LOCUS       c00022_CAKNNQ0..       14899 bp    DNA     linear   UNK 01-JAN-1980
DEFINITION  CAKNNQ010000022.1 TPA_asm: Lactobacillus johnsonii isolate
            ERR3414575_bin.48_metaWRAP_v1.1_MAG genome assembly, contig:
            NODE_2935_length_26636_cov_46.313118, whole genome shotgun sequence.
ACCESSION   CAKNNQ010000022
VERSION     CAKNNQ010000022
KEYWORDS    .
SOURCE      
  ORGANISM  
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.0.0
            Run date     :: 2022-06-19 15:51:29
            Original ID  :: CAKNNQ010000022.1
            NOTE: This is a single cluster extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 14899
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..14899
                     /aStool="rule-based-clusters"
                     /contig_edge="True"
                     /core_location="[2361:4899](+)"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      2362..4899
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /neighbourhood="10000"
                     /product="lanthipeptide-class-iv"
                     /protocluster_number="1"
     cand_cluster    1..14899
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(cds(LANC_like and Pkinase) and not
                     micKC)"
                     /kind="single"
                     /product="lanthipeptide-class-iv"
                     /protoclusters="1"
                     /tool="antismash"
     region          1..14899
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="lanthipeptide-class-iv"
                     /region_number="1"
                     /rules="(cds(LANC_like and Pkinase) and not micKC)"
                     /tool="antismash"
     CDS             2..85
                     /locus_tag="ctg22_1"
                     /transl_table=11
                     /translation="LSSSLIKSVQFIIAIYEKIEIKNFRKK"
     CDS             152..349
                     /locus_tag="ctg22_2"
                     /transl_table=11
                     /translation="MIKYKHKYKSLERRDFMDDFFNSILKLQNKKTKQKTIKKDGSKGT
                     RRSLICFHDFSLGWLKDFRI"
     CDS             369..491
                     /locus_tag="ctg22_3"
                     /transl_table=11
                     /translation="MLPIINLQAVNRTAHTEYMGAPKKKRRVTTTIICWNQFQK"
     CDS             650..2359
                     /gene_functions="transport (smcogs) SMCOG1288:ABC
                     transporter related protein (Score: 266.7; E-value:
                     7.2e-81)"
                     /gene_kind="transport"
                     /locus_tag="ctg22_4"
                     /transl_table=11
                     /translation="MKRDRIYLFKIDVLLLIAILLSVAGSVCNLILPLFVRQFIDVRAT
                     SLMSFDSLLPILTVLMMGSIVNAVSMYLISVSGDRRIRDIRENIEEKLLKLPISFYKEN
                     ASGELVSRIINDSLIIKEFTTNEVPNAIVSIITLIGSIGILLYLDLKLTLVIVLSFTIV
                     AIIAYPLGKINEGYSFLIQDYLSKLSQVITENIQNIQIIKLYNAQKEVKHKFKKINNNI
                     YGLSKKIDKIFSITGPIQTMFTLLAFLIIVLYGSTRVSQHTLSMGILASFMMYIFEIIT
                     PINTLANFYVSYSEAKGASKVISRIMNTTEEKVTGKDINGIKEPYIEMKNISFKYGKKS
                     SLVLKRVSVSFDSLKKIAIVGPSGAGKTTLISILTRLQEKYDGLVFLNGRNSKDYSLAS
                     WRSLFSVVTQENSIFSGSIRDNLTFGLIDKPSEEELNQALKVASMSKDIDKFPGKLDFD
                     VGENGGKLSGGQRQKIQIARAYLRDTPFIIFDEATSNLDPESESEILSSIDELSSKKTL
                     IVIAHRLSTIVNADKIYFLDNHQILGAGTHEELLRKVEKYKTFVNDQFISKE"
     CDS             2362..4899
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: LANC_like"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     lanthipeptide-class-iv: Pkinase"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1030:serine/threonine protein kinase (Score: 59;
                     E-value: 8.6e-18)"
                     /gene_kind="biosynthetic"
                     /locus_tag="ctg22_5"
                     /sec_met_domain="LANC_like (E-value: 5.3e-11, bitscore:
                     32.6, seeds: 47, tool: rule-based-clusters)"
                     /sec_met_domain="Pkinase (E-value: 9.3e-16, bitscore: 48.7,
                     seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKYTIQDYLPFLNDKDNFFIDPSNTVDNFNITPPSKEWKIYKDKH
                     WTFLRKLSVKLPTQGWKIHLSAGYDKAELQLMINTACDYLFANNICFKVTNSYEEWLIK
                     NSKSADRVSAGKFITIYPQNETQFKQIVEKLKILLQPYKIGPYILSDKRYQETNIYYRY
                     GGFKEIKNNNGELCIRDQQGNLIPDERLPFYKKPDFVEDPFEKATKDKSNKIVNKDKLD
                     SYNISSALHFSNAGGVYLGQCGERKYVIKEGRKNAGIDSHLQDGFSRIKHEATFLNKLK
                     DSPYVVNIKDYFQVWIHNYLVEDYLPLENLGDYISNKFPVHGDEAHYVEKIKTIAKNLV
                     TAVDDVHERGVALGDLQPDNILINESKNQVLLIDLEQANKLMAQYDPGLKTVGFVDSNM
                     VISTYEQADWLATYKTIRYALEPLIDIDSLSTYNEKYRDLNWMKYREEVKKFLQEFKLE
                     CFKRGHINHKNDNVPTNPVMLGTLDENITKLKRGIVSNIDDTQSTINGDIEQFLSSTGK
                     INVLNGLMGLGLVEQEKTEPIFRLYTNLYLNSKDQLVQIGSKDNGLFTGAAGIGSLIYN
                     WFDKKIGEQIINNIDATKIHNMSLKSGLAGIGLAKLALYQANKQEEQKVEVQKIASIVT
                     SHYKACQTLGILDGKLGLLLFLEKVGIYFNDSNLIKIVKQEINNFVAVHLSFNDGVYLA
                     GTALGRESYFPYLNSGTAGLALVLLEFMYDEIVSNEIRPLINKLIETLDVNLTYMNGLF
                     DGFGGLMLVDLAAKNYGYPNYLAKKIDLINNYLDIEEDQILVPGPYGLKNSMDLASGAI
                     GMLTVFQGIKENNWGKWIPLVHSTNFSLFEGGE"
     CDS             5139..5270
                     /locus_tag="ctg22_6"
                     /transl_table=11
                     /translation="MSKKRNLISFQGVLGFNPNVSFFSQGSSKEKSLTKFLKKYFGF"
     CDS             5274..6605
                     /locus_tag="ctg22_7"
                     /transl_table=11
                     /translation="MLSTILDVILLLLSPLVDFVNYFKIIKFKTKGKISRILILLIFLV
                     TVFEEIVTDLIAFPPLDALATIIEMGLLILVGSRSKKDYRMLLTGALIIGIIDLGNNIV
                     VSFLGKLFDMSAEISTVIYIFLVLLSYIFISYYAKKINKLISGRNKNILLNSAIYLYIS
                     SIIAYIIASIEKTLSTALVILIGILIIQGVYTIVNVKISVRTSKNILNEAEQNYLKKQN
                     AQLQRNNNQLKEYANSLEKDEDRLRRFKHDYRNILNSLKISAQKEDSKVLIKQLDEYTK
                     EHFDSDALSKFKDVNHIHDELVKSIIITKLSKMFNNGIKYRFSCEKDINTFPFLSSSEH
                     MDVVRILGITFDNAIEATKKEKDPKIEAMLYQNNGNLEFIIRNSIAKEINKNEVFQMGH
                     TTKENHSGIGLNNVLKIVEKYPNNMMVDINTEAGWFTFNLVIFK"
     CDS             6720..7382
                     /locus_tag="ctg22_8"
                     /transl_table=11
                     /translation="MEFDVIKNASSYEEATSYIENTHISAGIYFLDIEIGKKLHEKNGI
                     DLGEVIKEKDEKAQLIFITSHEDMAFLTFERRLGAIDFIVKSSDLDKTRARILYAIENA
                     IDKISKFDYIKRNTFSYRFGQEIKNISLDDVIYITTTNVGHKLQLVKKTGWAEFIGSLK
                     DIPTRYSQLVQISQSCVINPHNVQNIDLKEKKIIFINGDIEYFSVRNTRKVKTLFKM"
     CDS             7564..8898
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1175:pyridine nucleotide-disulfide oxidoreductase
                     (Score: 296.5; E-value: 4.5e-90)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_9"
                     /transl_table=11
                     /translation="MKKYDYIILGTGPAAYQLIKLLATQHKSILVVESGLFGGTCPNVG
                     CEPKIYLDGAVQAILSSRQFEKEGIISQIGKLNWSQLMKEKKERFASWPNETRKNISKI
                     SDVISGSAHFVDRQTIEVNRQYFQGNRIIIATGRRPHELSIPGAKFLHDSSDVLSLNKL
                     PEHVTFIGGGYVAMELATFLAAAGSQVTILVRGDRVLRYFYQKYSRELVVKMKERGIQF
                     KFETEPTRITQLSDKYVVELNQDGPMVTDYVVNASGRTPNIEKLDLSAAQIDYSTRGID
                     VDRHLQTNVKNIYAIGDVTSQDVPNLTPVAEFQAQYLFNSLEKGLTQTINYPAMGTGVF
                     AFPQLAQAGINPDSVLEDGDNFEIREYELSQSSLYAGQKERGLLTVVYDKANYIVGVSE
                     ISMSAVNDINYFVPIIGLRINKNEWHRNVLPIYPALADKIEGILR"
     CDS             complement(8943..10097)
                     /locus_tag="ctg22_10"
                     /transl_table=11
                     /translation="MSLWETKLAKKGLTFDDVLLIPAESHVLPNEVKLDTKLAPNLQLH
                     IPLISAGMDTVTEGNMAIAMAENGGLGVIHKNLSIEAQVDEVKKAKGKTVDPNLPHPAV
                     DNQGRLLAAAAVGVTSDTFERAESLLEAGADAIVIDTAHGHSAGVLRKIKEIREHFPNA
                     TLIVGNVATGEGTAALFDAGVDVVKVGIGPGSICTTRIVAGVGVPQITAIYDAASVAQK
                     YGKKIIADGGIKYSGDVVKALAAGGNAVMLGSMFSGTTEAPGTVFTNEGKQFKSYRGMG
                     SVGAMSQQHGSSDRYFQGGVNEANKLVPEGVEALVPYKGDVSNIIYQIDGGLRAGMGYV
                     GAGTIEELIENSQFVQITNAGLRESHPHDVQMAKEAPNYGGSDL"
     CDS             complement(10171..10812)
                     /locus_tag="ctg22_11"
                     /transl_table=11
                     /translation="MMIKKILRFSQGLFSTLKDFLLMKLLLTGDSIIARSENHSIPEIN
                     FQLQKLNSYQIYNTAISGINSGGLGLSLPNLVFNQPKCDYLIILIGTNDLAVHKQVPVQ
                     QFEDNLKLIASSIIWLYYPGKVIFVTPPAVDENKQKVRNNLLVQEYSNIIKHVTKEYKF
                     LFIDLASKMQASKNFPEIFNGKKNDGLHFGVKGYELLAKLIVQKLNQISN"
     CDS             complement(10823..11836)
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1072:dehydrogenase (Score: 307.4; E-value: 1.3e-93)"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="ctg22_12"
                     /transl_table=11
                     /translation="MTKIFAYAIRKDEEPFLNEWKDAHKDIEVEYTDQLLTPETAKLAK
                     GADGVVVYQQLDYTPETLQALADAGVTKMSLRNVGVDNIDMDKAKELGFEITNVPVYSP
                     DAIAEHAAIQAARVLRQDKRMDEKMAKRDLRWAPTIGREVRDQVVGVVGTGHIGQVFMK
                     IMEGFGAKVIAYDIFKNPELEKKGYYVDSLDDLYKQADVISLHVPDVPANVHMINDESI
                     AKMKDGVVIVNCSRGPLVDTDAVIRGLDSGKIFGFVMDTYEGEVGVFNEDWEGKEFPDA
                     RLADLIDRPNVLVTPHTAFYTTHAVRNMVTKAFDNNLKMINGEKPDSPVALDKNKF"
     CDS             12093..14747
                     /locus_tag="ctg22_13"
                     /transl_table=11
                     /translation="MSVVVKYVDLDNNLVELANSGELEGKIGERIDYRTEDEIRKILAA
                     GYVLINNPFDPNDKVNFFNEDSQEFTLTFKHGKEEITAKNLKYGCHLEDVQMKGEQVVH
                     YVGLDQSIPDKVTEVAFNRKIIYDKVTKKKLLTNTWQPEKYSFPLVASPTVMNYTPDKA
                     VIGGETATIQQPKYEYVVTYSPNKKNARRQKAEIKFIDVDDNNREVATSGELKGKPEKE
                     IPYNTAEVLKNLTAKGYEVVTNDFDSEEQKPVFGNSRDYVQIFFVVLKHKKQVVNSEHP
                     FSGIDASLYEKEVHRTIRFSGIDNKKLDDVVQTAILKRNLTVDLVTKKIIPGEYTSQWH
                     SSETYPSVSVPVVSGYHTKISEVVASPVEKQDVTEEVKYYSNGYLIPVDVNHNGFSEID
                     KKQLITNSIDPTKVVLSELDLKNIVLKQIKEVEIADPSRNYEIPYLLVHKYVAVDEKHP
                     QEVISPAYYRRIVTARVHYQGAGDQTPPDAEQTVRWTRTITYDEVSKEIIENGMYTTDW
                     VADKDIFEATPTPVIKGFAANIGLIGEHPVTATDLMATITYTPLGKMIPVDEHGNEIKN
                     AMHPTYVNDPYDPVRVLFTEEVPEVPGYAPVKNTISVNDPFTDIKVSYTLKPRYIPVNS
                     EHPYRPIKPTLYSVPVKEIIKYQGAGDQTPITRIQGANWTRTLTVDENTGELVDAGKYT
                     TGWLVDKKQYIAVKTPVIDGYHADKNIIDEEKVKKADLNFTVTYKANGRIVPVDAKGNV
                     LNGVEQPTYVTDPSDATKVIKTQGVPRIMNYIPDRATITVKDASENTLVKYYTFDEMSE
                     LKVEYKKIEQEKSKDIKPKKKAEEKGAKEEEQSLKTEEEKKAEMASKKEATQVDGQNEQ
                     ERKVLRHIFPWMK"
ORIGIN
        1 tctatcaagc agcttgatta aaagtgttca atttattatt gcaatttacg aaaaaattga
       61 gataaaaaat tttagaaaaa agtaattact cttttacgaa tttgggtcta ttttgatcga
      121 ttttgtgttt ttaataatta tttaagagaa catgataaag tataagcata aatataaaag
      181 tttagagaga agagatttta tggatgattt ttttaactcg attttaaaat tgcaaaataa
      241 aaagacaaag caaaagacga ttaaaaaaga tggttctaaa ggaactagaa gaagtttaat
      301 ttgttttcac gattttagtt taggttggct taaagatttt agaatttagc agaaaggaaa
      361 agctaaagat gttaccaatt attaatttac aagctgtaaa tcggactgca cacacggaat
      421 atatgggagc tccaaagaaa aaaagaagag taacaacgac tattatttgt tggaatcaat
      481 ttcaaaaata gtgaggaggc attaacatgc aaaactatga agttctaaag ttacaaggaa
      541 gtcaaacatc taatatgcag gcgactggat tattggaatc taaaagaatt agcgtatttt
      601 gttttaataa aagaggtaag caccgtctgc cgaatgtata ttgggactaa tgaaaaggga
      661 tagaatttat ttatttaaaa tagatgtttt attgttaatt gcaattctat taagcgttgc
      721 gggaagtgta tgcaatttga ttttaccact tttcgttaga caatttattg atgttagagc
      781 tacaagtcta atgtcatttg attctctgct accaattctt actgtattaa tgatgggatc
      841 aattgtaaat gcagtaagta tgtatctaat tagtgtgtct ggtgacagaa gaataagaga
      901 tattcgtgaa aatatagaag aaaaattgct taaattgccc atctcttttt ataaagaaaa
      961 tgcaagcgga gaattagtaa gtcggattat aaacgattca ttaattataa aagaatttac
     1021 tactaatgaa gttccaaatg caatagttag tatcattacg cttattggaa gtataggtat
     1081 tctattatat ttggatttaa agttaacatt agtaattgtt ctttctttta ctatagtagc
     1141 gattattgct tatcctttag gaaaaataaa tgaaggttat tcattcttga ttcaggacta
     1201 tctgagtaaa ttatcgcagg taataactga aaatattcaa aatattcaaa ttatcaagct
     1261 atataatgct caaaaagaag taaaacataa gtttaaaaag ataaataata acatttatgg
     1321 attatcaaaa aaaatagata aaatttttag cataactggc ccaattcaga caatgtttac
     1381 acttttggct ttcttaataa ttgtacttta tggaagtact agagtatcac aacatacgct
     1441 ttcaatggga attttagcat catttatgat gtacatattt gaaattatta ctccaataaa
     1501 tacgttagcc aatttttatg ttagttattc cgaagctaaa ggtgcatcta aggtaattag
     1561 ccgaataatg aatactacag aggaaaaagt aactggaaaa gacatcaatg gcataaaaga
     1621 accatatata gagatgaaaa atatttcatt taaatatggg aagaagagct cactggtatt
     1681 aaaacgtgta tcggtatctt ttgattcatt aaaaaagatt gctatcgttg gaccttcagg
     1741 agctggaaaa acgacgctaa ttagtatttt aactagactc caagaaaaat atgatggact
     1801 ggtattttta aatggaagaa atagtaaaga ttattcctta gctagttggc gtagtttgtt
     1861 tagtgtagtt actcaagaaa atagtatatt ttcaggaagt ataagagata atttaacttt
     1921 tggattaatc gataagccaa gtgaagaaga attaaatcaa gcgctgaaag ttgcttctat
     1981 gagtaaagac atagataagt ttcctggaaa attagatttt gacgtaggtg aaaacggtgg
     2041 aaagttatca ggtggtcaac gacaaaaaat tcaaattgct agagcatatt tgagagatac
     2101 accgtttatt atttttgatg aagctacatc aaatttagat cctgaatctg aatcggaaat
     2161 tttaagttca atagatgaat tatcatcaaa aaagacatta atagtaatag ctcataggct
     2221 ctctacaatt gtaaatgcag ataagattta ttttcttgat aatcatcaaa tcttaggagc
     2281 agggacgcat gaagagcttc taagaaaagt tgaaaaatat aaaacgtttg tgaatgatca
     2341 gtttatatct aaagagtaat tatgaagtat acaattcaag attatttacc atttttaaat
     2401 gataaagata atttctttat tgatccatcc aataccgtgg ataattttaa tattactcca
     2461 ccatctaagg aatggaaaat atataaagat aaacattgga cttttttaag aaaacttagc
     2521 gtaaaattac caactcaagg ttggaaaata catttgtcgg caggctatga taaagcagag
     2581 ttacaattga tgattaatac tgcttgtgat tatttatttg caaataatat ttgttttaaa
     2641 gtaactaata gctatgagga atggttaata aaaaattcta aatcggcaga tagagtttct
     2701 gcaggaaaat ttataactat ctatcctcaa aatgaaactc aatttaagca aatagtagaa
     2761 aaattaaaaa ttttattgca accatataaa attggtccat atattctgtc agataaaaga
     2821 tatcaagaaa caaatattta ttatcgttat ggtggtttta aagaaattaa aaataataat
     2881 ggggaattat gtattaggga tcagcaagga aatctaattc ctgatgaaag attaccattt
     2941 tataagaaac cagattttgt tgaagatccg tttgaaaaag ctacaaaaga taaatcgaat
     3001 aaaatagtta ataaagataa attagatagc tacaatattt ctagtgctct gcattttagt
     3061 aatgcaggtg gggtatattt aggacagtgt ggagaacgaa aatatgttat caaagaagga
     3121 agaaaaaatg ctggaataga ttctcatctc caagatggtt tttcaagaat taagcatgaa
     3181 gctacctttt taaacaagtt gaaagattct ccatatgttg taaatattaa agattatttt
     3241 caagtatgga tacacaatta tttagttgaa gattatttac cgttagaaaa tttgggagat
     3301 tatataagca ataaattccc tgttcatggt gatgaagcac actatgtaga aaagattaaa
     3361 actatagcta aaaacttagt gactgccgta gatgatgttc atgaacgagg agtagcatta
     3421 ggagatttac agccagacaa tattctgata aatgaaagta aaaatcaagt tcttttaata
     3481 gatttagaac aagctaataa acttatggct cagtatgatc ctggtctaaa gacggtagga
     3541 tttgtagatt caaatatggt tattagtacg tatgaacaag cagattggct ggcaacatat
     3601 aaaactatta gatatgcttt agagcccttg attgatattg attccttgag tacatataac
     3661 gagaaatata gagatctaaa ttggatgaag tatcgagaag aagtaaaaaa attcctccaa
     3721 gaatttaaat tagaatgttt taaaagagga catattaatc ataaaaatga caatgttcct
     3781 actaatcctg ttatgctagg aactttggat gaaaatataa cgaagctaaa gcgggggata
     3841 gtaagtaata tagacgatac acaatcgact attaacggag atattgaaca atttctgtct
     3901 tcgactggaa agattaatgt attaaacggc ttgatggggc tcgggttagt tgaacaagaa
     3961 aaaacagagc caatttttcg tttatatact aatttatatt taaatagtaa agatcaactt
     4021 gtccaaatag gtagtaaaga taatggtttg tttactggag cagcgggaat tggttcactt
     4081 atttataact ggtttgataa aaaaattggt gaacaaataa ttaacaatat tgatgcaact
     4141 aaaatacaca atatgtcttt aaaaagtgga ttagctggaa ttggattagc taaactagct
     4201 ttgtatcaag ctaataaaca agaagagcaa aaggtagaag ttcaaaaaat tgcaagcatt
     4261 gtaacaagtc attataaggc ttgtcaaact ctaggaatat tggatggaaa gttaggccta
     4321 ctattatttt tagaaaaagt aggaatatat tttaatgatt caaacttaat taaaattgta
     4381 aagcaagaaa ttaataattt tgttgcagta catctcagtt ttaatgatgg ggtatattta
     4441 gccggaactg ctttaggtag agaatcatat tttccatatc ttaatagtgg cactgctggc
     4501 ctggccctag tattattaga atttatgtat gatgagattg tttcgaatga aattaggcca
     4561 cttattaata aattaataga gactttagat gttaatttaa cttacatgaa tggtctattt
     4621 gatggttttg gtggattaat gctagtggat cttgcagcca aaaattatgg ctatccaaat
     4681 taccttgcta aaaaaataga cttaataaac aactatcttg atatagaaga agatcaaatc
     4741 ttagttccgg gaccatatgg attaaagaat tcaatggact tagcatctgg tgcaataggg
     4801 atgctaactg tctttcaggg aattaaagag aataattggg gaaagtggat accacttgtt
     4861 catagcacta acttttctct atttgaagga ggtgaataaa tatgcaaaat gatgaaaaac
     4921 aatcattact tggcttacaa gctgcaagcc catttgtaag ctttagaaaa aaaggtggta
     4981 gtactcataa ccacaatact tataattctg ttatttgttg gaataaaatt attaccttgt
     5041 ttggttaatt ttagtgtatt taaaaaagcg taacttttgt tgcgcttttt ggcatataaa
     5101 cgtaatctaa aatttaaatc tagaagggaa gagactaaat gagtaaaaaa agaaatttaa
     5161 ttagcttcca aggcgtattg ggatttaatc ccaatgtaag tttcttttcg caaggatcat
     5221 ctaaggaaaa gtcattaact aaatttttaa agaaatattt tggattttaa aagatgttat
     5281 caactattct cgatgtgatt ctattattgt tatcgccatt agtagacttc gttaactact
     5341 ttaaaattat taaatttaag acaaaaggaa aaataagtag gattttgatc ttacttattt
     5401 ttttggtgac agtttttgaa gaaatagtca cagatttaat agcttttcct cctcttgacg
     5461 ctcttgccac aataatagaa atggggcttc ttattttagt aggctctcga tcaaaaaaag
     5521 actatagaat gcttttaact ggcgcattaa ttattggaat tattgacttg ggcaacaata
     5581 tagtagttag ttttttgggt aagctatttg atatgagtgc agagattagt acagtaatct
     5641 acatcttttt agttttacta tcatatattt ttattagtta ttacgctaaa aagattaata
     5701 agttaattag tggtaggaat aaaaatattc tcttaaattc tgctatttat ctatatattt
     5761 caagtattat tgcctatata atagctagca ttgaaaagac tttgtctacg gccttggtta
     5821 tcttaatagg aattttgata attcaaggag tatatactat cgttaatgta aaaatcagtg
     5881 tacgaacaag taaaaatata ctgaatgaag ctgaacaaaa ttatctaaaa aaacaaaatg
     5941 cgcaattaca acgtaataat aatcagttaa aagaatacgc taattcgttg gaaaaagacg
     6001 aagatagact ccgtagattt aaacatgatt atcggaatat tttaaatagt ttgaaaatta
     6061 gtgcgcaaaa agaagattct aaagtgttaa taaaacaact tgatgaatat actaaagagc
     6121 attttgattc agacgcctta agtaaattta aagacgtaaa ccatattcat gatgagcttg
     6181 taaaaagtat tataataacg aaactgtcta aaatgtttaa caatggaata aaatatagat
     6241 ttagttgcga aaaagatata aatacttttc cttttttatc ttcttccgaa catatggatg
     6301 tggttagaat tctgggaatt acgtttgata atgctattga agctacgaaa aaagagaaag
     6361 atcctaaaat tgaagctatg ctttatcaga ataatggtaa tttggaattc ataattagaa
     6421 actctatagc taaagagata aataaaaatg aggtcttcca gatgggacat acaacaaaag
     6481 aaaatcattc aggcatagga ttaaacaatg ttttaaagat tgttgaaaaa tatccaaaca
     6541 atatgatggt ggatattaat acagaagcag gatggtttac gtttaatttg gttatattta
     6601 agtaaggagg aattaaaatt aagtattcag tttttatatg tgatgatgat ttacaacaga
     6661 taaaatttat aaatgattgt ttagaaaaag ctagcataat cttaagcgat gaagaaaaaa
     6721 tggaatttga tgttataaag aatgctagta gctatgaaga ggcaacatca tatattgaaa
     6781 atacacatat aagtgccgga atttattttc ttgatataga gattggtaaa aagttacatg
     6841 aaaaaaatgg aattgatcta ggtgaagtca ttaaggaaaa agatgaaaaa gcccaattga
     6901 ttttcattac tagccatgaa gatatggcat ttttaacgtt tgaacgaaga ttaggcgcaa
     6961 tagactttat tgttaaaagt agtgatttag ataaaacccg tgcgcgtata ttgtatgcaa
     7021 ttgaaaatgc aatagataaa atttcaaagt ttgattatat aaaaagaaat acgttttctt
     7081 atcgatttgg tcaagaaata aagaatataa gtttagatga tgtgatttac attacaacta
     7141 cgaatgttgg tcataaacta caattagtaa agaagacagg ctgggcagaa tttattggta
     7201 gtttaaaaga tattccaaca agatacagtc aactggtaca aattagtcaa tcttgtgtga
     7261 ttaatccgca taatgtacaa aatattgatt tgaaagagaa aaaaataatt tttataaatg
     7321 gagatattga atacttttca gtaagaaata ctcgtaaagt taaaactttg tttaagatgt
     7381 aggttattag ataactttaa ttaaaaatgc aatatttaaa tatatcatga gtagtcttgg
     7441 gtacaggaga tatccctaag actatttttt gttatttttt ataaaaaatc caagtgctaa
     7501 taataacgat ttcatatatt tttttgataa actgaaaatg aaagaaagat atgaggcaat
     7561 gttatgaaaa aatatgatta tataatttta ggaacaggtc ctgctgcata tcaattaatt
     7621 aagctcttgg ctacacaaca taaatctatt ttggttgtag aaagcggctt atttggtgga
     7681 acttgtccca acgttggatg tgaaccgaaa atatatctag acggtgctgt tcaagcaatc
     7741 ttatctagtc gtcaatttga gaaagagggg ataatatctc aaattggaaa actaaattgg
     7801 tcccagttaa tgaaggaaaa gaaagaaaga tttgctagct ggccaaatga aacaagaaag
     7861 aacattagta aaatcagtga tgtaattagc gggagtgccc attttgttga tcgacaaaca
     7921 attgaagtaa atagacaata tttccaggga aatagaatta taattgcaac tggaaggaga
     7981 ccccatgaac tctcgattcc aggggcgaag ttcttacatg atagttccga tgttctctct
     8041 ttaaataagc ttccagagca tgttacgttt attggcggtg gatatgtagc aatggaatta
     8101 gcgacatttt tagctgctgc tggtagtcaa gtaactattt tagtgcgagg agatcgagta
     8161 ttacggtatt tttatcaaaa atatagtcgt gaattggttg taaaaatgaa agagcgagga
     8221 atccaattta aatttgaaac ggaaccaact cgtattactc aattaagtga taagtatgtt
     8281 gttgaattaa atcaagatgg accaatggta acggactatg tagtaaatgc tagtggacgt
     8341 actccaaata ttgaaaagct agatctatca gctgctcaaa ttgattattc aactagaggt
     8401 attgatgtag accgccacct tcaaacaaac gttaagaata tttatgcaat tggagacgtt
     8461 acaagccaag atgtgcccaa cttaacaccg gttgcagaat ttcaagcaca atacctcttt
     8521 aattctcttg aaaaggggct tactcaaacg attaattatc cagctatggg aacaggagta
     8581 tttgcttttc cgcaactagc tcaagccgga atcaatcctg atagtgttct tgaagatgga
     8641 gataatttcg aaattagaga atacgaacta agccaaagta gtttatatgc tggtcaaaag
     8701 gagagaggct tgttaactgt cgtttatgat aaagccaatt acattgttgg ggttagtgaa
     8761 ataagtatga gtgcagttaa cgacataaat tattttgtac caattattgg tctaagaatt
     8821 aataaaaatg agtggcatcg aaatgtattg ccaatttatc ctgcactggc cgataaaatt
     8881 gaaggaattt tgagatagaa aaaaagcacc tcgtggtgct ttttttatta caaatctaaa
     8941 ttttataagt cgctaccgcc atagtttgga gcttcttttg ccatttgaac atcgtgtgga
     9001 tgagattcac gtaaaccagc attagtaatt tgaacaaatt gactattttc aattaattct
     9061 tcaattgtac ctgcacctac atatcccata cctgcacgta gaccaccatc aatttggtag
     9121 atgatatttg aaacatcgcc tttataagga actaaggctt caacaccttc aggaactaat
     9181 ttatttgctt cattaactcc accttggaag taacggtcag atgatccatg ttgttgagac
     9241 atagcgccaa ctgaacccat accgcggtag gatttgaatt gtttgccttc attagtaaag
     9301 actgttcctg gagcctcagt ggttcctgag aacattgaac caagcattac agcatttcct
     9361 cctgcagcta aagccttaac aacatcgcca gaatatttaa taccaccatc agcaatgatt
     9421 ttcttgccat atttttgtgc aacactagca gcgtcataaa tagctgtaat ttgtggaacg
     9481 cccacaccag caacaatacg tgtagtacaa attgaaccag gtccaattcc tactttaaca
     9541 acatctactc cggcatcaaa tagcgcagca gttccttcgc cagtagcaac atttccaacg
     9601 atcagtgtag cattaggaaa atgctcacga atttccttaa ttttacgtaa aacgccagca
     9661 gaatgaccgt gtgctgtatc aataacaatt gcgtcagcac cggcttcaag tagactttca
     9721 gcacgttcaa aagtatcact tgtaacgcca acagcagctg cagctaagag acgaccttga
     9781 ttatcaactg cagggtgagg taagttagga tctacagttt tacctttagc ttttttaact
     9841 tcatcaactt gggcttcgat tgaaaggttt ttatgaataa cccctaagcc accattttcg
     9901 gccatggcaa ttgccatgtt tccttcggta acggtatcca ttcctgcgga aatgagtgga
     9961 atatgaagtt gaagattggg cgctaattta gtatctagtt taacttcatt cggcagcaca
    10021 tgactttcag ctggaattaa aagtacatca tcaaaagtta atcctttttt ggccaatttt
    10081 gtttcccaca aactcattgt aaagtcctct ctttagaagc aacgttttaa tattaaatta
    10141 gctaaacttt actcgaatat ctggcagaag tcaattagaa atttgattta atttttggac
    10201 aattaatttt gctaagagct cataaccctt aacaccaaaa tggagtccat cattcttttt
    10261 accattgaaa atttctggga aatttttact tgcctgcatc ttacttgcta gatcaataaa
    10321 taaaaattta tattcctttg taacgtgttt gattatgttg ctatattcct gcactaagag
    10381 gttatttcgc actttttgct tattttcatc aactgcaggt ggggtaacaa agataacctt
    10441 tcctgggtaa tagagccaaa taatgctaga agcaattaat tttagattat cttcaaattg
    10501 ttgcacaggg acttgcttgt gtactgctaa gtcattagtg ccaattaaaa tgatcagata
    10561 atcgcatttt ggctgattga ataccaaatt gggtaaagag aggccaaggc caccagaatt
    10621 gattcccgag atagctgtat tgtaaatctg atacgaattt agtttttgca attgaaagtt
    10681 aatttctgga atagaatgat tttcagagcg tgcaataata ctgtcgccgg taagaagtaa
    10741 tttcattaat aaaaaatcct ttagggtaga aaaaagacct tgagaaaatc tcaagatctt
    10801 tttgatcatc ataatttgat ttttagaact tgttcttgtc caaagcaact ggagaatctg
    10861 gtttttcacc gttgatcatc tttaagttgt tgtcaaatgc tttagttacc atgttacgta
    10921 cagcatgagt agtgtagaaa gcagtatgtg gagttaccaa tacatttgga cgatcgatta
    10981 agtcagctaa acgagcatct gggaattctt tgccttccca atcttcgtta aatacaccaa
    11041 cttcaccttc gtaagtgtcc attacgaaac caaagatttt accagaatct aagccgcgga
    11101 taacagcgtc agtgtcaaca agtggaccac gtgagcagtt tacgattaca acgccatctt
    11161 tcatcttagc gattgattca tcattaatca tgtgaacatt tgctggaaca tctggaacgt
    11221 gaagtgaaat tacatcagct tgcttgtata agtcatcaag tgagtcaacg tagtaaccct
    11281 tcttttcaag ttctgggttc ttgaagatat cgtaagcaat aacttttgcg ccaaagcctt
    11341 ccataatctt cataaatact tgaccgatgt gaccagtacc tacaacacca acaacttggt
    11401 cacgaacttc acgaccaata gtaggtgccc agcgtaagtc gcgcttagcc atcttttcat
    11461 ccatacgctt atcttgacgt agtacgcgag cagcttgaat tgcagcatgt tcagcaattg
    11521 cgtcaggaga gtatacagga acgttagtga tttcaaagcc taattcctta gccttgtcca
    11581 tgtcgatgtt atcaacacca acgttacgta atgacatctt agttacgcca gcatcagcta
    11641 aagcttgaag agtttctgga gtgtagtcta attgttggta aacaacaaca ccatcagcac
    11701 ccttagctaa tttagcagtt tcaggagtca aaagttgatc agtgtattca acttcaatat
    11761 ccttgtgtgc atctttccat tcgtttaaga aaggttcttc atctttacga atagcgtaag
    11821 caaaaatctt tgtcataaat taaacctccg tcaaaattaa tagtatgacc gtcttttatt
    11881 atacacttga gtttgttaat aaaaacacaa aatctgattt ttttgaaact tcttttgcag
    11941 atgtttcatg tgaaactgtt aatgttataa aaaatatatt ttcttttgct tatcaatata
    12001 gggtgcctta tgataatggt tagggaaaaa gaatgataag taagctacta tatgttatta
    12061 aaatttgatc aagatagatg agggaataag taatgtcagt tgttgttaaa tatgtagacc
    12121 tagacaataa tttggttgaa cttgcaaatt caggagagtt agagggaaaa ataggagaaa
    12181 gaatagacta caggacagaa gatgagataa gaaaaatact agctgctggt tatgtactga
    12241 ttaataatcc ttttgatcca aatgataaag taaatttctt taatgaagac tctcaagaat
    12301 tcacgcttac ttttaaacat ggtaaagaag aaataactgc caaaaattta aagtatggtt
    12361 gccatttaga ggatgtccaa atgaaaggtg aacaagtagt tcactatgtt ggactcgatc
    12421 aaagtattcc tgacaaggtt actgaggttg cttttaatag aaaaattatt tatgacaaag
    12481 tcactaagaa aaaattatta actaatacct ggcaaccgga aaagtattcc tttcctttag
    12541 ttgcaagccc aactgtgatg aactatacac ctgataaggc agtaattggt ggagagacag
    12601 caactattca acagccaaag tatgaatatg tagtcactta ttcacccaat aagaaaaatg
    12661 ctagaaggca aaaagctgaa ataaaattta ttgacgttga tgataacaac cgcgaagtag
    12721 caacttctgg agaattaaaa gggaaacctg aaaaagaaat accttataat accgcagagg
    12781 ttttgaaaaa tttaacagct aagggatatg aagtagttac taatgatttt gattctgagg
    12841 aacagaagcc tgtttttgga aatagtagag actatgttca aatctttttt gtggttttaa
    12901 agcataaaaa acaagttgtt aattctgaac atccattttc aggaattgat gcaagtttgt
    12961 acgaaaaaga agttcatcga acaattcgtt tttcaggaat agataataaa aagctagatg
    13021 atgtagttca aacagctatt ttaaaacgga acctaacagt tgatctcgta actaaaaaaa
    13081 ttattccagg agaatacaca agtcaatggc atagtagtga aacttacccg tcagtctccg
    13141 tgcctgtagt ttcgggatat catactaaga ttagtgaagt agtagcctca ccagtagaaa
    13201 aacaagatgt aactgaagaa gttaaatact attcaaacgg atatttaatt cctgttgatg
    13261 taaatcataa tggattttca gaaatagata aaaagcaact aattactaat tcaattgatc
    13321 caactaaggt cgttttatcg gaattagacc taaaaaatat tgtcttaaaa caaattaaag
    13381 aagtggaaat tgcagaccca agtcgtaatt atgaaattcc atatttatta gttcataaat
    13441 atgttgcagt cgatgaaaaa catccccaag aagtaataag tccggcatat taccgccgaa
    13501 ttgttaccgc ccgagttcat tatcaaggag ctggagacca gactcctcca gatgccgaac
    13561 aaacagtgcg ttggacaaga acaattactt atgatgaagt aagtaaagaa attattgaaa
    13621 acggtatgta tacgaccgac tgggtagctg ataaagatat ttttgaagca actcctacac
    13681 ctgtaattaa gggcttcgcc gcaaatattg gcttaattgg cgaacaccca gttacggcaa
    13741 ctgacttaat ggctacaatt acctatactc cgcttggaaa gatgatccca gttgatgagc
    13801 atggaaatga aattaaaaat gctatgcacc caacatacgt taatgatcca tatgatcctg
    13861 tgcgtgtcct ctttactgaa gaagtaccag aagtgccagg atatgcacca gttaaaaata
    13921 caatttctgt caatgatcct tttacggata ttaaggtgtc ctatacctta aagccacgct
    13981 atatccctgt gaatagcgaa catccttatc gtccgattaa gccaactttg tatagtgtcc
    14041 cagttaagga aataattaaa tatcagggag cgggagacca gaccccaatt actagaattc
    14101 agggtgctaa ttggacgaga actttgactg ttgatgagaa tacgggtgaa ttagtagatg
    14161 ctggtaagta tacaacagga tggttggtag acaagaagca atatatagcc gtaaaaacac
    14221 cagtcattga tggttatcat gcagacaaaa atataattga tgaagaaaaa gtaaaaaaag
    14281 ccgatctaaa cttcacggta acttataaag ccaatgggcg gatagtacca gttgatgcaa
    14341 aagggaatgt tttaaatggt gtagaacagc caacatatgt aaccgatcca agcgatgcaa
    14401 ctaaagtgat taaaacacaa ggtgtaccga gaattatgaa ttatattcca gatcgagcaa
    14461 caattacggt aaaagatgct agcgaaaata cactggttaa atattatact tttgatgaga
    14521 tgagtgaatt aaaagtagaa tataaaaaaa tagagcaaga aaaaagcaaa gatataaaac
    14581 ctaagaagaa agcggaagaa aaaggtgcaa aggaggaaga gcagtcatta aaaacagagg
    14641 aagaaaagaa agcggagatg gcttctaaga aagaagctac acaggtagat ggacaaaatg
    14701 aacaagagcg taaagtttta aggcatattt ttccatggat gaaataggag ataaaaaagc
    14761 tagatttgat taagtaaatc tagctttttt aattttaaaa gtttttagac caatttcgat
    14821 gaagaagtgt ataattaatt ttcgaaaaaa ttttttcgga ggaaaaattg tgtctgataa
    14881 aagcgagtct ttgaccaaa
//
