LOCUS       c00004_CAJNQD0..       12732 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  CAJNQD010000004.1 Bacillus subtilis isolate NRS6131 genome assembly,
            contig: NODE_4, whole genome shotgun sequence.
ACCESSION   CAJNQD010000004
VERSION     CAJNQD010000004
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-19 20:39:02
            Original ID  :: CAJNQD010000004.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 385333
            Orig. end    :: 398065
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12732
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[390333:393065]"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      5001..7732
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..12732
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12732
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="3"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             47..577
                     /locus_tag="ctg4_387"
                     /transl_table=11
                     /translation="VKKDTRKYMIYFFGALGGLLYGYDTGVISGALLFINNDIPLTTLT
                     EGLVVSMLLLGAIFGSALSGTCSDRWGRRKVVFVLSIIFIIGALACAFSQTIGMLIASR
                     VILGLAVGGSTALVPVYLSEMAPTKIRGTLGTMNNLMIVTGFCSPISLTICSHRLKRGA
                     GWSVWPQCLPCFY"
     CDS             538..1431
                     /gene_functions="transport (smcogs) SMCOG1169:sugar
                     transport protein (Score: 262.1; E-value: 1.5e-79)"
                     /gene_kind="transport"
                     /locus_tag="ctg4_388"
                     /transl_table=11
                     /translation="MVGLAAVPAVLLLIGIAFMPESPRWLVKRGREEEARRIMNITHDP
                     QDIEMELAEMKQGEAEKKETTLSVLKAKWIRPMLLIGVGLAIFQQAVGINTVIYYAPTI
                     FTKAGLGTSASALGTMGIGILNVIMCITAMILIDRVGRKKLLIWGSVGITLSLAALSGV
                     LLTLGLSASTAWMTVVFLGVYIVFYQATWGPVVWVLMPELFPSKARGAATGFTTLVLSA
                     ANLIVSLVFPLMLSAMGIAWVFMVFSVICLLSFFFAFYMVPETKGKSLEEIEASLKNRF
                     KKKKSTQNQVLNERTL"
     CDS             complement(1473..3353)
                     /locus_tag="ctg4_389"
                     /transl_table=11
                     /translation="VAKKEFKAESKRLLDMMINSIYTQKEIFLRELISNSSDAIDKIYY
                     KALTDDALTFDKDSYYIKVAADKDARTLTISDTGIGMTKDELEQHLGTIAKSGSLAFKK
                     ENELKDGHDIIGQFGVGFYAAFMVADVVTVISKALGSEEAYKWESAGADGYTIEPCEKD
                     SVGTDIILKIKENTEDDSYDEFLEEYRLKAIIKKYSDFIRYPIKMDTTINKPKEGSENE
                     FEEVQEEQTVNSMVPIWRKNKSELTDEDYEKFYAEKHYGFDKPLTHVHISVDGAVRYNA
                     ILFVPENMPFDYYSKEYEKGLELYSNGVLIMNKCADLLPDHFSFVKGMVDSEDLSLNIS
                     REMLQHDRQLKLIAKNISKKIKSELQSLLKKDREKYETFYKSFGRQLKFGVYNDFGANK
                     DQLKDLLLFYSSKEKKLVSLDEYVSRMPEEQKYIYYATGDSYDRIEKLPQTEMVADKGY
                     EILYFTEDIDEFAIKMLASYQEKEFKSVSSGDLGIDTDEDQKQSEEEESKYKDLFEEMK
                     NILSDKVKNVRISKRLKSHPVCLAADGELTIEMEKILNAMPDSQNVKAEKVLEINPNHE
                     VFQTLQDAFEQDKEKLSLYTNLLYNQALLIEGLPIQDPVEFTNNICKVMV"
     CDS             complement(3522..3773)
                     /locus_tag="ctg4_390"
                     /transl_table=11
                     /translation="LKVQHKKELKFYCFVTIPSAFVVLTVISFLLQEITFPVTASAFLN
                     ASWHNLLFLIPFGLFFYPVHIWMKREFGRWNDTEKKRG"
     CDS             3890..4699
                     /NRPS_PKS="Domain: PKS_KR (7-160). E-value: 2.3e-09. Score:
                     29.1. Matches aSDomain: nrpspksdomains_ctg4_391_PKS_KR.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     247.6; E-value: 2.2e-75)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_391"
                     /sec_met_domain="adh_short (E-value: 1.6e-32, bitscore:
                     107.9, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 7.9e-37, bitscore:
                     122.5, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGRLENKTAVITGAATGIGQATAEVFANEGARVIIGDINKDQMEE
                     TVDAIRKNGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHEYP
                     VDLFDRIIAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKGGIT
                     NLTKAMAIDYARNGIRVNSISPGTIETPLIDKLAGTKEQEMGEKFREANKWVTPLGRLG
                     QPKEMATVALFLASDDSSYVTGEDITADGGIMAYTWPGKMLIDEKWK"
     aSDomain        3911..4369
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg4_391_PKS_KR.1"
                     /evalue="2.30E-09"
                     /label="ctg4_391_PKS_KR.1"
                     /locus_tag="ctg4_391"
                     /protein_end="160"
                     /protein_start="7"
                     /score="29.1"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="TAVITGAATGIGQATAEVFANEGARVIIGDINKDQMEETVDAIRK
                     NGGQAESFHLDVSDENSVKAFADQIKDACGTIDILFNNAGVDQEGGKVHEYPVDLFDRI
                     IAVDLRGTFLCSKYLIPLMLENGGSIINTSSMSGRAADLDRSGYNAAKG"
     aSModule        3911..4369
                     /domains="nrpspksdomains_ctg4_391_PKS_KR.1"
                     /incomplete
                     /locus_tags="ctg4_391"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       3917..3994
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ctg4_391_0001"
                     /evalue="1.80E-05"
                     /label="PKSI-KR_m1"
                     /locus_tag="ctg4_391"
                     /protein_end="35"
                     /protein_start="9"
                     /score="17.4"
                     /tool="antismash"
                     /translation="VITGAATGIGQATAEVFANEGARVII"
     CDS             5001..5198
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: Bacteriocin_IIc"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_392"
                     /sec_met_domain="Bacteriocin_IIc (E-value: 3.6e-14,
                     bitscore: 47.9, seeds: 35, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKELSNLELEKVEGGNWQNVTKNTLFAAADGAAIGGMFGGPAGAF
                     VGAHYGAAAYAIGYALDHRK"
     CDS             5222..5467
                     /locus_tag="ctg4_393"
                     /transl_table=11
                     /translation="MNNLENKSFEVLSDNQLELVEGGSGYGDGVAGGLTGGAILGGVVK
                     GAQNGAKYGRLGGAWGVAAGVVVGGAIGGYLGYKGA"
     CDS             5549..7732
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 289.6; E-value:
                     8.2e-88)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg4_394"
                     /sec_met_domain="TIGR01193 (E-value: 3.5e-237, bitscore:
                     784.2, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 1.3e-45, bitscore:
                     149.5, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MFFKKYQYVKQIDEKDCGAACLATILKHYGSKLSINKIRDIAGTD
                     KQGTSALGLVRAAEQLGFSAKGVKADKTALEEPFTLPAIAHIILNGQLLHYVVIHKITK
                     DQIIIADPGRGIIKYTKKEFLEVWTGILILLTPSETYKIHVETSTMRSDIFKLILHQKS
                     LIIHTILASFIITVFGIMGTFYFQTVIDEILPNGLNSTLHILSFSLIIMYLFKVLLTAF
                     RQYLMIFLGQKLSISIMFGYFKHVLSLPMKFFSTRKIGEIISRFNDASKVIDAIISASL
                     SVVLDTVMLVMVGIFLYLQNTTLFLITLAFIPFYVLTVWFFMKPYESINNTEMENNAQL
                     TSKIVETLNGIETIKAYNAEYMMSYETEKRFVKYLRSAFKHGVIDNLQNSIKMFLDLAS
                     GAFIMWIGSTQVMKGTLSIGQLITYNALLTYFLNPLQNIIGLQSKLQSASVASKRLGEI
                     LEVEHEIKDKDAQITTPGSINGPIEFTKINFRYGTRRLILKDITLRIDKGEKVAFIGES
                     GSGKSTLTKLLMKFYTAESGDILINGYHINDIHAHSLRESISYIPQESHFIQGSIFENL
                     LLGNSGSFTFEEIIEVCKQTNVHDFVNDLPMRYDTLVEENGSNLSGGQKQRLAIARALL
                     RKPNILIMDESTSNLDTTTEQGISKMIYDQTVGITTIIIAHRLSTIMNCDKIFVMENGE
                     IIEYGNHNDLLKKKGKYYELWENQMPSRGMVTI"
     CDS             7733..9202
                     /gene_functions="transport (smcogs) SMCOG1029:RND family
                     efflux transporter MFP subunit (Score: 71.6; E-value:
                     9.6e-22)"
                     /gene_kind="transport"
                     /locus_tag="ctg4_395"
                     /transl_table=11
                     /translation="MKRNFFNLHDLKDSREFYESKPKPIGVFFTYILIALLIACIVFSF
                     YGKKEVILKTTADIQYTKPNSNVTNEVAGKVKTVDIKQVDKVKKGDTLLTLDNTEIQAQ
                     KKAVKADIKDLKEQAALNKTLKKSIENDKNLFSEDDHWGYQDQYLSYEKQSILLESSKE
                     NAKTQQKKLKKQKKSIKDSLDKTKNKVKLKLQRISDLQDSIKNNKSFAKQDDKYSSYYN
                     SYQTNKQNVEQQLDDLRKMKDELDKNRFSQQKENLNGQLESLKQDMLVKLSEEKDELNQ
                     SLDEINSSIKSDDSDSDSDNSEETNYKLSIEQLKTNLLNQTSQKQTDLQTTLKSKEDDL
                     KMIDLQLEKYKIKAASDGYVNVLTNISPGDNLQAGTAILTIIPDKEKLKANIYIPSHEI
                     TNINEKDEVRFHIENTNQTIKGVITKISPDSISDQNGQKFYIAESTIEKNKVMNDNGST
                     LHLKNGMQTDVSIIVDSKRYIDYLLEILHLQ"
     CDS             complement(9720..10220)
                     /locus_tag="ctg4_396"
                     /transl_table=11
                     /translation="LAEKQDYAGITISDITRKSNIRRATFYDHYASKEELLQTMIQQSC
                     AEMIDHLTIASSPNELSFEEAEEALAGLLSALDRMPIVHLLNRDWVVPHVIPELLKALE
                     SFYLHQQTNIPAEKKLYAYYVSAMIIGLILYRLDEGKAHAPEVLARKFLQFLDVKKYKV
                     VLL"
     CDS             complement(10168..10863)
                     /locus_tag="ctg4_397"
                     /transl_table=11
                     /translation="VPESAEAQVKEALLALLKERDIQHITMKEIAEKAKVSRGSLYLYY
                     EDKFSIIEDLIEDMKEGLGKALFDAFSHLDTLHLNKKRQTVHPTLSFVHEHQSFFSVMM
                     NRGHFHRFFKDVFQHDVLLAPIHVNLTPIEREIYGHYRALYTYAIILYWLNEDAAATPE
                     AISQKVWELVSQKRFYWLFGQAVPGEREKDKPNRQAGGSNERGAPAGISGRIGGETRLR
                     GHHDFGYYA"
     CDS             11006..12343
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1017:aldehyde dehydrogenase (Score: 303.4; E-value:
                     3.5e-92)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg4_398"
                     /transl_table=11
                     /translation="MEQQVKDDIQRVFQLQKKQQKALRASTAEQRREKLQRFLDSVIAH
                     EEEIIEAIRKDVRKPYHEVKKAEIEGTKKAIRDNMNNLEQWMAPKEVGSSLSPDANGIL
                     MYEPKGVTLILGPWNYPFMLTMAPLAASLAAGNSAIVKLSDFTMNTSNIAAKVIRDAFD
                     EKEVAIFEGEVEVATELLDQPFDHIFFTGSTNVGKIVMTAAAKHLASVTLELGGKSPTI
                     IDSEYDLMDAAKKIAVGKFVNAGQTCIAPDYLFIKKDVQDRFAGILQTVVNAGFMEDDH
                     TPDRSKFTQIVNDRNFNRVKDLFDDAIEKGAEVVFGGVFDASDRTISPTVLKNVTSDMK
                     IMQEEIFAPILPMMNYEDIDEVIDYVNDRDKPLALYVFSKNQDLIDNVLQHTTSGNAAI
                     NDVVVHFSDVNLPFGGVNTSGIGSYHGVYGFKEFSHEKGVLIQAAK"
     CDS             12428..12598
                     /locus_tag="ctg4_399"
                     /transl_table=11
                     /translation="MYSDKIPFSLRDQIPLVYLIETAQPLTYNIPENLKGENIIHGKAS
                     WILDSGSCLYY"
ORIGIN
        1 cacattttag atactcattg gctcaacaac tgaggaggag acatttgtga agaaagacac
       61 aaggaaatat atgatctact ttttcggcgc tttaggggga ctgctatatg gttacgatac
      121 aggcgttatc tcaggagcac tcctgtttat caataacgat attcctttaa cgacattgac
      181 agaaggattg gttgtcagca tgctgctcct tggcgcgatt ttcggttctg ccttgagcgg
      241 cacatgctca gaccgctggg gcaggagaaa ggttgtattt gtcctttcca tcatttttat
      301 tatcggtgcg ctcgcttgcg cgttttctca aacaatcggc atgctgattg catctagggt
      361 gattctcggg ttggccgtcg gcggttcaac ggcacttgtg cccgtgtatc tttccgaaat
      421 ggcaccgacg aaaattcgcg ggacactcgg cacaatgaac aacttaatga ttgtcacagg
      481 attttgctcg cctatatcgt taactatctg ttcacaccgt ttgaagcgtg gcgctggatg
      541 gtcggtctgg ccgcagtgcc tgccgtgctt ctattaatcg gcatcgcgtt catgccggaa
      601 tcgccaagat ggctcgtgaa gcgcggccgt gaagaagaag cgagacgaat catgaacatc
      661 actcatgatc cccaagacat cgaaatggaa ttggcagaga tgaagcaagg ggaagcagag
      721 aaaaaagaaa cgacactcag cgtcctaaaa gccaaatgga ttcgccccat gcttctgatt
      781 ggcgtcggcc ttgccatttt ccagcaggcg gtcggcatta acacggtcat ctactacgcg
      841 ccaaccattt ttacgaaggc cggtcttggc acatcagctt cggcgctcgg cacaatgggg
      901 atcggcatcc tcaacgtcat catgtgtatc actgccatga tcttaattga ccgtgtcggc
      961 cgcaaaaaac ttctgatctg gggaagtgtc ggcatcacac tgagccttgc tgctttatca
     1021 ggcgtgctcc tgacactggg gctttccgca tcaacagcgt ggatgacagt agtctttctc
     1081 ggtgtctata tcgtctttta ccaggcgaca tggggtccgg tagtgtgggt gctcatgcct
     1141 gagctcttcc cgtccaaagc acgcggagcc gcgacagggt tcacgacttt ggtgttatcg
     1201 gcagctaacc tgatcgtgtc gctcgtcttc ccgctgatgc taagcgcgat gggcatcgca
     1261 tgggtcttta tggttttctc agtcatttgt cttctctcat ttttcttcgc gttctacatg
     1321 gtgccggaaa ccaaagggaa aagcttggag gaaattgaag caagcctgaa aaaccggttt
     1381 aaaaagaaga aaagcaccca aaaccaagtg ctgaatgagc gtacattata aaaaaaggaa
     1441 tcgtctcctt atgggacgat tcctttttct gtttacacca tgaccttgca aatattgttc
     1501 gtaaattcca cagggtcctg aatcggcagg ccttcgatga gaagcgcctg attgtacaga
     1561 aggtttgtgt acaggctcag cttctcttta tcttgttcaa acgcgtcctg cagcgtttgg
     1621 aatacctcgt gatttgggtt gatttccagc actttttccg ccttcacatt ttggctgtca
     1681 ggcatcgcgt ttaagatttt ttccatctca attgtcaatt cgccgtcagc agcaaggcag
     1741 actggatgtg atttaagccg ttttgagatt ctgacgtttt tcactttgtc tgacagaatg
     1801 tttttcattt cctcaaacag atccttatac ttgctttcct cttcctcgga ctgcttttga
     1861 tcctcatccg tgtctatgcc aaggtctccg cttgatacgg acttgaattc tttttcctga
     1921 taagaagcca gcattttaat tgcaaactca tcgatgtcct cagtaaagta gaggatttca
     1981 tagcctttgt ccgccaccat ttccgtttgc ggcagtttct caatgcggtc gtaagaatca
     2041 ccggtcgcgt aataaatgta tttctgctcc tctggcattc tggaaacata ctcgtctaag
     2101 ctgaccagtt ttttctcttt tgaagagtag aataatagga gatccttcaa ttgatcctta
     2161 ttcgcgccaa aatcattgta cacgccgaat ttcagctgtc tgccgaacga cttgtagaac
     2221 gtctcgtatt tctcgcggtc ttttttcaac aggctttgca gctcgctttt gattttcttg
     2281 ctgatgtttt tcgcgatcag cttcagctgg cggtcatgct gcagcatttc tctggaaata
     2341 ttcagcgaca gatcctcaga atcgaccatg cccttcacaa agctgaagtg gtccggtagc
     2401 aggtctgcgc acttattcat gatcagcacg ccattggaat acagctccaa gcctttctca
     2461 tattccttgg aatagtagtc aaacggcatg ttttcaggga cgaatagaat cgcgttgtag
     2521 cgcacggctc catccacact aatatgaacg tgtgtcagcg gtttatcaaa cccgtaatgc
     2581 ttttcagcat agaatttttc ataatcctca tctgtcagct cgcttttgtt ttttctccag
     2641 atcggcacca tgctgttgac cgtctgctct tcctgcacct cttcaaattc attttcgctg
     2701 ccttccttcg gcttattaat ggttgtatcc attttgatcg ggtagcgaat gaagtcggag
     2761 tacttcttga tgatcgcttt taaacgatat tcctctaaaa actcgtcata gctgtcatct
     2821 tctgtgttct ctttgatttt caggataatg tctgtaccga cagaatcctt ttcacacggc
     2881 tcaatcgtat agccgtctgc acccgcagac tcccatttat aagcctcttc gctgccaagc
     2941 gctttactga tgactgtcac gacatcggca accataaatg ccgcgtaaaa accgacaccg
     3001 aactgcccga taatgtcatg tccgtctttc agctcgtttt cctttttaaa cgcgagggaa
     3061 ccgctttttg caattgttcc aagatgctgt tcaagctcat cctttgtcat tccgatcccc
     3121 gtatcagaga tggttaatgt tctcgcatct ttgtcagctg cgacctttat gtagtaactg
     3181 tctttatcaa acgtaagcgc atcgtccgta agcgctttgt aatagatttt gtcaatcgca
     3241 tcactcgaat tggagattaa ctcgcgcagg aaaatttctt tttgggtata aatggagtta
     3301 atcatcatat ccagcaagcg tttagactct gctttaaact cttttttcgc cactcttgat
     3361 cgctccttta ccattatgta aacccttttc agcatctatt tatcacataa gatgacaatt
     3421 gtcaattaga ttgatagatg catatatatg taaatttaac attagttgga tttgttttca
     3481 ctctttttct cactcattct cataaaaaaa gagaggcttc atcatcctct ctttttttct
     3541 gtgtcattcc agcggccaaa ctcccgcttc atccatatat gcaccgggta gaaaaacaaa
     3601 ccgaacggta tcaaaaacaa tagattatgc catgaagcat tcagaaatgc gcttgcagtc
     3661 accggaaacg taatctcttg caataaaaaa gagatgacag tcagcacaac aaatgcagat
     3721 ggaatggtca cgaagcaata aaacttgagc tccttcttat gctgtacctt caaacttaga
     3781 aacctcccaa caatttctaa ttcatcttaa catatgccgg cctttctttt ctcgcatgtt
     3841 tatcactgca catagcggga agacaaatag aaaaaggagg tctcgtatca tgggaagact
     3901 tgaaaacaaa acagcagtga tcacaggcgc cgcgacaggc attgggcaag cgacggcaga
     3961 ggtttttgcc aatgaaggcg cgcgtgtgat catcggagat atcaataaag atcaaatgga
     4021 agaaacagtt gacgcaatca gaaaaaacgg aggacaggcc gaatcctttc acctcgatgt
     4081 gtcagatgaa aacagtgtga aagcatttgc tgatcaaatc aaggatgcat gcggaacgat
     4141 tgatattctg tttaataatg ccggcgttga tcaggaaggc ggaaaggtgc acgaatatcc
     4201 ggttgacctg tttgaccgca ttatcgctgt cgacctgcgc ggcacattcc tttgcagcaa
     4261 atatttgatt ccgctcatgc tcgaaaatgg aggctccatc atcaacacct cctccatgtc
     4321 aggccgtgcc gcggatcttg accgctccgg ctacaacgca gcaaaaggcg gcatcaccaa
     4381 cctgacaaaa gcgatggcga tcgactacgc acggaacggc atccgcgtca attccatttc
     4441 accgggtacg atcgaaaccc cgctgattga caaattagca ggcaccaaag aacaggaaat
     4501 gggcgagaaa ttccgcgaag ccaacaaatg ggtcacgccg ctcggccgcc tcggccagcc
     4561 gaaggaaatg gcgacagtgg ccctgttcct cgcgtcagac gacagctcat acgtcacagg
     4621 agaggacatc accgcagacg gcggcatcat ggcatacaca tggccaggga aaatgctgat
     4681 tgatgagaaa tggaaataaa attcagatga ttcattaaga gagggtggat agaaatctgc
     4741 cctcttttat tgaatttagg attagcattt caaaaatctt atacagtaga ttattagaac
     4801 attatagtaa taatccaatt tatcctcttg aatatacatt taaagtcaag tcgtttgtcc
     4861 aaaagaaatt aaataaactc caacatcttc atcatctaaa agtaagttaa ttaccaaaga
     4921 aaaatatagt aaatgatatt gattttacca ataatttata ctagaataac taggaaacca
     4981 gtacaaaagg agggttattt atgaaagaat tatctaattt agaattagaa aaagtggaag
     5041 gcggaaactg gcaaaatgtt acgaagaata ctctatttgc tgctgctgat ggagctgcaa
     5101 tcggaggaat gtttggtggt ccagcgggcg cttttgttgg ggctcattat ggagctgctg
     5161 catacgctat tggttacgct ttggatcaca gaaaataata caatgttagg ggaatataca
     5221 tatgaataat ttagaaaata aaagttttga agtcttatct gataatcagc ttgagttagt
     5281 agaagggggt tcaggctatg gtgatggtgt agctggagga ctcacaggag gagctatact
     5341 aggcggtgta gtaaaagggg cccaaaatgg cgcgaaatat ggaagactag gtggagcatg
     5401 gggagttgcc gctggtgttg tagttggagg agccatcggt ggttacttag gatataaagg
     5461 ggcttaaaaa tcccttaact taagacgatc tgtttgatta acagattgtc tttctttttt
     5521 aaaataatta gaatcatgga gtatttagat gttctttaaa aagtaccaat atgtaaaaca
     5581 aattgatgaa aaagactgtg gagcagcttg tctagccact atattgaagc attacggctc
     5641 caaattatca ataaataaaa ttcgagatat tgcgggaaca gataaacaag gcacaagcgc
     5701 acttggacta gtcagagcag ctgaacaatt aggcttttca gcaaaaggag taaaagctga
     5761 caaaacagct ttagaagaac cctttacact gccggctatt gcacatatca ttcttaatgg
     5821 acaattatta cattatgttg ttattcataa aatcacaaaa gaccagatta tcattgcaga
     5881 tcctggccgc ggaatcatta agtacacaaa aaaagaattt ttagaggttt ggacaggaat
     5941 cttaatttta ctgactcctt ctgaaacata taagatccat gtagagacca gtactatgcg
     6001 aagtgatata ttcaaattaa tacttcatca aaaatcattg atcatccaca caattttagc
     6061 atcctttatc attacagttt tcggtattat ggggactttt tattttcaaa cggtcattga
     6121 tgagatttta ccaaatggat tgaatagcac gttacatata ctttcattca gcctcatcat
     6181 tatgtactta tttaaagtcc ttttaacagc ctttaggcaa tatttaatga tattcttggg
     6241 ccaaaaatta agtatttcaa taatgtttgg ttatttcaaa catgtactta gcttaccgat
     6301 gaagtttttt agcactagaa agatcgggga gattatatct agatttaatg atgctagcaa
     6361 agtaattgat gctattatta gcgcctctct atcagtagta cttgatacag taatgcttgt
     6421 aatggtaggc atctttttat atctacaaaa tacaacttta tttttaatta cattggcttt
     6481 tatcccattt tatgttctta cagtttggtt ttttatgaag ccatatgaat ccatcaacaa
     6541 tactgaaatg gaaaacaatg ctcagctgac ttcaaaaata gttgagacac ttaacggtat
     6601 tgaaacaatt aaagcatata atgctgaata tatgatgtca tatgagacag aaaagagatt
     6661 tgtgaagtat ttgcgctctg cttttaagca tggagttatc gataatcttc aaaattctat
     6721 taaaatgttt ctggatttag caagtggagc attcataatg tggattggtt caactcaagt
     6781 gatgaaagga actctttcaa taggtcagct cattacatac aatgcattgt taacatattt
     6841 tttgaatcct ttacagaaca taataggcct tcaatcgaaa ctccagtcag cttctgttgc
     6901 ttctaaacga ctgggagaaa tactagaagt agaacacgaa ataaaagata aggatgctca
     6961 aataacaacg ccagggtcta ttaatggccc aattgaattt actaaaatta actttcgata
     7021 tggtactcgg cgactaatcc taaaagatat tacactacgt atagataaag gggagaaagt
     7081 cgcttttatt ggagagagcg gttccggaaa atctactcta actaagctct taatgaaatt
     7141 ttatacagct gagtctggtg atattttaat taatggttat catatcaatg atattcatgc
     7201 tcattcatta agagaaagta taagttatat ccctcaagaa tctcacttta tacagggttc
     7261 catttttgaa aaccttctgc tcggtaactc aggcagtttt acctttgaag agattataga
     7321 agtatgcaaa caaacaaatg tacacgattt tgtcaatgat ttaccaatga gatacgatac
     7381 tctcgtagag gaaaacgggt ctaatttatc tggaggccag aagcaaagac ttgcaattgc
     7441 cagagcatta ttaagaaaac ctaacattct cataatggat gaatcaacaa gcaatctcga
     7501 tacgactacc gaacagggaa tatcaaaaat gatatacgat cagactgttg gtataactac
     7561 gattataatc gctcaccgtt tgagtacaat tatgaattgt gacaaaatat ttgtcatgga
     7621 aaatggagaa atcatagagt atgggaacca caatgattta ttgaagaaaa aaggcaagta
     7681 ctatgagttg tgggagaacc aaatgccatc cagagggatg gtgactattt agatgaaacg
     7741 taactttttc aatttacatg atttgaagga tagcagagaa ttctatgaat caaaacccaa
     7801 accaattggt gttttcttta catatatact gatagcttta cttattgcat gtattgtttt
     7861 tagtttctat ggaaagaaag aagtgattct aaaaacgaca gctgacatcc aatatacaaa
     7921 gcctaacagc aacgtaacaa acgaagtagc cggcaaagta aaaacagttg acattaaaca
     7981 ggttgataag gtgaaaaagg gagatactct attaactcta gacaatacgg aaatccaagc
     8041 gcagaaaaaa gctgttaaag cagatatcaa agatttaaaa gaacaagctg cgttaaacaa
     8101 aactctaaaa aaaagtattg aaaatgacaa aaatttattc agtgaggacg atcattgggg
     8161 ttatcaagat caatatctct cgtacgaaaa acaaagtatt ttgttagagt catcaaaaga
     8221 aaatgcaaaa actcagcaga aaaaacttaa gaagcagaaa aaaagcataa aagatagtct
     8281 ggataagaca aaaaacaaag tcaaactaaa gcttcaaaga atttctgatc tgcaagactc
     8341 cattaaaaac aataaatcct ttgccaaaca ggatgataag tacagttctt actataatag
     8401 ttatcaaact aacaaacaaa atgtagagca gcagcttgat gatctacgga agatgaaaga
     8461 tgagctcgat aaaaaccgtt tttcacagca gaaagagaac ttgaacggac agcttgaaag
     8521 tttaaaacaa gatatgttag taaaactaag tgaagaaaaa gacgaattaa atcaatctct
     8581 tgatgagatt aacagttcaa ttaaaagtga cgattctgac agtgattccg ataactcaga
     8641 ggaaacaaat tataagcttt ctattgaaca gctcaaaaca aacttgctaa atcagacatc
     8701 tcaaaagcaa acagatcttc agaccactct taaatcaaaa gaggatgatc taaagatgat
     8761 agatttacaa ttagaaaaat ataaaataaa agcagcaagt gacggctatg ttaatgtact
     8821 aacaaatata tctccaggtg acaatttaca agcaggcact gctattttga ctattatccc
     8881 tgataaagag aagcttaaag ctaatattta tattccgagt catgagatca caaatattaa
     8941 tgaaaaagat gaagtaagat tccatattga aaatacaaat caaaccatca aaggtgtcat
     9001 tacaaaaata agtccagaca gtattagtga tcaaaacgga caaaaatttt atattgctga
     9061 aagcacaata gagaaaaata aagttatgaa cgataacgga tcaactttac acttaaaaaa
     9121 tggaatgcag accgatgtat caattatagt ggattctaaa aggtacattg attatctact
     9181 agaaatacta catttacaat aatataataa atataaatcc aacagaggca atctgtttat
     9241 gggttactca ccggtctgaa ataatgtact tagaataagt gaaccactca aaataaacta
     9301 ttatgcaatt tcatttttgt ggatttattt cttgttttat gtaattatgc tataattaca
     9361 actaaatttt caacagaaag gtcaagcaat ttatgtcgca aaacaaacta ttatttttac
     9421 tcttttcatt ttcttctatc attcacttgc tcttcaatac gattttagat cctacttcaa
     9481 gctggaaatc ttggtcggtg aacattgcgc taattctttt agcccttcta tttttaaatt
     9541 tcactttgaa agaaaagaaa gaaactcaca agaccaagtg acataacgac acaaagcccg
     9601 gactgactat ccgggcaaat ttatatcctg taaacgttac ctctcttagg ttttcttttc
     9661 ataacatact gaagttactc tccggccttc catttcagcc actggctggt ttctctcgtt
     9721 tatagcaata caaccttata cttcttcaca tccaaaaact gcaaaaactt cctcgccagc
     9781 acttccggcg catgcgcctt cccttcatcg agtcgataca atatcagccc gataatcatc
     9841 gccgatacat aataggcata aagctttttc tccgcaggaa tattagtttg ctgatgcaga
     9901 taaaatgatt ccaacgcttt gagcaactcg ggtatcacat gaggaacaac ccagtcccga
     9961 ttgagcaaat ggacaatagg catgcggtct aaagcagaaa gcaggccggc gagcgcctcc
    10021 tccgcttctt cgaaggaaag ctcattcgga cttgaggcaa tcgtcaggtg atctatcatc
    10081 tccgcacatg attgctgaat catggtctgc agcaattcct ctttgctggc atagtgatca
    10141 taaaaagttg cgcgccggat attgctttta cgcgtaatat ccgaaatcgt gatgcccgcg
    10201 tagtcttgtt tctccgccaa tacgtccaga aatgcctgct ggagcgcctc tctcgttcga
    10261 accacccgcc tgtcgatttg gcttgtcctt ctctcgctcc cctggcacag cttgcccaaa
    10321 cagccaataa aatctctttt gagaaacaag ctcccatacc ttttggctga tagcttccgg
    10381 agtcgcggcc gcatcctcat tcagccaata caggataatc gcgtacgtgt acaaggcccg
    10441 gtaatgtccg taaatttctc gttcgatcgg cgtcaaattc acatggatcg gagccagcag
    10501 cacatcatgc tgaaacacat ccttaaaaaa acgatggaaa tgccctctgt tcatcatcac
    10561 agaaaaaaag gattgatgct cgtgaacaaa ggacagcgtc ggatgcaccg tttgccgttt
    10621 tttgttcaaa tggagggtat ccaaatgact gaaagcgtca aaaagcgctt tacccagccc
    10681 ttccttcatg tcttcgatta aatcctcaat gattgaaaac ttatcctcat aataaaggta
    10741 gagcgatccg cggctcactt tggccttctc agcgatttct ttcattgtga tgtgttgaat
    10801 atctctttct ttcaataaag ccagcagcgc ctctttcact tgagcttcgg cagattctgg
    10861 cacaaaagac acctccaatc attagacaga tcttagatat atgtacggta acgtatagat
    10921 ggttcaccgt tgtctttctt acagaaaagg taccacctta taataggtcc gagaaaagaa
    10981 gaaagcaaat gagggggatt ttacaatgga acagcaagta aaggacgaca tccagcgtgt
    11041 ctttcagctt cagaaaaaac agcaaaaagc cttgcgcgct tcaacagcgg aacagcggag
    11101 agaaaagctt caacgctttt tagattccgt catcgcccat gaagaagaaa tcatcgaagc
    11161 gatccgcaaa gacgtccgca aaccatatca cgaggtcaaa aaagcggaaa tcgaaggaac
    11221 gaaaaaagcg atcagagata atatgaacaa cctggaacaa tggatggcgc ctaaagaagt
    11281 cggttcatcg ttaagccctg acgcaaacgg aattcttatg tacgagccta aaggcgtcac
    11341 actcatcctc ggcccgtgga actatccgtt tatgctgacg atggcgccgc ttgccgcttc
    11401 tctcgcagcc ggaaacagcg cgattgtgaa gctgtccgat ttcacgatga acacaagcaa
    11461 cattgccgct aaagtgatca gagacgcgtt tgatgaaaaa gaagtcgcga tttttgaagg
    11521 agaggttgag gtggcaaccg aactacttga tcagccgttc gaccatattt tcttcactgg
    11581 aagcacaaat gtcgggaaaa ttgtcatgac agcggctgcc aaacacttgg catctgtcac
    11641 acttgagctt ggcggcaaga gcccgacgat cattgacagt gaatacgatc tgatggacgc
    11701 agcaaaaaag atcgccgtcg ggaaattcgt aaacgccggc caaacctgca tcgcacctga
    11761 ttacctgttc attaaaaaag acgttcagga caggttcgcg gggattttac aaacagtcgt
    11821 caacgctgga tttatggagg atgatcatac cccagaccgc agcaaattta cgcagatcgt
    11881 caatgaccgc aacttcaacc gcgtcaaaga tctgttcgac gatgccatcg aaaaaggggc
    11941 ggaagtggtg ttcggcggcg tattcgatgc cagcgaccgc acgatctcac caaccgtttt
    12001 gaaaaacgtc acgtctgaca tgaaaatcat gcaggaggaa atcttcgcac cgatcctgcc
    12061 aatgatgaac tatgaagaca tcgacgaggt catcgattac gtaaatgacc gcgataaacc
    12121 gcttgcactt tatgtgttca gcaaaaacca agacctgatt gacaacgtcc ttcagcacac
    12181 gacatcagga aatgccgcca tcaatgatgt tgtcgttcac ttcagcgacg tcaacttgcc
    12241 gttcggcggc gtcaacacaa gcggaatcgg ctcctatcat ggggtatacg gattcaaaga
    12301 gttttctcat gagaagggtg tattgattca agccgctaaa taattgtagt gaagagaatc
    12361 tgcattaact tgcaggttct ctttttatca ttctattaac ctaaagacaa aaaggtaaaa
    12421 taaagaaatg tatagtgata aaataccatt ttcactacga gaccaaattc ctctagtata
    12481 tctcattgaa accgcacagc ctctaacgta taatatccca gaaaacctta aaggagagaa
    12541 tattatacat ggaaaagcca gctggatttt ggattcgggc agttgcctct attattgatg
    12601 atttaattat ctattttttt gcttttatta tgatccaaat taacaccttc attgtcctgc
    12661 ctctcattga tgcaggaagc tcctatatga cagaagatca atataaattt tatatcctga
    12721 tattcggtac ga
//
