LOCUS       c00034_CADBNU0..       11264 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  CADBNU010000034.1 Bacillus coagulans isolate RUG14133 genome
            assembly, contig: RUG14133_asm_34, whole genome shotgun sequence.
ACCESSION   CADBNU010000034
VERSION     CADBNU010000034
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2022-06-21 02:30:25
            Original ID  :: CADBNU010000034.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 11264
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..11264
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[639:8226]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      640..8226
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..11264
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..11264
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(3..131)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) HMGL-like"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg34_1"
                     /sec_met_domain="HMGL-like (E-value: 9.2e-17, bitscore:
                     50.8, seeds: 15, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEIKIFDTTLRDGEQTPGVNLNVMEKLEIARHLERLGVDRIE"
     CDS             complement(640..2361)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg34_2"
                     /sec_met_domain="ILVD_EDD (E-value: 1.1e-221, bitscore:
                     726.3, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRNEKDLRIKSHAFDGPVRSPNRAMLRAVGVTDEDFKKPMIGVAS
                     TWAEVTPCNIHLNDLASRAKQGVRDAGGVPLIFNTITVSDGISMGTQGMRYSLPSRDLI
                     SDSIETVVSAENMDGLVAIGACDKNIPGCLMGIANANVPAVFVYGGTIKPGKLNGKDID
                     IVSVFEGVGRFNAGQIDAKELSEIECSACPGAGACGGMYTANTMASAVEALGMSLPSSA
                     SHPAESNEKVDDVYAAGKAVYNLLEKGIYPKDIMTKKAFENAITVVMALGGSTNAFLHL
                     LAIAHTVGVDLTYDDFNRIQEKTPHIADLKPSGKYVMQDLFEAGGTQAVMKLLYDAGLL
                     HGDCLTVTGKTLAENLEDAPKLKDGQKVVMPLDKPLRKDGPLIVLKGNLAPEGAVIKMS
                     GVKVDHHTGPARVFDTEEEATAAVLNNEIKEGDVIIVRYVGPKGGPGMPEMLSLSGIIV
                     GKGLDEKVALLTDGRFSGGTHGLVIGHIAPEAQVGGPIALIQDGDIVTIDPGKKELSVA
                     LSEEEFEKRRKNWVAPPLYNKGVLGKYAHTVSSAAQGAVTDFVNRTEKAQEKQLVK"
     CDS             complement(2424..3401)
                     /locus_tag="ctg34_3"
                     /transl_table=11
                     /translation="VNNLQWLAKISSFAGNTFAIWIIIFASLSYFFPTGFTWIAPHISL
                     LLGIIMFGMGLTLTVDDFKTVLKIPKSVFIVSVAQYTIMPLMAFGLAYLFQLPPELAAG
                     VILVGCAPGGTASNVMTFLAKGNTALSVCATAVSTLLAPILTPFLTWLLASRWMDVSFW
                     TMFKTVIQVVLLPIVLGILMQYFFQKQVKKAVAILPLISVIGIVGVASAVVSVNRDSLF
                     VNGFLIFLVVLLHNGLGLCLGYWVAKLFRLNYADQKAVSIEVGMQNSGLASSLATLHFA
                     PLAAIPSVIFSVWHNISGPILATYWSRKEETKRKLVTDEKTLNN"
     CDS             3913..5646
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg34_4"
                     /sec_met_domain="TPP_enzyme_C (E-value: 3.1e-55, bitscore:
                     175.6, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VSLKVVKKQKEQVQQVTGSDILIDALTEQNVEFVFGYPGGAVLPI
                     YDALYRKKASFQHILTRHEQGAIHAAESYARITGKPGVVLATSGPGATNLVTGIADAMI
                     DSLPLVILTGQVAKGVIGTDAFQEADVIGITTPITKYNYQVNKIEDLPKIIKEAFYIAT
                     TGRPGPVVIDIPKNISQELSEPIKVEKNVKVHLQGYQPTIFPNPLQVVKLLESLKHAKK
                     PVVLAGAGVLFAEASCELKQFAEKYQLPVTNTLLGLGSFPGDHPLFLGMAGMHGTYAAN
                     MALTECDLLINIGARFDDRLTGNVEHFAPNAKVAHIDIDPAEISKNVDTEIPLVGDAKE
                     VLKLLLKHETETPDHSEWNYHLNQYKKEKPLWYEKPKEHLSPQWLVQQIFEITKGDAIV
                     TTDVGQHQMWAAQYYQFKKPNRWVTSGGLGTMGFGLPAAIGAQLAAPNDTVVSLLGDGG
                     FQMTLQELAVIRERNLPVKVIILNNQALGMVRQWQETFYEKRISESVFSYNPDFIKLAE
                     SYGIPGVLIEDERSARNKLEQVFHTDGPIVVDCHIAQSECVNPMVAPGKGLHEMIGVEK
                     E"
     CDS             5651..6166
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg34_5"
                     /sec_met_domain="ALS_ss_C (E-value: 4.7e-31, bitscore:
                     96.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRIITATVQNRSGVLNRVTGMLTKRQFNIESITVGESEKEGISK
                     MTFVIDVADHLKVEQLTKQLNKQIDVIKVQDITDKAHVVRELALIKVSASRQHQAEIQS
                     LILPFRATIIDVSKDSLVVEVTGKPEKINALIELLKSYGIKEITRTGITAFLRGYQPQV
                     SEMNTISI"
     CDS             6190..7224
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg34_6"
                     /sec_met_domain="IlvN (E-value: 4.5e-81, bitscore: 259.7,
                     seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="IlvC (E-value: 7e-70, bitscore: 223.4,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVKVVLEKDIERDVLQGKKIAILGYGSQGHAHAQNLRDNGHDVII
                     GLRQGKSFEKAKEDGFTVLPVADAVSLAEVVMVLMPDEVQPKVYEENIKPNLKSGAALV
                     FAHGFNIHYGQVKPPADVDVFLVAPKGPGHIVRRTFTEGAGVPALYAIHQDVTGEAKDL
                     ALSYAKGIGAARAGVLKTTFKEETETDLFGEQAVLCGGLSQLVKTGFEVLTEAGYQPEA
                     AYFEVLHEMKLIVDLMYEGGLAYMRYSISDTAQWGDFVSGPRVINNETKERMKEVLADI
                     QSGKFAKDWILENQVNRPQFNAINNREKEHPIEQVGRDLRALMPFIQKPEQEKEQEVKQ
                     LAKN"
     CDS             7228..8226
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: PALP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg34_7"
                     /sec_met_domain="PALP (E-value: 8.9e-84, bitscore: 270.7,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VCVYHGDYLTSDKINEAYKKLSQFVHQTPVMTSETTNRIVGKKVY
                     FKMENQQKTGAFKIRGALYKMMQLPEKLRRQGVITASAGNHAQGVAYAAKKANVKATIY
                     MPKHTPLNKVNATKAYGADVVLTGENFDEAFQASLKELDSGKVYIHPFDDYDVMAGQGT
                     VAIELLHEINELDTIIVPVGGGGLISGIAVAAKNIKPTIKIIGVQSNLASPIYRSFRNI
                     QLHVPSAISTIAEGIAVQNPGKKTLPIIENYVDDIITVTDGEIACSILYMLERNKTLVE
                     GAGAAAIAALFRYHQHIRSKQCGVIVSGGNIDIQQMTTIQEIAKKHYVQTG"
     CDS             complement(8440..9801)
                     /locus_tag="ctg34_8"
                     /transl_table=11
                     /translation="MDITLNEMLETIRMVQMENLDIRTVTMGISLKDCADADFNKMKDR
                     IYGKITHYAGQLKSVAEQVEKEYGIPIINKRISVTPIAEILGDRSVSEAVEIAKTLDRA
                     AKDLDVDFLGGFSALVHKGMTKADATLIEAIPEALTVTDRVCSSVSIGNTKAGINMDAV
                     RKMGEIIKEAAEKTKEQNGIACAKLVVFCNPVEDNPFMAGAFHGAGEGEVVLNVGVSGP
                     GVVLNALKRHPDADLGEVSEVIKKTAFKITRAGELIGRVVAKRLGVPFGIMDLSLAPTN
                     AMNDSVAEILEEMGLERVGTHGTIAALALMNDAVKKGGAMASSYVGGLSGAFIPVSEDN
                     GMIRGVQEGALTLSKLEAMTCVCSVGLDMIAVTGDASAETLSAIIADEAAIGMINKKTT
                     AVRIIPVPGKKAGEMVEFGGLLGRAPIMEVNQYNSVKFIQRGGRIPAPIQALSN"
     CDS             complement(9829..10104)
                     /locus_tag="ctg34_9"
                     /transl_table=11
                     /translation="METKRAVVSVVGKDQIGIISHVTSVLANNKVNILDISQTILQDFF
                     TMMMIVDVTNISSLEDLQAQLDEVGKKLALTIHVQMEEIFRSMHRI"
     CDS             10524..11243
                     /locus_tag="ctg34_10"
                     /transl_table=11
                     /translation="MNLKYLLSSIFLGVILLVGCSNNGDSNKDVNEESKIEENESEHVN
                     NEETDDKEDEATDDQENNKDIENKTDDSTNEDDLNNDKEETEHHDNNIDEDYTFNVTED
                     GNQVIVEVGAITFIYPNTFSETIAESQLIPTFEIANADQTIIINAAVEQLPMKMTPEEY
                     ISIASSNYGIEYEEVSMKTNANGIEFTEAITEQTGIKVNQRIIIVDNTAYIFSYASASY
                     EENLNIYDQIIDSIDIN"
ORIGIN
        1 gcttcaatac ggtctacacc aagtctttct agatgtcttg caatctctaa tttttccata
       61 acatttaaat tgacacctgg cgtctgttcc ccatccctta aagtcgtatc aaaaatttta
      121 atttcagcca ttatttcttt cctccttttc tttttccaaa acgtgataca ttgttcaact
      181 aacttaataa gtactagttt agaacaaata taaaaaagct catttctccc ataaagagtc
      241 ctttagacct ttaaatgggg agaaataagc tttctcggta ccacccatgt tcgtaatatc
      301 ctcacgaata ttacctcatg aagctagaaa aataatgtaa acttaatata atcatattct
      361 agcttccttt tggtaacggg tattgatacc cggctaaacc taataagtga agtgtaaacc
      421 gttcagtcta gcactcaggg atgaggctga aacagtgtgt atttccaggt ttccaccatc
      481 cccggatctc tataaataca ggctcactgt tccatagtcc cttcatcgtt ttattacatt
      541 aacgttttaa ttttttaaaa attccaattg attttattgt tcactataat aagatattta
      601 ttttaaataa tcaagagttt ttttgtaaat tttttagcct tatttaacta attgtttttc
      661 ttgagctttt tccgttcggt ttacaaagtc ggtaactgct ccttgtgctg cgctcgatac
      721 agtatgggca tatttcccta gcacaccttt attgtatagt ggcggtgcaa cccaattttt
      781 tctccgcttt tcaaattctt cttcagataa agcaacagat aattctttct ttcctggatc
      841 gattgtgacg atatcaccat cttgaataag cgcgatcggt ccaccaactt gagcttctgg
      901 agcaatatgt ccaattacta aaccatgagt accacccgag aagcggccat cagttagtag
      961 ggcaactttt tcatctaacc cttttcctac aattatgcca gaaagggaga gcatttcagg
     1021 cataccaggt ccacctttag gacctacata ccgaacgata atgacgtctc cttcttttat
     1081 ctcattattt aacacagctg ctgttgcctc ttcttctgta tcaaacacac gggcgggtcc
     1141 tgtatgatga tctactttaa ctccagacat cttaatgaca gccccttcag gtgctagatt
     1201 tcctttcaat acaataagtg gaccatcttt gcgtaaaggc ttgtccaacg gcataacaac
     1261 tttttgccca tcttttaatt ttggtgcgtc ttcaagattt tcagccaatg tctttccagt
     1321 aacggttaaa cagtctccat gcaatagacc agcatcatat aaaagtttca taacagcttg
     1381 agtaccgccg gcttcaaata aatcttgcat aacatatttt ccgctaggtt ttaagtcagc
     1441 aatatgaggt gttttttctt gaattcgatt aaaatcatcg tacgttaaat caacaccaac
     1501 ggtatgtgca atggccagta aatgtaaaaa tgcgtttgtt gatcctccta atgccattac
     1561 tactgtaatc gcattttcaa aagctttttt tgtcataata tcttttggat aaatcccttt
     1621 ttcaagtaaa ttgtaaacag ctttccctgc agcatataca tcgtccactt tttcattaga
     1681 ttctgcaggg tgagaagcgc tacttggcaa actcatacct aatgcttcta cagccgatgc
     1741 cattgtgttc gcagtataca tacccccgca agcaccagca ccaggacatg ctgagcattc
     1801 tatttcactt aattctttag catcaatttg tccagcatta aaacgcccaa ccccttcaaa
     1861 aacagacaca atatcaatat ctttgccatt taatttacct ggtttaatag ttcctccata
     1921 aacgaacacc gctggaacat tagcattagc aatccccatt aaacaacctg ggatgttttt
     1981 atcacaagca ccaatggcta caagtccatc catattttct gcactaacta ctgtttcaat
     2041 cgaatctgaa attaaatctc gacttggtaa tgaatagcgc attccttgtg ttcccattga
     2101 aatgccatca gaaacagtga tcgtattaaa aataagaggc accccaccag catctcgaac
     2161 accttgttta gctcgtgacg ccaaatcatt taaatgaata ttgcatgggg ttacttctgc
     2221 ccaagtacta gcgacaccta tcattggttt cttaaaatcc tcatctgtta caccaactgc
     2281 gcgaagcatc gcccggttag gtgatcgaac tggtccatca aaggcatgac ttttaattcg
     2341 taaatctttc tcattcctca ttataagatc cacctttcat tttttatttg tatttgcata
     2401 aacttaacta gtaaataaaa agactagtta tttaacgttt tttcatcagt aactagtttt
     2461 ctttttgtct cttcttttct actccaatac gttgctaaaa ttggtcccga tatattgtgc
     2521 caaacactga aaatgacact cggtattgct gccaacggcg caaagtgaag ggtcgctagc
     2581 gatgatgcta gtccggaatt ttgcataccg acttctatag aaaccgcctt ttgatcagca
     2641 tagtttaacc gaaatagttt cgctacccaa taacctaaac ataatccaag accattatgt
     2701 aataagacaa ctaagaaaat aaggaaacca tttacaaata aagaatcgcg attaacggaa
     2761 acaacagcag aagctactcc gacaatccca ataacggaaa taagcggtaa tatagcaaca
     2821 gcttttttta cttgtttttg aaagaagtat tgcataagaa ttcctaagac aattggaagt
     2881 aaaacaacct gaatgactgt tttaaacatc gtccaaaatg aaacatccat ccagcgactt
     2941 gctaaaagcc atgtcaaaaa cggtgtcaag ataggtgcga gtaaagttga tactgctgta
     3001 gcacaaactg ataaagcagt attcccttta gctaaaaatg tcatcacatt agaagctgtt
     3061 ccacccggtg cacaacctac gagaataaca cctgctgcaa gttctggggg aagttgaaat
     3121 aagtatgcta atccaaatgc catgagtggc atgattgtat attgggctac agatacaata
     3181 aaaacacttt taggtatctt caatacagtt ttaaagtcat ctactgttaa agtaagcccc
     3241 ataccaaaca taataatgcc taataataac gaaatatgtg gggcaatcca ggtaaaacct
     3301 gtagggaaaa aataacttaa actagcaaaa ataatgatcc aaatcgcaaa cgtattccca
     3361 gcaaaagaac taatttttgc taaccattgc aaattgttca ccccttcgaa gttttataga
     3421 acattataaa tttatttttt gatttttcaa tagctttaga taaaaaaact ttttctaaaa
     3481 tttttgtaaa agctattgac gaaattaatt ttatgtaata gactcctttt taaattatca
     3541 atattttaaa tcgttaaaca aatgaatctt ttttgaaatg cgatgagagg aatgggaaac
     3601 aatctaaaat gtatcctagc gatccaggga tggtggaagc ctggaataca tattgtttcc
     3661 agatcatcct tgagtggtaa gctgaacgga tttccttatt aggtttaccc gggtatggat
     3721 ttacccgtta ccaaaaatgg aagctactag cttcatgagg tagtattcgc aaggatacta
     3781 taaatttggg tggtaccgag gaaaggaggc tcttttctcc ccaagcaagc tgccattttg
     3841 cagcagtgat ggggtgaata gagtcttttt ttataactcc ttttctaaaa attatttagg
     3901 aggtaacaaa aagtgagtct aaaagttgtt aagaagcaaa aagagcaagt tcaacaagta
     3961 acaggttcgg acattttaat tgatgctctg accgagcaaa atgtggaatt tgtgtttggt
     4021 tacccaggtg gagctgtatt accaatttat gatgctctgt atcgtaaaaa ggcatctttt
     4081 caacatattc taactcgcca tgaacaagga gcgattcatg cagctgaaag ttatgcacga
     4141 atcactggaa aacctggtgt tgtgttagct acatctggac ccggagcgac aaatcttgtg
     4201 accggaattg cggatgcaat gattgactca ctacccttag ttatcctgac cggtcaagtt
     4261 gcaaaagggg ttatagggac tgatgcattt caagaagctg atgtcattgg tatcacaaca
     4321 ccgattacaa aatataatta tcaagttaac aaaattgaag acttaccaaa aattattaaa
     4381 gaggcctttt atatcgcaac gacaggaaga ccaggacccg ttgttattga tattccgaaa
     4441 aacatttcgc aagaattatc agagcctatt aaagtagaaa agaatgtcaa agttcattta
     4501 caaggttatc aaccgacaat ctttccaaat cctttacaag ttgtgaaact acttgaaagc
     4561 ttaaaacatg caaaaaaacc agttgtgctt gcgggagcag gtgttttatt tgctgaagcc
     4621 tcttgtgagt tgaaacaatt tgcagaaaaa taccaattac cagtaacaaa tacgctttta
     4681 ggcttaggaa gctttcctgg tgaccatcca cttttcctag gtatggcagg catgcatgga
     4741 acatatgcag caaatatggc actaacagaa tgtgatctat taatcaatat tggtgcccgt
     4801 tttgatgatc gcttaaccgg aaatgttgaa catttcgctc caaatgcaaa agttgcccat
     4861 attgatattg atccagctga aattagtaag aacgtagaca cagagattcc attagtcggt
     4921 gatgcaaaag aagttttaaa actattatta aaacatgaaa ctgaaactcc agatcatagt
     4981 gaatggaatt atcatttaaa tcaatataaa aaagaaaaac ctctttggta tgaaaaacct
     5041 aaagagcatc tctcaccaca atggcttgtg cagcaaattt ttgaaattac aaaaggggat
     5101 gctattgtga caaccgatgt tggtcagcat caaatgtggg ctgcacaata ctatcaattt
     5161 aagaagccga accggtgggt tacttcagga ggacttggaa caatgggatt tggtttacct
     5221 gcagctatag gggcacaact tgctgcacca aatgatactg tagtttccct tttaggggat
     5281 ggcggattcc aaatgacatt acaagaattg gctgtgatca gagaaagaaa tcttccagtc
     5341 aaagtcataa ttcttaacaa tcaagcatta ggaatggttc gtcaatggca agaaacattc
     5401 tatgaaaaac gtatttctga atctgtattt tcctataacc ccgattttat taaacttgcg
     5461 gaaagttatg gaattcctgg tgtcttaatc gaagatgaaa gaagtgctcg aaataagtta
     5521 gaacaagttt ttcatacaga cggtccaatt gtagtcgatt gtcacattgc acaaagtgaa
     5581 tgtgttaatc caatggttgc tccaggaaaa ggattacatg aaatgattgg tgtagaaaag
     5641 gagtgaaaaa atgagacgga ttataacagc tacggtacaa aatcgtagcg gtgttttaaa
     5701 tcgagtaaca ggcatgctaa caaaacgtca attcaatatt gaaagtatta ctgttggtga
     5761 gtcagaaaaa gaaggcattt ccaaaatgac ctttgttatc gatgttgccg atcacctaaa
     5821 agttgaacag ttgacgaaac aattaaataa gcaaattgat gtaataaaag ttcaagacat
     5881 aacagataaa gctcatgtag ttcgagaact tgcgctgatt aaagtttctg cctcaagaca
     5941 acaccaagca gaaattcaaa gtctcatatt accttttcgg gcaacaatca tcgatgttag
     6001 taaggacagc cttgttgttg aggtaacagg aaagcctgaa aaaatcaatg cattaattga
     6061 gttattgaaa tcctatggaa taaaggaaat tacccgaaca gggattacgg cgtttttacg
     6121 cggctatcaa ccacaagtat ctgaaatgaa tacaatttct atttaataat aaatgaagga
     6181 ggaattttta tggttaaagt tgtactggaa aaggatattg aaagggatgt attacaaggg
     6241 aaaaaaattg cgatattagg atatggttca caaggtcatg cccatgcgca aaacttaaga
     6301 gataatggtc atgatgttat tattggatta agacaaggta aatctttcga aaaagcaaaa
     6361 gaagatgggt ttactgtttt accagtagca gacgctgtta gtctcgctga ggttgtcatg
     6421 gttttaatgc cagacgaggt acaaccaaaa gtttatgaag aaaatataaa accgaatctt
     6481 aaatcaggag ctgcccttgt ttttgctcat ggtttcaata ttcactatgg ccaagtaaaa
     6541 ccaccagcag atgtagatgt tttcctcgtt gctccaaaag ggccaggtca tatcgttcgc
     6601 cgtactttta ctgaaggtgc tggcgtacca gcattgtatg caattcatca agatgtaacc
     6661 ggtgaagcaa aggatcttgc tctctcatat gcaaaaggca ttggagctgc ccgtgccggt
     6721 gttttaaaga caacatttaa agaagaaact gaaacagatt tattcggcga gcaagctgta
     6781 ctttgtggcg ggttatctca acttgttaaa actggattcg aagtgttaac agaagcaggc
     6841 tatcaacctg aagcagcata ttttgaagtt ttgcatgaaa tgaaactcat cgtagattta
     6901 atgtatgaag gcggtctagc atacatgaga tattccattt cagatacggc tcaatggggt
     6961 gactttgttt caggaccacg ggttataaat aatgagacaa aggaaagaat gaaggaagta
     7021 ttagcagata ttcaatctgg taagtttgct aaagattgga tcttagaaaa tcaggttaat
     7081 cgaccacagt tcaatgcaat caacaaccgt gaaaaagaac atccaattga acaagtcggt
     7141 cgcgatttac gggcattaat gccatttatc caaaaacccg aacaagaaaa ggaacaagag
     7201 gtaaaacaat tagcgaaaaa ctaaggagtg tgtgtatacc atggggatta tttaacaagt
     7261 gacaagatta atgaggctta caagaaacta tctcaatttg ttcatcaaac accagtgatg
     7321 acttccgaaa cgaccaatcg tatcgttggt aaaaaagttt attttaaaat ggaaaaccaa
     7381 caaaaaacag gtgcatttaa aattcgcggt gctttgtata aaatgatgca attgccagaa
     7441 aaattgcgga ggcaaggagt aattacagcc tccgctggta accacgcaca aggagttgca
     7501 tatgcagcaa agaaggcaaa tgttaaagcc acgatttata tgccgaaaca tacgccacta
     7561 aataaagtga atgcaacgaa agcatatggt gccgatgtcg ttttaacagg agaaaacttt
     7621 gacgaagctt ttcaagcatc actaaaagaa ctagattctg gaaaagttta tatccatccc
     7681 tttgatgact atgatgtaat ggcaggacaa ggaactgttg caatcgaatt actacatgaa
     7741 ataaacgaac tagatacgat tattgttccc gttggcggtg gcggtttaat aagcggtata
     7801 gctgtagctg cgaaaaatat aaaaccaaca attaaaatta tcggagtgca gtccaatttg
     7861 gcatcaccta tttaccgcag ttttcgaaat atacagttac atgtaccatc tgccatctca
     7921 acaattgctg aaggaattgc tgtacaaaat cctggtaaaa aaacattacc aattattgaa
     7981 aactatgtag atgatatcat caccgttact gatggagaaa tcgcatgtag tattttatac
     8041 atgttagaac ggaataaaac acttgttgaa ggagcaggtg ctgctgcaat tgctgcttta
     8101 tttcgttacc accaacacat ccgttcaaaa caatgtggag tgattgtgag tggaggtaat
     8161 attgatattc aacaaatgac caccatacaa gaaatagcaa agaaacatta tgtccaaacg
     8221 gggtaaaagc taaacgggct gtcacataag ttataaaaag cgatttttga agaaaggcga
     8281 cgactccagc aggaacagta aaagcttttg tatccaaagt gtaagcttaa ggcacacgag
     8341 cctcagccct caaacgcctt tgcgcgcttg aggtagctga agctgtgcca ctggatgtac
     8401 gttcatcaac gtacctatta aaaatcccca aaaacttttt taattactta atgcttgtat
     8461 aggtgctgga attcggccgc cacgttgaat aaatttcact gaattatatt gattcacttc
     8521 cataattggt gcacgcccta ataagccacc aaattctacc atctctcccg ctttcttacc
     8581 tggcacaggg ataatacgaa cagcggtcgt tttcttattg atcattccga tagcagcttc
     8641 gtcagcaata atggcagata atgtttcagc tgaagcatca ccggtaacag caatcatgtc
     8701 caatcctaca gaacatacgc aagtcattgc ttctaactta gataatgtca acgcaccttc
     8761 ttgtacacca cgtatcatcc cgttatcctc acttaccgga ataaatgcac cacttaaacc
     8821 accaacatag gaacttgcca tcgcgccacc tttttttaca gcatcgttca ttaaagcaag
     8881 tgctgcgatt gtgccatggg taccaactcg ttctaagccc atttcttcta aaatttctgc
     8941 cacactatca ttcattgcat tggtaggtgc aagggacaaa tccataattc caaacggaac
     9001 gccaagacgt tttgccacaa cccggccgat taattcacct gcacgagtta ttttgaaggc
     9061 agttttttta attacttcgg aaacttcacc aagatcagca tctggatgtc gtttcaatgc
     9121 attaaggaca acgcctggac cactaacccc tacgtttaag acgacttctc cctcgcctgc
     9181 accgtgaaaa gcaccagcca taaatggatt atcttcaact ggattacaaa agacaactaa
     9241 ctttgcacaa gcaataccat tttgttcttt tgttttttca gctgcttctt taattatttc
     9301 gcccatttta cggactgcat ccatattgat accagccttc gtattcccaa tcgatacaga
     9361 agaacaaacc cgatccgtaa cagttaaggc ttctggaatt gcttctatta atgttgcatc
     9421 tgcctttgtc attcctttat gtacgagtgc tgagaatcca ccaagaaaat caacgtctaa
     9481 atccttagcc gctcgatcta aggttttagc gatttcgacc gcttcactta cagaacgatc
     9541 acctaaaatt tctgcaatcg gtgttactga aatccgttta tttataatcg ggatgccata
     9601 ctctttttct acttgttcag caacactttt taattgacct gcatagtgag taattttccc
     9661 gtatatgcga tccttcattt tattgaaatc tgcatcagca caatctttca agctaattcc
     9721 catcgtaacc gttcgaatat ccagattttc catttgtacc atgcgaattg tttcaagcat
     9781 ttcatttagt gtgatgtcca ttttccttac tccttatcat taatatcatt aaatccgatg
     9841 catcgaacga aaaatctctt ccatttgcac atgaatcgta agtgctaatt ttttaccaac
     9901 ttcatctaac tgagcttgta aatcctctaa acttgaaatg tttgttacat caacaatcat
     9961 catcattgta aaaaaatcct gtaaaattgt ttgactaata tctaatatgt tgactttgtt
    10021 atttgctaaa accgatgtaa catgagaaat aataccaatt tgatctttcc caacaacact
    10081 aacgactgca cgctttgttt ccataacaac cgctcctata taaatttttc tataaaaata
    10141 aaaaagattg gagttctcca atctcaataa acaaatagaa taaccaatca tagttactct
    10201 tctgtccttt tgcctgagat tgtgaatcct tcggcgccga aaaacggtct ctccagaagc
    10261 tgctccattt gtagtgttac ccacaaactt catcactaat acgattataa aattttaata
    10321 aaaatatatt aacaacataa aagtgtttgg tcaatatatt ttataaaaat ttgcttaaat
    10381 atatttactt aaaaactata tccatcacgt atagaactga tttctgaatt ttttgtcatc
    10441 atctcattta atttgcatac tatttaaaat tgaggcctca ctgaaggcaa aaaattttaa
    10501 catcatagaa tgtgggggag agcatgaatc taaagtattt actgtcaagt attttccttg
    10561 gtgtcatttt acttgtgggc tgtagcaaca atggagactc gaacaaagac gtaaatgaag
    10621 aatcaaaaat agaagagaac gaaagtgaac atgtaaacaa tgaagagacc gatgataaag
    10681 aagatgaagc aacggacgac caagaaaata acaaagatat cgagaataaa accgatgact
    10741 ctacaaatga agatgattta aataacgata aagaagagac tgagcatcat gacaataata
    10801 ttgatgaaga ttatacgttt aatgtaactg aagatggaaa tcaagtgatt gtggaagttg
    10861 gtgctattac atttatatat ccaaatactt tttcagaaac aatagcagaa agtcaattga
    10921 ttccgacttt tgagatagct aatgcggatc aaaccatcat tattaacgca gcagtagagc
    10981 aactgccaat gaaaatgaca cctgaagaat acatttcgat cgcatcgtca aactatggaa
    11041 ttgaatatga agaagtttct atgaagacaa atgcaaatgg aattgaattc acagaagcca
    11101 ttactgagca gacaggaatt aaagttaatc aaaggattat aatcgttgac aatacggcct
    11161 atatattctc ctatgcatca gcatcttatg aagaaaactt aaatatatat gaccaaatta
    11221 tagattcaat tgatatcaat taaatgtcta aaagcctgac aata
//
