GCA_902167585.1 - 8 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

CABHMP010000004 (original name was: CABHMP010000004.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 4.1	lanthipeptide-class-ii	23,875	46,811

CABHMP010000006 (original name was: CABHMP010000006.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 6.1	RaS-RiPP,sactipeptide	3,829	26,369

CABHMP010000013 (original name was: CABHMP010000013.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 13.1	lanthipeptide-class-ii	1	19,665	staphylococcin C55 α / staphylococcin C55 β	RiPP:Lanthipeptide	30%

CABHMP010000016 (original name was: CABHMP010000016.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 16.1	NRPS,transAT-PKS	1	24,618

CABHMP010000018 (original name was: CABHMP010000018.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 18.1	lanthipeptide-class-i	950	17,416	streptin	RiPP:Lanthipeptide	70%

CABHMP010000022 (original name was: CABHMP010000022.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 22.1	RiPP-like	73,898	85,994

CABHMP010000039 (original name was: CABHMP010000039.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 34.1	RiPP-like	79,798	90,589

CABHMP010000041 (original name was: CABHMP010000041.1)

Region	Type	From	To	Most similar known cluster		Similarity
Region 36.1	RRE-containing	76,110	97,249

Region	Type	From	To	Most similar known cluster	Similarity
Region 4.1	lanthipeptide-class-ii	23,875	46,811
Region 6.1	RaS-RiPP,sactipeptide	3,829	26,369
Region 13.1	lanthipeptide-class-ii	1	19,665	staphylococcin C55 α / staphylococcin C55 β	RiPP:Lanthipeptide	30%
Region 16.1	NRPS,transAT-PKS	1	24,618
Region 18.1	lanthipeptide-class-i	950	17,416	streptin	RiPP:Lanthipeptide	70%
Region 22.1	RiPP-like	73,898	85,994
Region 34.1	RiPP-like	79,798	90,589
Region 36.1	RRE-containing	76,110	97,249

Compact view

c00004_CABHMP0.. - Region 1 - lanthipeptide-class-ii

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Location: 23,875 - 46,811 nt. (total: 22,937 nt) Show pHMM detection rules used

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

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Lanthipeptides

KnownClusterBlast

Lanthipeptide predictions

Lanthipeptide(s) for ctg4_38 - Putative Class II

ctg4_40 leader / core peptide: MLGNDKVIDSLEFEVAQQELEGSSGA - GDhbRDhbAIRMDhbDhaQGRCGWIFDhbFDhaYECDhaADhaHIRCDha
ctg4_43 leader / core peptide: MSRKNNSPDNGMMESFFG - ILKDhaEMFYRYGKMFKDhaLKQLEQAIVDYINYYNQRINVKLKLDhaNQGDhbYHQDhbWEDhaLCQKGDhaL
ctg4_44 leader / core peptide: MINKEEHEVIDSLEFEVSNQELEGQSGA - GWWDhbAIDhaLDhbADhaGRCGHVFDhbADhaFECDhbDhaNNVRCK
allorf_46443_46559 leader / core peptide: LVNILKSGVGA - DhbGDLDhaRDhaFPNHIPDDhaHDVFHCNYDhaGYL

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Similar known gene clusters

No matches found.

Lanthipeptides

Core peptide predictions

ctg4_40 - Class II

Cleavage pHMM score: 0.20

RODEO score: 0

Monoisotopic mass: 3449.7 Da

Molecular weight: 3451.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3469.9 Da N = 1; 3487.9 Da N = 2; 3506.0 Da N = 3; 3524.0 Da N = 4; 3542.0 Da N = 5; 3560.0 Da N = 6

ctg4_43 - Class II

Cleavage pHMM score: -3.20

RODEO score: 0

Monoisotopic mass: 7109.7 Da

Molecular weight: 7114.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 7132.2 Da N = 1; 7150.2 Da N = 2; 7168.2 Da N = 3; 7186.2 Da N = 4; 7204.3 Da N = 5; 7222.3 Da N = 6

ctg4_44 - Class II

Cleavage pHMM score: -2.90

RODEO score: 0

Monoisotopic mass: 3344.6 Da

Molecular weight: 3346.7 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 3364.8 Da N = 1; 3382.8 Da N = 2; 3400.8 Da N = 3; 3418.8 Da N = 4; 3436.8 Da N = 5

allorf_46443_46559 - Class II

Cleavage pHMM score: -4.20

RODEO score: 0

Monoisotopic mass: 2987.4 Da

Molecular weight: 2989.2 Da

Number of bridges: 1

Alternative weights: (assuming N unmodified Ser/Thr residues); 3007.2 Da N = 1; 3025.2 Da N = 2; 3043.2 Da N = 3; 3061.3 Da N = 4

c00006_CABHMP0.. - Region 1 - RaS-RiPP,sactipeptide

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Location: 3,829 - 26,369 nt. (total: 22,541 nt) Show pHMM detection rules used

RaS-RiPP: (PF04055 and TIGR01716)
sactipeptide: (subtilosin or thuricin or TIGR04404 or Subtilosin_A or skfc)

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KnownClusterBlast

Sactipeptides

Similar known gene clusters

No matches found.

Sactipeptide predictions

Sactipeptides - No core peptides found.

Sactipeptides

Core peptide predictions

No core peptides found.

c00013_CABHMP0.. - Region 1 - lanthipeptide-class-ii

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Location: 1 - 19,665 nt. (total: 19,665 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-ii: cds(LANC_like and DUF4135)

Legend:

core biosynthetic genes

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Lanthipeptides

KnownClusterBlast

Lanthipeptide predictions

Lanthipeptide(s) for ctg13_4 - Putative Class II

ctg13_2 leader / core peptide: MDKHSEVTLENEILFQEFDEDVFGA - CDhbDhbNDhbFDhaMDhaDYWGNKGNWCDhbLDhbHECMNWCR
ctg13_3 leader / core peptide: MEQNNLELGKYLESDLLSLTDENVDGG - DhbDhbPADhaPYDhbKDICRGIDhaIVDhbAFIDhaANDhbCPDhbDhbACDhbRAC
ctg13_8 leader / core peptide: MFNRFFDIIICIIVGNIVLTILESFGM - NVWIARLIACLVVGICGVLDhbYRFEKK

Lanthipeptide(s) for ctg13_6 - Putative Class II

ctg13_2 leader / core peptide: MDKHSEVTLENEILFQEFDEDVFGA - CDhbDhbNDhbFDhaMDhaDYWGNKGNWCDhbLDhbHECMNWCR
ctg13_3 leader / core peptide: MEQNNLELGKYLESDLLSLTDENVDGG - DhbDhbPADhaPYDhbKDICRGIDhaIVDhbAFIDhaANDhbCPDhbDhbACDhbRAC
ctg13_8 leader / core peptide: MFNRFFDIIICIIVGNIVLTILESFGM - NVWIARLIACLVVGICGVLDhbYRFEKK

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Similar known gene clusters

Lanthipeptides

Core peptide predictions

ctg13_2 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3462.4 Da

Molecular weight: 3464.9 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3482.9 Da N = 1; 3500.9 Da N = 2; 3518.9 Da N = 3

ctg13_3 - Class II

Cleavage pHMM score: -2.60

RODEO score: 0

Monoisotopic mass: 3535.8 Da

Molecular weight: 3538.1 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3556.1 Da N = 1; 3574.1 Da N = 2; 3592.1 Da N = 3; 3610.1 Da N = 4; 3628.2 Da N = 5; 3646.2 Da N = 6; 3664.2 Da N = 7

ctg13_8 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 2945.7 Da

Molecular weight: 2947.6 Da

Number of bridges: 1

ctg13_2 - Class II

Cleavage pHMM score: 2.00

RODEO score: 0

Monoisotopic mass: 3462.4 Da

Molecular weight: 3464.9 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3482.9 Da N = 1; 3500.9 Da N = 2; 3518.9 Da N = 3

ctg13_3 - Class II

Cleavage pHMM score: -2.60

RODEO score: 0

Monoisotopic mass: 3535.8 Da

Molecular weight: 3538.1 Da

Number of bridges: 4

Alternative weights: (assuming N unmodified Ser/Thr residues); 3556.1 Da N = 1; 3574.1 Da N = 2; 3592.1 Da N = 3; 3610.1 Da N = 4; 3628.2 Da N = 5; 3646.2 Da N = 6; 3664.2 Da N = 7

ctg13_8 - Class II

Cleavage pHMM score: -6.40

RODEO score: 0

Monoisotopic mass: 2945.7 Da

Molecular weight: 2947.6 Da

Number of bridges: 1

c00016_CABHMP0.. - Region 1 - NRPS,transAT-PKS

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Location: 1 - 24,618 nt. (total: 24,618 nt) Show pHMM detection rules used

Region on contig edge.

NRPS: cds(Condensation and (AMP-binding or A-OX))
transAT-PKS: (cds(PKS_AT and not (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) and (cds(ATd and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS)) or cds(tra_KS and PP-binding)))

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NRPS/PKS domains

KnownClusterBlast

Detailed domain annotation

Selected features only

Show module domains

Similar known gene clusters

No matches found.

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 24618:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (X - mal) + (cys) + (ohmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

ctg16_6

PKS_AT (6..282): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 67.0
inactive: 35.5
Methoxymalonyl-CoA: 15.9
Methylmalonyl-CoA: 11.2
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

ctg16_10

Search NORINE for peptide: strict or relaxed

AMP-binding (824..1226): cys

NRPSPredictor2: cys

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: cys
Small clusters prediction:: cys
Single AA prediction:: cys

Stachelhaus prediction details:

Stachelhaus sequence:: DLFNLSLvWK
Nearest Stachelhaus code:: cys
Stachelhaus code match:: 90% (moderate)

ctg16_11

Search NORINE for peptide: strict or relaxed

AMP-binding (11..360): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: N/A
Small clusters prediction:: phe, trp
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: ipWTIldtlK
Nearest Stachelhaus code:: phe
Stachelhaus code match:: 40% (weak)

c00018_CABHMP0.. - Region 1 - lanthipeptide-class-i

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Location: 950 - 17,416 nt. (total: 16,467 nt) Show pHMM detection rules used

Region on contig edge.

lanthipeptide-class-i: ((LANC_like and (Lant_dehydr_N or Lant_dehydr_C)) and not (YcaO or TIGR03882))

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core biosynthetic genes

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Lanthipeptides

KnownClusterBlast

Lanthipeptide predictions

Lanthipeptide(s) for ctg18_14 - Putative Class I

ctg18_17 leader / core peptide: MKNTIKDFDLDLKTTKNNSDEPL - VGDhaRYLCDhbPGDhaCWKLVCLDhbDhbDhbIK

Legend:

Dha: Didehydroalanine
Dhb: Didehydrobutyrine

Similar known gene clusters

Lanthipeptides

Core peptide predictions

ctg18_17 - Class I

Cleavage pHMM score: 6.80

RODEO score: 22

Monoisotopic mass: 2420.3 Da

Molecular weight: 2421.9 Da

Number of bridges: 3

Alternative weights: (assuming N unmodified Ser/Thr residues); 2439.9 Da N = 1; 2458.0 Da N = 2; 2476.0 Da N = 3

c00022_CABHMP0.. - Region 1 - RiPP-like

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Location: 73,898 - 85,994 nt. (total: 12,097 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

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KnownClusterBlast

Similar known gene clusters

No matches found.

c00034_CABHMP0.. - Region 1 - RiPP-like

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Location: 79,798 - 90,589 nt. (total: 10,792 nt) Show pHMM detection rules used

RiPP-like: (strepbact or Antimicrobial14 or Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or Lactococcin or Antimicrobial17 or Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or TIGR03975 or DUF692 or TIGR01193)

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core biosynthetic genes

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KnownClusterBlast

Similar known gene clusters

No matches found.

c00036_CABHMP0.. - Region 1 - RRE-containing

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Location: 76,110 - 97,249 nt. (total: 21,140 nt) Show pHMM detection rules used

RRE-containing: minimum(1, [Bottromycin_Methyltransferase_RRE, Cyanobactin_D_RRE, Cytolysin_C_RRE, Goadsporin_CD_RRE, Heterocycloanthracin_C_RRE, Lanthipeptide_LanB_RRE, Lasso_Fused_RRE, Mycofactocin_RRE, NHLP_CD_RRE, Other_Sactipeptide_rSAM_RRE, Pantocin_Microcin_RRE, Plantazolicin_C_RRE, PlpY_RRE, PqqD_RRE, Proteusin_Epimerase_RRE, Proteusin_Methyltransferase_RRE, Quinohemoprotein_rSAM_RRE, Ranthipeptide_rSAM_RRE, Stand_Alone_Lasso_RRE, Streptide_RRE, Subtilosin_rSAM_RRE, Thiaglutamate_B_RRE, Thiaglutamate_G_RRE, Thiaglutamate_I_RRE, Thiopeptide_F_RRE, Thuricin_rSAM_RRE, Thurincin_rSAM_RRE, Trifolitoxin_RRE])

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core biosynthetic genes

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Gene details

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KnownClusterBlast

Similar known gene clusters

No matches found.