LOCUS       c00022_CAJVVT0..       14891 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  CAJVVT010000022.1 TPA_asm: Streptococcus salivarius isolate
            DRR077041_bin.2_metaWRAP_v1.1_MAG genome assembly, contig:
            ERZ1744232.35, whole genome shotgun sequence.
ACCESSION   CAJVVT010000022
VERSION     CAJVVT010000022
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##gutSMASH-Data-START##
            Version      :: 1.0.0-1555cd7(changed)
            Run date     :: 2022-06-21 00:23:34
            Original ID  :: CAJVVT010000022.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14891
            ##gutSMASH-Data-END##
FEATURES             Location/Qualifiers
     CDS             complement(1..66)
                     /locus_tag="ctg22_1"
                     /transl_table=11
                     /translation="MSYHHFTIDERESILIYRTQGL"
     protocluster    1..14891
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[243:10510]"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
                     /tool="gutsmash"
     proto_core      244..10510
                     /aStool="rule-based-clusters"
                     /tool="gutsmash"
                     /cutoff="10000"
                     /detection_rule="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /neighbourhood="10000"
                     /product="TPP_AA_metabolism"
                     /protocluster_number="1"
     cand_cluster    1..14891
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(TPP_enzyme_C and not (PFL-like or
                     PFL_6_pcresol or PFL_9_tma or Gly_radical or Gly_430_pcre
                     or Gly_8-9_TMA or PFL_acetate1 or PFL_acetate2 or
                     Gly_radical_scatole or PFL_proline or PFL_toluene) and
                     minimum(2, [ALS_ss_C, AlaDh_PNT_C, Arginase, BKACE,
                     BcrAD_BadFG, Beta_elim_lyase, CPSase_L_D2, Cys_Met_Meta_PP,
                     ELFV_dehydrog, GRDB, Glu_syn_central, Glu_synthase,
                     Gly_reductase, HAAA1, HG2B1, HG2B2, HGD-D, HleuD1, HleuD2,
                     HleuS1, HleuS2, Homoserine_dh, ILVD_EDD, IlvC,
                     Lactoyl-CoA1, Lactoyl-CoA2, Lyase_aromatic, MAAL_C,
                     OKR_DC_1_5_lysine, OKR_DC_1_5_ornithine,
                     OKR_DC_1_7_arginine, OKR_DC_1_C, OTCace, PALP,
                     Proline_reductase, Sacchrp_dh_C, TPL, Thr_dehydrat_C, TnaA,
                     Urocanase]) and not (POR or POR_N or PFOR_II))"
                     /kind="single"
                     /product="TPP_AA_metabolism"
                     /protoclusters="1"
                     /tool="gutsmash"
     region          1..14891
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="TPP_AA_metabolism"
                     /region_number="1"
                     /rules="(TPP_enzyme_C and not (PFL-like or PFL_6_pcresol or
                     PFL_9_tma or Gly_radical or Gly_430_pcre or Gly_8-9_TMA or
                     PFL_acetate1 or PFL_acetate2 or Gly_radical_scatole or
                     PFL_proline or PFL_toluene) and minimum(2, [ALS_ss_C,
                     AlaDh_PNT_C, Arginase, BKACE, BcrAD_BadFG, Beta_elim_lyase,
                     CPSase_L_D2, Cys_Met_Meta_PP, ELFV_dehydrog, GRDB,
                     Glu_syn_central, Glu_synthase, Gly_reductase, HAAA1, HG2B1,
                     HG2B2, HGD-D, HleuD1, HleuD2, HleuS1, HleuS2,
                     Homoserine_dh, ILVD_EDD, IlvC, Lactoyl-CoA1, Lactoyl-CoA2,
                     Lyase_aromatic, MAAL_C, OKR_DC_1_5_lysine,
                     OKR_DC_1_5_ornithine, OKR_DC_1_7_arginine, OKR_DC_1_C,
                     OTCace, PALP, Proline_reductase, Sacchrp_dh_C, TPL,
                     Thr_dehydrat_C, TnaA, Urocanase]) and not (POR or POR_N or
                     PFOR_II))"
                     /tool="gutsmash"
     CDS             complement(244..771)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: IlvC"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_2"
                     /sec_met_domain="IlvC (E-value: 3.7e-64, bitscore: 205.3,
                     seeds: 295, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDWAKGIGSARVGLLVTTFKEETEEDLFGEQAVLMGGLTHLIEAG
                     FEVLTEAGYAPQLAYFEVLHEMKLIVDLIYEGGFKKMRQSCSNTAEFGDFVTGPRVIGP
                     EVKENMKAALADIQSGKFAREFVEDHDAGFPRLKAYRKEAEELEIEKIGAELRKAMPFV
                     GQNDDDAFKIYN"
     CDS             complement(723..1265)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) IlvN"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_3"
                     /sec_met_domain="IlvN (E-value: 1.5e-64, bitscore: 206.5,
                     seeds: 43, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVQMEYEKDVKVAALDGKKIAVIGYGSQGHAHAQNLRDSGHDVI
                     IGVRPGKSFDKAKEDGFDTYTVAEATKLADIIMVLAPDEIQKDIYKDEIEPNLSAGKAL
                     GFAHGFNIHFEFIKVPKDVDVFMVAPKGPGHLVRRTYTEALVFLHFTQYTKMLQVMLKI
                     SLWTGLKVLVLHVLDYL"
     CDS             complement(1340..1816)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ALS_ss_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_4"
                     /sec_met_domain="ALS_ss_C (E-value: 4.9e-29, bitscore:
                     90.4, seeds: 685, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRRMLTAKLQNRSGVLNRFTGVLSRRQVNIESISVGASEDPNVSR
                     ITIIIDVNSQNEVEQIIKQLNRQIDVIRIRDITDQPHLEREVILVKVSAPTSKRAEILA
                     IIQPFRASVVDVAPSSITIQMTGDAEKSEALLRVIRPYGIKNIARTGATGFTRD"
     CDS             complement(1809..3509)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: TPP_enzyme_C"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_5"
                     /sec_met_domain="TPP_enzyme_C (E-value: 1.3e-47, bitscore:
                     151.3, seeds: 323, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VKKIELEEARSGADLILDTLLELGISTIFGYPGGAVLPLYDAIYK
                     NDKINHILSRHEQGSLHEAEGYAKSTGKLGVALVTSGPGATNAITGIADAMSDSVPLLV
                     FTGQVATPGIGKDAFQEADIVGITMPITKYNYQIRDTADIPRIIREAVHIATTGRPGPV
                     VIDLPKDVVAKETAFINDPEINLPSYQPTLRPNEMQIKKILKQLGKAKKPVIVAGGGVS
                     YSESAKELVAFAERYQIPVVTSLLGQGTIATSHPLFLGMGGMHGSYAANIAMTDADFMI
                     AIGCRFDDRLTGNPKTFAKNAKVVHIDVDPAEIGKIIAVDLPVVGDAKQALEMLLAEPV
                     VQNNTEKWIEKVTKDKERVRSYDKKERMVQPQAVIERIGELTKGDAVVVTDVGQHQMWT
                     AQYYPYQNERQLVTSGGLGTMGFGVPAAIGSKIANPDKEVILFVGDGGFQMTNQELAIL
                     NIYKVPIKVVMLNNHSLGMVRQWQESFYEGRTSESVFDTLPDFQLMAQAYGIKSYKFDN
                     PETIDQDLEVIKEDVPMFIEVDISRKEHVLPIVPAGKSNHEMLGVKFNA"
     CDS             complement(3644..5365)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: ILVD_EDD"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_6"
                     /sec_met_domain="ILVD_EDD (E-value: 3.9e-225, bitscore:
                     738.1, seeds: 918, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRSDMIKVGVDKAPARGLLYATGQVKSAKDMQKPFIAICNSYIDI
                     VPGHVHLRELADIAKEAIREAGGIPFEFNTIGVDDGIAMGHIGMRYSLPSRELIADSAE
                     TVINAHWFDGVFYIPNCDKITPGMILAAMRTNVPAVFCSGGPMKGGVDMTGHQATLSSL
                     FEAVGTYQAGDMSKEELDYLEKNACPTCGSCSGMFTANSMNCLMEVLGLALPGNGTILA
                     VSDERRELVRQAATKLMDNIKNNVRPRDIVTKEAIDDAFALDMAMGGSTNTVLHTLAIA
                     REAGIDYDLKDINEIAKKTPYLSKIAPSSVYTMHDVHEAGGVPAIINQLIKKGAIKGDR
                     ITVTGKTLKENVAGAEIKNEEIIHPIEHPISPVGGLSILYGNIAQDGAVIKVGGVDPSV
                     KTFRGKAICCDSQDQALELIDNGTVKKGHVVVIRYEGPQGGPGMPEMLAPTSKIVGRGL
                     GKDVALITDGRFSGATRGIAIGHVSPEAAEGGNIALIEDGDEIVIDLPNRTLDLLVDDV
                     TLEERRKHLKPFKSKISSGWLRRYTAFAKSANVGGTLMSDEEFEERKAERQAQEKN"
     CDS             complement(5536..7203)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Dak2"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_7"
                     /sec_met_domain="Dak2 (E-value: 3.4e-44, bitscore: 140.7,
                     seeds: 138, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="VSKITTSLLQEMVQAAATRLGKQAEYVNSLNVFPVPDGDTGTNMG
                     MTMDNGAKAVADQSASTVGEVGQILSKGLLMGARGNSGVITSQLFRGFGQSIKDKTELD
                     GQDLAHAFQAGVEVAYKAVMKPVEGTILTVSRGAASAAIKKAESTNDAVEVMRAALDGA
                     KAALAKTPEMLPVLKEVGVVDSGGQGLVFIYEGFLSALTGEYIASEDFQATPATMTEMI
                     NAEHHKSVAGHVATEDITFGYCTEIMIGLKQGPTYVKDFDYEEFQNYLSNLGDSLLVVN
                     DDEIVKVHVHTEDPGLVMQEGLKYGALVKVKVDNMRNQHDAQVQKEEAIQAAPSAPKDF
                     ALIAVVAGDGLADIFKSQGVDYVISGGQTMNPSTEDIVKAIEQVNAKNVIILPNNKNIF
                     MAAQSAAEVVDVNAAVVETRTVPQGFTSLLAFDPSQSIEANVEAMTASLSDVTSGSVTL
                     AVRDTTIDGLEIHENDILGMVDGKILVSTPDMDQALLDTFDKMIDEDSEIVMIYVGEEG
                     NQEQAQALAEKLEEAHEDIEVEIFQGDQPVYPYLFSVE"
     CDS             complement(7203..7568)
                     /locus_tag="ctg22_8"
                     /transl_table=11
                     /translation="MTVKINTKDGQIELSDDVIATVVGGSATEIFGVVGMASKSAIRDN
                     FQALLGKENYAKGVVVKSTDAGITVDVYTVMSYGVKISEVSKNIQERVKFNLENQLGIK
                     AETVNVYVQNIKVVGEN"
     CDS             complement(7680..8345)
                     /locus_tag="ctg22_9"
                     /transl_table=11
                     /translation="VKQLEITKPFNRELLGIALPAAGERLMMRAGDVVIVAIIVTFGTA
                     VVGGNAIGENLTQFNYMPGMGVATATVILVANSLGRGDKTQMKRIIQESYWISTFLMVL
                     VSGSILLFGQGLSGLFTDNKAAIAASQVVILYSFLGNPVTSGTLVYTAVWQGLGKAKMP
                     FYATTIGMWIIRIFSGYFLGVSLGLGLAGVWIATVVDNVWRAIFLYVMYRRYLVKRKF"
     CDS             complement(8342..8965)
                     /locus_tag="ctg22_10"
                     /transl_table=11
                     /translation="MTETKKILNIALPAMAENLLQMLMGVVDSYLVAQVGIVAISGVSV
                     ANNIITIYQAIFIALGASSASVIARSLGKGDVKATNRDTWDAIIITLALSLILGLLSIF
                     GGGAILNLLGTEQSVTQAGSLYLALVGGGVVFLALMTTFGNILRAKGRPRISMVVSLLT
                     NVLNAILSSLAIFVGHWGIIGVATATVFSRLVGTVILWQARNWM"
     CDS             complement(9026..10510)
                     /gene_functions="biosynthetic (rule-based-clusters)
                     TPP_AA_metabolism: PALP"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_11"
                     /sec_met_domain="PALP (E-value: 5e-17, bitscore: 52.1,
                     seeds: 146, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTLVYQSTRDENNKVTASQAILQGLATDGGLFTPLSTPEVALDFD
                     QLKDASYQEVAKLVLSAFLDDFTEEELDYCITNAYDDKFDTAAIAPVVKLKNHYNLELF
                     HGSTIAFKDMALSILPYLLTTSAKKQGVDNKIAILTATSGDTGKAAMAGFADVPGTEII
                     VFYPKDGVSKIQELQMTTQTGANTHVIAIDGNFDDAQTDVKRMFNDVDLREKLLAHHTQ
                     FSSANSMNVGRLVPQVVYYVYAYAQLVKAGHIQNGDKVNFTVPTGNFGNILAAYYARQI
                     GVPVGKLICASNENNVLTDFFATGTYDKKRDFKVTTSPSMDILVSSNLERLIFHLLGND
                     ATKTKELMDALVTKGEYTLADADKDILDLFAAGFATEDETAAEIKRVYDENKYIEDPHT
                     AVASAVYEAYVQKTDDHTPTVIASTASPYKFPRVAISAVTGKDSGDDFKAVEDLHQLSG
                     VAIPAAVDGLEHAEVRHKTVVAAADMQKAVESYLGV"
     CDS             complement(10671..11648)
                     /locus_tag="ctg22_12"
                     /transl_table=11
                     /translation="MTREEWLDYFETVNGRKPSVQEMADALKAGEFVNEAPAKAEDTAT
                     TEPIKVEAEIVETSTSPLPTETAPVVTAPAPSTVAFPEGQAAMANLAPKKPMDPKKKKR
                     ILVSVLSAVVLVFLCIGGFMTYRYVTGNIDGKWYSSSLGREYSSSMSESLTDLDSKELE
                     KYFTDTAVTMKVKGSNAKVTASYTFDKKTYIKDYRERVQKSFSAFGDLFKAFYGDSFEN
                     YYSEETIEKELDEALEKAAKDSGQKYDSKTGETTTTLFKGKVSRLGHKMTVTSVNKDVD
                     IDGLNVKKGQELKVTKKDKKVTLSGDGKSKDITFSTKNDTKDKF"
     CDS             complement(11617..12519)
                     /locus_tag="ctg22_13"
                     /transl_table=11
                     /translation="MTKEEGLSLGETAHPLKPHKMGPSGALMEGNRATNKFKEFNADRM
                     VSVQFNPSQQVKESKEPVTSKNIVGMVSGVIAAILTILLIVCLVMGYRYRAASIEGDWT
                     SPTFSEKMLATLKDTANTKNKVSNALPQGQNLITDINTAMSITDNKAHLKVSFVYNRKG
                     LYQAYQSRVTELKGQYGEEFSEVFDSYSLSEKDYYKQFDETVKKELPKSYTYDAKTGRV
                     TTTAFTGDINRWEQTITVDKAGDSDAFKKGDVLDYTPNNEVLLSRHTVNLVTLALQKII
                     KKEIRKGNINDKRRMVGLF"
     CDS             complement(12680..14716)
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aldedh"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Fe-ADH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1035:Iron-containing alcohol dehydrogenase (Score:
                     373.4; E-value: 3.3e-114)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_14"
                     /sec_met_domain="Aldedh (E-value: 1.9e-10, bitscore: 29.7,
                     seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="Fe-ADH (E-value: 7.4e-115, bitscore:
                     373.4, seeds: 219, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNHPKIATVLATGGPGMVKAAYSTGKPALGVGAGNVPSYIAADAK
                     VKRAVNDIIVSKTFDNGMICASEQAAIVDAAIYDEVKAEFEAHQCVIISKKADIAKLEK
                     VVLNEARTAVNGAIVGHSAIEIAEKAGLKVPAGTKMLLAEIPDATMEHPLALEKLSPVL
                     ALIKSDGVEDGFKKAEGMLNLGGLGHTAVIHTENEELQLQYGIRMKACRVLVNSPSAEG
                     GIGNIYNNMIPSLTLGCGSYGHNSISHNVSSFDLLNVKTLSKRRNNMQWFRVPPKIFFE
                     KDSITYLRHIKAKRVMLVCDPGMVQFGYAALVKRQLELNRHDPMIEVFSDVEPNPSTNT
                     VYKGLERFVDFQPDVIIALGGGSAMDAAKAMWMFFEHPDVSFFGAKQKFLDIRKRTYKI
                     PYAEKTTFICIPTTSGTGSEVTSFAVITDSETHIKYPLADYALTPDIAIVDPALVMSVP
                     ASVTADTGMDVLTHAIESYVSVMASDYTRGLSLQAIKLVFENLEHSYRFGDEESREKMH
                     NASTMAGMAFANAFLGISHSLAHKIGPMYNIPHGRTNAILLPHVIRYNGRDPQKHAMFP
                     KYDYFRADKDYADIARFMGWGTDKQSDAELVELLAQKVYELGIAVGIDMNWKGQGVTKK
                     LLQDTAYTLAEHAYEDQCTTANPKEPLISELKEIIEIAFDYKG"
ORIGIN
        1 taggccttgc gtacggtaaa tgagaatact ttcacgctcg tctatggtaa aatgatggta
       61 gctcataaga tttcctttcg taactagttc gttcaattct attttactag aaaatcttat
      121 gagtttttat tgtgcactta tattgtatat tcaagaccaa aaaagagcag taggattgat
      181 taccaactac tctcttcaga acacaaaaaa accagtacta aactggtttt tgagactatc
      241 acattagtta tagattttga atgcgtcatc gtcgttttga ccaacgaatg gcattgcttt
      301 acgcaattca gcaccaatct tttcaatttc aagctcttca gcttctttac ggtaagcttt
      361 caaacgtggg aagccagcat catggtcttc aacgaattca cgtgcaaatt tacctgattg
      421 gatatcagca agggcagctt tcatgttttc tttgacttct ggaccgatga cacgtggacc
      481 agttacaaag tcaccaaatt ctgcagtatt tgaacatgat tgacgcattt tcttgaatcc
      541 accttcgtag atcaagtcaa caatcaattt catttcgtga agcacttcaa agtaagctaa
      601 ttgtggtgca tagcctgctt cagtcaagac ttcaaaacca gcttcaataa ggtgtgtcaa
      661 cccacccata agaaccgctt gttcaccaaa caaatcttct tcagtttctt ctttaaatgt
      721 tgttacaagt aatccaacac gtgcagaacc aataccttta gcccagtcca tagcgatatc
      781 tttagcatta cctgtagcat cttggtatac tgcgtaaagt gcaggaacac caaagcctct
      841 gtatatgtac ggcgtaccaa gtgacctggt cctttaggag caaccataaa gacatcaaca
      901 tctttaggaa ccttgatgaa ttcgaagtgg atgttaaatc cgtgtgcaaa accaagagct
      961 ttgcctgcac tcaagtttgg ctcaatttca tctttataga tatctttttg aatttcatct
     1021 ggtgccaaaa ccataatgat atcagccaat ttagttgctt ctgctactgt gtaagtatca
     1081 aaaccatctt ctttagcttt atcaaatgat ttacctggac gaacaccgat gatcacatcg
     1141 tgacctgaat cacgcaagtt ttgtgcatgc gcatgacctt gtgaaccgta accgataacg
     1201 gcgatttttt taccgtcaag tgctgctact tttacgtctt tttcatattc catttgaact
     1261 gccatagtaa tatgtctctt ttctaaaaaa tattttattg cctttttaag gctgggttaa
     1321 caaatttagg ttggattttt taatcacggg taaatccagt agcacccgta cgagcgatat
     1381 tcttgattcc gtaaggacga ataactcgta gaagcgcctc gctcttttca gcatcaccag
     1441 tcatctggat agtgatagag cttggtgcca catcaaccac cgaagcacgg aaaggttgaa
     1501 taatcgccaa gatttcagca cgcttagagg ttggtgctga taccttaact aggataactt
     1561 cacgttccaa gtgtggctga tccgtgatat cacggatacg gatcacatca atctgacgat
     1621 taagctgttt gatgatttgt tccacttcat tttgagaatt cacatcaata ataatcgtaa
     1681 tacgtgaaac gttaggatcc tcagaagccc ctacagagat actttcaata ttaacttgac
     1741 gtcgtgaaag aacacctgtg aagcggttaa ggacacccga acggttctga agtttagctg
     1801 ttaacattct acgcattgaa cttcaccccc aacatttcgt gattactctt accagccgga
     1861 acgattggca agacatgctc tttacgagag atatccacct cgatgaacat tggcacgtct
     1921 tccttgataa cttccaaatc ctgatcaatt gtctctggat tatcaaactt gtaagactta
     1981 atgccgtaag cttgagccat caattggaaa tctggaaggg tatcaaagac agactctgat
     2041 gtacgccctt cgtagaagga ctcttgccat tgacgtacca taccaagtga gtggttgttc
     2101 aacataacaa ccttgattgg caccttgtaa atatttaaga tagccaattc ttggttcgtc
     2161 atttggaaac caccatcacc aacaaagagg ataacttctt tatcaggatt agcaatttta
     2221 gaaccaattg ctgctgggac accgaatccc attgttccaa gaccacctga ggtcaccagt
     2281 tgacgctcat tttggtatgg ataatactga gctgtccaca tttgatgttg tccaacgtca
     2341 gtaacaacaa cggcatcacc cttagtcaat tcaccgatac gctcgataac tgcctgaggc
     2401 tgtaccatac gttctttctt atcgtaagaa cgtacacgtt ctttgtcttt tgtgactttt
     2461 tcaatccatt tttcagtgtt attctgaacc actggttctg ctaagagcat ttcaagagct
     2521 tgcttagcat caccaacaac tggaaggtcc actgcaataa ttttaccaat ctcagctgga
     2581 tctacatcaa tatggacaac cttagcattc ttagcaaatg ttttaggatt acctgtcaaa
     2641 cggtcatcaa aacgacaacc aatagcaatc ataaagtcag catcggtcat agcaatgtta
     2701 gccgcatatg aaccgtgcat accacccata cccaagaaaa gggggtggct agtagcaatt
     2761 gtcccttgtc ctagaagact tgtgacaact gggatttggt agcgttctgc aaaagcaact
     2821 agctccttag cagattcaga ataagacacc ccacctccag ctacaataac cggtttctta
     2881 gctttcccca actgcttcaa gattttcttg atttgcattt cgtttggtct tagcgtcggt
     2941 tggtaacttg gaagattaat ttcaggatcg ttgatgaagg ctgtttcctt agctacgaca
     3001 tctttaggga ggtcgataac aactggacca ggacgaccag ttgttgcaat atgaaccgct
     3061 tccctaataa tacgaggaat atcagctgta tcgcgaatct gataattgta ttttgtaatc
     3121 ggcatggtaa ttccgacaat gtcagcctct tggaaggcat ccttaccaat acctggtgtt
     3181 gcgacctgac cagtaaagac taggagaggt acgctatcac tcatagcatc tgcaatccct
     3241 gtaatagcat tagtggcacc aggaccactc gttacaagag caacaccgag tttaccagtt
     3301 gatttggcat aaccttcagc ttcgtgcaga cttccttgct catgacgaga taagatatga
     3361 ttaatcttgt catttttgta aatagcatca tacaaaggaa gaaccgctcc gccaggatat
     3421 ccaaagatag ttgaaatccc aagttcaaga agtgtatcaa gaatcaaatc agcaccagag
     3481 cgtgcttctt caagttcaat tttcttcaca tggacctcct ttagttagtt gtttttttcg
     3541 aattgtctaa aaattcaaaa ccttgtatac tatgataaca tttttaacca aatttgcaag
     3601 ggtttcagag aaaaatatca caaactcttc ggaaagaatg ttcttagttt ttttcttgtg
     3661 cttgacgttc tgctttacgt tcttcgaatt cttcgtcact catcaaagtt ccgccgacat
     3721 tggctgattt agcaaaggct gtatagcgac gcaaccaacc acttgaaatt tttgatttga
     3781 aaggtttcaa atgtttgcga cgttcttcaa gggttacatc atcgacaagc agatcaagag
     3841 tacggtttgg aagatcaatc acgatttcat cgccatcttc gattagggcg atattaccac
     3901 cttctgctgc ttctggagaa acgtgaccaa tagcaatacc acgagtagct cctgagaaac
     3961 ggccatccgt aatcagtgcc acatccttac caagaccgcg tccgacaatc ttagaagttg
     4021 gtgccaacat ttctggcata ccaggaccac cctgaggacc ttcgtatcga atgacaacga
     4081 catgtccctt cttaactgtt ccattgtcaa tcaactcaag ggcttgatct tgtgaatcac
     4141 aacaaatagc tttaccgcgg aaagttttaa cagatggatc tacaccacca accttgataa
     4201 cagctccatc ctgagcaata tttccgtaaa gaatagacaa accaccaact ggtgaaatag
     4261 gatgctcaat cggatggata atttcttcat ttttgatttc agcaccagct acattttctt
     4321 tcaaggtttt accagtaact gtaatacgat cacccttaat ggctcccttt ttaatcaact
     4381 gattgataat ggctggaaca ccaccagctt catgcacatc atgcatggtg taaacacttg
     4441 aaggggcaat tttagagaga taaggtgtct tcttggcaat ttcattaatg tccttaaggt
     4501 cataatcaat accagcctca cgcgcaatag caagggtatg gagaacagta ttggttgaac
     4561 cacccatagc catatcaaga gcaaacgcat catcgatagc ttctttggtc acaatatcac
     4621 gtgggcgaac attatttttg atgttatcca tcaattttgt ggctgcttga cgaaccaatt
     4681 cacgacgttc atctgagaca gctaggatag taccgttacc tggaagggca agacccaaaa
     4741 cttccatcaa acagttcatt gagttagcgg taaacattcc tgaacatgaa ccacaagttg
     4801 gacaagcatt tttctccaaa taatcgagct cttccttgct catatctcca gcctgatagg
     4861 tacctacagc ttcaaacaaa cttgatagcg tcgcttgatg accagtcatg tcaacgccac
     4921 ccttcatagg gccaccagaa caaaatactg ctggcacatt agtacgcatg gctgccaaaa
     4981 tcatccctgg cgtaatctta tcacagttag gaatatagaa aaccccgtca aaccagtggg
     5041 cattaataac tgtttctgca gaatcggcaa tcaattcacg agatggaaga ctgtaacgca
     5101 tcccaatatg ccccatggca atcccatcgt ccacaccaat ggtattaaac tcaaaaggaa
     5161 taccgccagc ctcgcggata gcttccttgg caatatctgc taattcacgc aagtgaacat
     5221 gccctggaac aatatcaata taagagttac aaatagcaat gaagggcttt tgcatatcct
     5281 tggcagattt aacttgccca gtcgcataca aaagtccgcg tgctggtgcc ttatcaacac
     5341 caactttgat catatcactt ctcatgatgt taccttcaat ctataaaatt tcttacaaca
     5401 tatgttacca ctttggaaag taatgtcaag gaattttcag aatatttctg taattccgaa
     5461 aagatgtccc aaccgtatca aaactgacaa aacaaaaagg aagccctaag acttcctaaa
     5521 tgattaattc aaaaattatt caacactaaa gaggtatgga taaactggtt ggtctccttg
     5581 gaagatttca acttcgatat cttcgtgagc ctcttccaat ttttccgcaa gtgcttgagc
     5641 ttgttcttga ttaccttctt cgccgacgta aatcataaca atttcactgt cttcgtcaat
     5701 cattttgtca aaggtatcaa gaagggcttg gtccatatct ggtgtagaca caaggatctt
     5761 accatcaacc ataccaagga tatcattttc atgaatctca agaccatcaa tagttgtgtc
     5821 acgtaccgcc aaggtcacgc taccactcgt tacatctgaa agactagctg tcatagcttc
     5881 aacgttcgct tcgatacttt gactaggatc aaaagcaagc aagcttgtaa agccttgtgg
     5941 caccgtacgc gtttcaacaa cagccgcatt gacatctact acttcagcag ctgattgtgc
     6001 tgccataaag atgtttttat tgtttggcaa gatgataaca ttcttagcat taacctgctc
     6061 aatagcctta acaatatctt ctgttgatgg gttcattgtt tgaccacctg aaatcacata
     6121 gtcaacacct tgtgatttga agatatctgc aagtccatct ccggcaacaa ctgcaataag
     6181 ggcaaagtct ttaggagcag aaggtgcagc ttggatagct tcttcttttt gaacttgtgc
     6241 atcgtgttgg ttacgcatgt tgtcaacctt aactttgaca agagccccat atttaagacc
     6301 ttcttgcatg acaagacctg gatcctcagt gtggacgtga actttgacaa tttcatcatc
     6361 gttaacaaca aggagagaat ccccaaggtt gctcaagtaa ttttggaact cttcatagtc
     6421 aaagtctttc acataagttg gaccttgttt gagaccaatc atgatttccg tacagtaacc
     6481 gaaggtaatg tcttctgttg caacatgacc agcaactgac ttatgatgtt ctgcattgat
     6541 catctctgtc atcgtagccg gtgtcgcttg gaagtcctct gaagcgatat actcacctgt
     6601 gagggctgac aagaaacctt cataaatgaa gaccaaacct tgaccacctg agtctaccac
     6661 accaacttct ttcaaaactg gaagcatctc tggtgtctta gccaaagcag ctttagctcc
     6721 gtcaagagct gcacgcataa cctcaacagc atcatttgta gattcagctt tcttaatcgc
     6781 tgctgaagct gcaccacgtg atactgtaag gattgttcct tcaacaggtt tcataacagc
     6841 tttataagca acttcaaccc ctgcttggaa ggcatgagct agatcttggc cgtcaagttc
     6901 cgttttatcc ttgatacttt gaccaaatcc acggaacaat tgtgaggtga taacacctga
     6961 gttaccacgg gcacccatca aaagaccttt agacaaaatc tgaccaactt caccaactgt
     7021 tgaagctgat tgatctgcga cagctttggc tccgttatcc atagtcattc ccatgtttgt
     7081 tccagtatct ccatctggta ctgggaagac attgagtgaa ttcacatatt ctgcttgctt
     7141 acctagacgt gttgctgccg cttggaccat ctcctgaagc aagcttgttg taattttaga
     7201 cactagtttt ctcctacgac tttaatattt tgaacgtaaa catttactgt ttcagccttg
     7261 ataccgagtt gattctcaag attaaatttc acacgttctt gaatattttt tgaaacctca
     7321 ctaatcttaa caccgtaact cataacagtg tagacatcca cagtgatacc tgcatcagta
     7381 gatttcacga caactccttt tgcgtagttt tcttttccaa gaagtgcttg aaaattatct
     7441 cggatagcac tcttacttgc cataccgaca acgccaaaaa tttctgttgc tgaaccgcca
     7501 actactgttg cgatgacatc atctgacaat tcgatttgac catcttttgt attgattttt
     7561 acagtcataa ttactacctc aaaaagtttt tatcagctta ttttaccata ttcgagccta
     7621 cttgtaaaaa ataagaagaa gatacccttt gaataagagt atctcctcag tatttatcat
     7681 taaaactttc tctttacgag ataacgacgg tacatcacgt agaggaagat cgcacgccat
     7741 acattatcaa caacggttgc aatccagact ccggcaagac ccagtcctag actcacccca
     7801 aggaagtatc ctgagaaaat tcggatgatc cacatcccaa tagtcgtcgc atagaaaggc
     7861 atcttagcct tacccagacc ttgccaaact gctgtgtaga ctagagtccc cgaagtcaca
     7921 ggattcccaa ggaaagaata aagaataact acctgactag ccgcaatagc tgctttatta
     7981 tctgtaaaga gacctgataa tccttggcca aagagcaaga tactccctga aaccagaacc
     8041 atcaagaagg tggaaatcca ataagactct tgtataatac gcttcatctg cgtcttatcc
     8101 cctcgaccca gactattggc aaccaagata accgtagccg ttgcgactcc cataccaggc
     8161 atatagttaa actgagtgag gttttcacca atggcgttac caccgacaac ggctgtacca
     8221 aaggtaacaa taatagccac gatgaccaca tctccagcac gcatcatcag tcgttcacct
     8281 gctgctggca gggcaatccc caacaactct ctattaaaag gtttggtaat ttcaagctgc
     8341 ttcacatcca gtttctcgct tgccagagta tcactgtccc aaccagacga gagaaaaccg
     8401 tagctgtagc taccccaata atcccccaat gtcccacaaa gatggctaaa gaagataaaa
     8461 tagcattaag aacattggtc aaaagactga cgaccatgga aatacgaggc cgtcccttgg
     8521 cccgtaggat gttaccaaaa gtagtcatca aggctaagaa gaccactcct ccaccgacaa
     8581 gagcaaggta gagactacca gcctgagtca cagattgctc agtacctaaa agattaagaa
     8641 tggccccacc accaaaaatg gaaagtagac caaggatgag actaagagca agggtaataa
     8701 taatagcatc ccaagtgtct cggttagtcg ctttaacatc accttttcct aaacttctgg
     8761 caatgacact ggcacttgag gctcctagag caataaagat agcttggtaa atcgtaatga
     8821 tattattggc tacggaaacc cccgatatag cgacaatacc cacctgagcc actaggtaag
     8881 aatcgacaac ccccatcaac atttgtagaa ggttttcggc catagcaggc aaggctatgt
     8941 ttagaatttt ctttgtttct gtcataatat tcttttctat attgataaaa atagggctga
     9001 tttctcagct cctatttttt tattcttata caccaagata gctttcaact gctttttgca
     9061 tatcagctgc cgcaacaact gttttatggc gaacttccgc atgttcaagt ccatctacag
     9121 cagctgggat agctacacct gaaagttggt gcaaatcttc tactgctttg aaatcatccc
     9181 cactgtcttt accagtgaca gctgaaatag ccacacgtgg gaatttatat gggctagctg
     9241 ttgaagcgat aactgtaggg gtgtggtcat ctgtcttttg aacataggct tcgtaaacag
     9301 ctgaggcaac cgctgtatga ggatcttcga tatacttgtt ttcatcatag acacgtttga
     9361 tttcagcagc tgtttcatcc tcagttgcaa aacctgctgc aaacaaatca agaatatctt
     9421 tatctgcatc agccaaagta tactcaccct tagtcacaag tgcatccata agctctttag
     9481 tcttagtagc atcattacca agaaggtgga aaatcaagcg ttccaagtta gaagatacca
     9541 agatatccat agaagggctt gttgttacct tgaagtcacg tttcttgtca taagtacctg
     9601 ttgcgaagaa gtctgtaagg acgttatttt cattagaagc acagattaat ttgccaactg
     9661 gaacaccaat ctgacgtgca taataagccg ccaagatatt accaaagttt cctgttggta
     9721 ctgtgaagtt caccttatct ccgttttgga tatgacctgc cttaaccaac tgtgcatagg
     9781 catatacata gtaaaccact tgcggtacca aacgaccaac gttcattgag ttagctgatg
     9841 agaattgcgt atgatgagcc aacaatttct cacgcaaatc aacatcatta aacatacgtt
     9901 tcacatctgt ttgagcatca tcaaagttac catcaatggc aataacgtga gtattagctc
     9961 ctgtttgagt ggtcatttgc aattcttgga tttttgaaac accgtctttt ggataaaaga
    10021 caatgatttc agttccagga acatctgcaa aaccagccat ggcagcctta ccagtgtcac
    10081 ctgatgtcgc tgtcaagatg gcaatcttat tatcaacacc ttgcttttta gctgatgttg
    10141 ttagcaagta tggcaagatt gaaagggcca tatctttgaa agcgatagta gaaccatgga
    10201 aaagttcaag gttgtagtgg ttcttaagtt taactactgg tgcaatggca gctgtatcaa
    10261 acttgtcatc ataagcattt gtgatacagt aatccaattc ctcttcagta aaatcatcca
    10321 agaaagctga caagaccaat ttagcaactt cttggtaaga agcgtctttc aattgatcaa
    10381 agtccaaagc aacctcaggc gttgacaacg gtgtgaacaa gccaccatct gttgccaaac
    10441 cttgaagaat agcttgacta gctgttactt tattattttc gtcacgtgtt gattggtata
    10501 caagtgtcat ggtaaatcct ctttttagat agtctgtggc tctattgtag cataattgtc
    10561 agaatatttc tacacgtttt atgacttgtg aaaaaaatca ttcggatatc accctatttt
    10621 ctcctctcaa agacatgaaa aaatccggaa tagctattcc ggatgtcatc ttaaaattta
    10681 tctttggtgt cattcttagt tgagaaagtg atatcttttg atttcccatc accactaagc
    10741 gttactttct tatctttttt agtcactttt agctcttgac cttttttcac attgagacca
    10801 tcgatatcaa cgtctttgtt gacagaagta acagtcatct tatgtcccaa gcgactaacc
    10861 ttccctttga aaagggttgt cgttgtttcg cctgtcttcg aatcatactt ttgaccgctg
    10921 tcttttgcag ctttttcaag agcttcatca agttcttttt ctatggtttc ctcactgtaa
    10981 tagttttcaa aggaatctcc atagaaggct ttaaataaat ctccaaaggc tgagaaggac
    11041 ttctgaaccc tctcacgata gtccttgata taggttttct tatcaaaagt atagctagca
    11101 gtcaccttcg cattgctacc ttttactttc atggttacag cagtatctgt aaagtacttt
    11161 tcaagctcct tactatccaa gtctgtcaaa ctttcagaca tgcttgaact atactctcta
    11221 cctagagaac tactgtacca tttgccatca atattacctg tcacataacg gtaagtcata
    11281 aagccaccga tacataagaa gacaaggact accgctgaca aaactgagac taggatgcgt
    11341 tttttctttt tgggatccat tggtttttta ggagccaaat ttgccatagc tgcttgtcct
    11401 tctggaaaag ctactgtaga aggtgctggc gctgttacta ctggtgccgt ttctgttggt
    11461 agaggactag tgcttgtctc gacgatttct gcctcaacct taataggttc agtagtagct
    11521 gtatcttcag ctttagctgg tgcttcatta acaaactctc cagctttcaa agcatccgcc
    11581 atttcctgaa cactcggctt acgtccgttt accgtctcaa aatagtccaa ccattcttct
    11641 cttgtcattt atattcccct ttctaatttc cttttttatt attttttgta aagctaatgt
    11701 caccaaattc actgtgtgcc ttgatagtaa aacctcattg ttaggcgtat aatctaagac
    11761 atcacctttt ttaaaagcat ctgaatctcc agccttatcc acagtgattg tttgctccca
    11821 acggttaata tcacccgtga aagcagttgt tgtaacacga ccggttttgg catcgtaggt
    11881 ataactcttt ggaagttctt tcttcactgt ctcatcaaac tgtttatagt agtctttttc
    11941 tgacaatgaa taactatcaa aaacctccga gaactcctca ccgtactgac ctttcaattc
    12001 agtaactcta ctctggtaag cctgataaag acctttacga ttgtaaacaa agctcacttt
    12061 taagtgagcc ttattgtcag taatactcat tgctgtattg atatcggtga taagattttg
    12121 accttgtggt aaagcattac taactttatt cttagtatta gcagtatctt tcagagtggc
    12181 taacattttc tcactaaagg ttgggcttgt ccaatcgccc tcaatgcttg cggctcgata
    12241 acggtatccc atcacgagac aaacgatcaa aagtatggtt agtatcgctg caatcacacc
    12301 tgataccatc cccacaatat tctttgaggt tactggctcc tttgattctt ttacttgttg
    12361 actaggattg aattgaacac tcaccatcct atcagcatta aactctttaa acttattagt
    12421 cgctctattc ccttccatga gagcccccga tggtcccatt ttatgaggct taagagggtg
    12481 tgctgtttca cccaagctaa gcccttcttc ttttgtcata ggaatctcct tatcttgctg
    12541 taaggttatt ataacaattc ttaaagcgtt tttctatctt attcaagaaa gtcctttatt
    12601 tttaatttgg ataaacactc taatatagaa gattcctggc aaaaaaagta gcccttatag
    12661 agctacttta gtctatcact taccctttat aatcaaaggc aatttcgata atttctttca
    12721 attctgaaat aagcggttct ttcggattag ctgttgtaca ttggtcttca taagcatgtt
    12781 cggccaaagt ataggcagtg tcttgaagaa gtttcttagt gacaccttgt cccttccagt
    12841 tcatgtcaat accaacggca atacctaatt cgtatacttt ttgtgccaaa agttcaacca
    12901 attcagcatc tgattgtttg tcagtacccc atcccatgaa acgagcaata tcagcataat
    12961 ccttgtctgc acggaagtag tcatatttag ggaacatggc gtgtttttga ggatcacgac
    13021 cattgtagcg gataacgtga ggtagaagaa ttgcattggt acgtccgtgt ggaatattgt
    13081 acattggacc aatcttatgt gctaatgagt gactaatacc aaggaaggca ttggcaaagg
    13141 ccataccagc cattgttgac gcattatgca ttttttcacg tgattcttca tcaccaaaac
    13201 ggtaagaatg ttcaagattt tcaaaaacaa gtttaatcgc ttgaagtgaa agtccgcgtg
    13261 tatagtcgct agccatgact gatacataag attcaatagc gtgagtcaaa acgtccatac
    13321 ctgtatctgc tgtaacgctg gcaggtacac tcataaccaa agcagggtcg acgatagcaa
    13381 tatccggagt caaagcgtaa tctgccaatg gatacttgat atgagtttca ctatcagtga
    13441 taaccgcaaa tgacgttact tctgaacccg tacctgaagt tgtagggata cagataaatg
    13501 tggtcttttc agcatatgga atcttatagg tacgtttacg aatatctaag aatttttgtt
    13561 tagcaccgaa aaagcttaca tctgggtgtt caaagaacat ccacatagcc ttagccgcat
    13621 ccattgcaga accaccacca agggcaataa tgacatctgg ttggaagtct acaaagcgtt
    13681 ccaagccttt ataaaccgta ttcgtagatg ggttaggctc aacatctgag aaaacttcaa
    13741 tcattggatc gtgacggttg agttccaatt ggcgtttaac caaggcagcg tagccaaact
    13801 gaaccatacc tggatcacag accaacatta cacgcttagc tttgatatga cgcagatatg
    13861 ttattgagtc tttttcaaag aagatttttg gtgggacgcg aaaccattgc atattattgc
    13921 gacgctttga caatgttttt acgttaagaa ggtcaaatga actaacattg tgagagattg
    13981 agttgtgtcc gtatgagcca caaccaagag tcaatgatgg gatcatgtta ttgtagatat
    14041 taccgatacc accttcagct gatgggctat ttaccaagac acggcaggct ttcatgcgaa
    14101 taccatattg gagttggagc tcttcatttt cagtgtggat aacagctgtg tgtccgagac
    14161 cacccaaatt gagcatacct tctgcttttt tgaatccatc ttcaacgcca tcagatttga
    14221 taagagcaag tactggagac aatttttcca aggcaagtgg gtgttccatt gttgcatctg
    14281 gaatttctgc caaaagcatt tttgtacctg caggaacttt aagaccagct ttttcagcaa
    14341 tttcaatagc tgagtgacct acaatggcac catttacagc tgtacgagct tcattaagaa
    14401 caactttttc caatttagca atgtcagctt ttttagaaat gatgacacat tgatgtgctt
    14461 caaattcagc cttaacttcg tcatagatag ctgcatcaac gatagctgct tgttcagaag
    14521 cacaaatcat accattatca aaagtttttg aaacaatgat atcgttgaca gcacgtttaa
    14581 ccttggcatc agcagcaata taagatggga cgtttccggc tcctacacca agcgctggtt
    14641 taccagttga ataagcagcc ttaaccatac caggtccacc agtcgcaagt actgtggcga
    14701 ttttaggatg gttcatcaaa agaccagttg cttcgataga gggctcttca atccactgga
    14761 tgcagtctta ggtgcacctg cttcaatagc tgacatcacg gacgatacga gctgcctctg
    14821 cagatgattc tgagctgatg ggtggaaggc aaatacaatt gagttacgtg ttttcaacgc
    14881 aatcaagctt g
//
