LOCUS       c00008_CAJTCB0..       12082 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  CAJTCB010000008.1 Limosilactobacillus reuteri isolate 2.LR.Ymh
            genome assembly, contig: MGBC000088.8, whole genome shotgun
            sequence.
ACCESSION   CAJTCB010000008
VERSION     CAJTCB010000008
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-19 18:19:15
            Original ID  :: CAJTCB010000008.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 41534
            Orig. end    :: 53616
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..12082
                     /aStool="rule-based-clusters"
                     /contig_edge="False"
                     /core_location="[46534:48616](-)"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(5001..7082)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /neighbourhood="5000"
                     /product="RiPP-like"
                     /protocluster_number="1"
     cand_cluster    1..12082
                     /candidate_cluster_number="1"
                     /contig_edge="False"
                     /detection_rules="(strepbact or Antimicrobial14 or
                     Bacteriocin_IId or BacteriocIIc_cy or Bacteriocin_II or
                     Bacteriocin_IIi or Lactococcin or Antimicrobial17 or
                     Lactococcin_972 or Bacteriocin_IIc or LcnG-beta or Cloacin
                     or Linocin_M18 or TIGR03651 or TIGR03693 or TIGR03601 or
                     TIGR03795 or TIGR03975 or DUF692 or TIGR01193)"
                     /kind="single"
                     /product="RiPP-like"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..12082
                     /candidate_cluster_numbers="1"
                     /contig_edge="False"
                     /product="RiPP-like"
                     /region_number="1"
                     /rules="(strepbact or Antimicrobial14 or Bacteriocin_IId or
                     BacteriocIIc_cy or Bacteriocin_II or Bacteriocin_IIi or
                     Lactococcin or Antimicrobial17 or Lactococcin_972 or
                     Bacteriocin_IIc or LcnG-beta or Cloacin or Linocin_M18 or
                     TIGR03651 or TIGR03693 or TIGR03601 or TIGR03795 or
                     TIGR03975 or DUF692 or TIGR01193)"
                     /tool="antismash"
     CDS             1951..3138
                     /NRPS_PKS="Domain: Aminotran_1_2 (36-387). E-value:
                     6.4e-72. Score: 234.4. Matches aSDomain:
                     nrpspksdomains_ctg8_33_Aminotran_1_2.1"
                     /NRPS_PKS="type: other"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1019:aminotransferase (Score: 267.4; E-value:
                     3.5e-81)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg8_33"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.7e-07,
                     bitscore: 22.9, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPTTKKEFLNRLNNNFAKLTPGGIREFDYQVSAIPGIIKLTLGEP
                     DFNVPVAMKQAAIDSINANDSHYAPGNGTLALRQAIAHFMQDRYQLDYNPENEIAVTVG
                     ATEGIFASLSTIINPGDEIIIPTPTFPFYMAVTKILGGIPIEVDTSSDDFVLTPAKLQS
                     VLEEHPNAKGLVLNYPSNPTGVTYTQDQIKALANTIKSTNLIVIADEIYSELVYGATHT
                     SIANYIPEQTLILNGASKSHAMTGYRIGFIAGPQELMKSVSVIHAMLVTAASNPAMAAA
                     VAAFGTDEGKTATQEMKDAYEQRRDFVVNSLQKLGFELINPQGAFYVFAKIPEQYGNDD
                     LKFATDLANEGKVAVIPGSFFGAGGQGYVRISYATSMENLTGALDNIASFINKEN"
     aSDomain        2059..3111
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ctg8_33_Aminotran_1_2.1"
                     /evalue="6.40E-72"
                     /label="ctg8_33_Aminotran_1_2.1"
                     /locus_tag="ctg8_33"
                     /protein_end="387"
                     /protein_start="36"
                     /score="234.4"
                     /tool="antismash"
                     /translation="IIKLTLGEPDFNVPVAMKQAAIDSINANDSHYAPGNGTLALRQAI
                     AHFMQDRYQLDYNPENEIAVTVGATEGIFASLSTIINPGDEIIIPTPTFPFYMAVTKIL
                     GGIPIEVDTSSDDFVLTPAKLQSVLEEHPNAKGLVLNYPSNPTGVTYTQDQIKALANTI
                     KSTNLIVIADEIYSELVYGATHTSIANYIPEQTLILNGASKSHAMTGYRIGFIAGPQEL
                     MKSVSVIHAMLVTAASNPAMAAAVAAFGTDEGKTATQEMKDAYEQRRDFVVNSLQKLGF
                     ELINPQGAFYVFAKIPEQYGNDDLKFATDLANEGKVAVIPGSFFGAGGQGYVRISYATS
                     MENLTGALDNI"
     CDS             3140..4135
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072:dehydrogenase (Score: 301.4; E-value: 8.9e-92)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg8_34"
                     /transl_table=11
                     /translation="MTKILMTSVRDDEQTAINEYAKEHNIEIITTPKLIDDAVELTADV
                     DGLVIQQRSKVPADIYEKLHTNGLKQIATRTAGFDMVDIKKANENGLVVTNVPAYSPRS
                     VAEFALMQIFRLLRKTYRFDHQVAENDFRWFSDEQSTEIHTATIGIIGVGRIGGTLAKL
                     LHALGATVLGYDTNQRTDLDGIVQFVSKEELLKQADVVSLHVDLNPTSKGLLTANDFAM
                     MKPTAGLVNASRGPVVNTADLVAALKKGTIAAAALDTFEGEETVAATNRREKGLDDQPL
                     VKELHEMDNVILTPHIAFFTNLAVKNMVDISLDDVMTILNGEKSPHEITL"
     CDS             4204..4632
                     /locus_tag="ctg8_35"
                     /transl_table=11
                     /translation="MSKYKVTATKTTTGMQVSAGTRGFEITFDEPESTNTGMNPVEILL
                     ASFGACQAITAQALAKKRNFDLRAFWVTIEGDLGREDVADGKNVRKFTEIRYQPHLRSS
                     ESDEDIKKFLADVAAKCSVENTLTYGTKFVQDGFVKVD"
     CDS             4784..4969
                     /locus_tag="ctg8_36"
                     /transl_table=11
                     /translation="MKIHFNKDFWRDGFFYIYLLLLLLWIAPFSDGSLPLDEELLCIFF
                     IIFTIGSMLAIMFNKD"
     CDS             complement(5001..7082)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     RiPP-like: TIGR01193"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Peptidase_C39"
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 327.3; E-value:
                     3.1e-99)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg8_37"
                     /sec_met_domain="TIGR01193 (E-value: 7.5e-267, bitscore:
                     879.4, seeds: 5, tool: rule-based-clusters)"
                     /sec_met_domain="Peptidase_C39 (E-value: 3.7e-30, bitscore:
                     96.7, seeds: 36, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MILHNFGSVYPIAKLRDLARTTKQGTTALGLVKAAKHLGLDVIPI
                     QADISLFDDPEITYPLIAHVIKDDLLHYCVVFKADQDYIYVADPDPATKVQKMTRDEFD
                     RLWSGVCLLFSPAKGYTPQKEPLAGLTTMFQQLTNYKKDISGIVIAAMLITFISIVGSY
                     YLQLIIDRFIPSKNINGLAILAGSLLVVYVFNSFFNYLRDVLLTRLDQKLTSQISLRYI
                     HHVYRLPMRFFSTRKTGEITSRFNDINKIIDALSSTIISMFLDVGVMVIIGIVLSLYDR
                     SLFLTTISTIPIYVIIIYAFNKRFAKLDQEQMESNAQLSSAIIEDLKGVETLKVLQLEN
                     IRYKNVEKQFADFLRKNLTYVKTKSFQDAIKMWIQYGLVTIILFQGAILVIQDRLSIGT
                     LMAFNALLAFFVSPLQNIINLQPKLQEAKVANNRLNEVLQVDTEKSDTNSQDQTDLIGP
                     ISIQHVDYSYEYSRPILQDINLQIGCNDKLAIVGLSGSGKSTLAKLLVGFYLPTQGQIE
                     FNQHKTTEINLCDIRQYVHYLPQSPQLFSGTIKDNLLMGLDREVSAEEIDNACKLALIY
                     NDIQEMPLKYETKLDEEATALSGGQKQRLTIARALLTSARVLIFDESTSSLDPITEKRI
                     VENLLEIEDRTMIFIAHRLSIAKKVNKVVVMRDGKIIEQGTHQELLNHHQEYYNLWNA"
     CDS             complement(7428..7589)
                     /locus_tag="ctg8_38"
                     /transl_table=11
                     /translation="MIYCKLGFDELSEVSGGWGVTPWSVAWQTGKVAYSLVKHRRSYYA
                     GYQDSPFH"
     CDS             complement(7631..7789)
                     /locus_tag="ctg8_39"
                     /transl_table=11
                     /translation="MTYRKLGFDELSKVSGGWSLSSQVNELVGEVVNSLKKWAQSCYAG
                     YQDSPFH"
     CDS             complement(7791..7958)
                     /locus_tag="ctg8_40"
                     /transl_table=11
                     /translation="MIKMLTTTELAGINGGFKHNIWYYYGWGRASCIGTQRRNPSAFLN
                     HPNFIVLGGN"
     CDS             complement(8186..8953)
                     /locus_tag="ctg8_41"
                     /transl_table=11
                     /translation="MLKVIILENDDYQADYTERLVAQRKLINATPNSYDIELYLRTNDP
                     QEVIDSIKDEAYLAILDIELDNQLSGIDVAEQIRKRAEFAEIIFVTAYQEYLPYTVSRR
                     IEPFDYISKGEKIESIADRLRIDIDEAYARYQNYMNSNQKHQEKFTYEPTHGVKRQVDF
                     ENLYYIESVKNTNRRLRIVGKDIRIEYRGELGQINHEHLLKVNQSTLINPKAIREFNRK
                     ERVVYFDENREIKITVSYRKIKSLVNFLEKENH"
     CDS             complement(8961..10268)
                     /locus_tag="ctg8_42"
                     /transl_table=11
                     /translation="MIQLTFFQSFISDFLNIVEIITIYRLLVKEVTVKKILIDCGVSII
                     ILLIGAFILSSFYIVLIVFYLWLFDRIKMNPYILLNSIFAMFTAVILSSLFDLVDHCTY
                     VLFIQKNTDLSLVGWLIPFNDFLTATFVSILILKLVRPKINKFIENFPRPFHLWEITAV
                     FFMLYIWLTAIAEKEGIANKYASLLLIMYFIIIIISVVGFLNFVKSSEQNQHQQRLIDN
                     YKAQIASAHKINKQYNEIRRERHDTRNMLLSVQGYIRDHKDKEAEKLLATFLQNDTVEK
                     HYGEIDNALDKIKISGLHNLIKEKAYKIVEKGIPFSFEVNAEIDELPGSEIKTARIIGI
                     LMDNAIEATFKQAKPYIQFALLKHSPEVYELVIANSIEQKLNINTALKFEHSTKEGHQG
                     IGLSNVTQLVENDDRYSFSAEVKDKVIMMTCFIQGK"
     CDS             complement(10265..10390)
                     /locus_tag="ctg8_43"
                     /transl_table=11
                     /translation="MLEKKYKILTKKELLKLYGGWGYSLWLKYGWKKTVRQWLKG"
     CDS             complement(10419..10577)
                     /locus_tag="ctg8_44"
                     /transl_table=11
                     /translation="MDLEKKKNLVIINLFYVGLILIYCILHAGPLNLMVFLVMLIIANL
                     VGILSNN"
     CDS             complement(10588..10686)
                     /locus_tag="ctg8_45"
                     /transl_table=11
                     /translation="MRPSAERSIMIAVVCFILTIIISFALSEGWIK"
ORIGIN
        1 tgcttcttca agtcagcaat cttttccttg gcatcttggg cagccttgta atcttctttc
       61 ttagcagctg ctttttgctt cttttcttct gcttcgatat ctttttcaat tgccttagca
      121 tcacgtgctg ggtgctttgc tgctaagtga gcagcggtca tatcgattaa gtcgatagcc
      181 ttgtcaggta atgcgcgttg tggcatgtat tgaacagagt aatcaacagc agcttggaga
      241 acgtcatctg gtaactttac attgtggtga cgttcgtaca agtcacggat acctttaagg
      301 atggcaactg tatcagcctt gcttggagca ttaacagtaa cagaattgaa ccgccgtgct
      361 aatgcagcat ctttcataat agtgttccgg tattcatctt gagtagttgc accgataacc
      421 gttagttcac cacgggataa tgctggctta ataatgtcag acataccctt ggaaccacta
      481 gaatcaccag ttgaaccggc accgataatt tggtgaattt catcgaagaa gaggatgata
      541 tttccagcct tcttgacttc atcaaccaac ttttgcatgt tttcttcaaa gctaccacgg
      601 tattgagtac ctgcttcaag gccagaaata tcgatactga taatttcctt gtccttgata
      661 gcagctggta catcgccaga aacaattgct tgtgctaacc cttcaacaac agcagtctta
      721 ccaacaccag cgtccccaac taatacaggg ttgttctttg tccgccggct taaaatttca
      781 gctgtttctt ggatttcctt gttccgacca ataacagggt caagttcatg ttcacgagct
      841 tcttgagtta agtttcgacc taacttgtgt aagatactgt ccttacctgc gttaggttga
      901 gggccaggtt gcccaccttg ttgaggattt gcaccgcctg gcaattgacc agttctacga
      961 tattcagcaa attcttctgg tgttacttca cgaccattga ttaggtaacg ccgattatca
     1021 gaattgaaac cattcatgcc acccattaat tgattaaaga tgtcattcat gtcattgtca
     1081 aatggattca ttgggttttg agccatatgc aatccctcct caattaaata taatattttg
     1141 ttttctaagt ttcgtagtct aagtattcta gaagtcaaaa gttaacgcat ttaacttcct
     1201 gtggctacag caaagccaca atctcattcg aggtaatgct cttctagttc tttaaggacc
     1261 tcccacatgc tcttgtcctg agcgcgagcc aaagcatcaa gatcacgcag gttaagcgag
     1321 gtcgaactag actgtggttt gttaaacgat ttgtgtaaag tcgtgtagcc gtaaccggaa
     1381 cgcttggaaa cttgataaat ggtcaagtgg ttaacttcca aataatgttt gatgtcgatc
     1441 cgcattgcta cccacttcct ttacgattaa tattatatca catttgtgga gtaagacaac
     1501 aaaaaagaca cgaaaaaaat aaaaaaattg tagaatataa atttaatatt aaattaaagg
     1561 cgaactaata atcacaaaca tttttgcact ttattatatt tacatttgtc atcaataaat
     1621 aattttgtaa ttaataattt ttctcaatca actcttgaca aaaattaaaa aacaattaga
     1681 attattaata atcagttaat caaaaggagg acacaataat gagcactgcg acaattcact
     1741 tgaatcaagc gtatgtcttc tggtttagcg cgattaccgt ccgctaacca gcagtgattt
     1801 tatcattgtg atgttcccgg atgaccccca aacatccgag agcctctttt atactcattc
     1861 caatctgatc aagaagccct ggatgttttt cctatagcat tcagggcttc ttttttctaa
     1921 atctacatat ttatattgga ggaatttatc atgccaacta ctaaaaaaga atttctcaat
     1981 cgtcttaaca ataatttcgc taaactcact cctggcggga tccgcgaatt tgactaccaa
     2041 gtcagcgcaa ttcctggcat cattaaacta acattaggtg aaccagactt taatgtgcca
     2101 gtcgcaatga agcaggccgc aatcgatagc attaatgcca atgattcaca ctatgctccg
     2161 ggaaatggga ccttagcact acgccaagcc atcgctcatt tcatgcaaga tcgttaccag
     2221 ctggactaca atccggaaaa cgaaatcgct gttacagttg gcgcaacaga aggaattttc
     2281 gcttctcttt ctactattat taatcctggc gacgaaatta tcattccaac cccaactttc
     2341 cccttctaca tggctgtcac aaagattctt ggtgggattc cgattgaagt tgatacaagc
     2401 agcgatgatt ttgttctcac acccgcaaaa ctccaaagcg tcctagaaga acatcctaat
     2461 gcaaaaggac tagttcttaa ctacccatcc aacccaactg gtgttactta cacccaagat
     2521 caaattaaag cactagccaa tacgattaaa tcaactaacc tgattgtaat tgcagatgaa
     2581 atttactcgg aacttgttta cggagctact catacttcaa tcgctaatta catccccgaa
     2641 caaacgctaa ttttaaatgg tgcctcaaaa tcacatgcaa tgactggtta ccggattggt
     2701 tttatcgctg ggccgcaaga attgatgaaa tcagtcagtg tcattcacgc aatgttagta
     2761 actgctgctt ctaatccagc aatggccgct gcagtagccg catttggtac tgacgaagga
     2821 aaaacagcta ctcaagaaat gaaagatgcc tatgagcaac gacgagactt tgttgttaat
     2881 agcctccaaa aattagggtt cgagctgatt aatcctcaag gagccttcta cgtttttgcc
     2941 aagattcctg aacaatatgg taatgatgac cttaaatttg cgacagatct tgccaatgaa
     3001 ggaaaagttg ctgtgattcc tggttccttc tttggagctg gcggccaagg atatgttcga
     3061 attagttacg ccaccagtat ggaaaatcta accggagctc ttgataacat tgcatccttc
     3121 attaataagg agaattaaca tgacaaaaat cttgatgact agtgtgcggg acgatgaaca
     3181 aaccgccatt aacgaatacg caaaagaaca caatatcgaa atcatcacaa cgccgaaatt
     3241 gattgacgat gctgttgaat taacggccga tgttgatgga ctcgtgattc agcaacgtag
     3301 taaagttcca gccgatattt atgaaaagct tcataccaat gggctcaaac agattgcaac
     3361 gcggacagct ggttttgaca tggtcgacat caaaaaggct aacgaaaatg gcttagtcgt
     3421 gaccaatgta ccagcatatt caccgcggag tgtcgccgag tttgcattaa tgcagatttt
     3481 ccggttactt cggaaaactt accgctttga ccaccaagtc gccgaaaatg atttccgctg
     3541 gtttagcgat gaacaatcga ctgaaattca tactgccacg attgggatta ttggtgttgg
     3601 acgcattggc ggaaccctgg caaaacttct tcatgcatta ggggctaccg ttctaggata
     3661 tgatacgaat cagcgcactg acctcgatgg aattgtccag ttcgtttcta aagaagaatt
     3721 actaaagcaa gccgatgttg ttagtctcca tgtcgattta aacccaactt ctaaagggtt
     3781 gttgactgct aacgactttg caatgatgaa accaactgcc ggcttggtca atgctagccg
     3841 tggtccagtc gttaatacag ctgatttagt tgcagcccta aaaaagggaa caattgcggc
     3901 agccgctctt gacacttttg aaggtgaaga aacagtggcg gccacaaatc gccgagaaaa
     3961 agggcttgat gatcagcccc ttgttaaaga attacacgaa atggataatg tcattcttac
     4021 tcctcacatt gccttcttta ctaatttagc ggtcaaaaat atggtggata tttcacttga
     4081 tgatgtgatg acaatcctta atggcgaaaa atcaccacat gaaatcacct tataattgag
     4141 caccctcatt gaccaaaagt atcgtctcga ttacactatg agtattaaaa ggagggaacg
     4201 gctatgagta aatataaagt aacagcaact aagacaacaa cggggatgca ggtttcagcc
     4261 ggtacgcgtg gctttgaaat tacgtttgat gaaccagaaa gtacaaatac ggggatgaat
     4321 ccagtagaaa ttctccttgc atcatttggt gcctgccagg caatcactgc ccaagcatta
     4381 gctaaaaagc gtaactttga tttacgagct ttttgggtaa caatcgaggg ggatcttggt
     4441 cgtgaagatg ttgctgatgg taagaatgtt cgtaagttta ctgagatccg ttaccaacca
     4501 catcttcgca gtagcgagtc tgatgaagac atcaagaagt tcctcgctga cgttgccgca
     4561 aagtgttccg tggaaaacac tctaacctac ggaacgaaat ttgttcaaga tggatttgta
     4621 aaagttgatt agttgaaaaa acgtcttgga tttttccagg gcgtttttct aaataggcaa
     4681 cctatacgaa ttctgcaaga aacttaacga attttgcaaa atgtccttta aattagattt
     4741 ttcattataa taaggtacac atactgtctt agggggagaa ctaatgaaaa ttcatttcaa
     4801 taaggacttt tggcgggatg gtttctttta tatatactta ttacttttgc ttctctggat
     4861 tgctccattt tcagatggtt cgcttccatt agatgaggag ctactatgta tcttctttat
     4921 aatttttact atcggttcca tgctcgcaat tatgtttaat aaagactgaa aaaagctcca
     4981 acagcaatgt tcggagcctt ttatgcattc cacaaattat agtattcttg atgatgattc
     5041 aaaagttcct ggtgagtacc ctgttcaatg atttttccgt cgcgcattac taccacttta
     5101 ttgacctttt tagcaattga aaggcgatgg gcaataaaaa tcattgtgcg gtcttcaatt
     5161 tcaagcaaat tctcaacgat tcttttttca gtaattggat ctaagctact tgttgattca
     5221 tcaaaaatta aaacacgcgc agaagttagg agtgctcgtg caatcgtcaa gcgttgtttt
     5281 tgaccaccag ataatgcggt tgcttcttca tctagttttg tttcatattt taagggcatc
     5341 tcttgaatat cattatagat taatgccaat ttacatgcat tatcgatttc ttcagcagat
     5401 acttcacggt ctaatcccat tagcaagtta tctttgattg ttcccgaaaa taattgtggc
     5461 gattgaggta agtaatgcac atattgtcta atatcacaaa gattaatctc tgttgtttta
     5521 tgctgattaa attctatctg cccttgagta ggtaaataaa agccaactaa caactttgcc
     5581 aaggtcgatt taccagaacc gctcaaccct acaattgcca atttgtcatt acaaccaatt
     5641 tgaagattga tatcttgtaa aattggacga ctatattcat atgaatagtc aacatgttga
     5701 atgcttatcg gccctattaa atctgtttga tcctgagaat tcgtatctga cttttcggta
     5761 tcaacttgca gaacttcatt caatcgatta ttcgctactt tagcttcttg gagtttaggt
     5821 tgaagattaa taatattttg caatggactg acaaaaaagg ctaataacgc attaaaagcc
     5881 atcaatgtcc caatacttaa tcggtcctga attaccaaaa ttgctccttg aaaaagaatg
     5941 attgttacta aaccgtattg aatccacatt ttaattgcat cctgaaaaga tttagtttta
     6001 acatatgtta gattctttcg taagaaatcc gcaaattgct tttcaacatt tttataacgg
     6061 atattttcaa gttgcagcac tttcaacgtc tctacgcctt ttaaatcctc aataattgca
     6121 gaacttaatt gagcattact ttccatctgt tcctgatcaa gtttagcaaa gcgcttatta
     6181 aaggcataaa tgataatgac ataaatcgga atggtactaa ttgtagttaa aaataatgac
     6241 cgatcatata aagaaagaac aattcctata atcaccatca cgccaacgtc taagaacatt
     6301 gaaataatag tgcttgataa agcatcaata atcttattaa tgtcattaaa ccgtgaagta
     6361 atttctcccg tttttcttgt ggagaaaaat cgcatcggta gacgataaac atggtgaata
     6421 tatctaagac ttatttgtga tgtcagtttt tgatccagcc tagtcaaaag aacatcccgc
     6481 agataattaa aaaaagaatt aaacacataa actactaata aactaccagc aaggatcgct
     6541 aagccattaa tatttttcga gggaataaac cgatcaataa ttaattggag atagtatgaa
     6601 ccgacgatgc tgatgaaagt aattagcatt gccgcaataa caattcctga tatatctttt
     6661 ttataattag ttaattgttg aaacatcgtc gttaatccag ctaaaggttc tttttgcggt
     6721 gtatacccct tagcaggcga aaaaagcaaa catacacctg accataaacg atcaaattca
     6781 tctcgagtca ttttttgtac tttcgtagca ggatctggat cagctacata gatgtaatct
     6841 tgatcagcct taaaaacgac acagtaatga agtaaatcat ccttaatcac atgtgcgatc
     6901 aatgggtaag taatttcagg atcatcaaac aatgatatat ctgcttgaat gggtataacg
     6961 tctaatccaa gatgcttcgc tgcttttaca agtcctaagg cagtagttcc ttgcttagtc
     7021 gtccgggcta ggtcacgtaa ttttgcgatt ggataaacag agccaaaatt gtgcaaaatc
     7081 attgctaaag cagcgactcc acaatctgct tcatcaactt gagctacata atgaggataa
     7141 ttgattttcc ttcaccttgc tttctaatta gacaaagaaa taaagtccaa aattaataat
     7201 gattctgggc tttatattct tataagatac tatttatttt ttaaataaaa ttcgtagagc
     7261 tgcaaaaata ccaatgattg tgcaagctat acatataatt gtttcataaa tgttacttgc
     7321 cttgggaatt gctaaaaccc agaagaatgt aactataata tagatataaa aatcaagatt
     7381 ggtgtaaaaa tcgcggttaa atttcataat cattaagtta taaactatta gtgaaatgga
     7441 ctatcctgat agcctgcata atacgaacgc cgatgtttaa caagcgaata agcaactttt
     7501 cctgtttgcc atgcaacact ccaaggagtg actccccagc caccagaaac ttcacttaat
     7561 tcatcaaagc ccaatttaca gtaaatcatt ttaattacct ccatcttaaa ataactgttc
     7621 tttattattc ctaatgaaac ggactatctt ggtaacctgc atagcaagat tgtgcccatt
     7681 tctttaacga attaacaacc tctccaacca gttcattaac ctgcgaagat aagctccagc
     7741 caccagaaac tttacttaat tcatcaaagc ccaatttacg gtaagtcatt ttaattgcct
     7801 cctaatacaa tgaagttagg atgatttaag aatgcactag gattacgacg ttgcgttcca
     7861 atacacgatg cccttcccca gccataatag taccaaatgt tatgcttaaa tccaccgtta
     7921 attcctgcaa gttcagtcgt agtaagcatt ttaatcataa ttactcctcc tcgtaattat
     7981 taattttagg aaatcaagtt actccctgac ttgattacac tgatagtata taagcaaaaa
     8041 ggttctgtgt gtcattttgc agaattcgtc agcctttctg cagaattcgt agtaaattca
     8101 aatgaaaacg tttactaaaa ttacttgcta ataaaaaaga aaccatgaca gcttttttgc
     8161 cacagtttct ttgaaaataa aatagttagt gattttcctt ttcaagaaaa ttaactagtg
     8221 attttatttt tcgataacta acggttatct taatttcccg gttctcatca aagtaaacca
     8281 cacgttcttt acgattaaat tcgcggattg ctttgggatt aatcagcgta ctttggttta
     8341 cttttaataa atgctcgtga ttaatttgac ctaactcgcc tcgatattca atccgaatat
     8401 cttttcccac aattcgtaac cgtcgatttg tattttttac cgattcaata tagtagaggt
     8461 tttcaaaatc aacttgcctt tttactccat gagtcggttc ataagtaaac ttttcttgat
     8521 gtttttgatt actgttcatg taattctgat agcgagcata tgcttcatca atatcaatcc
     8581 ggagtcgatc cgcaatcgac tcaatctttt ctccctttga tatatagtca aatggttcaa
     8641 ttcggcgcga aacagtataa ggtaaatatt cttgataagc agttacaaag ataatttcag
     8701 caaattcagc tcttttgcgg atttgttcag caacatcgat cccactaagt tgattgtcta
     8761 gctcaatgtc taaaatcgct aaataagcct catctttgat gctatcaatc acttcttgcg
     8821 gatcatttgt ccgcaaatat aattctatgt cataactatt tggagtagcg ttaatcaatt
     8881 ttcgctgagc aactagacgc tcagtataat cagcttgata atcatcattt tccaaaataa
     8941 ttacttttaa cattttattc tcactttccc tgaataaaac aagtcatcat aattacctta
     9001 tctttaactt ccgctgaaaa agaataacgg tcatcatttt ctaccaactg ggtcacattt
     9061 gaaagaccaa ttccttgatg tccttccttg gtcgaatgct caaatttcag tgcagtatta
     9121 atattaagtt tttgttcaat cgaattagca attaccaatt cataaacttc tggactgtgc
     9181 ttaagcaatg caaactgaat atatggttta gcttgtttga aggttgcttc aattgcattg
     9241 tccattaaaa ttccaataat tctagcagtt tttatttctg aacccggtaa ctcgtcaatc
     9301 tcagcattaa cttcaaatga aaatggaata cctttttcta ctattttata agccttttcc
     9361 ttaataagat tatgcaaccc tgaaatttta atcttatcta atgcattatc aatttcacca
     9421 taatgcttct caactgtatc attttgaaga aacgttgcta gtaatttttc tgcttcctta
     9481 tctttgtgat cacgaatata tccttgaaca ctgagaagca tattacgtgt atcgtgacgt
     9541 tcacgccgaa tttcattgta ttgtttattt attttgtggg cactagcaat ttgtgcctta
     9601 tagttatcaa taagtcgttg ttgatgctga ttttgttcac tgcttttaac aaaattaaga
     9661 aagccaacga cggatattat aatgattata aagtacatta ttaataataa agaagcatat
     9721 ttattagcga taccttcttt ttcagcaata gctgttaacc aaatgtatag cataaaaaat
     9781 acagcagtta tttcccatag atgaaagggg cgaggaaagt tttcaataaa tttattaatc
     9841 ttaggacgaa ctaattttag tattaaaata ctaacaaaag ttgcagtaag aaaatcatta
     9901 aatggaatca gccatcccac taaagataaa tccgtatttt tttgtataaa aagaacataa
     9961 gtacaatgat caactaagtc aaaaagagac gacagtataa ctgctgtaaa catcgcgaat
    10021 atactgttta aaaggatata cggattcatt ttaattctat caaataacca taaataaaaa
    10081 actataagta ctatatagaa tgaacttaat ataaatgcac ctattagtaa aataataata
    10141 gaaacgccac aatcaattag tatttttttt acagttactt cttttactag taacctataa
    10201 attgttatta tttcaacaat atttaagaag tctgatataa atgattgaaa aaatgttaat
    10261 tgaatcatcc cttaagccac tgtcttactg tctttttcca accatatttt agccacaaag
    10321 aataacccca tccaccatat agtttgagta gttctttttt tgttaaaatt ttatactttt
    10381 tctctaacat gactaaatcc tcccataaca ttttaaaatt aattattact taatattcct
    10441 actaaattcg caataattaa cattactaaa aacaccatta aattcagtgg ccctgcatgt
    10501 aaaatacagt aaatcaaaat taatccaaca taaaatagat taataattac caaatttttc
    10561 ttcttttcta agtccatcgt taaatcccta ctttatccat ccctcagaca aggcgaatga
    10621 aataataatt gttaatatga aacaaacaac cgcaatcatt atcgagcgtt cagcacttgg
    10681 gcgcataata aattctcctt taatagataa ttacaggctc atttttctgt aagtcatgaa
    10741 aggcttgacc agcaacatct ggatgcatat tgatacatcc atgcgatccg ccacctttag
    10801 cgaggtaagc ttgtttcgac cagtcatgac gccagcttgc atcatgaaat ccacatccac
    10861 tatcagtaaa aggagaccaa tactggactt tacttgcata tttcgaacca tcatcattaa
    10921 gtcctcgaag aacagacggt gtttgctggt acatgatata ccagacgcct tttggcgtct
    10981 cattatcttt gttattggtc ccactaacaa tgtcagtact aagaacgcat ttaccatcct
    11041 tatagaacca tgcatgttga tcggctagcg aaacttcggc ataggtatta ccaatgccat
    11101 tattagttgt ggttccataa cctgttccat gctgattata tcccttacca tagatatcat
    11161 ttttggcgtt tactgtttgc ttatttgcaa ccaatgcatt cgtaagagtc tttccagctt
    11221 gtttcttact gatcttccaa ccatacgagc cagcatctgt tgttttgatc actgatccat
    11281 tatgggtctt gaattcaaat gatttgccaa gagttgcttg ggtattatta atttcatcaa
    11341 tctttgaatc agcagctcta gtatcaaaat gatattttcc attttgatag gttgctctgg
    11401 taataatctc accacaattt aattgatact ttttgttttg tacttggtat gttacagttc
    11461 gttttgataa ttcttcgagc tttgcttttt cattctgaac agttttacta tttgcagaaa
    11521 gcggagcttt gtatactggc ctcaagtaaa tagttccgcc agcaatctca ttctcaactt
    11581 tattatgcaa accatctaaa ctgtattgag taccaccaac tgctggtttt acttgtactc
    11641 ggccattttc atatacagcg taagcatcaa caggagcttt tcgaccatta tttaattctg
    11701 ttaccttttg actgactgct tgatcaatct ttgatacttc atcttgatta acattttgag
    11761 gcttaatcgc aatgttcttt gccttagatg atgggaagaa agtatactga ctatgtaatg
    11821 catttttaat tttttgttcg tcagcactac taaactttgc tactgattgc ttatccgtaa
    11881 atactaactc attgttaaca taaatttttg gcgattgtgg attatcttgt aaattcttta
    11941 atgcttgctc agcagtcaat ccaccaaccg acacattatc aatcttaacg ttcttattaa
    12001 aatgacgacg ctggtgaata gtcatgcagc caaccaccag cactaataag cacaatgtga
    12061 ttattattag ttgtttaata ga
//
