LOCUS       c00007_CABFMJ0..       15789 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  CABFMJ010000007.1 Streptococcus salivarius isolate
            Streptococcus_salivarius_BgEED36 genome assembly, contig:
            NODE_16_length_49594_cov_23598441, whole genome shotgun sequence.
ACCESSION   CABFMJ010000007
VERSION     CABFMJ010000007
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-19 21:36:31
            Original ID  :: CABFMJ010000007.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 33805
            Orig. end    :: 49594
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..15789
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[43805:46430](-)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(10001..12625)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     cand_cluster    1..15789
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..15789
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-iv"
                     /region_number="1"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     CDS             complement(157..1173)
                     /locus_tag="ctg7_30"
                     /transl_table=11
                     /translation="MLIDNLGHSGTSVDFQYAFVDLDKDGQDELLIGKQDYISAIYYLK
                     NSQPTLLHVAYAASVGGARSSLTAYENGQVVFAAWQSSNPEVNLTLYKVEASVPNKQKE
                     TTIQMNDKKKIEDELGISSTALNLKNLKWESIDKGSTTSSKESDMKSSSQSEDIKSETG
                     FQVRVQISDLEIRKEPSAKSQSLGKISQGIHTISETTSAEGYTWGKLQSGQGWIALDYT
                     ERIEGEKKTQLESSSMNIQEIQTGNFSSVKGSWRNAQGNSITFDANGLTQVNGNPAGDV
                     VFDKFAVQGEKFTAVTKTSEGISETPIVFTPRGQDGRESIFWSKNHVSDGTDVYYRE"
     CDS             complement(1246..1488)
                     /locus_tag="ctg7_31"
                     /transl_table=11
                     /translation="VGNQIKTFRGNKYIERAGEFNMKKWILISFLSLSTLTLVACGSNQ
                     MKQVTQQSSSSSKQELKKNSQEAFQTVLDRYKSYQ"
     CDS             complement(1672..2034)
                     /locus_tag="ctg7_32"
                     /transl_table=11
                     /translation="MKKVLIIVSVVVIALAGIGVGAYFLTREKSPEQQVVGTWYDGEND
                     VTIELKSNKSLKITKESGESRTGTWRIAGDKIKFTATSGPKAEGELSSGKIESIFFEFT
                     NTNVSYALHDATYEKQ"
     CDS             complement(2183..5254)
                     /locus_tag="ctg7_33"
                     /transl_table=11
                     /translation="LKIKGVLALMEKKEAIKVLASVSTVIAATGLTSVANANQQEALKT
                     EVDALSSKVTVQALKEAENKQSVAVQAVNAQQDIVKQAITEEEKAGKTEATAKEGLDEA
                     QIIKDKATPAEIDKTKQNISETESAIENQDVQLLNAQAETAKAQDKVNKQTEIVNSDQA
                     EITTQETNVANAKTNVEIAQKNLDGTGAKEIISERDNAQTDLAAKKDAETNAKSKLEEA
                     QKADADKKAKLEQAEKDEKLQAKAVEDTSKTLSDAEAKAKQTKEQLNNANIAVTNAQAA
                     LDGTGAKEIISERDNAQTDLATKKDAEAEAERKLKEAQKTDADKKDKIQALTETLTAQQ
                     NVASRTSTELTAAIAVAADAKSKKEEADKAVKRLEDKLTSLENLSTIEIPEEVASAYRS
                     FYEDKTEANKDKLFDAVQTWWDNRDYSKENNYPADDTVINDLSNLTKEQIANLSLYQAG
                     LIQQVRKTIWGDSEVLVTEDVVTAMKNITTAYSNMSNPDGDHLFSALTNDGTDTTHWKA
                     ENLGYIKAKPTTMSALYKGIYKSIINTFGSDYNQNYAHVITTVGGKPDYKNGKVVPNYI
                     GAATSVTPEGLGLMHEIHFNHTSSDTDKILANPFDSSVVKTQLADAKAVQTSADNANKT
                     AQNRLTTASVANKAAQDAVSNTTKTLNALKAISDLTPDAKAKLDEAIEARKNSETRLNN
                     AQKAVDNLNADVATKTNALVNAKVAQEKADNANKVANEELNSAQAKNKLANEVLSETRN
                     KIAPLKATADLTTDAKVKLAEATSARELAELRLVNAQKAVNNLNSDVETKTKALADAKA
                     TLQNEEAKLDDLKAQKTKDEKELASLQETVNALKANEVKIKDEIKSLQTKLQETKDYLS
                     KLENADSNLEKARAAYKLAVEKHKEAKSILDKETEKFKQLLINKRDAVAQYEAVKEAYI
                     QAQVKAQYEVISQRGDVPVPLLNENGQIVGYNSSFSRDVRTAVRTITDNVVSKHGVPIY
                     QASLPETGEGDTAIYTLSGITFLALAGVMRKKKL"
     CDS             5388..5714
                     /locus_tag="ctg7_34"
                     /transl_table=11
                     /translation="MSNLQEYISKRIRVLRIKEGMTQEMLEEKAELGTNYVYKIENLEP
                     NIKIKTLEKIMKALDVDIPTFFDVTLKEEDSDLVKLIDNLKALPAYKQKKLIKAINTIM
                     TETK"
     CDS             complement(5979..7322)
                     /locus_tag="ctg7_35"
                     /transl_table=11
                     /translation="MFKLIYYQFKYSKKQWLGMFPLFFASSLLVGMCLSVAFSTIKYQQ
                     VFRDVGSPTLLFVGPVLFGGFTLLFLVSGLIRLFLNLAKEDYRQWSINGGSRVQLSLLI
                     SGQLTIFAFLVSIVGSFFSIFCARFYYSYAQYLGGEKLLPTIPIDFSISAFLLTILIIC
                     LLAFIGSFLYLYKILGNAVLLGDRFDSKNHFVVKIIKVLGFAISLGFWLKLLIPFFTVS
                     VNKPNENLLFRLDDSILLILVMHLFLLAFISPHIQIFLTKILLAWRSSYDFVMAKWIIL
                     KDKEYLKSLTVSISIIAILISELMIYSDIAYSNLAKKTASVEINAVLLFFVVGPLVVVI
                     ANLISITVLSSVKEKEENLQWERIGISHKQTVTIRSVQAITYAVIMLISTVFFNIIFFV
                     LMHKEALLLGIKQMNYGTIIYYPIIISIVMYLFVFITKSWFDVKNKAN"
     CDS             complement(7329..8063)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 187.5; E-value:
                     5e-57)"
                     /gene_kind="transport"
                     /locus_tag="ctg7_36"
                     /transl_table=11
                     /translation="MNTVAVEVKHLSKKFQIDKNKDISVLRDISFEANYGEFVSILGVS
                     GSGKSTLLNCISSLSAPTEGVVKVNNCNPYQLKNSRLSKFRREDISFIFQSYNLLPALP
                     VLENVALPLRLSHKKVCRDDIQTLLDKMNFRADLMSSVSSLSGGEKQKVAIARAILSKT
                     RIIFADEPTGALDSTSRKIIFEMLADLAQEGRCVIMVTHDIELASQTDRALILKDGKIY
                     QELFNPTAEALYKALEIENSGD"
     CDS             complement(8060..9982)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_S9"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg7_37"
                     /sec_met_domain="Peptidase_S9 (E-value: 2.3e-35, bitscore:
                     113.4, seeds: 64, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSEKQNYYMEIIENSMKKITDFNSFLFRMGNYWYRYENWNLRDS
                     GIIRRWNAFDKDFVPKKSYNHNYNIQNSHVIFDIDDSLNIFGLKKSMIRSVAITEDGNL
                     LSFIIEDNKNFDLYVYSLLKKRKICYLTNINLESSFFVGSNGVIYCRSDSNHRPSSLYY
                     FSYSTCKEQLIYIETNDARRIRIFQISTGKGNTCMVSSKDFIKGELFLCDLFKEKTLLT
                     PLVIDSIFSDCFDILHLNNRRYFVLYTKDEISINDVETNKIFRTKVQVRNISFLSCVGS
                     TIILGIGEDRKRFLVIRVSLDKERPIFEKNFIKFPQNVQLYENNYSTNMLFFIGEENFN
                     LDLFTYYIENKKIEREFCLSVLDSDPDICYNKEVIWTHSNDYETSIPITLVWKSKKSRS
                     FPRKQKCIFSVYGAYGKNDDVTIDSTILSIIEAGFIFATIHVRGGGFLGGDWYRAGKGL
                     KKWNSIKDFIHGVRYLVDRGFVDEHHLGLISSSAGGIVAGATLNEDNNLFRSMLLFSPF
                     VNPFEALQCRDDPMSKTELFEWGDIRDANVKNYIYSYSPQQNVEKSLGSKTKVISILGA
                     RDPYINNQHVIKWSDSLNSFGVESKVYLNPNAGHGGISESESHILIKILSHFLEIVSSD
                     IERKI"
     CDS             complement(10001..12625)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg7_38"
                     /sec_met_domain="LANC_like (E-value: 4.3e-15, bitscore:
                     46.7, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 1.5e-11, bitscore: 35.6,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYDYSLRHPLFYICNNDSIDTSNRYSVSLPLDWYEIASDPEWVN
                     QYPINGEIERQGWKVHISSDFKSSHEVLNIVAGLCHDENVAFKHLSTEDKFVLRNDKLI
                     DRGYSGKFITCYPHEYQLENFLDKLESNLSGFNGPYILSDKRWKEAPIFLRYGVFREGN
                     IDEPYADLKIDELLVEGKVIRDSREPKFTIVEGLKNPKFIEEWLHSRNIESGSELPFKI
                     DSAIRFSNCGGVYRARLSNENKKMILRESRPYTGLDFTGEYSVDRLLKERQALEKLRNV
                     EGVPKVVWSGKIWENSYLGVQVMEGKSLNDWLIGNFPLYAHSDKDYSYLQRVVKIIVQI
                     MSILEQAHDNNVFHLDIHLGNILVDDFDNVSIIDWEQCTLENRSKVGQKMAAMGFGSWI
                     EDYPSQIDWNGVRQIAHFLFYPLIEQSSLVLDYTVQTTKYGKKLFYSHKYSNDDIARIL
                     QILNDLDDRCTKFDDLSERKKLGCYKGNLEVKDRGEIEEIVRKLLEGLSLVKQEWENVS
                     RSSHVFPVHYYGLNINQGIAYSDIGILMSYQKLLSLANVEPSQFYGEFKQNLINDTYTK
                     LKVNDEEKLGLFDGVAGTLWAIYELGEHDLVNNFIRDNFERLLYESNSNNLYSGKAGIF
                     LVGLYFLSKEPRFRNKEEKIINHLVIFAEEYLDDENFLGEKTFVKQTNDPYENKGGLLY
                     GHLGLGWLFGEAYRFTKKDIFKECLNLSLEREFESYELDSSAGFQYRQEKRLLPYIATG
                     SAGALLVIKRNRAFIESRFLDKIGSLESALEFNFCVFPGLFNGCSGLVLAKYFKDAAGS
                     FVGLKEVIESLYVFLISIGKGLVLAGDGGTKITCDIATGFGGVALALASIQNNKIEFLP
                     SID"
     CDS             complement(12640..14241)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 124.4; E-value:
                     1e-37)"
                     /gene_kind="transport"
                     /locus_tag="ctg7_39"
                     /transl_table=11
                     /translation="MTIKDFFRGIPKYKLIFLVIFMILAGFDGVVMSQVISSVTKFNSK
                     STIQDIVYLLVYGIVFYLFIQLSSMIVSIINNNIIYNLNQYYKKKLVRSMSLSRSANSN
                     TDGILSLLNIDLKLVEEKYFSVILSSLYLIIMGLVSLLYLVYLSPLLAMLFIVCSFLPI
                     LPSIIFGPLLSNATVKFTKSSEDVITNINDFSQGIEEIRTYSAFPSFLERSEALIHDME
                     RDYELLGNKHSFIGFSSAMLSWFSYLIPISIALFLVIKGDLDSTIVIAIFLASDRVISP
                     FRSLSDSLRLIKSTEITRKKLCELIDNKNNIVSKTNLNRPDLYFENVSFSYDKDVISNI
                     SFLIPYGSKVIITGPSGSGKTTLLNLIQGVLIPTEGKIFIKDGEDIKSVAPEIMSRIYQ
                     EPYYFRLSLRDNLLMGEKDIPDTVLYEFLDYVGLKAELGSDCLDNFYGEWGKNLSGGQK
                     QRIEIIRALLHKRKILLVDEGTSSVDYSSAQKIRNIFSKMDNTVFEIAHYYDKQLDQIY
                     THHIRFEDNGVSIETL"
     CDS             complement(14448..14597)
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg7_40"
                     /transl_table=11
                     /translation="MSEEILMLQSMSVEEEINEVNGQRFSTMSNYHCGGANFSLASNHY
                     CRRK"
     CDS_motif       complement(14535..14597)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MSEEILMLQSMSVEEEINEVN"
                     /locus_tag="ctg7_40"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(14448..14534)
                     /prepeptide="core"
                     /locus_tag="ctg7_40"
                     /peptide="lanthipeptide"
                     /predicted_class="Class III"
                     /score="1.30"
                     /molecular_weight="3103.4"
                     /monoisotopic_mass="3101.4"
                     /core_sequence="GQRFSTMSNYHCGGANFSLASNHYCRRK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MSEEILMLQSMSVEEEINEVN"
                     /leader_location="[14534:14597](-)"
                     /alternative_weights="3121.4"
                     /alternative_weights="3139.5"
                     /alternative_weights="3157.5"
     CDS             14833..15402
                     /locus_tag="ctg7_41"
                     /transl_table=11
                     /translation="MVIGTQDKIINSFFKLAERYPKRSSFSIAEIACEAKVSRQAIYQK
                     HFKSYEEIVDFIMQSIDTTINEHFLLFEEHNLSIEVFFSKVIIPELYKYRDWLRCIYST
                     SAIPNWRNYLREKYSNWLLNAPINLSHSFLHNDALSSYIVNCVLSIIETWITEPFPSPP
                     EVFSKQFIELINTPLNNHISPIKHDS"
ORIGIN
        1 atgtcagaaa agttgaattt taaaaaaaca aaataatttt ttttataaag acccacagcc
       61 caaagattat acagaaataa tctacctttt gaagtatatt aaaagagccg ctaatgaaaa
      121 gcgactcttt tgtgattcaa taaaatgact agtcttctac tctctataat aaacatccgt
      181 accatcactg acatgatttt tactccaaaa aattgactct cttccatctt gtccccttgg
      241 agtaaacact attggtgtct cactaatacc ttctgatgtt tttgtaacgg ctgtgaactt
      301 ttctccttgg acggcaaact tatcaaaaac tacatcaccc gcaggattac cattcacttg
      361 ggtcaagcca ttggcatcga aagtaatact attaccttgt gcatttctcc aagatccttt
      421 aacacttgaa aaattacctg tttgaatttc ttgaatgttc atactactag attccaattg
      481 agtttttttc tcaccttcta ttcgttccgt ataatcaaga gcaatccatc cttgaccaga
      541 ctgtagtttc ccccaagtgt aaccttctgc acttgttgtt tccgaaatag tgtgaatacc
      601 ttgagatatc ttgccgagag actgagactt tgcactaggt tctttgcgta tttccaaatc
      661 cgatatttgc acacgaacct gaaaaccagt ttctgactta atatcctcac tctgactaga
      721 agatttcata tcactttctt ttgaagaagt cgttgaaccc ttatcaattg attcccactt
      781 taagtttttg agattcaaag ccgtagacga aatacctagt tcatcttcga ttttcttctt
      841 atcattcatt tgtatcgtag tttctttttg cttatttggg acactagctt caactttgta
      901 taaagttagg tttacttccg gattcgatga ctgccaggca gcaaatacca cctgaccgtt
      961 ttcataagca gtgagagatg aacgtgcccc accaacagag gctgcataag ctacatgtaa
     1021 caaagtgggt tgactatttt ttagataata gattgcagaa atataatctt gtttaccgat
     1081 taataactcg tcctgtccat ctttatctaa gtctacaaac gcatattgaa aatcaactga
     1141 cgttcccgaa tgccctaaat tatcaatgag catatattcc tcagatgtag cttcgatctg
     1201 ttttaaggct tcagataaac gactatcatc accactattt attgcttatt gataagattt
     1261 ataacgatct aagaccgttt gaaatgcttc ctgactattc ttctttaatt cttgcttact
     1321 agacgaagat gattgctgtg ttacctgctt catttgatta gagccgcatg caaccaaggt
     1381 caaagtactc agacttaaaa acgatatcag tatccatttt ttcatattaa attctcctgc
     1441 tctttcaata tatttatttc ctctaaatgt tttgatttga ttacccacca ctactcatta
     1501 gcaaattttc tacaacttaa cattgatcaa actaaaatat agggtagaaa tagttagtaa
     1561 atctttcaat aagtcaatat taattggaag attctatatg caaaaactat ttcagcaaaa
     1621 taggactccg ttgaagagta caatgaatct tcataagagt cctataacta tttattgttt
     1681 ttcataggtg gcatcgtgaa gtgcataact cacattggta ttagtgaatt caaagaaaat
     1741 agattcaatc tttcctgatg aaagttcacc ttcagctttt ggaccacttg ttgctgtaaa
     1801 cttaatttta tcacctgcaa tgcgccaagt acctgttcta gattcaccac tttctttggt
     1861 aattttcaga ctcttatttg atttcaactc aatcgttaca tcattttcac cgtcgtacca
     1921 agtccccaca acctgctgct ctggcgactt ttcacgggtt aagaaatatg ctcctacacc
     1981 aatacctgct agtgcgatta caacaacaga aacaataatt aatacttttt tcattatata
     2041 ttctcctatt tattattaat aaaacttatt tttttattct caacatctct agaatatgga
     2101 agtaattgtg attgaattaa ggcagtgatt ctttagttat gtcataactt ctcactcagt
     2161 aaagcaattt agaaactgta atttataact tcttctttct catcactcca gctagagcaa
     2221 gaaacgtaat tcctgaaagc gtataaatcg ctgtatcacc ttcacctgtt tcaggtaatg
     2281 atgcttgata gatcggtacg ccatgtttcg aaacgacatt atcggtaata gtgcgaacag
     2341 cagttctgac atctcgggaa aatgaagaat tataacctac tatttggcca ttttcattaa
     2401 ggagaggaac gggaacatcg cctcgttgag aaatgacttc atattgagct tttacttgag
     2461 cttgtatata agcttctttt acagcttcat attgagctac tgcatcacgt ttattgataa
     2521 gcaactgttt aaatttttca gtttctttat caagaattga tttggcttct ttatgttttt
     2581 ctactgctag tttataagct gctctagctt tttctagatt actatcagca ttttctagtt
     2641 tgctaagata atcttttgtt tcttgaagtt tagtttgaag agatttaatc tcgtctttga
     2701 ttttaacttc attcgctttc aaagcgttca ctgtttcttg aagagaagca agttcttttt
     2761 cgtctttagt tttttgagct ttaaggtcat ccaacttagc ttcttcattt tgaagtgttg
     2821 ctttagcatc cgcaagagcc ttagtcttag tttcaacatc tgagttaaga ttattaactg
     2881 ctttttgagc attgactaat cttaactcag ctaattcacg cgccgaagtc gcttcagcca
     2941 attttacttt agcatcagtt gtgaggtcag cagttgcttt gagtggagca attttattgc
     3001 gagtttctga aagtacttca ttagcaagtt tatttttagc ctgcgcagaa tttaattctt
     3061 cattagcaac tttgtttgca ttgtcggctt tttcttgtgc tactttcgca ttgacaagag
     3121 cgttagtttt agtagcaaca tcagcgttaa ggttgtcaac tgctttttga gcgttgttca
     3181 aacgagtttc agagttctta cgtgcttcaa ttgcctcatc caacttagct ttggcatcag
     3241 gtgtgaggtc agaaattgct ttgagtgcgt tcaaagtttt tgttgtgtta gatacagcat
     3301 cctgagctgc tttatttgct actgatgctg tagttaatcg gttttgggct gttttgttag
     3361 cattatctgc agaagtttga acagctttag cgtcagctaa ctgagttttt acaactgaag
     3421 agtcaaatgg attagctaat attttatcag tatctgacga agtgtgattg aaatgaattt
     3481 catgcatcaa tccaagacct tctggtgtta cgcttgttgc agcaccaata taatttggaa
     3541 caaccttacc gtttttatag tcaggttttc ctccaactgt tgtaatgaca tgtgcataat
     3601 tctgattgta gtcactacca aaagtattga taatagattt ataaatacct ttatacaaag
     3661 ctgacattgt agttggttta gctttgatgt aaccgaggtt ttctgccttc caatgcgtag
     3721 tatcagttcc atcattagtt agagcactaa aaaggtggtc accatcagga tttgacatgt
     3781 tcgaataagc agttgtgata ttcttcatcg ccgtaacaac atcttctgtt acaaggactt
     3841 ctgaatcacc ccagatagtt tttcgcactt gttgaatcaa gcctgcttga taaagtgaga
     3901 ggttagcaat ttgttctttt gttaaattgc taagatcgtt gattacagta tcgtcagcag
     3961 gatagttgtt ttctttgcta taatcacggt tatcccacca agtttgaaca gcatcgaaga
     4021 gcttatcttt gtttgcttct gttttatctt catagaagct tcgataagca cttgcaacct
     4081 cttctggaat ttcaatagtg ctaagatttt ctaaactagt tagtttatct tccaaacgtt
     4141 ttacagcttt gtctgcttct tcttttttag acttagcatc agccgcaaca gctatagcag
     4201 ctgtcaattc tgttgaagtt ctcgaagcta cattttgttg agctgtcaaa gtttctgtca
     4261 atgcttggat tttatctttt ttatcagcat cagttttttg agcttctttc aactttcttt
     4321 cagcctctgc ttcggcatct tttttcgttg ccaaatcagt ttgagcattg tctcgctctg
     4381 agatgatttc tttagctcct gtaccatcaa gtgctgcttg agcattagtt acagcaatat
     4441 tagcattatt gagttgctct ttagtctgtt ttgctttagc ttcagcatca ctcaaagttt
     4501 tagaagtgtc ttcaacagct ttagcttgaa gtttttcatc tttttcagct tgttcaagtt
     4561 tagctttttt atcagcgtca gctttctgtg cttcttctag cttgctttta gcattagttt
     4621 cagcgtcttt tttcgctgcc aaatcagttt gagcattatc tcgttctgag atgatttctt
     4681 tagctcctgt accatcaaga tttttttgag caatttctac attggtttta gcatttgcta
     4741 cattagtttc ttgagtagta atctctgctt gatcactgtt aacaatttca gtttgtttat
     4801 taactttatc ttgagcttta gcagtctcag cttgagcatt gagaagttga acgtcttgat
     4861 tttcgattgc tgattctgtc tcactaatat tttgtttagt tttatcaatt tcagcaggag
     4921 tggccttgtc tttgatgatt tgagcttcat caagaccttc cttagccgta gcttcagttt
     4981 tcccagcttt ttcttcttca gtgatagctt gcttaactat atcttgttga gcgtttactg
     5041 cttgtaccgc tacactttgc ttattctcag cttctttaag agcttgaaca gtcactttag
     5101 aacttaaggc atcaacttct gtttttaggg cttcttgttg attagcattc gcaacagacg
     5161 ttaatcctgt cgctgcaatc actgtagaga cactagctaa tacctttata gcctctttct
     5221 tttccattaa cgctaaaact ccttttattt tcaataaatt atacaattcc tatattgtaa
     5281 tgtttacatt atataactta aaaacaacct tgtaaagttg tttttaacct tttaaggtgt
     5341 tataaccaac cttttatggt tgtaaaataa accttgcgag gtggtttatg tcaaatctac
     5401 aagaatatat cagtaagcgt attagagtct tacgaataaa agagggaatg acccaagaaa
     5461 tgcttgaaga aaaagctgaa ttggggacaa attacgttta taaaattgaa aatctagaac
     5521 ctaacattaa aatcaaaact cttgaaaaaa ttatgaaagc cttagatgtg gatatcccca
     5581 ctttctttga tgtcacacta aaagaagaag atagcgattt ggtaaaactt attgataatt
     5641 taaaagcgtt gcctgcgtat aaacaaaaga aattaatcaa agctatcaat actattatga
     5701 ctgaaacaaa atagaagaac ctttttgaac tgaacaacta ctttaggtta aaatagaatt
     5761 taagtaaaag acttatctct atattgcata gagataagtc tttttagctt tatttatcat
     5821 tgtgatatac aaaccgattt ttattccata caaaagtaca tccttgtttc agaaatttac
     5881 agatttgtat cttatcttca aaagttaatt tcataataaa aacaccccaa aagttagatt
     5941 tttcctgtct aacttttggg gtgtagttca ataatatatc aatttgcttt atttttaaca
     6001 tcaaaccaac ttttggtaat aaaaacaaac aaatacataa ctatagaaat aataattgga
     6061 taataaataa tagttccata attcatctgt ttgatcccta ataatagagc ttctttatgc
     6121 attaatacga agaatataat attgaagaag actgtgctaa taagcatgat aactgcatat
     6181 gttattgctt gtacagacct aatagttaca gtctgcttat gtgatattcc aattctctcc
     6241 cattgcagat tctcttcttt ttctttgact gaagaaagaa cggtaataga aataagattg
     6301 gctatcacaa ctactaatgg tcccactaca aaaaatagta gaacagcatt tatttcaact
     6361 gatgctgttt tctttgctag atttgagtag gcaatgtcag aataaatcat taattctgat
     6421 attaagattg ctattatcga aatagatact gttaatgact ttaaatactc tttatccttc
     6481 agaataatcc attttgccat tacaaaatca taagacgaac gccaagctaa taaaatttta
     6541 gttagaaaaa tttgaatatg tggtgaaatg aaggccaaca aaaacaaatg cataactaag
     6601 ataagtaaga ttgagtcatc caatctgaat aataagtttt cattaggctt gtttacagat
     6661 actgtgaaga atggaataag caattttaac cagaacccta aactaatagc aaagcctaat
     6721 acctttatta tcttaacaac aaagtggttt ttagagtcaa atctatcacc aagcaaaact
     6781 gcattcccta gaattttata taagtaaaga aagctaccta tgaaagcaag taggcaaata
     6841 ataagtatgg tcaagaggaa tgctgatata ctgaaatcaa tcggtatagt tggtaataat
     6901 ttttctcctc ccaaatattg cgcataactg taataaaatc ttgcacaaaa aattgagaaa
     6961 aaacttccta ctatacttac taaaaatgca aaaatagtaa gttgtccgct aatcaataac
     7021 gacaactgaa ctcggcttcc tccatttatt gaccattggc gataatcctc ttttgctaaa
     7081 ttcaaaaata gtcggattag accggaaacc agaaataata aagtaaatcc tccaaaaaga
     7141 actggcccta caaataataa ggtaggactc ccaacatctc gaaatacttg ctgatacttt
     7201 atggtactaa atgctacaga cagacacatc ccaactaata aactcgaagc gaaaaatagg
     7261 ggaaacattc caagccactg tttttttgaa tacttaaatt gataataaat taatttgaac
     7321 attttaagtt aatccccact attttctatc tctaatgcct tataaagagc ttcagctgtg
     7381 gggttgaaca attcctgata gattttgccg tctttcaaga ttagagccct atctgtttga
     7441 cttgctaact caatatcatg ggtcaccatg atgacacatc ttccctcttg ggctaaatca
     7501 gctaacatct caaaaataat cttccttgac gtactatcca atgcacctgt cggttcatct
     7561 gcaaatatga tacgagtttt tgaaagaatc gctcttgcaa tagctacttt ctgtttttct
     7621 ccaccagata acgaagaaac tgaagacatc aaatcagctc taaaattcat cttatctaac
     7681 aatgtctgaa tatcgtctct acatactttt ttatgggaca atctaagagg caaagctaca
     7741 ttctccagaa ctggaagagc tggaagtagg ttataagact gaaaaataaa actaatatct
     7801 tctcttctaa attttgataa tctactattc tttaattgat aaggattaca attattaacc
     7861 tttacaaccc cttctgttgg tgctgataaa ctcgatatac aatttaacaa ggttgactta
     7921 ccagacccgc ttactcctag tatagaaaca aactcaccat agttcgcttc gaaagaaatg
     7981 tctctaagaa ccgaaatgtc cttattttta tcaatttgaa atttcttaga taagtgtttt
     8041 acttctactg caactgtatt catattttcc tttctatatc actacttact atttctaaaa
     8101 aatgggaaag aattttaatt aatatatgac tttcactctc tgagatacct ccatgacctg
     8161 cgtttggatt caaataaact ttactctcaa cgccaaaact attaagtgaa tcactccatt
     8221 ttattacatg ttggttattt atgtagggat ctctagctcc caatatacta attaccttag
     8281 tttttgaacc aagagatttt tcaacatttt gttgaggtga gtagctatat atgtaatttt
     8341 tcacattggc atctcttata tctccccact caaataattc cgtttttgac attggatcat
     8401 ctctacactg taatgcttca aatggattta caaatggtga aaataataac atgctcctaa
     8461 ataaattatt atcttcattt aaggtagctc ccgctacaat tccacctgca ctagatgata
     8521 tcagacctaa atgatgttca tcaacaaagc ctctatcaac aaggtatctc accccatgaa
     8581 taaagtcttt aattgaattc catttcttta gcccttttcc agcacgatac caatcacctc
     8641 ctagaaaacc tcctcctcta acatgtattg ttgcaaatat aaatcctgct tctataattg
     8701 ataatatagt agaatctatg gttacgtcat cgttttttcc ataggcccca tatacactaa
     8761 aaatacattt ttgttttctt ggaaagcttc tgcttttttt acttttccag actagagtta
     8821 ttggtataga cgtctcataa tcattactat gagtccatat aacttcctta ttatagcata
     8881 tatcgggatc cgaatctaaa accgacaagc aaaactccct ctcgattttt ttattttcaa
     8941 tataataagt aaaaagatct aaattgaagt tttcttctcc tataaaaaac aacatattcg
     9001 ttgaataatt attctcatac aattgaacat tttgtgggaa cttaataaaa tttttttcaa
     9061 aaatgggccg ttctttatcc aagctgactc taattactaa aaatcgtttc cgatcttctc
     9121 cgattcctaa tattatagta cttcccacac aacttaaaaa agaaatattt cttacctgaa
     9181 ctttagttct aaatatttta tttgtctcaa catcgttaat agatatttcg tctttggtat
     9241 ataaaacaaa ataccttcta ttattcaagt ggagaatatc aaaacagtct gagaatatac
     9301 tatcaattac caatggggta agcaacgttt tttctttgaa taggtcacaa agaaacaatt
     9361 ctcctttaat aaagtccttt gaactgacca tacaagtatt accttttccc gtagatattt
     9421 gaaatatacg aattcgtctt gcatcattcg tctctatgta aataagttgc tccttacaag
     9481 tagaatatga aaaataatat aaagaagatg gacgatgatt actatccgaa cggcagtata
     9541 ttactccatt actacctaca aaaaatgaac tttctaaatt gatatttgtg agataacaaa
     9601 tttttctttt ttttaacaaa gagtatacat acaaatcaaa atttttatta tcttcaataa
     9661 taaatgataa taaatttcca tcttctgtta ttgcaacact tctaatcatc gattttttta
     9721 aaccaaatat attaagagaa tcatcaatat caaaaatcac atgtgaattt tgtatattat
     9781 aattatgatt gtatgatttc ttaggaacaa agtctttatc gaacgcattc catcttctta
     9841 taatcccgga atctcgtaaa ttccaattct cataacgata ccaataattt cccattcgga
     9901 ataagaagga attgaaatct gttattttct tcattgaatt ttctattatt tccatataat
     9961 aattctgttt ctcacttcgc attcaaccac ctttatactt tcaatcaatg cttggcaaaa
    10021 attcaatctt gttattctga atagaagcta atgccaaagc tacacctcca aatccagtag
    10081 cgatgtcaca ggtaatcttt gtccctccat cacctgctaa cactaaacct ttccctatag
    10141 aaatcaaaaa gacataaaga gactcaataa cctctttaag accaacaaaa gaaccagcag
    10201 catctttgaa gtactttgca agtaccaatc cagaacaacc attgaatagc ccaggaaata
    10261 cacaaaaatt gaattctaat gcagactcaa gagaaccaat tttatccaaa aatcttgatt
    10321 ctataaacgc tctatttctt ttaatgacaa gcaaagcccc tgcacttcca gtagcaatat
    10381 aaggtaataa ccgtttttct tgacgatact gaaaacctgc acttgaatct agttcatagc
    10441 tttcaaactc tctctccaaa gataaattca aacattcttt aaagatatcc ttcttggtaa
    10501 atctatatgc ttctccaaac aaccacccta agcctaaatg accgtacaat agtccacctt
    10561 tattttcgta tgggtcgtta gtttgtttaa caaatgtctt ttcacccaaa aaattttcat
    10621 catccaaata ttcttctgca aatatcacta agtgatttat tatcttttct tccttattcc
    10681 taaatcttgg ttctttagac agaaaatata gaccaactaa aaagatacct gctttaccgg
    10741 aatataaatt atttgaattt gattcatata acaacctttc gaaattatct ctaataaaat
    10801 tgttaaccaa gtcgtgttca cctaattcat agatagccca taaagttcca gcaacaccat
    10861 caaagagacc tagcttttct tcatcgttga cctttaattt agtgtatgta tcattaataa
    10921 gattttgttt aaattctcca taaaattgtg agggttcaac attggctaat gaaagcaact
    10981 tttggtaact catcagaatg ccaatatcag aatatgcgat tccctgatta atatttaatc
    11041 cataataatg aacaggaaat acatgtgaac ttctagaaac attttcccac tcctgcttta
    11101 ctaacgaaag accttccaat aattttctta ctatttcctc aatttcacct ctatctttta
    11161 cttcaagatt tcctttataa catcctagtt tttttctctc cgataaatca tcaaattttg
    11221 tacacctatc atctaaatca tttaatattt gaagaattct ggcgatatca tcatttgagt
    11281 atttatgact ataaaatagt tttttcccat atttcgtagt ttgaactgta taatctaaaa
    11341 ctagtgatga ctgttctatc aagggataaa acagaaaatg tgcaatttgt cttacaccat
    11401 tccaatcaat ttgactagga taatcctcaa tccaagaacc aaagcccata gcagccatct
    11461 tttgaccaac tttacttcta ttttctaaag tacactgttc ccaatcaata atagaaacgt
    11521 tatcaaaatc atcaactagg atattaccta gatgaatatc tagatgaaat acattattat
    11581 catgagcttg ttctaaaatt gacataattt gaacaataat cttaactact cgttgtaaat
    11641 acgaataatc tttgtcagaa tgagcatata aaggaaagtt accaatcaac caatcattaa
    11701 gagatttgcc ctccataact tgaactccta aatatgaatt ttcccatatt tttccactcc
    11761 aaactacttt cggcactcct tcaacatttc tcagtttctc taaggcttgt ctctctttta
    11821 ataatctgtc tactgaatac tctccagtaa aatctaaacc tgtatacggt ctagattctc
    11881 gcaatatcat ttttttattt tcatttgaaa gtctagctct atatactccc ccacaattag
    11941 aaaaacgaat cgcactgtca attttaaatg gtaattctga acctgattct atatttctac
    12001 tatgtaacca ttcttcaata aatttcggat tttttaatcc ttctactata gtaaatttag
    12061 gttctctaga atctctaatt actttacctt ccactagtag ttcgtctatc tttaaatcag
    12121 catatggctc atcaatgtta ccttccctaa aaacaccata tctaagaaaa atcggtgctt
    12181 ccttccatct cttatcactt agaatatagg gaccattaaa accagataga tttgattcta
    12241 atttatctag gaaattttct aattgatatt catgcggata acaagtgata aattttccag
    12301 aatagcctct atcaattaat ttatcgtttc ttaatacaaa tttatcctct gtacttagat
    12361 gtttaaacgc aacattttca tcatgacaca aacctgcgac aatatttaac acttcatgag
    12421 aagatttaaa atcggaacta atatgtactt tccatccttg acgttcaatc tctccattaa
    12481 tcggatactg atttacccat tctggatcac tagcaatttc ataccagtct agcggaagag
    12541 agaccgaata tctattcgac gtatctattg aatcattatt acatatgtaa aaaagtggat
    12601 gtcttaaact ataatcatac ttcatgtttt tctccaattc tataaggttt caatactaac
    12661 tccattatct tcaaacctta tatgatgtgt atatatttga tctaactgtt tatcataata
    12721 atgagcaatt tcaaaaacag tattatccat ttttgaaaat atattccgga ttttttgggc
    12781 agagctataa tcaaccgatg aagtcccttc atcaaccaaa agtattttcc ttttatgtaa
    12841 taatgcccta attatttcta ttctctgttt ttgaccacct gataagtttt ttccccactc
    12901 accataaaaa ttatccagac agtctgatcc taactctgct tttaatccta cataatccaa
    12961 aaactcatat aagacggtat ccggaatatc tttctctccc atcaataaat tatctcgcaa
    13021 acttaatcgg aaataatatg gctcctggta tattctggac attatttccg gagcaacact
    13081 tttaatatcc tctccgtctt taatgaaaat ttttccttct gtcgggataa gcacaccctg
    13141 tatcaaattt aacaatgttg ttttcccact acctgacgga cctgtaatga taaccttact
    13201 accgtagggt attaaaaatg atatgttaga aatcacatct ttatcatacg agaagctgac
    13261 attttcaaaa tacaagtctg gcctatttaa atttgtttta cttactatat tatttttatt
    13321 gtctatcaac tcacataatt ttttcctagt aatttcggtt gattttatta gtcttagcga
    13381 gtcagacaaa cttctaaatg gagaaatgac cctgtcactc gcaagaaata tagcaattac
    13441 aatggttgaa tccagatctc cttttataac taaaaagagt gctatactaa ttggtattaa
    13501 ataactaaac caagataaca tcgctgaact aaaacctata aatgaatgct tattcccaag
    13561 aagctcatag tctctttcca tatcatgaat taacgcctca gaacgttcta aaaagcttgg
    13621 gaatgctgag taggttctta tttcttcaat tccctgtgaa aaatcattaa tattagtgat
    13681 gacatcctcg cttgattttg taaattttac tgttgcatta ctcaataagg gaccaaatat
    13741 aatcgatggt aatatgggca agaaagaaca gactataaat aacatagcaa gaagaggact
    13801 taaatatacc aaatatagaa gagatactag tcccataata atcagatata agctacttaa
    13861 tattactgaa aaatattttt cctcaaccaa ttttaaatct atattaagaa gagatagaat
    13921 accgtctgta ttgctattcg cacttctact aagagacata gaccttacta attttttttt
    13981 ataatactga tttaggttat aaataatatt attatttata atagaaacaa tcatgcttga
    14041 taattggata aagagataaa aaactattcc atatactaat aaatagacaa tatcttgaat
    14101 agtagatttt gaattaaatt tagtaactga cgaaataact tgtgacatta caactccatc
    14161 aaaaccagct aaaatcataa atattactag aaaaatcaac ttatatttgg gtattcctct
    14221 aaaaaaatcc ttaattgtca taacatcctc cttatttttt attatcttta cttaaaacat
    14281 tcattaatat tattttgatt atctacttat aaaaataatc tatgtagtac aattataagt
    14341 agatagtcaa aataaatttg cctccagtta aaaccgaagg caaattatat ccatatcaca
    14401 tttataattt aataatgtga tagtaacaat aatgcaataa caaccaatta tttacggcga
    14461 caataatgat tacttgctag actaaaattc gcaccaccac aatgataatt actcatggta
    14521 ctaaatcttt gtccattgac ttcattgatt tcttcctcta cagacataga ctgcaacatt
    14581 aaaatttctt ctgacatgct ttgttccttt cgttttaaaa aaagttctgt ttttgaacta
    14641 ttattaattt gtaaatatgt tcgaacaact tacaaattaa taatacatgt aaacaatata
    14701 gattacaacc taaaaaaatt gacaatttgt gaatatttta aggttgtaat ctgtgttatt
    14761 ttacattaaa attagtttat acaataatat ctttaacaaa ttgtaaataa tttattttag
    14821 gatttttaaa ttatggtaat tggtacccaa gataaaataa taaattcatt ctttaagctg
    14881 gcagaacgat atcctaagcg ttcttcattt agtattgctg aaattgcttg tgaagcaaag
    14941 gtctcaagac aagctattta ccaaaaacat ttcaaaagct atgaggaaat agtagatttc
    15001 atcatgcaat ccatagatac tactataaat gaacactttt tactgttcga agaacacaat
    15061 ctttcaatcg aagttttttt ttcaaaagtt attattccag aattatataa atatagagat
    15121 tggctccgct gtatctactc tacctctgct attcctaatt ggcgaaatta tttacgagaa
    15181 aaatattcca actggctact aaatgcacct attaacttaa gccactcgtt tctacataac
    15241 gacgctttat caagttatat tgtaaattgt gtattaagta ttatagaaac ctggattact
    15301 gaaccttttc cctcccctcc agaagtcttt tcaaaacagt ttattgaatt aataaatact
    15361 cctctaaata atcatataag tccaataaaa catgactcat aactaaatat aacttatgat
    15421 tttcacttaa actataattc attctattta agactaatta tatctcccgc atttgctaat
    15481 aacagtaaag tgcttcttca gataaactta tattaaattc gtattaagca tatagtaaac
    15541 atactaagat tagtagtgaa gaaatctccg acgggagaga gtactcacta ctttttttgt
    15601 gttaaggtag aggtgtcttg ttaagtcatg gcttcttttg gcgctaggcg ttgtacaaaa
    15661 aactgacaaa acacctgttt tagatggaat tttatcaaag tatgttggac gttagacgtc
    15721 gagtattgaa aatgaaatca ctaaaataag gaatcattca agacaaagag gtaaacataa
    15781 tgcggacag
//
