LOCUS       c00091_JAJAOS0..       12893 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  JAJAOS010000074.1 Limosilactobacillus fermentum strain QAULFN55
            NODE_76, whole genome shotgun sequence.
ACCESSION   JAJAOS010000074
VERSION     JAJAOS010000074
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-20 00:01:27
            Original ID  :: JAJAOS010000074.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 12893
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12893
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2726:10609]"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2727..10609
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(HMGL-like and AMP-binding)"
                     /neighbourhood="10000"
                     /product="betalactone"
                     /protocluster_number="1"
     cand_cluster    1..12893
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(HMGL-like and AMP-binding)"
                     /kind="single"
                     /product="betalactone"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12893
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="betalactone"
                     /region_number="1"
                     /rules="(HMGL-like and AMP-binding)"
                     /tool="antismash"
     CDS             complement(186..1094)
                     /NRPS_PKS="Domain: PKS_ER (2-209). E-value: 3e-12. Score:
                     38.0. Matches aSDomain: nrpspksdomains_ctg91_1_PKS_ER.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1040:alcohol dehydrogenase (Score: 198.5; E-value:
                     2.2e-60)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg91_1"
                     /transl_table=11
                     /translation="MILGHEACGVVVEVGEDVKDFKPGDRVLVPAITPNWSDVYSQAGY
                     ATDSDGMLGGWKFSNIKDGVFATRFHVNDADGNLAHLPDEIDPAEACMLSDMIPTGLHA
                     SEMAGVTFGDDVAVIGIGPVGLMALRGAVLHGAGRVFAVGSREKTVEVAKKYGATDIID
                     YHNGRISDQILEATGGQGVDKVLIAGGNAKDTFEEAVRMLKPGGSIGNVNYLNGHDDVV
                     FNAGDWGVGMGHKTIHGGLMPGGRLRMEKLAVLVVNGRIDPSLMITHRFEGFEKIPDAI
                     ELMHHKSADLIKPVVICNDID"
     aSDomain        complement(468..1088)
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg91_1_PKS_ER.1"
                     /evalue="3.00E-12"
                     /label="ctg91_1_PKS_ER.1"
                     /locus_tag="ctg91_1"
                     /protein_end="209"
                     /protein_start="2"
                     /score="38.0"
                     /tool="antismash"
                     /translation="LGHEACGVVVEVGEDVKDFKPGDRVLVPAITPNWSDVYSQAGYAT
                     DSDGMLGGWKFSNIKDGVFATRFHVNDADGNLAHLPDEIDPAEACMLSDMIPTGLHASE
                     MAGVTFGDDVAVIGIGPVGLMALRGAVLHGAGRVFAVGSREKTVEVAKKYGATDIIDYH
                     NGRISDQILEATGGQGVDKVLIAGGNAKDTFEEAVRMLKPGGSI"
     aSModule        468..1088
                     /domains="nrpspksdomains_ctg91_1_PKS_ER.1"
                     /incomplete
                     /locus_tags="ctg91_1"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       complement(663..689)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg91_1_0002"
                     /evalue="5.30E+00"
                     /label="PKSI-ER_m2"
                     /locus_tag="ctg91_1"
                     /protein_end="144"
                     /protein_start="135"
                     /score="0.9"
                     /tool="antismash"
                     /translation="GAGRVFAVG"
     CDS_motif       complement(1050..1088)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg91_1_0001"
                     /evalue="6.00E-03"
                     /label="PKSI-ER_m2"
                     /locus_tag="ctg91_1"
                     /protein_end="15"
                     /protein_start="2"
                     /score="9.7"
                     /tool="antismash"
                     /translation="LGHEACGVVVEVG"
     CDS             complement(1109..1255)
                     /locus_tag="ctg91_2"
                     /transl_table=11
                     /translation="MKGFAMLGPNKTGFIEKEDPKVGSRDALVRPLAVAPCTSDIHTVF
                     EDA"
     CDS             complement(1486..2676)
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 230.9; E-value: 3.3e-70)"
                     /gene_kind="transport"
                     /locus_tag="ctg91_3"
                     /transl_table=11
                     /translation="MDAKPNRRALSLGSFVILYLGYMLLFADRTVLNLSLAAIGKDFSV
                     SPAALGATSSVFFLGYTIMQIPGGWLTDRFSSRKVIIATLAFWSVMTIFTGLAWSLAAL
                     LVIRFLFGIAEGPYPPAAMKQVAQDFPVNKRAQLTAALISSNYAGAALAPFIIVPIIAA
                     TGWRSAFFWLGGFGLLLMVSYLFFRGHGGGQTVTKQERQKINWKEIDPRVWAFVVIGLA
                     LNIITKGMETWMPVYFLNARHINLANLAWLVPLPTIAGGIAALISGYVMVHIFKNHERL
                     MIILASFLTVLTMFGLYKSTSLVWLVIFQMATYFVKSLAFTGIFSYAAQLFPQKTYGSQ
                     IGTINFGGQLGGFFGPLLIGWIVQLSGSYDTAFFGLVISALVAGVASLFIGNLKAK"
     CDS             complement(2727..4151)
                     /NRPS_PKS="Domain: AMP-binding (8-379). E-value: 2.2e-71.
                     Score: 232.3. Matches aSDomain:
                     nrpspksdomains_ctg91_4_AMP-binding.1"
                     /NRPS_PKS="type: NRPS-like protein"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     307.2; E-value: 2.9e-93)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg91_4"
                     /sec_met_domain="AMP-binding (E-value: 4.1e-76, bitscore:
                     245.6, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEIPNWLLKQASLNPNRVAVNDGTTAYTFAQLVPLVAHRAGQIQA
                     QTDQPRVGVMTHNNLAGYLAALGVLAADKTIVWLNWRLAPEELSRQIGDAGLDLVLVDD
                     QLADRYYGGHRVLCSELTAGTAPAAVLTPTVDLDAVASIMYTSGTTGQPKGVLQTYGNH
                     LASAISSSLNLGVLPNDLWLCVAPIFHISGFSILMRGLIYGMGVRLVNHFDAQVVNQIL
                     EDEPVTIISAVPYMLKKMLEDVQANDHCYSSAFRLVLLGGGTIDRATLNACEESGLPIV
                     QCYGMTETCSQFVALSAEEAPYHLGSVGKPLFTTQLRLVGEHHEIEIQTPALTPGYLNQ
                     PAKFAAKHDGDWYRTGDVGHFDEDGFLYVDGRLDEMIISGGENIFPAEVENVLRQYPGI
                     QEIAVVGRNDQQWGAVPVAVVVSKQPVDFQQLEAFGREHLAHYKVPKVYLQTDALPKNA
                     SGKVQKFRLQDLVANA"
     aSDomain        complement(3015..4127)
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg91_4_AMP-binding.1"
                     /evalue="2.20E-71"
                     /label="ctg91_4_AMP-binding.1"
                     /locus_tag="ctg91_4"
                     /protein_end="379"
                     /protein_start="8"
                     /score="232.3"
                     /specificity="consensus: X"
                     /tool="antismash"
                     /translation="KQASLNPNRVAVNDGTTAYTFAQLVPLVAHRAGQIQAQTDQPRVG
                     VMTHNNLAGYLAALGVLAADKTIVWLNWRLAPEELSRQIGDAGLDLVLVDDQLADRYYG
                     GHRVLCSELTAGTAPAAVLTPTVDLDAVASIMYTSGTTGQPKGVLQTYGNHLASAISSS
                     LNLGVLPNDLWLCVAPIFHISGFSILMRGLIYGMGVRLVNHFDAQVVNQILEDEPVTII
                     SAVPYMLKKMLEDVQANDHCYSSAFRLVLLGGGTIDRATLNACEESGLPIVQCYGMTET
                     CSQFVALSAEEAPYHLGSVGKPLFTTQLRLVGEHHEIEIQTPALTPGYLNQPAKFAAKH
                     DGDWYRTGDVGHFDEDGFLYVDGRLDEMIIS"
     aSModule        3015..4127
                     /domains="nrpspksdomains_ctg91_4_AMP-binding.1"
                     /incomplete
                     /locus_tags="ctg91_4"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       complement(3681..3731)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg91_4_0001"
                     /evalue="4.30E-07"
                     /label="NRPS-A_a3"
                     /locus_tag="ctg91_4"
                     /protein_end="157"
                     /protein_start="140"
                     /score="22.4"
                     /tool="antismash"
                     /translation="ASIMYTSGTTGQPKGVL"
     CDS             complement(4161..4982)
                     /NRPS_PKS="Domain: ECH (18-261). E-value: 3.9e-63. Score:
                     204.7. Matches aSDomain: nrpspksdomains_ctg91_5_ECH.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023:enoyl-CoA hydratase (Score: 197.1; E-value:
                     4.6e-60)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg91_5"
                     /transl_table=11
                     /translation="MTSANWTPVKEYSEIIFERDDKIAKITMNRPEKHNAFTPVTVAEM
                     INAFNICRDDSTIGVIILTGAGDKAFSSGGDQSVRGNGGYVGPDHIARLNVLDLQHLIR
                     IIPKPVIAMVKGWSVGGGNVLQLVCDLTIAADNAMFGQTGPKVGSFDAGYGSGYLARVI
                     GHKRAKEVWFLNHFYTADEAYQMNWINKVAPLAEVESVTLDWCHEILKKSPTALRFIKA
                     AMNADTDGLAGLQQFAGDATMLYYTTDEGKEGRDAFNQKRDPDFDKFPKFP"
     aSDomain        complement(4200..4928)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg91_5_ECH.1"
                     /evalue="3.90E-63"
                     /label="ctg91_5_ECH.1"
                     /locus_tag="ctg91_5"
                     /protein_end="261"
                     /protein_start="18"
                     /score="204.7"
                     /tool="antismash"
                     /translation="RDDKIAKITMNRPEKHNAFTPVTVAEMINAFNICRDDSTIGVIIL
                     TGAGDKAFSSGGDQSVRGNGGYVGPDHIARLNVLDLQHLIRIIPKPVIAMVKGWSVGGG
                     NVLQLVCDLTIAADNAMFGQTGPKVGSFDAGYGSGYLARVIGHKRAKEVWFLNHFYTAD
                     EAYQMNWINKVAPLAEVESVTLDWCHEILKKSPTALRFIKAAMNADTDGLAGLQQFAGD
                     ATMLYYTTDEGKEGRDAFNQK"
     CDS             5017..5400
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1144:thioesterase superfamily protein (Score: 100.2;
                     E-value: 1.1e-30)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg91_6"
                     /transl_table=11
                     /translation="MNLLENLGIHQDLVTKDRVELSMPVQAKHLQPYGIVHGGINTVLA
                     ETAASLGANANVAPGRIAVGVNVTTQHIRAIREGEIFVVATPDHVGRTLQTWQARLLVN
                     DRLTATATITLMNVPAPTNNHKH"
     CDS             complement(5809..6186)
                     /locus_tag="ctg91_7"
                     /transl_table=11
                     /translation="MTNDINFWTGIKDPYLKPDKPFLTEDKELKIIHLIQSYPMHCPLC
                     GQLMRRNGFRKRPVTIKILTPAGKPAVLKIKKQQYLCPPSPQCPKRVTKVAEIQGVNFA
                     CRIANVVKYHIVQELSESVRN"
     CDS             complement(6399..7157)
                     /locus_tag="ctg91_8"
                     /transl_table=11
                     /translation="MMYEFPRLTAHHIQTTDQPVVTSTNEMAKERLKVKDQPFLISARQ
                     QTAGHGKTSRKFYSPAGSGAYFTLALPFSYLAKSAGQVTVTAAVAAYEVLSKQFTVPIT
                     IKWVNDLYCERKKVVGILAEMEMTANNQPRGIVVGWGINLAAPTAPLPPALQLRAGWLG
                     TTSIDDHQRLQIVDAVAAHFLDLLANASWKHILQVYQAHQYLINKLLLVDTGAERVRGY
                     FDHITDDGWLCVQTDNGPRAFMTGTVRELV"
     CDS             complement(7172..10609)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     betalactone: HMGL-like"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ATP-grasp"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1090:acetyl-CoA carboxylase biotin carboxylase (Score:
                     92; E-value: 5.7e-28)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg91_9"
                     /sec_met_domain="HMGL-like (E-value: 1.1e-36, bitscore:
                     116.3, seeds: 15, tool: rule-based-clusters)"
                     /sec_met_domain="ATP-grasp (E-value: 8.4e-12, bitscore:
                     34.5, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VFKKVLVANRGEIATRIIRDCHELGIKAVAVYAKEDEYSAHRFAA
                     DEAYQIGAGEHPLDAYLDIDEVIRVAKESGAEAVHPGYGFLAENADLAQACIDNGLKFI
                     GPKPEHLRMFGDKLVAKRVAVEAGLQPIPGLSGDVKNVDQVKDFAHQYGYPIMVKAANG
                     GGGRGMRIINDDQQLTDEFDQAKDEALKAFGSDEMYVEKDVQHPKHIEVQVIADEHGHV
                     MHLFERDCSVQRRHQKVIEFALSVVLTPERRVEVCGLAVKLMKSVHYQNAATIEFLATP
                     DHFYFIEVNPRVQVEHTVTELITGIDIVKTQIRVAAGEDLHQDIGLPQQDDLKFHGAAI
                     QCRVTTEDPENNFMPDTGQVTTYDAPGGTGVRLDGNVYPGYKVTPYFDSLLVKCCTRGE
                     DFSDARIKMLRALEEFKIRGVKTNIPFMINVLKHPTFIAGKCSTTFIDENPDLFSFAHR
                     PDTPNQLLQYIGNVTVNGFAGVTKRTKLVLPDMQEPQAGQLTPNQHTTKTAKDILDKQG
                     ADAAMQYVKDQPRVLLTDTTMRDAHQSLFATRMRTHDMLPAMKVYDRAMPNLFSVESWG
                     GATFDVCYRFLGEDPWTRLRLLKKYMPHTLQQMLLRASNAVGYQNYPDNELKRFIEHSA
                     ATGVDVFRIFDSLNWIDQMERSITYVRETGKIAEGTMCFTGDFLSPHEHKYTLDYYMKL
                     AQSLVDAGAQIIGIKDMAGLLKPKAAYELVGSLKAKFDVPVHLHTHDTTGNGVPTYVAA
                     TNAGVDVVDVAMSSMAGTTSQPSLATFYYALEGDKRQPDLNMHNVAVLNRYWSNVRPLY
                     NDFSNGVNAPQPDLYQTEMPGGQYSNLKQQAQSLGINDFSLVEEKYREVNQLLGDIIKV
                     TPSSKVVGDMAIFMIQNHLDKDNILTKGQRVDFPESVVNFFAGDLGQPYRGFPKDLQKV
                     VLKDHPAITVRPGSLAKPVDFAAVKQELAAKINQEPSEDDLQGYIMYPKVFTTYFRNHQ
                     RYGEVMDLDTTTYYQGMRPGEILHVKYGQGKEMIIKLDFVSAPDDDGDRFLFFELDGRI
                     LKIKVKDNSMKDKVVSVSKADPDKSNEIGMPLNGNVVKVNVAEGDQVKVGDVLVVTEAM
                     KMESAVKAPFTGKVTKVYAKVGDALKSQDLLLTLTEDA"
     CDS             11310..12254
                     /locus_tag="ctg91_10"
                     /transl_table=11
                     /translation="MTRKVAVVGMGHVGATVAHYLVAGGFTDDLALYDTNEAKVRADAL
                     DLRDAMANLPFHTNLTVNDDSQLADCDVVISTLGKSKLVDTPDHDRFAEFKFTRTQVPL
                     VAKKLVDNGFHGKLVDVTNPCDVITSMYQKLTGLPKNHVMGTGTLLDSARMRACVGEAL
                     HVDSRSVVGFNLGEHGNSQFTAWSTVRVLGKRVLDLVDERHLDLTDMEERARQGGYMVY
                     KGKKYTNYGVATAAVRLTNALLSDARTEMPVSNYREEYGTYLSYPAVVGRDGVVEQLHL
                     DLTAAEKEKLATSAKYIKDRLSAEEQRAAQQDA"
     CDS             12621..12893
                     /locus_tag="ctg91_11"
                     /transl_table=11
                     /translation="MVIDTHTEIYDLLREYERTCVTITFKDGTSKKIFFLDVDDEYQEN
                     DVRPEKDCIVYNITDSISYGNGIPLDKLRSSPKCWCKLNSANLSFH"
ORIGIN
        1 catcagaagg gtgcttgctc acaagctact gactttagtc agtggtggtt gactttgcgt
       61 atgttagata gaaaacgtgg tcaataacca caggcctagt gtctaagccg gccgaagaac
      121 gatgcgttcc gcccctagct tagtcatacg acctgccaag caagttattt gccactccct
      181 tttaattagt cgatatcgtt gcaaattacg accggcttga ttaagtccgc cgacttgtgg
      241 tgcatcagtt cgatggcgtc cggaatcttc tcgaagcctt cgaagcgatg ggtgatcatt
      301 agtgatggat cgatccggcc gttcaccacg aggacggcca gcttttccat ccgcaggcgg
      361 ccaccaggca tcaggccacc gtggatggtc ttgtgaccca tcccaacacc ccagtcaccg
      421 gcgttgaaga ccacgtcgtc gtgaccgttt aagtagttaa cgttcccgat tgagccaccc
      481 ggcttgagca tccggacggc ttcttcaaag gtgtccttgg cgttcccacc ggcgatcagg
      541 accttgtcga ccccttggcc accagtggct tccaggattt ggtcggaaat ccggccgttg
      601 tggtagtcaa tgatgtcggt tgcgccgtac tttttagcca cttcgaccgt cttttcccgt
      661 gaaccaaccg caaagacgcg gccagccccg tggagcaccg ccccgcgcag ggccatcaag
      721 ccaaccgggc cgatcccaat cacggcgacg tcatccccaa aggtcacgcc cgccatttcg
      781 gaagcgtgga ggccagttgg gatcatgtcg gaaagcatgc aggcctcggc cgggtcaatt
      841 tcatccggta ggtgagccag gttcccgtcg gcgtcgttaa cgtggaaacg agtggcgaag
      901 accccgtcct tgatattaga gaacttccag ccgcccagca tcccgtcgga atcagtggcg
      961 tagccagctt gggagtaaac gtcagaccag tttggcgtga tcgccggaac gagtacccgg
     1021 tcacccggtt taaagtcctt gacgtcttca ccgacttcca caaccacccc gcaggcttcg
     1081 tggccgagaa tcatattctc ccgtggccct aggcatcttc aaacacggtg tggatgtcag
     1141 aagtacacgg ggcaacggct aggggacgta ccagggcgtc acggctgccc accttgggat
     1201 cttctttttc aataaagccc gtcttgttgg ggcccagcat tgcaaaacct ttcattcata
     1261 actaccacct ttcttgatta gttgccgtca ttctaacata aatcatgtta taaccaagtc
     1321 ttcatatgtg agtttaatta attttaaaga aagcgtccac attctctgaa agggttaaaa
     1381 taacagggat tatgatagtt aagaaattga tttgaaataa ataaaatgac tgtgataatc
     1441 ccgtacgagg tcaccacagt cattaatcat tctataatta gcggattatt tagcttttaa
     1501 attcccaatg aagagggacg ccaccccggc caccaaggcg gagatgacca ggccgaagaa
     1561 ggccgtgtcg tatgaaccgc tcaactgaac gatccagccg attaagaggg gaccgaagaa
     1621 gcccccgagt tggccaccaa agttaatcgt cccgatctgg gagccataag tcttttgcgg
     1681 gaagagttgg gccgcgtagg agaagatccc ggtgaaggct agcgacttga cgaagtaggt
     1741 ggccatttgg aagatcacta accaaaccag gctggtggac ttgtagagtc caaacatggt
     1801 caggaccgtt aaaaaggagg ccaggataat catcaggcgt tcgtgatttt taaagatgtg
     1861 caccattacg taaccggaaa tcaaggccgc aatccccccg gcaatcgtcg gtaggggaac
     1921 taaccaagcc aagttggcta agttgatgtg gcgggcgttt aagaagtaaa ccggcatcca
     1981 ggtttccatc cccttggtga taatgtttaa ggccagcccg atcaccacga aggcccagac
     2041 ccgcgggtcg atttccttcc agtttatctt ttgccgttct tgtttcgtta ccgtttgtcc
     2101 accgccgtga ccgcggaaga agaggtagct gaccatcaag agtaggccaa agccccccaa
     2161 ccagaagaag gccgagcgcc aaccggtagc ggcgatgatt ggcacgatga tgaaaggggc
     2221 cagggccgcg ccggcgtagt tagaggaaat taaggcggcg gtcagttggg cacgcttgtt
     2281 gaccgggaag tcctgggcga cttgcttcat ggcggccggt gggtaagggc cctcggcgat
     2341 cccaaacagg aaccgaatta ccaagagggc ggctaaggac caggccagcc cggtaaagat
     2401 cgtcatcacc gaccaaaagg cgagggtggc gatgatcacc ttacgggaag agaagcggtc
     2461 ggtcagccag ccccccggga tttgcatgat cgtgtagccc aagaagaaga cggaactagt
     2521 cgcccccagt gcggccgggc taacggagaa atccttgccg atcgcggcca acgataagtt
     2581 aagcacggtc cggtcggcga ataagagcat gtaaccaagg tataaaatca caaaggaacc
     2641 gagcgacagc gcccggcggt tgggttttgc atccatcatt tatttgtatc tttcttttct
     2701 caattgatta ttctgttgtg gcatgactaa gcgttagcga ccaggtcttg taagcgaaac
     2761 ttttggacct tgccgctggc gtttttcggt agggcgtctg tttgcaagta gaccttgggt
     2821 accttatagt gggccaggtg ttcacgcccg aaggcctcca actgctgaaa gtcgacgggt
     2881 tgtttgctga cgaccacggc cacgggaacg gcgccccact gttgatcatt acggccgacc
     2941 acggcaattt cttggatgcc tgggtactgg cgcaagacgt tttccacctc ggcggggaaa
     3001 atgttttcgc ccccggagat gatcatttca tctaaccgtc cgtcgacgta caagaaaccg
     3061 tcttcatcaa agtggccgac gtcgccggtt cggtaccagt cgccatcgtg cttagccgca
     3121 aacttggccg gttggtttaa gtaacccggg gttaaggccg gggtctggat ctcgatttcg
     3181 tgatgctcac ccaccaaacg cagctgggtg gtaaacaggg gcttaccgac cgaaccaagg
     3241 tggtaaggcg cctcttcagc cgagagggca acgaactgcg agcaagtttc ggtcatcccg
     3301 taacactgga caatcggcag cccactttct tcgcaggcgt taagggtcgc ccggtcaatc
     3361 gtcccaccgc cgagtagcac caggcgaaag gccgatgagt aacagtggtc atttgcttgg
     3421 acgtcttcga gcatcttctt tagcatgtag ggaacggccg aaatgatcgt aaccggttcg
     3481 tcctccagga tttggttgac cacttgcgca tcgaaatggt tgactaggcg aacgcccatc
     3541 ccgtaaatca ggccccgcat tagaattgaa aagcccgaaa tgtggaagat gggggcgacg
     3601 cacaaccaga ggtcgtttgg caacaccccg aggttcaaag atgacgaaat ggcggaggcc
     3661 aagtggttgc cgtaggtttg caagacgccc tttggctgac cggtggttcc cgaggtgtac
     3721 atgatcgagg ccacggcgtc taggtcaacc gtcggcgtca acactgccgc cggggcagtg
     3781 ccggctgtca attccgaaca gaggacccgg tgcccaccgt aatagcggtc ggctagttgg
     3841 tcatcgacta agactaggtc gagccccgcg tcgccgattt ggcggctcag ttcttcaggg
     3901 gcaaggcgcc aatttagcca aacgatggtc ttgtcggcgg ctaagacccc cagggcggct
     3961 aagtaaccag ccaggttatt gtgggtcatc accccaaccc ggggctggtc cgtctgcgct
     4021 tgaatctggc cagcacggtg ggcgaccagg ggaaccagct gggcaaaggt gtaggcggtg
     4081 gtaccgtcgt taaccgccac ccggttaggg tttagcgaag cctgtttgag gagccaattt
     4141 ggaatctcca tgacggcctc ctacgggaac ttcgggaact tatcgaagtc ggggtcgcgc
     4201 ttttggttaa aggcgtcgcg cccttccttt ccttcgtcag tcgtgtagta aagcatcgtg
     4261 gcgtcaccgg caaattgttg aagccccgct aaaccatctg tatcggcgtt catggccgcc
     4321 ttaatgaagc gaagggcggt cggtgacttc tttaagattt catgacacca gtctaaagta
     4381 actgattcga cctcagctag gggcgccacc ttgttaatcc agttcatttg gtaagcttcg
     4441 tcagccgtgt agaagtggtt taagaaccaa acttccttgg cccgcttgtg gccgatcacc
     4501 cgggctaggt aacccgagcc ataaccggcg tcaaaggaac ccaccttcgg ccccgtttgc
     4561 ccaaacatgg cgttatcggc ggcgatcgtc aggtcacaaa ccagttgtaa gacgttcccg
     4621 cccccgactg accagccctt gaccatggca atcaccggct tggggatgat ccgaatcaag
     4681 tgttggaggt ccaaaacgtt gagccgggcg atgtggtcgg ggcccacgta acccccgtta
     4741 ccccgcacgg attggtcacc accggaagaa aaggccttat cgccggctcc ggtaagaata
     4801 atcacgccaa ttgtgctatc atcacgacag atgttaaacg cgttgatcat ttcggcgacc
     4861 gttaccgggg tgaaggcatt gtgcttttcc ggccggttca ttgtaatctt ggcaatctta
     4921 tcgtcgcgtt caaaaataat ttcggaatac tccttaacgg gggtccagtt agcactcgtc
     4981 ataacaaact cctttacaaa atccagaggt acaaaaatga atttacttga aaacttaggc
     5041 attcaccagg acttggtgac caaagaccgc gttgaactct ccatgccggt ccaagcaaag
     5101 cacttgcaac cgtacgggat cgttcacggc ggaattaaca ccgtgctggc ggaaaccgcg
     5161 gcctccctag gggctaacgc caacgtagcg ccggggcgaa tcgcggtcgg ggtcaatgtt
     5221 accacacaac atatccgtgc gatacgggaa ggggagattt ttgtggttgc aacccctgat
     5281 cacgttggtc gcacacttca gacctggcaa gcccggctac tggttaacga ccgattaacg
     5341 gctaccgcaa ccatcaccct gatgaacgtc ccagcaccaa ccaacaatca taaacattaa
     5401 ttcacaaatt ggctactatt atgcttagaa agttgccggg tgaccattgg gggattacct
     5461 aaatcacatt ttttaatttt atattatgta aatcaatcga gaagtcgtcg gctaactgtt
     5521 atgaaagggg cgccactacg cagtcgattt aagttggccc cgattttgta ttagtgttgc
     5581 aaccagtacg caaaagcaca cataatttat cgaggggagg accagatatg aggaaatggt
     5641 gggtggaatt gaaactggtc gtcttttgca tcgccgctct tttcaggtaa ttactctaac
     5701 ggcgctaatt agacttactt ctgtaaattt acattatgta aagatatcgt ttgatgatta
     5761 aagaagcctc aaaggccctc cgaggatgac aatacagatg ttcaagactt aattacgtac
     5821 gctctcactg agttcctgaa caatatggta tttaacgaca ttcgcaattc gacaggcaaa
     5881 attaactcct tgaatctcgg caaccttggt aactcgcttg gggcattggg gcgatggtgg
     5941 acagagatac tgttgtttct tgatttttaa gacagctggt tttccagccg gtgtaaggat
     6001 tttgatcgtt acgggccgct tacggaagcc attacgacgc atcaactggc cgcaaagcgg
     6061 acagtgcatg ggataagact gaattaaatg gataatcttt agttctttat cttcagttaa
     6121 aaatggtttg tcaggtttta agtaaggatc cttgattcca gtccaaaaat tgatatcatt
     6181 agtcatgagg aatatatcct ttctaagaca actgagtggt tatggggata acttaagaca
     6241 gttgtctttt tttattttta aatcaatggt acagcaagta acaaaaaacg gtaaagacaa
     6301 gaaatcatct tatccttacc gaatatcata gaaccttcaa ggataactgc ggtcaaaaca
     6361 cgtccgcgtt tgtccaagaa ggactgcttt tttaattact aaaccagttc ccgaaccgtc
     6421 cccgtcatga atgcgcgggg cccgttatct gtctgcacac ataaccagcc atcatccgta
     6481 atatggtcaa agtatcccct aacacgttcc gctcctgtat caacgaggag cagcttgtta
     6541 ataaggtatt gatgagcctg gtaaacctgc aggatgtgtt tccaggacgc gtttgctaac
     6601 aggtcaagga agtgcgcagc gactgcatca acgatttgta gccgttgatg gtcatcaatt
     6661 gaggtggtgc cgagccatcc cgcacgtaac tgaagtgctg gcggcaaggg agcagttggt
     6721 gccgccaggt taatccccca gccgaccact attccccgcg gctgattatt cgcggtcatt
     6781 tccatttcag caagaatccc caccaccttc tttcgctcac agtacaggtc gttcacccat
     6841 ttaatagtaa tgggaacagt gaattgcttg ctgaggactt cataagcagc gaccgcggca
     6901 gtcaccgtta cctgaccagc actttttgcc aggtagctaa agggtaaggc aagggtgaag
     6961 taggccccac ttcccgcggg tgaataaaac ttccggctgg tctttccgtg gcctgccgtt
     7021 tgctgccggg cggagatgag aaagggctga tctttcacct ttaaccgttc ctttgccatt
     7081 tcgttagtcg aagtgaccac tggctgatcg gttgtctgga tatgatgtgc tgtcagtcta
     7141 ggaaattcgt acatcattgc tactctcctt atcaagcatc ctcagtcaat gttagtaaga
     7201 ggtcctgact ctttaacgca tcgccaacct tagcgtatac tttcgtcacc ttaccagtaa
     7261 atggcgcttt aactgctgat tccatcttca tcgcctcagt aacaaccaga acgtcaccaa
     7321 ccttgacctg gtcaccttct gctacgttaa ccttgaccac gttcccgttc aacggcatcc
     7381 cgatctcatt actcttatcg ggatcagcct ttgaaacact gacaaccttg tccttcatgc
     7441 tattgtcctt aacttttatt ttaaggatcc gcccgtccag ttcaaagaag aggaagcgat
     7501 caccgtcatc atctggtgct gaaacaaagt cgagttttat aatcatttct tttccctgac
     7561 catacttaac atgcaaaatt tcaccaggac gcataccttg atagtaggtc gtggtatcaa
     7621 ggtccatcac ttcaccgtac cgctgatggt tgcggaagta agtggtaaag actttcggat
     7681 acatgatgta accctgcagg tcgtcctcgc tcggttcctg gttgatcttt gcggccagtt
     7741 cctgcttaac ggcggcaaaa tcaaccggtt tagcaaggct cccgggccga accgtgattg
     7801 caggatggtc cttcaagaca accttctgta ggtccttggg gaagccccta tatggttgac
     7861 caaggtcgcc agcaaagaag ttaaccactg attctggaaa gtcgactcgt tgcccctttg
     7921 tcaggatatt gtctttatca aggtggtttt ggatcatgaa gattgccatg tcgccaacca
     7981 ccttcgagct tggcgtcacc ttgatgatgt caccgagcaa ctgattgacc tcccggtatt
     8041 tttcttccac caggctaaaa tcattgattc ctagtgactg ggcctgttgc ttcaggttcg
     8101 agtactggcc acctggcatt tccgtctggt ataggtctgg ttgcggtgcg ttgaccccgt
     8161 tgctgaagtc gttgtaaagc ggccggacat tggaccagta ccggtttaag accgccacgt
     8221 tatgcatatt aaggtccggt tggcgtttat ctccttctag cgcgtagtaa aaggtggcta
     8281 aactaggctg actggttgtc cccgccattg aagacatcgc cacgtccacc acgtcaacac
     8341 ccgcatttgt ggcggcaacg taggttggaa ctccattacc cgttgtgtca tgagtgtgga
     8401 ggtgaacagg aacatcaaac ttagccttca aactaccgac tagttcgtaa gcggcctttg
     8461 gtttcaagag gccggccata tccttaatac caataatctg cgctcccgcg tcgactaatg
     8521 actgtgccaa cttcatgtaa taatctaggg tgtacttgtg ctcgtgagga ctaaggaagt
     8581 cgccggtaaa gcacattgtt ccttcggcga ttttgccggt ttcccgaaca tatgtaatgc
     8641 tacgttccat ctggtcaatc cagttgaggg agtcaaagat ccggaaaaca tccaccccgg
     8701 ttgcggcact gtgctcaatg aaccgcttca gttcattatc cggataattc tggtaaccga
     8761 ccgcgttcga cgcccgcaac aacatctgct ggagagtatg tggcatgtac ttcttcaata
     8821 atcgtaatcg ggtccacggg tcttcaccaa ggaaccggta gcacacgtca aaggttgccc
     8881 cgccccagct ttcaacagaa aagaggttag gcatcgcccg gtcgtaaacc ttcattgcgg
     8941 gcaacatatc gtgcgtccgc atccgagtgg caaaaaggct ttggtgagca tcacgcattg
     9001 tggtatcagt cagtagtacc ctcggctggt ccttaacata ctgcatcgcc gcatcggctc
     9061 cctgtttatc caggatgtcc tttgctgttt ttgttgtatg ctggttaggt gtaagttggc
     9121 ctgcttgtgg ttcttgcatg tcaggcaaaa caagtttggt ccgcttggtt acccctgcaa
     9181 agccattgac ggtaacattg ccaatatatt ggagcaactg gttaggcgta tcgggccggt
     9241 gcgcaaagct aaagaggtcg ggattctcgt cgataaacgt tgtcgagcat tttccggcaa
     9301 taaacgtggg atgctttaac acgttgatca tgaagggaat attagttttg actccccgaa
     9361 tcttgaattc ttcaagcgcc cgcagcatct taatccgggc atcactgaag tcttcacccc
     9421 gggtacaaca cttaacgagc aaggaatcaa agtaaggagt gaccttatag ccgggataga
     9481 cgttcccgtc aagccggaca ccggttcccc ctggcgcatc ataggtcgta acctgtcccg
     9541 tatctggcat aaagttattc tcgggatctt ctgttgtgac ccggcactga atggctgccc
     9601 cgtggaactt gagatcgtct tgctggggaa ggccaatatc ttgatgaaga tcttcaccgg
     9661 ccgcaacccg aatctgggtc ttaacaatat caatcccagt aatcaactcg gtaacggtgt
     9721 gttcaacctg cacccgggga ttaacctcaa tgaagtaaaa atgatccggg gtcgccaaga
     9781 attcgatcgt cgccgcattc tggtagtgaa cactcttcat cagcttgacg gccaggccac
     9841 aaacttcgac ccgccgctca ggggtcaaga caacgctaag tgcaaattca ataaccttct
     9901 ggtggcggcg ctggacagag cagtcacgtt caaagaggtg catcacatgc ccgtgctcat
     9961 cagcaattac ctgcacttca atatgcttcg ggtgttggac gtccttttcg acatacatct
    10021 catccgatcc aaacgccttc agcgcctcat ccttcgcctg atcaaactcg tcggtgagtt
    10081 gctggtcgtc attgatgatc cgcatccccc gaccgccacc accattagca gccttaacca
    10141 tgatcgggta accatattgg tgagcaaaat cctttacctg gtcaacattt ttaacatccc
    10201 ccgataaacc gggaattggt tgcagccctg cctcaacggc cacacgttta gcaaccaact
    10261 tatccccaaa catacgaagg tgttccggct taggtccaat aaactttaat ccattatcaa
    10321 tacaggcctg cgcaaggtca gcgttttctg ccaggaagcc ataaccaggg tgaacagctt
    10381 ctgccccgct ttctttggcc acccgaatta cttcatcaat atccaggtaa gcatcaagcg
    10441 gatgttcacc agccccgatt tggtacgcct catcagcagc aaagcggtgc gcactatact
    10501 catcctcctt agcataaact gcgacggctt tgattcccag ctcatgacag tcgcgaataa
    10561 tccgtgtagc aatttcacca cggttagcaa ctaaaacttt tttaaacaca attatccacc
    10621 atccttttta ttaatccttc acgcccatca cgtcattact attggcggtg agggtggctg
    10681 tatttgtaga aatattaata ttaccaacca ttgcactcac ctcctcattt ttctaatcaa
    10741 attttaaaac aaactataat caatctaagc taacgtgtca ataatttttc ctcaagaaat
    10801 gcccgctatc aaacgaattt atactataaa ttatctgcct ttgcacccat cttttctcat
    10861 ctttttttaa tttttatctt gacttcccta tctgcctagt gatatagtac ttaacaatca
    10921 attgaaacaa gttaaagacg ttgagcgaga aacagcgatg aggccgaagc aagagagctg
    10981 gtgggtggtg tgaaccagtg agaggccgca cctactaatc actcgtgagt cgtacgccga
    11041 acggattccc tagtagagcg tattggtagc acccattacc gtgccggcta ataccacatt
    11101 atttgtggcg gttggttgag gcgacattat gtcgtaaaga aaggtggtac cacgcacaag
    11161 cgtccttttt agttcttaga tttatcaaga gctagaaagg acgctttttg ttttgatatt
    11221 aaaggtggtg gtgatcatgg cagacagtga tatttctgac attagtaaga ttaaaggcaa
    11281 caatacgata atcgaaagga agttttatta tgacaaggaa agtagcagta gttggaatgg
    11341 ggcacgttgg cgcaactgtc gcccattatc tcgttgctgg tggattcact gatgatttag
    11401 ccctctatga tactaacgaa gcaaaggtcc gtgccgatgc gcttgacctc cgtgacgcca
    11461 tggcgaatct cccgttccac acaaacttaa ccgttaatga tgattcacaa ttagctgact
    11521 gtgacgttgt aatctctact ctgggaaagt ctaagctggt ggacacaccc gatcacgacc
    11581 gctttgcaga atttaaattt acccggactc aggttccatt ggtcgctaag aaactcgttg
    11641 ataacggttt tcatggcaaa cttgtcgacg ttaccaatcc ctgtgacgtc atcacttcaa
    11701 tgtatcagaa gctcacgggg ctaccaaaga atcacgtgat gggtacgggg accctgctag
    11761 actccgcacg aatgcgcgca tgtgttgggg aagccctcca tgttgactca cgatccgtgg
    11821 tcggcttcaa tcttggtgaa cacggtaact cccaatttac tgcctggtca acagtccggg
    11881 ttctcggcaa acgagtacta gatctggtgg atgaacggca cctcgacctt accgacatgg
    11941 aagaacgcgc acggcaagga ggctacatgg tctataaggg aaagaagtat accaactacg
    12001 gtgttgctac tgccgcagtc cggcttacca atgccctact aagtgatgcc cggactgaaa
    12061 tgccagtttc aaattaccgt gaagaatacg gaacgtacct ctcctacccc gcagtcgttg
    12121 gtcgtgacgg ggtggtggaa caacttcacc tggaccttac cgctgctgaa aaagaaaagc
    12181 tcgctacctc tgccaaatac atcaaggatc gcctttctgc agaagaacaa cgggcagctc
    12241 aacaagacgc ctaacttgct ggtattaaat gatctctcct caaacatatc cctaataaag
    12301 caccaacctt attctgtata actgaaactt gaaagctgat aaccatgtca aacaggcgag
    12361 gttatcagct ttcaagtttc agttaattaa tcaacggcgg agccagctta aatagctggc
    12421 ttttattatg cagaaaggag gtaaaaatag ctaaagttca aaacgaaatg gcgacccgga
    12481 tcactgttga tactgtccag gcggctaatt ccatgcaggc aatgcgtcag gctatctcag
    12541 ccaatacgaa tgcatggaag gcaattaaaa atcaaccatt ctgtgacaga atattaagta
    12601 gtactgggga gtgaataaag atggtgatcg acacacatac tgaaatatat gacctcctaa
    12661 gggaatatga acggacttgt gtgaccatta cgtttaaaga cggaacgtcc aagaagattt
    12721 tctttctgga tgttgacgat gaataccaag aaaatgatgt gagacctgaa aaagattgta
    12781 tcgtatacaa tataacggat tcgatatcat atggtaatgg catcccgcta gataaactta
    12841 ggtcaagtcc aaaatgttgg tgtaaattaa attccgcgaa tttatcattt cac
//
