LOCUS       c00018_CABFMM0..       16467 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  CABFMM010000018.1 Streptococcus salivarius isolate
            Streptococcus_thermophilus_BgEED37 genome assembly, contig:
            NODE_26_length_17416_cov_28140146, whole genome shotgun sequence.
ACCESSION   CABFMM010000018
VERSION     CABFMM010000018
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-19 21:38:34
            Original ID  :: CABFMM010000018.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 949
            Orig. end    :: 17416
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..16467
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[10949:15170]"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03882))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      10001..14221
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03882))"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-i"
                     /protocluster_number="1"
     cand_cluster    1..16467
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="((LANC_like and (Lant_dehydr_N or
                     Lant_dehydr_C)) and not (YcaO or TIGR03882))"
                     /kind="single"
                     /product="lanthipeptide-class-i"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..16467
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-i"
                     /region_number="1"
                     /rules="((LANC_like and (Lant_dehydr_N or Lant_dehydr_C))
                     and not (YcaO or TIGR03882))"
                     /tool="antismash"
     CDS             complement(523..2583)
                     /locus_tag="ctg18_4"
                     /transl_table=11
                     /translation="LKRIGDKAARVLLTIFGVKTTVIIGIILTFAVILIGIITGMLGTI
                     STEGGKSGKTNAQCVTYQKDGDEEDDDEEDDEGSKPQSTSTKTDSSSAGDSDPFTKGTK
                     AYENAHKVFMAFVNSGMSGESAAGAVGWANSEGSYDIIGRAQGHYGGGINDSISKGAVP
                     TTGGTSNTLGGGGIFQFDPYTKYAPLNSPDWEDADKMVAFVIDAISKGDWSPAYDESGH
                     NWSFQEFAKQTNIDETAMSWNAYERGNMAYVRPEQKKADARKFAEVFEASKYKYDDAKF
                     QKAFGGGGASSNNSSSSSQSSDDDDGDDDEEDSENEDNDSDSSSSSSSSDFSNKVSKKD
                     SDKDKKTIDTDKAIKWYKDKLGKVKYSRDARTGPDSYDHSSALYYALVDGGAKESGTPV
                     DTDSEHDWLKDNGYELVYEGAWSSKDDVQNREKGDVIVWGTKGSSSGDKGQTMLVEDKE
                     NIIQCSPSTDGIAENNYGQYRDRITMDYGKVYVYRPKKSEDKKDKDDNKDEVDESECGD
                     SDSSNLSTDTGQPLDVPYTITQLFGASANAGGPNAGSGHTGIDLAAPEGSPIYAVTDGE
                     VVEVNEEAMNIDGNHVMHTLPDGTIIYYGHMRDVPLVKKGDKVKKGQLIGYVGHTGAAT
                     GPHIHFERRKTKVFQYGDFLSPASIILGDTQPQVGMVIDPKTQKGGAPSKE"
     CDS             complement(2605..3027)
                     /locus_tag="ctg18_5"
                     /transl_table=11
                     /translation="MVSYRFKRDGQYIQRELELDSPNDYQDQGYPETLEEQGDYSAFYD
                     TYYDGFDEDSISREQEKKQGLIARGKETIVNFKEDVTDYYNLQVERHKDYYSEEDSFWM
                     RKQQQKRNRKFIKQSILLALGLLLVFGWYWLTAILQ"
     CDS             complement(3031..3729)
                     /locus_tag="ctg18_6"
                     /transl_table=11
                     /translation="MTTLMQLSLWVNNIAYDVKTLRFFRIVSFLISLVLGLVGFYSYLM
                     LYQTLLFAYGVHFMALAYTPYVFCALIVAVYHLLTGKRRERIKKAKRILMFSLLPICLM
                     NTWGFITLVTWGIAWVMARLEYNHRKRAVKIVSFFSKDYSPLFEKRLANRNNYYAYQSA
                     YRLLDLIEVSAYEELYKEEVTEKDYKAGLVVKELHRTFKIKGVPFSKITVTDKLYIAPQ
                     KMPIIGLRRF"
     CDS             complement(3733..4038)
                     /locus_tag="ctg18_7"
                     /transl_table=11
                     /translation="MNLVQPHSGEEFQLQTKILTEDNPEDLERIVNAYLEVLSYKKDSC
                     VVDITYQMQKTHLSSSLCGLFGSQQVDEYSAMIVYQEPSRFKSRIFETDEEPEEEL"
     CDS             complement(4063..6024)
                     /locus_tag="ctg18_8"
                     /transl_table=11
                     /translation="MDLSSRKIKKYIREGYDLNLISRIQSDIPDFKYDDRYWRQANGYY
                     KIAHVPYDRYPEHGLPDFWMSDLMLVDNVISFMSLEHASNNEMSDLASRAISNMLATQN
                     TKAAQDADDKKRIGSLLGYREKLDNNVPSKKIHTRFLLAANTLNELVEREADLKQQLNQ
                     YSISSSDGMQDVEYHSAFIPASRLEDTPLRRKGQAASVWDLGAGYPFNHTNLMDTYGVY
                     LGETRTGGVVNFDLLHEDRERKIPTMMIAGAGNGKMKLLGNLIDTYFAKGHTIFNIDLT
                     GHLKELTELQGGRYVKMSGTNNRNHINLMQIIATASSADGETTDQIQSYYAHRNKLRAL
                     AQILDPGLKNSDLNNLSSALNDFYEDRSLWNRNAEVMNQEDLTITNVIPEDYPTLSHWV
                     ERLNKLKEDKIAEGNKIDAASYDRLYNAFSGLLGDYRFLNATSQFEDFSNEQVVTFDLS
                     GIQDTELLNIQLYQVLSIISSYAVANGKRVSEYFRRGIIGGAKSQRPHSIITINGAHKL
                     FNYRYSESLNFLKDLIENVSSNYSAFIMEMSSLDNILLNANSTDAVDYILATRAIFSMM
                     TYRVFSQLGDLTIPRLADALQGEMTESELSSLKYLRDGDFFLNIASVKNLVFNHQLADN
                     TSYGKYPYDEFLRYAFLP"
     CDS             complement(6036..6923)
                     /locus_tag="ctg18_9"
                     /transl_table=11
                     /translation="VSLGYERPMLFFRIVENNVYGGNAMPGLIEEPVLTKKELRKRKKE
                     EARKSKQAKKKEKQTKFESIDLGERAGEEFVYVPLNKKKRKDFLDTVAISDVKSILYGY
                     PNQPIRLANPYSGYVQIFEVFGQDIQAMSNKEQAAIQLGFTLFLSGTAFDMMIQTTKLP
                     TDVSSQSNEFLRLLDEVKQEQNAPELITKDGDDIDTISRKERRVYQLRQREDILKTKYL
                     VQQVIAVNQQNIEFFIWVFGDTLAEIDSNTRTTLTIASSHGFTPKVVSVEKKEELLTQY
                     YNFNDSLNVSLNQY"
     CDS             7062..7424
                     /locus_tag="ctg18_10"
                     /transl_table=11
                     /translation="MLDFLQDFYFSLYISTWTSFKWLLFSVLIGIACFFLTLLFSTISE
                     AAETIWFKFSLSLTGIFALFCLFMTLHGIIRSIGLFIGAISSFFYPMFGLLLVGGILLF
                     FISLFNPLFLFFMAKK"
     CDS             complement(7823..8545)
                     /locus_tag="ctg18_11"
                     /transl_table=11
                     /translation="MKSYIYSSFLKIKNTSYLLVHILAALLFPLLLFLYWNQRGGLQSR
                     AVLFSYFQIVGVLLPFASSIVNIQLKNLEESSGKFKYLLGYSQSNYKPFFAELVFLWLC
                     YCIVLIVSITIFIFLLKTIGIVVSLRLLILISLFYIILGYIAYMLNQIISYLFSTGVAL
                     GISMMGVIISAFCETSLGDKVWFLIPWAWFLRVSDTLFNQQKIDITSLMIIFVISIIIV
                     FFHFLLFQKWNQDRLISG"
     CDS             complement(8548..9297)
                     /locus_tag="ctg18_12"
                     /transl_table=11
                     /translation="MKQVFLSNLIKIKNTSIFRLIFIFPFICVILSLLFSSLGGKEVLS
                     LTAETTVNQWGVIWINVIIAVNSALLNKLELDSNKYSVYLSRNVNLKKVEYARIILVAF
                     LNLIISMILSLILILMGLILPTPSLISIWRMLLTILLIWLTTLWQIPFILWLSRKTNLY
                     FAMIINTISPLIIGTSFSLLDTWYLFPYDWSLKLLEPMTKMRINGIPIGSEYIPDYSMI
                     FVSFFLGITFFILLVELSAISFKRQVK"
     CDS             complement(9294..9989)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 182.7; E-value:
                     1.5e-55)"
                     /gene_kind="transport"
                     /locus_tag="ctg18_13"
                     /transl_table=11
                     /translation="MLKIQNLRKSYGKRTVLDNVNMNIPKGKVYALIGPNGAGKSTIMK
                     ILTGLINKTSGSITFEGREWSRRDLQKIGSIIEEPPLYKNLSAYDNMKVVTTMLGISNS
                     TILPLLNKVGLGNIDRRPVKQFSLGMKQRLGIAIALINSPKLLILDEPTNGLDPIGIQE
                     LREIIESFKSDGMTVMISSHILSEVEHLADFIGFIYEGKIVLEKEYDGSENLEELFNNQ
                     IIYEKGRRL"
     CDS             complement(10001..12961)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_N"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: Lant_dehydr_C"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Lanthipeptide_LanB_RRE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1155:Lantibiotic dehydratase domain protein (Score:
                     781; E-value: 2.5e-236)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_14"
                     /sec_met_domain="Lant_dehydr_N (E-value: 9.8e-95, bitscore:
                     308.0, seeds: 73, tool: rule-based-clusters)"
                     /sec_met_domain="Lant_dehydr_C (E-value: 4.8e-19, bitscore:
                     59.1, seeds: 35, tool: rule-based-clusters)"
                     /sec_met_domain="Lanthipeptide_LanB_RRE (E-value: 6.4e-14,
                     bitscore: 42.7, seeds: 20, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYNVFPRGMIRVPLQKQEFYEKGYDELIKDKVFMEQLLVASPSLY
                     HSVKNIDKCNEKKKQKIKISIKSYAKRAALRTTPFGIFTAINVVDLKNETDSNVKKISF
                     TKKATPDYLWIYSLVKSYEIKNIEELAFKINTAAFIQGDRYVLPFTVSEFEEDRNISLS
                     KPVQILIEKCQKNYVNYEELIKILKTSYPEIALEVLTSFIYNLVENDFLISDLRPPICN
                     INPLDYLLSKLEKGRLKNDLQHLKNMIENYNDLKIGEGCNLLLQIFDVMKNIHKYDIGG
                     NYLKVDSIANFNGRFDVLSEKSFEIIKQLAEMFVKLNNNVKRRGGRKNSLKEYQLKFIG
                     KYGENCAIPLVEVINKDVGIGFPDYYKDESGEAIEFSDPIMQMFEKKYEEALLDGKSIE
                     FRSKDLHDFKLNQNNSLESFELNFNIKKLNDDIKLYLGANIGSGQAGRSFGRFYTLSEQ
                     LKTTIQKLDQKNCMNVELSFVPNQIRIANVMQNYSAETFNTSFFTTSWDSTNEIRLEDI
                     YIRYSEGKFHFTTSDGKNELKFTMNNMLNPDSQSKVLRLLVDISEFEDGLSHWSLFPWD
                     ILAQEKVYIPEISFEGITIATAQWNLSMIREQLLTKNKFIDKKVIFDNFRKTYKIPNDI
                     ILKYADNELRLDLSMDDDLEILFKNIKKHVYVSLREIEKGESIFKEYLGNYNAEIVVPI
                     IKEIDRNASHETNLIFKTEIKRTYLPFCDWLFLKLYGPKERQNELLGYWSNYFANILPR
                     NYNQPKMFYMRYYDTNDHIRMRVNSGSFENNFSLYLSVVRDLLPMLIEKGIVSDIEVST
                     YKPEVNRYGGPNLIHYAEEIFCKESILFMNHIISLSENERLVCATYLVLYYLNYFFKDE
                     VTKCSFLLENYTGKYKKEFKNLPIDLPIEYMKSLKGVASALDRYDYFQEMDKYLTSYME
                     EYNRFDSTNDLYNTKFNLVGSFLHLSMNRLNGINREFEEKVYCFAYYTLNAQQYIE"
     CDS             complement(12980..14221)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-i: LANC_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1140:Lanthionine synthetase C family protein (Score:
                     254.6; E-value: 2.6e-77)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg18_15"
                     /sec_met_domain="LANC_like (E-value: 2.5e-69, bitscore:
                     223.8, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTPQIEQILDYVADRFTNYEQIVAESTNETLISIESKYKNTFFEK
                     SLSHGIPSLILMYSSLYKVTRQDKYMDLSNSYISKLVEIISKDGIESPSLYAGTAGISL
                     AIREASISGKYYTKLLDSLHRLLKEQIQEKLIISLSNIDKGIIDPFDYDMVNGFSGIAN
                     YLMLEREYFFEALKQIGMYLLKYIETIFSKVKNCSIDSKIEFDLGIAHGIVGPMLILAK
                     LRSERILEDNDEILNKAIKLVFLYRREDKLWPGKIYSDNILNRDFKNLPTRMAWCYGTP
                     GTSLALFKICQLMDLNYTDSIIESLIAQITSPEKNIYSLTMCHGLSGVSFIYDLIGRSN
                     SNVRLVNFAECLRQEIIIQFSGQKIFGYTDREKLGEVEIEFESVGILQGVSGIILFLLN
                     PYSDEKLLWERMFI"
     CDS             complement(14205..15995)
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 168.9; E-value:
                     2.4e-51)"
                     /gene_kind="transport"
                     /locus_tag="ctg18_16"
                     /transl_table=11
                     /translation="MIKNQLKNLMKTINLVKEAGFSLLLLSIGISIIQGILPIVSMLLV
                     QNMLNIITSSIERFQTLMITFILFVALTLLTTIVGEVDGYIDAKLQILLHYKMNHLVMQ
                     KTVKLTLAEFETPEIYDDITRIQNQISYKPFQIYKSIISVLSSLVSFISSFIILLNWKT
                     SIFPLLIILPVISIYIYLKIGKNEFEMLYKRSSDERANWYISHILTHDFAVKELRLGIL
                     ENYFLKKFDKNNQLFITQENSINKSKMGNGILLGILEIIIESIIMFLAVREAFLGIILI
                     GNVTTFIRSLSTMQTSTKNIVNNIYSFYNGSLYMELLYDFTHSETEYNNLKDKVVNDIK
                     SIEFENVSFSYDGKENVINNISFSIKSGEKIAIVGENGSGKSTIFKLVCGLYDNYEGNI
                     YINGNNIRSIQKKSYYKRISALFQDFLKYELTLRENIGLGELSKLYNDESLINTLKRTG
                     IDSIFYKKEGKTNQLDLEQQLGNWFEDGRQLSGGQWQKIALSRVYLKEADCYFLDEPSS
                     ALDPKSEAKIFKTFFELSQNKIGIFITHKPSITQFVDKILYLENGKIVETGSFNDLNFK
                     GKKFKNLLDKEIGIVYDTSN"
     CDS             complement(16104..16244)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) TIGR03731"
                     /gene_functions="biosynthetic-additional (lanthipeptides)
                     predicted lanthipeptide"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg18_17"
                     /sec_met_domain="TIGR03731 (E-value: 9.8e-10, bitscore:
                     28.6, seeds: 23, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKNTIKDFDLDLKTTKNNSDEPLVGSRYLCTPGSCWKLVCLTTTI
                     K"
     CDS_motif       complement(16176..16244)
                     /prepeptide="leader"
                     /note="peptide class: lanthipeptide"
                     /note="predicted sequence: MKNTIKDFDLDLKTTKNNSDEPL"
                     /locus_tag="ctg18_17"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
     CDS_motif       complement(16104..16175)
                     /prepeptide="core"
                     /locus_tag="ctg18_17"
                     /peptide="lanthipeptide"
                     /predicted_class="Class I"
                     /score="6.80"
                     /molecular_weight="2421.9"
                     /monoisotopic_mass="2420.3"
                     /core_sequence="VGSRYLCTPGSCWKLVCLTTTIK"
                     /aSTool="lanthipeptides"
                     /tool="antismash"
                     /leader_sequence="MKNTIKDFDLDLKTTKNNSDEPL"
                     /leader_location="[16175:16244](-)"
                     /alternative_weights="2439.9"
                     /alternative_weights="2458.0"
                     /alternative_weights="2476.0"
ORIGIN
        1 caatatcatt aataagtgaa tgttcatttt ctaatctagt ttcagtagat ctcttcaaac
       61 caagatattt cacatcgata acattcttga atagataacg tttaaataag atcgagctta
      121 attttgaacc tacaacataa agaatgagac caataactaa tagtactaaa atataagtta
      181 cttcagtctc tgtaatatgt gttggcctca acaaaagaac acacaaggtt agcatctcaa
      241 tgaaactaat taagatgtta taaaccaaca attcactacc atttctgtat ttttgaatga
      301 ctctaaacgt gaatgatgct agataaatgc cttcgataac actaataaat aataatgctt
      361 gtagacctgg cattgtctta aaaaggatat tcaagaaaag tgtccacata attaaaaaga
      421 accataagaa agcttttcgc aaacaccagt ctaggcacaa tgcagtaaat aatgatatgc
      481 ttttttgctt aatttttgtt ttcatttttt ctcctttttg atttattctt tagatggtgc
      541 tccacctttt tgtgttttag ggtcaatcac cataccaact tgtggttggg tatcccctag
      601 aataatcgat gctggactca agaaatcacc gtactggaag actttcgttt tacgacgttc
      661 aaagtgaata tgtggtcccg ttgctgcacc cgtatgccca acataaccga taagttggcc
      721 ttttttgact ttatcacctt ttttaacaag aggaacatca cgcatatgac cataatagat
      781 aatagtacca tcaggaagag tgtgcatcac gtggttaccg tcaatgttca tagcttcttc
      841 attgacctct accacctcac cgtccgtaac ggcataaatt ggagagcctt ctggtgctgc
      901 aaggtcaatt cctgtatgtc ctgaacctgc atttggacca ccagcattgg ctgatgcacc
      961 gaaaagttgg gtaatggtat aaggaacatc aagtggctga cctgtatctg tactgagatt
     1021 actactatcg ctatcaccac actcactttc gtctacttca tccttattat cgtctttatc
     1081 cttcttatcc tctgattttt ttggacgata gacatagact tttccgtagt ccatagtaat
     1141 acggtctcga tattggccat aattattctc agcaatcccg tctgtcgaag gggaacattg
     1201 gataatattc tccttatcct caactagcat ggtctgtcct ttatctccgg agctacttcc
     1261 tttcgtaccc cagacaatga catctccttt ttcacggttt tgaacatcgt ctttggacga
     1321 ccacgcaccc tcatacacta actcataacc attgtctttc aaccagtcgt gttctgaatc
     1381 agtatctact ggagtccccg attctttagc accgccgtca acaagggcat agtaaagagc
     1441 agatgaatgg tcgtagctat ctggtccagt tcgagcatca cgagaatact taacctttcc
     1501 tagcttatcc ttataccact tgatagcctt atcggtatca atagtctttt tatccttatc
     1561 actgtctttt ttgctaactt tgttgctaaa gtcacttgac gaactacttg aactgctatc
     1621 gctatcattg tcttcgttct cgctatcttc ttcatcgtcg tcaccgtcat catcatctga
     1681 gctttgacta cttgacgagg agttattgga agaagcacca ccacctccaa aagctttttg
     1741 gaacttggca tcatcgtact tatacttgct tgcttcaaag acttccgcaa acttccttgc
     1801 atccgccttc ttctgctctg gtctgacata agccatattg cctcgttcgt aggcattcca
     1861 tgacatagca gtttcatcga tatttgtttg tttggcaaac tcctggaatg accagttatg
     1921 gccagattca tcataagctg ggctccagtc accttttgag atggcatcta taacaaaggc
     1981 aaccatctta tcagcatctt cccaatcagg actatttaaa ggggcgtatt tcgtgtaggg
     2041 atcaaactgg aatattcccc cacctccgag cgtattagac gtaccacctg tcgttggaac
     2101 agctccctta gaaatggaat cattgatacc accaccataa tgcccttggg cacgtccaat
     2161 aatatcatag ctcccttcag agtttgccca gccaactgca cctgcagcag attccccgga
     2221 cattcccgaa ttcacaaaag ccataaagac tttgtgggca ttctcataag cttttgttcc
     2281 cttcgtaaaa ggatcagagt cacctgcaga tgatgagtca gttttagtag aagtcgattg
     2341 aggcttagag ccttcatcgt cttcttcatc atcgtcttct tcatcaccat ctttttgata
     2401 ggtcacacat tgagcgttag tctttccaga ttttccgcct tcagtactaa tcgttccaag
     2461 cataccagta ataattccaa ttaaaattac agcaaaagtt aaaataattc ctataataac
     2521 tgttgtcttt actccaaaaa tcgttagaag aacacgagca gctttatcac ctattcgttt
     2581 caaatacctt tgtcaccccc tcccttattg cagtattgcg gttagccagt accaaccaaa
     2641 tacaagtaat agtcccaaag caagtaatat actttgtttt atgaactttc gatttcgctt
     2701 ttgttgttgc ttacgcatcc aaaatgaatc ttcttctgag taatagtcct tgtgacgttc
     2761 aacttgcaaa ttataataat cagtcacgtc ttccttaaaa ttaacgattg tttctttccc
     2821 acgcgcaatg agaccttgtt ttttctcttg ctcacgtgag atactgtctt catcaaaacc
     2881 gtcataatag gtatcgtaaa atgctgagta atctccttgc tcttcgaggg tttccggata
     2941 gccttggtct tgataatcat taggagaatc tagctctagt tcacgttgaa tatactgacc
     3001 atctcgttta aaacgataag ataccatata ttaaaacctc cttaagccaa taattggcat
     3061 tttttgtgga gcaatataga gtttgtctgt tactgttatc ttagagaaag gtacaccttt
     3121 gattttaaaa gtacggtgta actctttaac aacgagacca gctttataat ctttttccgt
     3181 cacttcctcc ttatagagtt cctcataagc tgacacctca atcaagtcca agagacgata
     3241 agcagattga taagcataat agttatttcg attagccaat ctcttttcaa aaagaggaga
     3301 atagtctttt gagaagaagg agactatttt aaccgcacgt tttctatggt tatattctag
     3361 tctagccata acccaagcaa tcccccaagt cacaagcgta ataaagcccc aggtgttcat
     3421 caaacaaatg ggaagaaggc taaacataag gatacgttta gctttcttta tgcgttcacg
     3481 tctcttacct gtgagtagat gataaacggc cacaatcaag gcacaaaaca catacggtgt
     3541 ataggcaaga gccatgaaat gaacaccgta agcaaataaa agtgtctgat aaagcattaa
     3601 ataactatag aaaccaacca atccaagaac taaactgatc agaaaggaaa ctatcctaaa
     3661 gaaacgaagt gttttaacgt cataagcaat attattaacc catagtgaca attgcattag
     3721 tgttgtcatt gattaaagct cctcctctgg ttcttcatct gtttcaaata ttctcgattt
     3781 aaatcgagaa ggctcttgat agacaatcat agcagaatac tcatctactt gctgactgcc
     3841 aaataagcca cataagctac ttgaaaggtg tgttttttgc atttgataag taatatcaac
     3901 aacacaacta tcttttttat aggataagac ctccaagtaa gcattcacaa ttctttccaa
     3961 atcctctgga ttatcttctg ttagtatttt agtctgtagt tgaaattcct caccagaatg
     4021 tggttgtact aaattcattc tattttcctc cttttaccat tactacggta ggaaggcata
     4081 gcgtaagaac tcatcatatg gatacttccc ataagacgta ttatctgcta gttgatgatt
     4141 aaagactaag ttcttgacag aggcaatatt taagaaaaag tcaccatctc ttaaatactt
     4201 cagtgaagaa agttcgctct cggtcatttc cccttgtaaa gcgtctgcca gtcgaggaat
     4261 agtcaaatca cctaattgag aaaagacacg atacgtcatc atcgagaaaa tcgcacgtgt
     4321 cgctaaaatg taatctactg cgtctgtaga attcgcattc aaaaggatgt tatctaatga
     4381 gctcatttcc atgataaacg cagaatagtt actacttaca ttctcaatca aatcctttag
     4441 aaagttgaga gactctgaat aacgataatt aaagagctta tgggctccgt taatggtaat
     4501 aatactatga ggtcgttgac ttttagctcc cccgattatc cctctacgga aatactcaga
     4561 tactcttttt ccatttgcta cagcataaga tgaaatgatt gataacactt ggtatagctg
     4621 aatattaaga agctctgtat cttgaatacc agataaatca aaggtaacga cttgttcatt
     4681 tgagaaatct tcaaactgtg aggtcgcatt taagaagcga taatctccca agagaccaga
     4741 gaaagcatta tacagacggt cataacttgc agcatcaatt ttattgccct ctgcgatttt
     4801 atcctcttta agtttgttta aacgttctac ccaatgagat agagtcggat aatcttctgg
     4861 aatgacattc gtaatcgtta agtcttcttg attcattact tcagcattac ggttccacaa
     4921 actacggtct tcgtagaagt cgtttaaggc agacgacaaa ttattgaggt ctgaattctt
     4981 taacccagga tcaagaattt gagccaaagc ccttaattta ttacgatggg cataataaga
     5041 ttggatttgg tctgttgttt ctccatctgc agaggaagcc gttgcaataa tttgcatgag
     5101 gttaatatga tttcgattat tagttccgga cattttgaca tatcgaccac cttgcagttc
     5161 cgtaagttct tttaagtgac cagtaaggtc gatgttaaaa atggtatgtc ctttagcaaa
     5221 ataggtatca atcaaattac ctaatagctt cattttccca ttccctgctc cagcaatcat
     5281 catcgtagga attttacgtt ccctatcttc atgcaaaagg tcaaagttta ctaccccacc
     5341 ggtacgggtt tcgcccaggt aaacaccata ggtatccatt aagtttgtat gattaaaagg
     5401 atagccagca cctaaatccc agacagatgc agcttgtcct tttcgtcgca atggagtatc
     5461 ttccaagcga gaagcaggaa taaaggctga atgatattcg acgtcttgca tgccatctga
     5521 agaagaaata gagtactgat ttaactgttg tttgagatca gcttctcgtt ctaccagttc
     5581 gttcaaagta tttgcagcta ataaaaaacg agtgtgaatt tttttagaag gaacattatt
     5641 atctagtttt tcgcgatagc ctaataaaga accaatacgt ttcttatcat cggcatcttg
     5701 tgcagccttt gtattttgtg ttgctaacat attcgaaata gctcttgaag ctaagtcgga
     5761 catttcatta tttgaggcat gttctaagga cataaaactg ataacattat caacaagcat
     5821 taaatcgctc atccagaagt caggtaaccc gtgctctgga tatcggtcat atggtacatg
     5881 agcaatctta taatacccgt tagcttgtct ccaatatctg tcatcatatt taaaatctgg
     5941 gatatcactt tgaatcctac taataagatt aaggtcataa ccttctcgaa tatatttctt
     6001 gatttttcgt gaacttaaat ccatgtatac tccttctagt actgattaag cgaaacatta
     6061 agtgaatcat taaagttgta atattgcgtc aataactctt ccttcttttc gacagataca
     6121 acctttgggg taaatccgtg actcgaagca atagttaatg tggtacgggt attggaatca
     6181 atttcagcca aagtatcccc aaacacccaa ataaagaact caatattttg ttgattgact
     6241 gcaatgactt gttggacgag atattttgtt tttaaaatat cttcacgttg tcttagttga
     6301 taaacacgtc tctctttacg tgaaattgtg tcgatgtcat caccatcttt ggtaattaat
     6361 tccggagcgt tctgttcctg tttgacttca tctaaaagac gcagaaattc gttagattgg
     6421 cttgagacat ctgttggcaa ttttgttgtc tgaatcatca tgtcaaaggc agtaccagac
     6481 agaaacagtg taaatcctag ttgaatagct gcctgttctt tgttagacat agcttgaata
     6541 tcttgcccaa acacctcaaa tatttgcaca tatcctgagt agggattagc taatcgaatc
     6601 ggttgattag gatagccata tagaatagac ttcacatctg atatcgcaac agtgtctaaa
     6661 aaatctttac gctttttctt attgagcgga acatacacaa actcctcacc agcacgttcg
     6721 ccaaggtcga tactttcaaa ttttgtttgt ttttccttct ttttagcttg tttactttta
     6781 cgtgcttctt ctttttttcg ttttctaagt tctttttttg ttaatactgg ttcttcaatt
     6841 aaacctggca tagcatttcc tccataaaca ttattctcca ctattctaaa aaacaacata
     6901 gggcgttcgt aacccagtga cacctcttaa ctactgaatc tcatcggtat gttttggatt
     6961 atttacatct atttagggct ctctgtcctt gtctagctac ttaaaaactg ttacaatcaa
     7021 ataaatacaa tcgcaacaat cttttttagg agggttttag gatgcttgac tttttacaag
     7081 atttttattt ttcactttat ataagcactt ggacctcgtt taaatggcta cttttttcag
     7141 tactaattgg tatcgcttgc ttctttctca cacttctttt ttctacgata agtgaggctg
     7201 cagaaacgat ttggtttaaa ttttcgttgt ctcttactgg aatatttgct ctgttttgtt
     7261 tgttcatgac acttcatggc atcattcgtt ctataggcct ctttatagga gctatctcta
     7321 gtttctttta cccaatgttt ggcttattgc ttgtcggggg gattttgcta ttcttcatca
     7381 gtcttttcaa tccattgttc ttattcttca tggcaaagaa ataacgaggg gaaacctatt
     7441 cagccgatgc tattatgtta agaaaataaa aaaacaaacc acctttgaaa aagtagtttg
     7501 tctattgtct aagagaggta gtccaaggct acctctcttt tttatattgg ccagcctcca
     7561 aacagcgagg aagaaagtag ctagtcaaat aaaactttat attaaatgtc ctatgtaaca
     7621 catatatttt tttaaatcgt aactgtcatt acttttttta aaaagtttat tgaaattgat
     7681 tcaaattttc atcattaaaa gtaaatctat gaaaatatat gttaaaatca tactataaaa
     7741 tccaaggata taagatgtta tagccatttc ctaatcaaac ataattagat tgtattaatt
     7801 atagatagaa aactgaacat atctaaccac ttatcaagcg gtcttgattc cacttttgaa
     7861 atagtaaaaa atgaaaaaat actattatga tagaaataac aaatataatc ataagtgaag
     7921 tgatatctat tttttgttgg ttgaatagtg tatctgatac tctcaaaaac catgcccatg
     7981 ggattagaaa ccatacctta tcaccgagac tcgtttcaca aaacgcagaa ataatgactc
     8041 ccatcattga aatacctagt gccacacctg tgctaaataa ataactaata atctgattaa
     8101 gcatatatgc tatatagcct aaaataatat aaaataaact aatcaaaata agtaatctta
     8161 gagatacaac tataccaata gttttcaaca aaaagataaa tatagtgatt gaaactatta
     8221 aaactataca ataacataac cacaaaaata ccaattctgc aaaaaatggc ttataattcg
     8281 attgtgaata ccccaacaaa tatttaaatt tcccagatga ttcctccaaa ttttttagtt
     8341 gaatattcac aatactagaa gcaaaaggaa gaagtactcc tactatttga aagtaagaaa
     8401 ataataccgc cctgctttgt aaccctccac gttgattcca atataggaac aaaagtagtg
     8461 gaaataataa tgcggctaaa atgtgtacta gcaaataaga agtgtttttt atttttaaaa
     8521 aactagagta tatatatgat ttcatgacta tttaacctgt cttttgaaag agatagcaga
     8581 tagttcgacc aataaaatga aaaaagtaat ccctaagaaa aatgaaacga aaatcattga
     8641 ataatcagga atatattcag atccaatagg tataccattt attctcattt ttgtcattgg
     8701 ttcaagtagc ttcaatgacc aatcataagg aaacaaatac catgtatcta agagagaaaa
     8761 acttgtacca ataattagtg gtgatattgt attaataatc atagcaaaat acaaattagt
     8821 ttttcttgat agccataaaa taaatggaat ttgccataat gttgtcaacc aaatcaataa
     8881 aatagttaat agcatcctcc atatactaat aagacttggt gtgggtaaaa ttaaacccat
     8941 taagataagt attaggctta aaatcatact aattattaaa tttaaaaaag ctaccaatat
     9001 gattcttgcg tattctacct tttttaaatt aacattcctt gataaataaa cagaatactt
     9061 atttgaatct aattccaact tatttaacaa agcggaattt acagctataa ttacattaat
     9121 ccaaataacc ccccactgat tcacggtggt ttctgcagtt agacttaata cttccttacc
     9181 acccaatgat gaaaacaata aagaaagaat gacacaaatg aaagggaaaa taaaaattaa
     9241 cctaaaaata ctcgtattct ttattttaat taaatttgat aaaaaaactt gtttcataat
     9301 ctcctccctt tttcatatat aatttgatta ttaaataact cctcaagatt ctcagaacca
     9361 tcatattcct tctccagtac aatctttcct tcataaataa aaccaataaa atcagctaga
     9421 tgttcgacct ctgaaagaat atgacttgaa atcatgactg tcatcccatc tgatttaaat
     9481 gactctataa tttcccttaa ttcttgaatt ccaataggat ccaacccgtt ggtaggctcg
     9541 tccaatataa gtaatttagg tgaatttatt aaagcgatag ctattcctaa cctttgcttc
     9601 atccctagag aaaattgctt tactggtctc ctatcaatgt ttcctaaacc tactttattt
     9661 aatagcggaa gtattgtact atttgaaata ccaagcattg ttgtaacgac tttcatatta
     9721 tcgtatgcgc tcaaattctt gtaaagtggt ggttcttcaa taatacttcc aattttctgc
     9781 aaatctcgac gtgaccattc tctaccttca aaagtgatag aaccactggt tttattaatt
     9841 aaaccagtca aaattttcat aatagttgat tttccagcac catttggacc tattaaagca
     9901 tacacttttc ccttaggaat attcatattg acattatcta gtaccgttct cttaccataa
     9961 gattttctta agttttgtat ttttaacata ttgattactc ctattctata tactgttggg
    10021 catttagtgt gtaataagca aaacaatata ccttctcttc aaattctcta ttaatcccat
    10081 ttaatcggtt cattgataag tgtaaaaaac ttcctactaa attaaatttt gtattatata
    10141 gatcatttgt actatcgaat cgattgtatt cttccatata agaagtaaga tatttatcca
    10201 tttcctggaa ataatcatat ctatctagcg ccgatgctac tcccttcaaa ctcttcatat
    10261 actctatggg taaatcaatt ggtaaatttt taaattcttt cttatatttt ccagtataat
    10321 tctcaaggag aaaagaacac tttgtcactt catctttgaa gaaataattt agatagtata
    10381 aaactaaata tgtagcacaa actaatcttt cattttctga caaacttatt atatgattca
    10441 taaataaaat agattctttg caaaaaattt cttcagcata gtgtattaaa ttaggtcccc
    10501 catatctgtt tacctctggc ttataagtac tcacctctat atctgagaca ataccttttt
    10561 ctatcaacat aggtaataag tcacgaacta ctgacaaata taaagaaaaa ttattctcaa
    10621 aagaaccaga atttactcgc attcttatat gatcatttgt gtcataatat ctcatataaa
    10681 acattttggg ttgattataa tttcttggta gtatattcgc aaaataattg ctccagtaac
    10741 ctaatagttc attttgtcgt tctttaggac catacaactt taaaaatagc cagtcacaaa
    10801 atggtaaata tgttctctta atttcagttt taaagattaa attagtttca tggcttgcat
    10861 ttctatctat ctctttaata attggaacaa caatttctgc gttatagtta cctaaatatt
    10921 ctttaaaaat tgattctcct ttttcaattt ctcttagcga aacgtatacg tgttttttaa
    10981 tatttttaaa taaaatctct aagtcatcat ccatagataa atctagcctt aattcattat
    11041 ctgcatattt taaaatgatg tcatttggaa tcttgtatgt ttttctaaaa ttatcaaaaa
    11101 taactttttt atcaataaat ttatttttag ttagtaactg ttctcttatc attgataagt
    11161 tccattgtgc ggtagctatc gtaattcctt caaacgaaat ttcaggaata tagacttttt
    11221 cctgagctaa aatatcccat ggaaataaag accaatgtga caatccatcc tcaaactctg
    11281 atatatcaac caacaatctc agtaccttac tttggctgtc aggattcaac atattattca
    11341 tagtaaattt caactcattt ttcccatcac ttgttgtaaa atgaaactta ccttcactat
    11401 atcttatata gatgtcttct aatctaattt catttgtcga atcccatgat gttgtaaaaa
    11461 atgatgtatt gaaggtttca gcgctataat tttgcattac attcgctatt cttatctgat
    11521 tcggaacgaa tgatagctct acattcatac aatttttctg atctaatttt tgaatagttg
    11581 ttttcaattg ttcgcttaat gtatagaatc taccgaaact tcttccagct tgaccagaac
    11641 caatattggc acctaaatat aacttgatat catcatttag ttttttgata ttaaaattta
    11701 attcaaatga ttctaaacta ttattttgat ttaatttaaa atcatgtaaa tcctttgacc
    11761 gaaattcaat acttttacca tctaaaagag cctcctcgta tttcttttca aacatttgca
    11821 ttattggatc actaaactct attgcttctc ctgattcgtc tttgtaataa tcagggaaac
    11881 ctataccaac atccttattt attacttcta caagaggaat tgcacagttt tccccatatt
    11941 ttccaataaa tttcaactga tattctttaa gtgaattttt cctgccacct cttcttttaa
    12001 cgttattatt taacttcaca aacatctctg caagctgctt tataatctca aaagactttt
    12061 ccgataagac atcaaatcta ccattaaaat ttgctatgga atctaccttt aggtaatttc
    12121 caccaatatc atatttatgg atatttttca tgacatcaaa tatttgaaga agtaaattac
    12181 agccctcacc tatttttaaa tcattataat tctcaatcat attttttaaa tgttgtaaat
    12241 cgttttttag tcttcccttt tccaatttcg ataataaata atctagtgga ttaatattac
    12301 aaataggtgg tcttagatct gaaattaaaa aatcattttc aaccaaattg taaataaatg
    12361 atgttagcac ttctaaagct atctccggat aactggtttt aagtattttt atcaattctt
    12421 catagttcac atagtttttc tggcattttt caatcaatat ctgaactggt tttgaaagac
    12481 ttatatttct atcttcctca aactcactca ctgtaaatgg taatacatat ctatcccctt
    12541 ggataaatgc tgctgtatta attttgaagg caagttcttc tatattcttt atttcataag
    12601 atttcaccaa agaatatatc caaagataat ctggtgtcgc ttttttagta aaactaattt
    12661 tttttacatt ggagtctgtt tcatttttca ggtcgactac atttattgcg gtaaaaattc
    12721 caaacggagt agtacgtaat gccgcccttt ttgcgtaact ttttattgat atttttattt
    12781 tttgtttttt cttttcgtta catttatcaa tattttttac actatgatag agactaggac
    12841 tagcaactaa aagttgctcc ataaaaactt tatcttttat cagctcatca tatccttttt
    12901 cataaaattc ctgtttttgc aaaggaacac ggatcatgcc tcttggaaat acattataca
    12961 tcttgttctc ctctcttaat taaataaaca ttctttccca caagagtttc tcatcgctat
    13021 aaggatttaa taaaaataag ataattcccg ataccccctg taatatacca actgattcaa
    13081 attcaatttc tacttctcct aatttttctc tatcagtata tccaaatatt ttctgacctg
    13141 agaattgtat tattatttcc tggcgtaaac actctgcaaa attcactaat ctcacatttg
    13201 aattgcttct accaatcaaa tcgtatataa aggaaacacc tgataatcca tgacacattg
    13261 tcagtgaata aatatttttt tcgggactag ttatctgagc aatcaaactc tcgataatac
    13321 tatcagtata gtttaaatcc atcaattgac atattttaaa taaggcaagt gatgtaccag
    13381 gagtaccgta gcaccaggcc atcctagtag ggagattttt aaaatcacgg ttcaaaatat
    13441 tatcagaata tattttacca ggccatagtt tatcttctct tctatataaa aatactagct
    13501 tgatagcctt gttcaatatc tcatcattat cttctaagat tctttctgat cttaacttcg
    13561 ccaatattaa cattggacca actattccat gagcaatacc taaatcaaat tcaatttttg
    13621 aatctataga acaatttttc actttactaa aaattgtctc aatatacttc aaaagataca
    13681 ttcctatttg tttcaacgct tcaaaaaaat attctctctc aagcattaaa taattagcta
    13741 ttccactaaa accgttaacc atatcatagt caaatggatc aataatccct ttatctatat
    13801 ttgataaact tataatcaac ttttcttgaa tttgttcttt caataggcga tgtaaagagt
    13861 ccaatagctt ggtataatat tttcctgata tactagcttc cctaattgcc aatgaaatac
    13921 cagcagtccc cgcatagaga gagggagatt ctattccgtc tttggagatt atttcaacta
    13981 atttactgat atagctgtta gacagatcca tatacttatc ttgtctagtt actttatata
    14041 gcgagctata cattaaaatt aatgatggaa ttccgtgact taaagatttt tcaaaaaaag
    14101 tatttttgta tttagattct atgctaatta gcgtctcatt tgtactttct gctactattt
    14161 gttcatagtt cgtaaatcta tcagcaacat aatctaaaat ttgttcaatt tgaggtgtca
    14221 tatacaattc caatctcctt atctaacaag tttttgaatt tcttaccttt aaaatttaaa
    14281 tcattgaaac ttcctgtctc aactatttta ccattctcca agtatagaat tttatctaca
    14341 aattgagtaa tacttggctt atgtgtaatg aaaatgccaa tcttattttg tgacaattca
    14401 aaaaaagttt taaaaatttt tgcttcagat tttggatcta aagctgaact aggctcatct
    14461 aaaaaataac aatcagcttc tttaagataa actcttgaca atgcaatttt ttgccactgc
    14521 ccaccagata actgtctccc gtcctcgaac caatttccta gttgctgttc taagtctaac
    14581 tgattagttt ttccttcttt cttataaaat attgaatcaa ttcccgtacg ctttaatgta
    14641 tttattaaag actcatcatt atacagtttt gataactcac ctaaaccaat attttctcga
    14701 agtgttaact cgtatttcaa gaaatcctga aataaagctg atatccgctt ataatatgat
    14761 tttttctgta ttgaacgaat attattaccg tttatataaa tgtttccttc ataattatca
    14821 taaagtccgc agactaattt aaaaatagta ctcttccctg aaccattttc accaacaatt
    14881 gctatttttt ctcctgattt gattgaaaaa cttatgttat ttatcacatt ttccttacca
    14941 tcatatgaaa aagaaacatt ttcaaactcg atagacttaa tatcgttaac tactttgtct
    15001 tttagattat tgtattcagt ctcactatga gtgaaatcat atagtaactc catgtacagt
    15061 gatccattat agaaggaata aatattgttc actatatttt tggtactcgt ttgcattgtt
    15121 gacaaagatc taataaaggt tgttacattt ccaattaaaa ttattcctaa aaacgcctct
    15181 ctaactgcaa gaaacattat tattgactct attataatct ccaatattcc caataaaata
    15241 ccatttccca ttttagattt atttatgcta ttttcctgag taataaatag ttgattattt
    15301 ttgtcaaatt tttttaaaaa atagttttct aatataccta accttaactc cttaacagca
    15361 aaatcatgtg ttaaaatatg gcttatgtac caatttgccc tttcatcact actccgctta
    15421 tataacattt caaattcgtt tttacctatt tttaagtata tataaattga aattaccgga
    15481 agaataatca agagtggaaa aattgatgtt ttccaattca acaaaatgat aaaggaagaa
    15541 ataaatgata ctaatgaaga aagtacagaa ataatagatt tatatatttg aaatggttta
    15601 taggatattt gattttgtat acgtgtaata tcatcatata tttctggagt ttcaaattca
    15661 gctaatgtta gctttacagt tttctgcatg accaagtgat tcatcttata atgcaaaagt
    15721 atctgcaatt tagcatcaat ataaccatca acttctccaa ctatggtagt caataatgtt
    15781 aaagcaacaa aaagtataaa agtaatcatc aatgtttgaa aacgttcaat actactagta
    15841 ataatattta acatattttg caccaatagc atactaacaa ttggtaagat tccttgaatt
    15901 atactaatac caatcgagag caacaacaat gaaaatcctg cttcttttac aagattgatt
    15961 gttttcatta agttcttcag ttgattttta atcatatata acttccttat ctaccaataa
    16021 aggagcaaac taaaaacagt ctactcctct aaattcataa acatatcgga ttatctaaaa
    16081 ctaaagtaat tatattaatt aaattattta atagttgttg taagacaaac taatttccaa
    16141 caagaacccg gtgtgcaaag atagcgacta cccacaagtg gttcatcaga gttattttta
    16201 gttgtcttta aatctaggtc gaaatctttg attgtatttt tcatcttata tttcctctct
    16261 tatttatatg tccgatatat ttacgatgtc attatttcat cttaagttca gaatctgttc
    16321 agaaaaaaag catttggaca taaaattgta agaaattttc tgtccaaatg ctttaaatta
    16381 tgtggcttta agtccgtttc gctccgaagg tgcgaaacaa ataaaccacc cgctatgcgg
    16441 gtgcgcatcg aaggttatac cgtcata
//
