLAVRDEATAKTDALNNEHDPAK
                     RNALFRELVGQTGVKPFVNPNFHCEFGRNIRVGDHFYANYDCTILDGAPVTIGDHVLFG
                     PKVGLYTSNHLFDPLERQLGGCIAKPIVVGDGCWLAANVTVLPGVTIGAGTIIGAGSVV
                     THDIPARVIAAGNPCEVLREITAADKTGFAGHDMI"
     CDS             complement(4091..4399)
                     /locus_tag="ctg56_6"
                     /transl_table=11
                     /translation="MDKIISIIIVILILLATIAFYLAPFVGGLWQGAARSKVIAKILLL
                     NRDLKLSSKGLSRLINPQNPYIVLTTLDGRLDFTFISMSNLKKLKSELMSLEIKSMD"
     CDS             complement(4535..4750)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg56_7"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 7.7e-10,
                     bitscore: 29.2, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MISKEVGITLKQHDLVLIQGGAKRRNKPSGCIVSTIGGAVAGAAG
                     LNPFTTVAGAAIGLSLCLSTNYIHPA"
     CDS             complement(4747..5052)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg56_8"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 4.3e-15,
                     bitscore: 46.0, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYVKDSKVDLTQNNLLPFEEKRKIMSYNYRQLDDFQLSGVSGGKK
                     KFDCAATFVTGITAGIGSGTITGLAGGPFGIIGGAVVGGNLGAVGSAIKCLGDGMQ"
     CDS             complement(5252..6205)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1039:aldo/keto reductase family oxidoreductase (Score:
                     221.6; E-value: 2.1e-67)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg56_9"
                     /transl_table=11
                     /translation="MKQVRLGGSNWQASSVALGIMRMNVLAPDKAANVLDSAYNDGINF
                     IDSADIYGQGKSEEVFGEALKQASVSRDQLFIQSKVGIVVDPKRSHGSLVFGKRYDFSK
                     DHLLSAVDHILKRLQVDYLDSVLLHRPDPLMEVDDVAAAFDALEQSGKVRHFGVSNFNP
                     EQIALLESGIRQPLLIDQVQFSVAHTGMVNAGMHTNMADAASVDHDGSLLPYLQRKHMT
                     LQAWSPFQYGMFEGTFIDSPKFKALNDELQKVADHYHTNKNAIAVAWLLRHPVGVQVIL
                     GSMNPEHIKESAEGADSTLTRQEWYDIYFAAGNDLP"
     CDS             6410..7144
                     /NRPS_PKS="Domain: PKS_KR (6-169). E-value: 3.6e-12. Score:
                     38.3. Matches aSDomain: nrpspksdomains_ctg56_10_PKS_KR.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     192.9; E-value: 1.1e-58)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg56_10"
                     /sec_met_domain="adh_short (E-value: 3.6e-35, bitscore:
                     111.6, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="LTVKDKVVVITGASSGIGAATVQVLAEAGAKLVIGARRTERLAEL
                     AASFTDGQVLYQQTDVTDQQQVKALIDLALDKFGHVDVLYNNAGLMPLSEMAELKVNEW
                     ERMIDVNIKGVLYGIAAVLPPMIAQHSGQIITTDSVAGHIVHPGTAVYSGTKWAIQAIM
                     DGLRQEQAANHIKTTMISPGAVNTELFSTITDPKRREAVEADEKNNGLSASDVAKAVLY
                     AIDQPANVAINEVLLRPVTQER"
     aSDomain        6428..6916
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg56_10_PKS_KR.1"
                     /evalue="3.60E-12"
                     /label="ctg56_10_PKS_KR.1"
                     /locus_tag="ctg56_10"
                     /protein_end="169"
                     /protein_start="6"
                     /score="38.3"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="VVVITGASSGIGAATVQVLAEAGAKLVIGARRTERLAELAASFTD
                     GQVLYQQTDVTDQQQVKALIDLALDKFGHVDVLYNNAGLMPLSEMAELKVNEWERMIDV
                     NIKGVLYGIAAVLPPMIAQHSGQIITTDSVAGHIVHPGTAVYSGTKWAIQAIMDGLRQE
                     "
     aSModule        6428..6916
                     /domains="nrpspksdomains_ctg56_10_PKS_KR.1"
                     /incomplete
                     /locus_tags="ctg56_10"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       6431..6511
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg56_10_0001"
                     /evalue="1.90E-04"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg56_10"
                     /protein_end="34"
                     /protein_start="7"
                     /score="14.1"
                     /tool="antismash"
                     /translation="VVITGASSGIGAATVQVLAEAGAKLVI"
     CDS             7170..8333
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1217:NADH:flavin oxidoreductase/NADH oxidase (Score:
                     289.8; E-value: 4.6e-88)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg56_11"
                     /transl_table=11
                     /translation="MSGYHFLKPFTFKHQTITLKNRIVIPPMTTRLSFEDGTVTRDEIR
                     YYQQRAGGVGMFITGTANVNALGKGFEGELSVADDRFIPGLSKLAAAMKTGGTKAILQI
                     FSAGRMSNSKILRGEQPVSASAVAAPRAGYETPRALTPAEIEATIHDFGQAVRRAILAG
                     FDGIELHGANTYLIQQFYSPNSNRRTDEWGGDRDKRMRFPLAVVHEAEKMIATIADRPF
                     LLGYRISPEELEQPGITLDDTLALIAALKQTKIDYLHVSQSDVWRTSLRNPEDTAIMNE
                     QIRNHVAGAFPVIVVGGIKTPADAEKAAESFDLVAIGHEMIREPHWVQKVLDHDEKAIR
                     FQIAPADLEELGIAPTFLDFIESISGGAKGVPLTTAQSVTSSNVTQD"
     CDS             complement(8595..9971)
                     /locus_tag="ctg56_12"
                     /transl_table=11
                     /translation="MSKYRTETDTLGPVEIPANALWGPQTERSRHNFQAGPLMPMPVIR
                     ALLQLKKAAARANVAADVLPAPKGQLITRAVDALLALPDEKLQKDFPLHVYQTGSGTQT
                     NMNVNEVISHQAAKLNPDLPILPNDDVNHSQSSNDTFPTVMNITSAIAVNQLLHAVNQL
                     CSVLYSKAVTYARVVKIGRTHLQDATPLTFGQEISGWVAMMEHDQIALKRLQPNLFYLA
                     IGGTAVGTGLNADPNFGKIVAGRLSDVYQLPLSAKTNKFAALAAHSEISVVHGAIKTLA
                     ADLLKIANDIRFLASGPRAGYGELRIPANEPGSSIMPGKVNPTQAEALTMAAVRVMGND
                     TTITVAASQGNFELNVYKPVIISTFLESADLLTKTVTSFTEKLAAGLTIHAPHMRALVD
                     HSLMLVTALAPHIGYEKSAAIAQLAEQENLDLKAAAIKSGDVTAAQFDKWVDPLKMTRA
                     "
ORIGIN
        1 ggttataatg gccatgggac ctgtccttct ctctagatgg tatgttatgc aaacaccatt
       61 ttagcaagaa cggacaggtc ttttttcaca ttttctgggt ggtaacttta attatgcaat
      121 ctagggtatc attacctgta ttgctgacaa agcaaggatc ataatcattc tttgactttt
      181 tttagatttg gtcacttgat tcagctcctc ttttttggat cttcctataa ttaaataagc
      241 gattatcata tccagtaata aagttttccg caattgcgag tgaatgtgtc caagatacta
      301 taaacttatt tgattgcttg gcctgctaac cttgccatga acccttcttc gtcatgacag
      361 tgccatagga cccacatgga aatggccaag taaatcgtag cccagatcaa cgaaacagtt
      421 atgagcgtcg cttcgtcact taccccattt aatttgctag gataagggcc gtgaatcagc
      481 gttaccaagc agtcgatcat gaaatgaaca aaaatcggca tcagtaatgt gccataacga
      541 acgtagagag cagccagcag catacccatc ccgctgactt gaatcatctg acccacagtt
      601 gcaacagcac cttggcttgg cagattactc aagtgtgcaa gcgaaaacgc cagactgctt
      661 agtaacatgc aatagagaaa gttacgtttg gtaccaccac ggttagcaag gtaaaaggcg
      721 cggagcaatc caccgaaaat aaccccgcga tacaggtact cttcaggaac agcggcgatg
      781 gtaccaatga cacttgcttg taaaatatct aggaagtttc ggttggtaaa gatttgccaa
      841 gctacaaggc agcccacaat atcccagaac acaaatttct gccagcttgg ccagccaaat
      901 gacgtcctaa agataatctt ttgtcttaac agcaacagat tgagccccag aatgataact
      961 aaactaagta ctttatagag cacaatgtct gcccaaaaat ccagctgtag aaaacttaaa
     1021 aatggggtga acacaaatgc ttctataaat tcatccaaga taaaaatgta taaaacccgt
     1081 aatccaggcg tgaacaaccg ttgccgtttc ttttccattc cgtcaccttc atccaagttg
     1141 acaaagccgg ctttttccga cattgctatg aacaatatac cggttaatga atggctttta
     1201 gtcaactaat tttaaacgtc gtgttttcgc catttaacgt tgacgatcat ccgtcaaaaa
     1261 ttcgctagcg atcatttatt gacaaaaaaa gccacttcac tcggcaaacg acgctacgct
     1321 aagccaagaa gaagtgacgc tgcagtgttg aaaaagtcgc ggagcttgca attggcgcaa
     1381 ttcttcaccg gtcacaaaca cctacatgcc ctgccatccc tttaaaaacc ccgcaataat
     1441 ttggtcagtg tgtgaccaag catctatcgc aatcaatcct aaaatcagca ttgtcaggaa
     1501 tttacgtcag gtcatcccgt caatcatttg ttgcaaatca tcattcttta ttcgatgcat
     1561 ctcatcgtgc tccttcccca accagtctaa atcaagtggt aagtcacagt ataaacagcg
     1621 taacactcga cttccgactt cgcatttgca tgtgccaata ttgggaacaa accgatcaag
     1681 taatgaagtg cggtccgcca acctgactca gctcttcatg aatatcattc tccataaaat
     1741 ttttcagttg ttgccaccac tgatcagctt ctggggataa tttcatcccc tgtaggccaa
     1801 ttaagcgaac gaaccgagaa tacaggcgcg ctaatgcgta atcaatggct ctattttgaa
     1861 gcacattttc tttttccaaa atatgtagcg catcatcaat gacctcttgt gcatcggtat
     1921 tcatgacact gacggttgca gttttttgaa agctttcgtt gagccctgtc ataataaaat
     1981 agactttatt tcgctgaatc atgttcataa tatgtcacca ttccttttga tgtcgtgaca
     2041 atttttctat agaaatgttt gaaaagtatc gatgctatgg cttttaggca aagcaccgga
     2101 aaacaatggc tttatagcct gactgatgga tcttgatacc gtcttgtatc tgaactcttt
     2161 tagatatgag tcatcgtaac cgattacatt ttaaaatcag tttgtccttg tgtacagaaa
     2221 ttcggcttca cgtttttctg ccttctaagc agacccaatt caatgcctcg ctttttcata
     2281 tccggcatca gtttcccgca acaacgtgag tcctgccgcc aaaagcagta gtggcagcgc
     2341 aaagtcacct tggttgaccc agcccatggc ggcagccagc gtaaaaagaa agacaccact
     2401 gatgcctatc agtaaaagat aatgaattgc tttattcaac gtcatcgcca acttgtatcc
     2461 ccccgtccag atgaacttcg actttttctc gcggatgctt ttacgcacac tatactggat
     2521 agttcacaca acagcgcaaa ctttttttaa acgtagggtt ttgcccgatt aacgtcgctt
     2581 ttttgtcaaa tatcgaccaa attttctctt tatcgatctg ctactcggtt tttcttaact
     2641 ggtgtcaaca agtttcatgg caaaaaaata gccgcagatc ttagtctgcg acgttttttt
     2701 gcaaatgata actgattgct tgatcatcaa ctttagcctc accgtttaaa attcacagtt
     2761 gtacatcggc taatgccccc aaacaatggg aatggcaact aagccagcgg ccaaggcttg
     2821 cgcgcgataa cgtgctgcat caatatcggc agcaggtaca tcttttttga tgtaattgaa
     2881 gacggccacc agctcttctg gtacggcgtg atgaatcaga tagtatttgg aaatgtcgtg
     2941 ggacaactga gtgacagccg tcacataagc cttttcgtca tcaccttcat caaccttttt
     3001 ggcgttggtt tcgataagcg cccgtaatgc cggctctgct ttgatcgttg gattagcgta
     3061 tgccttgctt agcatcgaca ttaaagtttc acgtttgtct gtcatcctgc acttcctttc
     3121 gatgattaac ttggcaattc atgctcactc ggagcacctt agtctttgtg aatattgtta
     3181 ggatgcgctt gtcgattgtt aatttcaagt atcgatttgg cgtttagatc atgtcatgcc
     3241 ctgcaaaccc tgttttatca gcagccgtga tctcgcgcag cacttcgcaa ggattacccg
     3301 ccgcaatcac gcgcgctggg atgtcgtggg tgacaacact acctgccccg ataatcgtcc
     3361 ccgcaccaat cgtgacgccg ggtagcaccg tcacattggc agcgagccaa cagccatccc
     3421 cgactacaat cggtttagca atgcagccac caagttgtcg ttcaagtgga tcaaaaaggt
     3481 ggttgctggt gtacaaaccg actttcgggc caaacaaaac gtgatcgcca atggtcaccg
     3541 gcgccccgtc caaaatggta cagtcataat tggcataaaa atgatcacct acgcggatat
     3601 tccggccaaa ctcacaatga aagtttggat tcacaaacgg tttgacgcca gtttggccta
     3661 ccaattccct aaacaaggca ttgcgtttgg ctggatcgtg ttcattgtta agcgcatcag
     3721 ttttggcagt tgcttcatcc cgcacagcca gtaacaaagg gtccatgtcg tcgtatggct
     3781 taccagttgc catgaaagca aatttttctt ctagattcat tgcgccaccc ctctttcttg
     3841 gctcaagttt accagacatt tgcgcactgc gttgataatt gccaatatgt taaggtgtgc
     3901 ttatcggtac gcatgaagtc tacaaaaagc caccacttct tgaagaaatg gtggcttgaa
     3961 aacaatgaca tcgcgtctgc acacagaacc acgcctgttt tgttacaaac agaaacatac
     4021 agttacagtc ttcatcgtca caaaattctg gcgttaggaa atttcagcta cttcctcgga
     4081 ctttatcagc ttaatccata gacttaatct caagtgacat taactcagat tttagctttt
     4141 ttaaatttga catagagata aatgtaaagt caagtcttcc atctagagta gtgagaacta
     4201 tataagggtt ctggggattg attaacctac tcagcccctt actagatagt ttcaaatctc
     4261 gatttaacaa aagtatcttg gcaatgactt tgcttcttgc tgccccttgc caaagtcctc
     4321 caacaaatgg tgctagataa aaagcgatcg tcgccagtaa aatcaagata actatgatga
     4381 tacttattat cttatccatt tgtatttcct cttccttttg cacaaataga ctaatttgaa
     4441 atcgatcttt gactaagaca agaaaaagtg agcactacca aggtgttagt tatattgaac
     4501 agttgcgata ggagctaacc gtctttgtcc aatattaggc tgggtgaatg taattagtgc
     4561 tgagacacaa ggataatcct attgcagcgc ctgcaacagt tgtaaatgga tttaatccag
     4621 ctgcccctgc taccgctccc ccgatcgtgg acacaataca cccactaggt ttattgcgtc
     4681 gcttggctcc tccttggatt aagaccaaat catgctgttt taaagtaatg cccacttctt
     4741 tacttatcat tgcatcccat ctcctaagca tttaatagct gacccaaccg ctcctaagtt
     4801 tccaccaact acggcgccgc cgattatccc aaaaggacca ccagctaggc cagtaatcgt
     4861 tcctgatcca atacctgccg tgatgccagt aacaaatgta gcagcacaat caaatttctt
     4921 tttcccacct gaaacccctg acaactgaaa atcgtcgagc tggcgataat tataagacat
     4981 aattttcctt ttttcttcaa aaggcaacaa gttattttgt gtaaggtcga ctttactgtc
     5041 tttaacatac attaattatt tgtgtaaaat gccaaaattt tttaaacgta ggaaatttcc
     5101 agtttaacgt cgtctttaca cttttattgt tcagttgcgc tttaaaagtc aaaaattctt
     5161 aacgtttaaa tctccttgct tggtaaaaac ttcaattttt tgcaaaaaaa atcgtctcag
     5221 caatttgaga caattttttc atatcatcaa cttacggcaa atcattcccc gccgcaaagt
     5281 aaatgtcata ccattcttgt cgggtcaacg tgctgtccgc gccttccgca ctttccttga
     5341 tatgttcagg attcatagag ccgagaatca cctgcacacc aactggatgg cgtaatagcc
     5401 aagcgactgc gattgcattt ttattggtgt ggtagtggtc agcgactttc tgcagttcat
     5461 cattcaacgc cttaaacttc gggctatcga taaaggtgcc ttcaaacatg ccgtattgga
     5521 atggtgacca tgcttgtaag gtcatgtgtt tgcgttgtaa gtatggtaat aggctgccat
     5581 catgatcgac cgaggcagcg tcggccatgt tggtgtgcat ccccgcattg accatgccag
     5641 tatgggcaac ggagaattga acttggtcaa tcagcaaagg ctgccgaatg ccgctttcaa
     5701 gcaacgcaat ttgttcaggg ttaaagttgg agacgccaaa atgccgaacc ttgccacttt
     5761 gttccaatgc atcaaaggcc gccgcaacgt catcgacttc cattaacgga tctggccgat
     5821 gcagcaagac cgaatcaagg taatcaacct gcaaccgttt caaaatgtga tcaaccgctg
     5881 acagtaagtg atcttttgaa aagtcgtacc gtttgccgaa taccaaactg ccatgagagc
     5941 gttttggatc aacgacgatc ccgactttcg attgaatgaa taactgatcg cgggaaacgc
     6001 tggcttgctt caaggcttca ccaaaaactt cttcggattt gccttggcca taaatgtcgg
     6061 ccgagtcgat aaagttgatg ccgtcattgt acgcactatc cagcacattg gccgctttgt
     6121 cgggggccag cacattcatc cgcatgatgc ccaaggccac acttgacgcc tgccaattgg
     6181 atccgcctaa tcgaacttgt ttcataaaca caaaactccc ttcgatacgt catttcaaat
     6241 tatgttactg acgacaagtt aagtgtagcc cctaaagtcc acttgaggtc aagccaatat
     6301 tagaatttca ataaaacagc ttgcatggtg ctgagctgcg cggtaggtta aactgtgttt
     6361 gttacttatt ttttcttagc aggataagcc cataaaggag gccgtgattt tgacagttaa
     6421 agataaagtg gttgtaatca caggtgcatc gagcgggatt ggcgcggcaa cggtacaagt
     6481 gttggccgag gctggtgcaa aactagtcat cggtgcgcgg cgcacagaac ggttggctga
     6541 attggcggcc agctttacgg acggtcaggt gctgtatcaa caaaccgatg tgaccgacca
     6601 gcagcaagtg aaagcgctga ttgatttggc gttggataag tttggtcatg tggatgtttt
     6661 gtataacaac gctggcctga tgccactttc tgaaatggcc gaactcaaag tcaacgaatg
     6721 ggagcggatg attgacgtca acattaaagg cgtcttgtat gggatcgccg cggttttacc
     6781 gcctatgatt gcccaacaca gtggccaaat tatcacaaca gactcggtcg ccggtcacat
     6841 tgttcaccct ggaaccgccg tttactctgg taccaagtgg gctatccagg cgatcatgga
     6901 cggcctgcga caagaacaag cggctaatca tattaaaacg accatgatct cgcccggtgc
     6961 cgtgaatact gagcttttca gcacaattac cgatcctaag cgccgtgaag ctgttgaagc
     7021 cgatgaaaaa aacaatggcc tcagcgcctc ggatgttgcc aaggcagttt tgtatgccat
     7081 tgatcaaccg gccaatgttg ccatcaatga agtgctctta cggccagtca cgcaagaacg
     7141 ttaattttcg tctaaaggag tgtgattgca tgtcgggtta tcatttttta aaaccgttca
     7201 ccttcaagca ccaaaccatc acgttgaaaa atcgcattgt cattccgccg atgacaacgc
     7261 gcctgtcgtt tgaagacggc actgtgacgc gggacgaaat caggtattac cagcaacggg
     7321 ccggtggcgt cggcatgttt attaccggta ccgccaatgt caatgcgctt ggcaaaggat
     7381 tcgaaggtga gctaagtgtc gctgatgatc gattcatccc cggtttgagc aaactcgccg
     7441 ctgcgatgaa aacaggcggc accaaggcta ttttgcaaat cttcagtgct ggccgcatga
     7501 gcaatagcaa gattctgcgc ggtgagcagc cagtcagtgc cagtgcggtt gctgcgccac
     7561 gggcgggtta cgaaacaccg cgcgcattga caccggcaga aattgaggcc actattcacg
     7621 attttggtca ggccgtgcgc cgcgccatcc ttgctggttt tgatggcatc gaactgcatg
     7681 gtgccaacac atatctgata cagcaattct attcgccaaa ctctaatcgc cgaaccgatg
     7741 aatggggcgg tgaccgcgat aagcggatgc gttttccgtt ggcagtcgtt catgaagcag
     7801 aaaaaatgat tgccacaatt gctgaccggc catttttgtt aggctaccgc atttcgccgg
     7861 aagagttgga acagcctggc attaccttgg atgatacctt ggccttaatc gccgctttga
     7921 aacaaaccaa gattgattac ctgcacgtct cccaaagtga cgtttggcga acctcattgc
     7981 gcaaccccga ggacacagcc atcatgaatg aacaaattcg taaccacgtc gccggtgctt
     8041 ttccagtgat tgtggtcggt ggcattaaaa cccccgccga tgctgagaaa gcggcagaat
     8101 cctttgattt ggtcgcgatt ggtcacgaaa tgattcgcga gccgcactgg gttcagaagg
     8161 tcttagacca tgacgaaaag gcgatccgtt tccagatcgc ccctgctgat cttgaagaac
     8221 ttggcattgc gccgaccttc cttgatttta tcgaaagtat ttccggtggg gcaaaaggtg
     8281 tcccgttaac aactgcgcag tctgtgacat caagcaacgt gactcaagat taatctagca
     8341 tttcaaatca tcgtgcgagt cgagctgtaa aaagctcgcc ttttttcttg ccgtcttcaa
     8401 cttacgcgat ggtgcctgaa gctaccagtg atttataagt tttaaatcaa ggtgtgatca
     8461 tcacctgctc acgctctgat ttaaacgcgt tcaccagcgc agctcggcta tgcgaagaac
     8521 agtgacacag atggtccaaa gcccagacca tctgtgtcac tgccacttcg ctacgccgag
     8581 ctaaccgcgc cagttcacgc tcttgtcatt tttaacgggt cgacccattt atcaaactgc
     8641 gctgctgtga cgtcgccgct tttgatggcg gctgctttta gatcgaggtt ttcttgctca
     8701 gccaattgcg cgatggcggc acttttttcg tagccgatgt ggggtgcgag ggcggtgacc
     8761 agcatgagcg aatgatcaac gagtgctctc atatgcggtg cgtggatggt caagccggca
     8821 gctaattttt cagtgaaact cgtgactgtt ttggttagta gatcagctga ctctaaaaag
     8881 gtactgatga taaccggctt gtagacgttc aattcaaaat tgccttgtga agcggccacc
     8941 gtgatcgtcg tatcgttgcc catgactcga acagcggcca tggttagcgc ttcggcctgt
     9001 gtgggattca ctttgcccgg catgatggaa ctaccaggct cattggccgg aatgcgcaac
     9061 tcgccgtatc cagcacgtgg accactggca aggaagcgaa tgtcattggc gattttaagc
     9121 agatcagccg ctagcgtttt aatggcacca tgaacaacgc taatttctga gtgagccgct
     9181 aaagcagcaa acttattggt tttcgccgaa agtggtaatt gataaacatc gctcaatcgg
     9241 cccgccacaa tcttgccaaa gttagggtca gcgttaagcc ccgttccgac tgctgttccg
     9301 ccaatggcta agtaaaaaag attgggctga agccgcttta aagcaatctg atcatgttcc
     9361 atcatggcca cccatccgct gatttcttgg ccaaacgtta gcggcgttgc atcctgtaaa
     9421 tgagttcgac cgattttaac aacacgagcg taagtgacgg cttttgaata taaaacactg
     9481 cacagttggt tgacagcgtg cagcaactga ttcactgcaa tagccgacgt aatattcatc
     9541 acagttggaa aagtatcatt ggagctttga ctgtgattca catcatcatt cggtaagatc
     9601 ggcaagtcgg ggttgagttt tgcagcttgg tggctaatga cttcgttcac attcatattt
     9661 gtttgtgtgc cagacccggt ttgatagaca tgcagtggaa aatctttttg cagtttttcg
     9721 tctggcaagg ccaacaaggc atcgactgct cgcgtgatta attggccttt tggtgccggt
     9781 aaaacatcag cggccacatt tgctcgcgct gccgcttttt tgagttgcag caaggcccta
     9841 atcactggca tcggcatcaa tggaccagcc tgaaaattat ggcggctgcg ctctgtttgc
     9901 ggtccccaca aagcgtttgc cggaatttca actggtccta atgtgtccgt ttctgttcga
     9961 tatttgctca tgtttacctc cgtcatcacc atcagaaaaa ttcaaccaac atgcctattt
    10021 gcatagacct attttacacg aattcgccca cg
//
