Probiotic potential risk score


ARGs (CARD) VFs (VFDB) PGs (PHI-base) PPRS
22135310338.83

PPRS is classified as low-risk (≤4), medium-risk (4-6), and high-risk (≥6).

Antibiotic resistance genes


Comprehensive Antibiotic Resistance Database (CARD)

ARO accession ARO name Identity Coverage CARD name Accession no.
ARO:3003922oqxA100.00100.00oqxAEU370913.1
ARO:3004580Klebsiella pneumoniae KpnE100.00100.00Kpne_KpnEAP006725.1
ARO:3004583Klebsiella pneumoniae KpnF100.00100.00Kpne_KpnFAP006725.1
ARO:3005049CrcB100.00100.00CrcBHF536482.1
ARO:3005059LptD100.00100.00LptDCP007727.1
ARO:3003923oqxB99.81100.00oqxBEU370913.1
ARO:3004588Klebsiella pneumoniae KpnG99.74100.00Kpne_KpnGACWO01000051.1
ARO:3005044OmpA99.7295.19OmpAFO834906.1
ARO:3005047eptB99.4697.04eptBFO203501.1
ARO:3004111FosA699.28100.00FosA6KU254579.1
ARO:3005053ArnT99.27100.00ArnTFO834906.1
ARO:3000518CRP99.05100.00CRPAP009048.1
ARO:3003890Escherichia coli UhpT with mutation conferring resistance to fosfomycin95.03100.00Ecol_UhpT_FOFHG738867.1
ARO:3004597Klebsiella pneumoniae KpnH94.02100.00Kpne_KpnHASTU01000063.1
ARO:3003950msbA92.78100.00msbAU00096.3
ARO:3000263marA92.7497.64marAAP009048.1
ARO:3000516emrR92.57100.00emrRU00096.3
ARO:3000828baeR91.25100.00baeRAP009048.1
ARO:3001328Escherichia coli mdfA85.61100.00Ecol_mdfAJQ394987.1
ARO:3005069rsmA85.25100.00rsmAAF061757.1
ARO:3003378Escherichia coli AcrAB-TolC with MarR mutations conferring resistance to ciprofloxacin and tetracycline84.03100.00Ecol_MarR_MULTU00096.1
ARO:3003578PmrF83.69101.55PmrFU00096.1

RGI v6.0.0 (Database: CARD Variants v4.0.0, Jul. 2022 release)

ResFinder

Resistance gene Identity Coverage Phenotype Accession no.
mef(A)100.00100.00Macrolide resistanceU83667
msr(D)100.00100.00Macrolide, Lincosamide and Streptogramin B resistanceAF274302
OqxA99.23100.00Disinfectant resistanceEU370913
OqxB99.11100.00Disinfectant resistanceEU370913
fosA99.05100.00Fosfomycin resistanceACWO01000079

ResFinder v4.0 (Database: resfinder_db, May 2022 release)

AMRFinderPlus

Gene symbol Sequence name Method Identity Coverage Accession no.
fosAFosA5 family fosfomycin resistance glutathione transferaseEXACTX100.00100.00WP_004146118.1
mef(A)macrolide efflux MFS transporter Mef(A)EXACTX100.00100.00WP_000417519.1
msr(D)ABC-F type ribosomal protection protein Msr(D)EXACTX100.00100.00WP_000420313.1
oqxAmultidrug efflux RND transporter periplasmic adaptor subunit OqxAEXACTX100.00100.00WP_002914189.1
oqxBmultidrug efflux RND transporter permease subunit OqxBBLASTX99.90100.00WP_004149399.1

AMRFinderPlus v3.10.42 (Database: Oct. 2022 release)

Virulence factors


Virulence Factor Database (VFDB)

Gene ID Gene name Identity Coverage e-value VF name VF category Accession no.
VFG049219dotU100.00100.000.0T6SS-IIIEffector delivery systemYP_005227576
VFG048245fimA100.00100.000.0Type I fimbriaeAdherenceWP_002916190
VFG048230fimB100.00100.000.0Type I fimbriaeAdherenceWP_042931240
VFG048287fimF100.00100.000.0Type I fimbriaeAdherenceWP_014906962
VFG003114fyuA/psn100.00100.000.0YersiniabactinNutritional/Metabolic factorWP_000784549
VFG048683hcp/tssD100.00100.000.0T6SSEffector delivery systemYP_005226602
VFG048549iroB100.00100.000.0SalNutritional/Metabolic factorWP_004890934
VFG048553iroD100.00100.000.0SalNutritional/Metabolic factorWP_014907291
VFG048327mrkH100.00100.000.0Type 3 fimbriaeBiofilmWP_004152886
VFG048348mrkJ100.00100.000.0Type 3 fimbriaeBiofilmWP_004149658
VFG049007rcsA100.00100.000.0RcsABRegulationWP_002911561
VFG003386ybtA100.00100.000.0YersiniabactinNutritional/Metabolic factorWP_000140406
VFG048585ybtU100.00100.000.0YbtNutritional/Metabolic factorWP_000982853
VFG048839wcaJ100.0097.750.0CapsuleImmune modulationWP_041937831
VFG048861KPN2242_RS1628099.92100.000.0CapsuleImmune modulationWP_004180513
VFG048872KPN2242_RS1628599.91100.000.0CapsuleImmune modulationWP_004180514
VFG048883KPN2242_RS1629099.91100.000.0CapsuleImmune modulationWP_004180515
VFG049313A79E_RS1021599.89100.000.0T6SS-IIIEffector delivery systemWP_002910453
VFG000366ybtQ99.89100.000.0YersiniabactinNutritional/Metabolic factorWP_002212761
VFG048263fimC99.86100.000.0Type I fimbriaeAdherenceYP_005228657
VFG048385mrkB99.8696.690.0Type 3 fimbriaeBiofilmYP_005228646
VFG048277fimD99.85100.000.0Type I fimbriaeAdherenceWP_009308599
VFG049018rcsB99.85100.000.0RcsABRegulationWP_002913007
VFG048395mrkA99.84100.000.0Type 3 fimbriaeBiofilmYP_005228647
VFG048355mrkF99.84100.000.0Type 3 fimbriaeBiofilmYP_005228643
VFG048332mrkI99.83100.000.0Type 3 fimbriaeBiofilmWP_002916079
VFG049134acrA99.8399.920.0AcrABAntimicrobial activity/Competitive advantage-
VFG048927KPN2242_RS1630599.82100.000.0CapsuleImmune modulationWP_004180522
VFG048787sciN/tssJ99.82100.000.0T6SSEffector delivery systemWP_004176417
VFG048894KPN2242_RS1629599.81100.000.0CapsuleImmune modulationWP_004180517
VFG049287sciN99.81100.000.0T6SS-IIIEffector delivery systemWP_004175532
VFG003381ybtE99.81100.000.0YersiniabactinNutritional/Metabolic factorWP_001088826
VFG048663dotU/tssL99.8176.960.0T6SSEffector delivery systemWP_004176431
VFG043624mrkD99.80100.000.0Type 3 fimbriaeBiofilmWP_004149659
VFG049209impJ99.78100.000.0T6SS-IIIEffector delivery systemYP_005227577
VFG048535iroE99.7899.360.0SalNutritional/Metabolic factorWP_004148380
VFG000363irp299.77100.000.0YersiniabactinNutritional/Metabolic factorWP_002212775
VFG048905KPN2242_RS1630099.77100.000.0CapsuleImmune modulationWP_004899437
VFG002747ybtP99.77100.000.0YersiniabactinNutritional/Metabolic factorWP_001327262
VFG048375mrkC99.76100.000.0Type 3 fimbriaeBiofilmYP_005228645
VFG048438entC99.75100.000.0EntNutritional/Metabolic factorWP_004176916
VFG000360ybtT99.75100.000.0YersiniabactinNutritional/Metabolic factorWP_002212799
VFG048744KPHS_2313099.74100.000.0T6SSEffector delivery systemYP_005226613
VFG049195clpV99.73100.000.0T6SS-IIEffector delivery systemWP_004150973
VFG049281impH99.70100.000.0T6SS-IIIEffector delivery systemWP_072157837
VFG048541iroN99.6886.260.0SalNutritional/Metabolic factorWP_041169040
VFG048307fimH99.67100.000.0Type I fimbriaeAdherenceWP_041937815
VFG048255fimI99.63100.000.0Type I fimbriaeAdherenceWP_004174507
VFG048776tssG99.63100.000.0T6SSEffector delivery systemYP_005226618
VFG048552iroC99.62100.000.0SalNutritional/Metabolic factor-
VFG012551irp199.59100.000.0Yersiniabactin siderophoreNutritional/Metabolic factor-
VFG048524entD99.5775.320.0EntNutritional/Metabolic factorYP_005225736
VFG049298impF99.55100.000.0T6SS-IIIEffector delivery systemWP_004175538
VFG049306impA99.51100.000.0T6SS-IIIEffector delivery systemYP_005227545
VFG048466fepD99.50100.000.0EntNutritional/Metabolic factorWP_004223587
VFG048507fes99.50100.000.0EntNutritional/Metabolic factorWP_019705362
VFG048615iutA99.50100.000.0AerobactinNutritional/Metabolic factorYP_005226287
VFG048794galF99.44100.000.0CapsuleImmune modulationWP_049256767
VFG048654vasE/tssK99.41100.000.0T6SSEffector delivery systemWP_004224345
VFG048850KPN2242_RS1627599.38100.000.0CapsuleImmune modulationWP_004899428
VFG048235fimE99.34100.000.0Type I fimbriaeAdherenceWP_002916189
VFG049269impG99.26100.000.0T6SS-IIIEffector delivery systemWP_004148784
VFG048487fepC99.25100.000.0EntNutritional/Metabolic factorWP_002893737
VFG048316fimK99.22100.000.0Type I fimbriaeAdherenceWP_015958940
VFG048409entA99.20100.000.0EntNutritional/Metabolic factorWP_086074289
VFG048630vipA/tssB99.19100.000.0T6SSEffector delivery systemWP_004224339
VFG048514fepA99.1786.140.0EntNutritional/Metabolic factorYP_005225737
VFG048606iucC99.14100.000.0AerobactinNutritional/Metabolic factorWP_004213922
VFG048428entE99.13100.000.0EntNutritional/Metabolic factorWP_012068426
VFG048770tssF99.09100.000.0T6SSEffector delivery systemWP_004892596
VFG048600iucA99.01100.000.0AerobactinNutritional/Metabolic factorWP_004213920
VFG048474fepG98.99100.000.0EntNutritional/Metabolic factorYP_005225742
VFG049082KPN2242_RS1619598.99100.000.0LPSImmune modulationWP_004899405
VFG048419entB98.94100.000.0EntNutritional/Metabolic factorWP_004210873
VFG048704vgrG/tssI98.90100.000.0T6SSEffector delivery systemYP_005226604
VFG048760impA/tssA98.87100.000.0T6SSEffector delivery systemWP_004183804
VFG048603iucB98.84100.000.0AerobactinNutritional/Metabolic factorWP_004213921
VFG049037cpsG98.8097.730.0LPSImmune modulationWP_020956641
VFG049058KPHS_3547098.74100.000.0LPSImmune modulationYP_005227847
VFG048996rmpA98.74100.000.0RmpARegulationWP_004213609
VFG048696clpV/tssH98.66100.640.0T6SSEffector delivery systemWP_040188146
VFG048949KPN2242_RS1631598.41100.000.0CapsuleImmune modulationWP_004184823
VFG048977KPK_RS0803598.31100.000.0CapsuleImmune modulationWP_012541091
VFG048610iucD98.28100.000.0AerobactinNutritional/Metabolic factorWP_004145304
VFG048970ugd98.20100.000.0CapsuleImmune modulationWP_004175261
VFG003509ybtS98.16100.000.0YersiniabactinNutritional/Metabolic factorWP_005168693
VFG049040KP1_RS1722598.0895.450.0LPSImmune modulationWP_074160401
VFG049102KPN2242_RS1620598.05100.000.0LPSImmune modulationWP_041937830
VFG048562ybtX97.97100.000.0YbtNutritional/Metabolic factorWP_014907272
VFG048754icmF/tssM97.9289.150.0T6SSEffector delivery systemWP_077250640
VFG048986KPR_RS0904597.71100.000.0CapsuleImmune modulationWP_004144150
VFG048712KPHS_2305097.69100.000.0T6SSEffector delivery systemYP_005226605
VFG040963gspG97.64100.000.0PulEffector delivery systemWP_002889054
VFG048938KPN2242_RS1631097.35100.000.0CapsuleImmune modulationWP_004899441
VFG049025KPHS_3544097.34100.000.0LPSImmune modulationYP_005227844
VFG006011STER_RS0532097.33100.000.0CapsuleImmune modulationWP_011681177
VFG048736tle197.3099.770.0T6SSEffector delivery systemYP_005226611
VFG006079STER_RS0708596.7498.330.0CapsuleImmune modulationWP_011681442
VFG040971KPK_RS2175596.63100.000.0PulEffector delivery systemWP_008807384
VFG006087STER_RS0710096.4999.520.0CapsuleImmune modulationWP_011681445
VFG006089rfbD94.95100.000.0CapsuleImmune modulationWP_011681446
VFG048828gndA94.88100.000.0CapsuleImmune modulationWP_004899420
VFG040961gspE94.7799.870.0PulEffector delivery systemWP_012542822
VFG005556tig/ropA94.70100.000.0Trigger factorStress survivalWP_011680653
VFG040962gspF94.57100.000.0PulEffector delivery systemWP_012542823
VFG040966gspJ94.47100.000.0PulEffector delivery systemWP_008807379
VFG006000STER_RS0531594.26100.000.0CapsuleImmune modulationWP_011681176
VFG005976STER_RS0530594.06100.000.0CapsuleImmune modulationWP_011681174
VFG040960gspD93.97100.000.0PulEffector delivery systemWP_162493344
VFG005359plr/gapA93.87100.100.0Streptococcal plasmin receptor/GAPDHAdherenceWP_002899102
VFG040964gspH93.8199.810.0PulEffector delivery systemWP_008807378
VFG040968gspL93.6871.260.0PulEffector delivery systemWP_012542825
VFG006022rfbB93.50100.000.0CapsuleImmune modulationWP_002947383
VFG040970KPK_RS2175091.1999.730.0PulEffector delivery systemWP_012542827
VFG040958gspB91.04100.000.0PulEffector delivery systemWP_012542819
VFG040969KPK_RS2174590.5599.790.0PulEffector delivery systemWP_012542826
VFG006041rfbA90.46100.000.0CapsuleImmune modulationWP_011681286
VFG034408yagZ/ecpA90.4199.320.0ECPAdherenceWP_000730972
VFG005579eno90.27100.000.0Streptococcal enolaseExoenzymeWP_000022815
VFG034492yagW/ecpD89.3997.870.0ECPAdherenceWP_001323478
VFG034447yagY/ecpB88.64100.000.0ECPAdherenceWP_000716398
VFG006047STU_RS1464088.4799.860.0CapsuleImmune modulationWP_011226047
VFG005325cbpD88.2399.880.0AutolysinExoenzymeWP_011680595
VFG040959gspC87.5699.880.0PulEffector delivery systemWP_008807374
VFG002415yagX/ecpC87.4699.920.0ECPAdherenceWP_001131063
VFG000477rpoS86.8199.800.0RpoSRegulationNP_461845
VFG034513yagV/ecpE85.0399.300.0ECPAdherenceWP_001339257
VFG001443ompA84.22101.920.0OmpAInvasionAAF37887
VFG005382srtA84.1699.740.0Sortase AExoenzymeWP_011681303
VFG034392ykgK/ecpR86.74100.002.48e-173ECPAdherenceWP_001323479
VFG049329KPR_RS1700099.39100.006.82e-172T6SS-IIIEffector delivery systemWP_004145442
VFG040965gspI96.17100.007.61e-172PulEffector delivery systemWP_004894160
VFG040957gspS92.80100.003.71e-155PulEffector delivery systemWP_012968915
VFG048740KPHS_23120100.00100.002.57e-135T6SSEffector delivery systemYP_005226612
VFG000478fur83.9896.477.97e-118FurRegulationNP_459678
VFG048498entF99.3260.660.0EntNutritional/Metabolic factorWP_012737619
VFG049244vgrG97.1263.240.0T6SS-IIIEffector delivery systemWP_004899018
VFG006075STER_RS0707594.4960.490.0CapsuleImmune modulationWP_011681440
VFG005189fbp5490.7363.590.0FBPsAdherenceWP_011227179

BLASTN v2.8.1+ (Database: VFDB, Jun. 2022 release)

VirulenceFinder

Database Virulence factor Identity Coverage Protein function Accession no.
virulence_ecolifyuA100.0100.00 Siderophore receptorCAY233333
virulence_ecolimchF100.0100.00 ABC transporter protein MchFAF063590
virulence_ecoliirp299.97100.00 High molecular weight protein 2 non-ribosomal peptide synthetaseNZ_NMCY01000014
virulence_ecoliiutA99.55100.00 Ferric aerobactin receptorCP003034
virulence_ecoliiroN99.54100.00 Enterobactin siderophore receptor proteinAP006726
virulence_ecolitraT97.54100.00 Outer membrane protein complement resistanceFLWH01000012
virulence_ecoliiucC90.82100.00 Aerobactin synthetaseAP018808
virulence_ecoliterC83.2696.48 Tellurium ion resistance proteinMG591698

VirulenceFinder v2.0.3 (Database: virulencefinder_db, Dec. 2022 release)

Pathogenic genes


PHI-base

Protein ID Gene name Identity Coverage e-value Function Gene ID
W9BBU8leuC100.0099.790.03-Isopropylmalate dehydratase large subunitAIT01851
W9BHK2ybtS100.0099.770.0Isochorismate synthase/isochorismate-pyruvate lyaseAIT04278
A0A086IQC3proV100.0099.750.0Glycine betaine/L-proline transport ATP-binding proteinAIS99989
W9BCN0leuB100.0099.730.03-Isopropylmalate dehydrogenaseAIT01852
O87753ompk35100.0099.720.0PorinADG27466
A6TF99arnC100.0099.700.0Putative sugar transferaseABR79233
A0A0W8AWM7yhbU100.0099.700.0Ubiquinone biosynthesis proteinARA47379
A6TF97arnD100.0099.670.0Hypothetical proteinABR79231
W1I1Q2lpxO100.0099.670.0Fe2+/alpha-ketoglutaratedependent dioxygenaseCDL64297
W9BEV6ycgE100.0099.590.0HTH-type transcriptional regulatorARA45326
A6TAW6gntR100.0099.580.0Fatty acid metabolism regulatorABR77737
W9BHK4irp299.8599.950.0YersiniabactinCDO15339
A6TF98arnA99.8599.850.0Hypothetical proteinABR79232
P46359psn99.8599.850.0Iron bindingCAA84487
U5U790oqxA99.7499.740.0RND family efflux transporterAIS72928
Q6U607iucA99.7399.860.0AerobactinAAR07714
W9B4Q6oqxB99.7199.900.0Multidrug efflux pumpCDO12913
A0A2X3EJX6fimD99.7188.090.0Type 1 fimbriae anchoring proteinSQC44282
A0A086VCI7ybtP99.6599.820.0ATP Binding Cassette ProteinAJE56481
W9BNM8entB99.6599.650.0Enterobactin and salmochelinANN51031
W9B3Z6yfiN99.5199.750.0c-di-GMP turnover enzymeCDO12934
A6TFA0arnB99.4799.740.0Putative aminotransferaseABR79234
A6TF96arnT99.4699.820.04-Amino-4-deoxy-L-arabinose transferaseABR79230
A0A076ZK37VK055_198099.4481.820.0HADa ATPase, P typeAIK80586
Q1RPI4ybtE99.4399.810.0YersiniabactinAIX63806
A0A076ZMY5VK055_195299.3899.800.0Betaine aldehyde dehydrogenaseAIK80558
B0LF88fimH99.3499.670.0Type 1 fimbriae adhesinABW24959
A0A0E0V727ybtQ99.3399.830.0ATP Binding Cassette ProteinAEQ13038
A0A164J6A6rarA99.3399.780.0Holliday junction DNA helicaseSAS94147
B5Y383pgaC99.3299.770.0Production of poly-b-linkedN-acetylglucosamineACI10823
B5Y1W2leuA99.2399.620.02-Isopropylmalate synthaseACI08908
Q6U5X7iroB99.1999.730.0SalmochelinAAR07744
A0A076ZHT9VK055_196199.1999.600.0Serine 3-dehydrogenaseAIK80567
B5XSN9phoQ98.9799.590.0govern the expression of cps and of the loci implicated in lipid A remodelingACI11151
A0A0F6AXS9lon98.8599.870.0ATP-dependent proteaseACY87051
Q7CPB9oxyR98.6999.670.0Regulatory protein sensor for oxidative stressAAL22963
P60651speB98.6999.670.0AgmatinaseAAC75974
P0AC41sdhA98.6499.830.0Succinate dehydrogenase avoprotein subunitAAA23895
P13445RpoS98.4899.700.0RNA polymerase sigma factorBAA02747
B0LF89fimK98.4499.780.0Pilus regulatory geneABW24960
Q8CL21ybtX98.1291.030.0Inner membrane protein, membrane permeaseAAS61888
A0A0F6B5R3STM14_RS1528598.0799.820.0Formate hydrogenlyase subunit 4ACY89857
P0A9E5FNR97.6099.600.0global regulatorAAA87981
A0A0D6I2I2spoT97.17100.000.0(P)ppGpp synthetaseAKH09371
P00722lacZ96.6899.900.0Beta-galactosidaseAAA24053
Q8ZLT3pnp96.4197.750.0polynucleotide phosphorylase, an exoribonuclease involved in RNA processing and degradationAAL22154
P0A2P8fruR95.8099.400.0Regulators of systemic infectionCRA_SALTY
P0A1P6glnA95.7499.790.0Glutamine synthetaseAAL22846
Q1JLQ2MntE95.5399.440.0Manganese HomeostasisABF32167
P0A7F6speD95.4599.620.0S-adenosylmethionine decarboxylase proenzymeAAC73231
D6QLX8OmpK3695.3899.460.0outer membrane proteinsADG56549
B5QZL1prt95.3299.670.0OAg biosynthesisCAR33649
P65882purA95.1499.770.0Pathogenicity islandAAL23186
P08982envZ94.9897.120.0Regulators of systemic infectionENVZ_SALTY
P75825hcp94.9199.820.0Hydroxylamine reductaseAAC73960
P13036fecA94.6486.580.0Ferric citrate outer membrane transporterBAE78282
A0A0F6B0W4sufB94.5599.800.0Sulfur mobilizationACY88142
D2TU77cpxA94.5399.780.0Two-component sensor kinaseCBG90543
Q8ZME2relA93.9799.870.0(P)ppGpp synthetase IAAL21836
D4HYB2guaB93.2499.800.0Inosine-5'-monophosphate dehydrogenaseCBA21987
Q97S31metE93.0699.870.0Methionine biosynthesis enzymesAAK74738
A0A0F6B941atpB92.9999.630.0F0F1 ATP synthase subunit AACY91043
P67331spr008492.8898.180.0pathogenitcity relatedAAK98888
C3T032ppk192.7399.710.0Polyphosphate kinase 1ACI80066
Q1J943prsA292.1998.460.0Ribose-phosphate pyrophosphokinaseABF36968
P63883amiC92.0999.760.0N-acetylmuramoyl-L-alanine amidaseAAC75856
P27550acs92.0399.850.0Acetyl-coenzyme A synthetaseAAC43163
P0A6Z3htpG91.6799.840.0heat shock protein 90 chaperoneAAA23460
P0A6T3galK91.6299.740.0GalactokinaseCAA26172
B5XY48OmpA291.29100.850.0outer membrane proteinsACI08342
P12681pgtP91.1499.780.0Phosphoglycerate transporter proteinAAL21299
D2TPE2tolB90.9399.770.0Colicin import proteinCBG87511
P32705actP90.9199.820.0Acetate/glycolate:cation symporterAAC77037
P05416glgA90.3499.580.0Glycogen synthaseAAL22395
P0A9G2nhaR90.1797.680.0Transcriptional activator proteinCAA27969
P36548amiA90.0099.660.0N-acetylmuramoyl-L-alanine amidaseAAC75488
Q99Z66ptsI89.9599.830.0Phosphoenolpyruvate-protein phosphotransferaseAAK34199
D4HXG4purF89.9099.800.0AmidophosphoribosyltransferaseCBA21663
P23865Prc89.8899.850.0Tail-specific proteaseBAA00577
E1AP33corA89.8799.680.0Magnesium/nickel/cobalt transporterHM852064
Q8DPC2potA89.8499.480.0ABC transporter ATP-binding protein - spermidine/putrescine transportAAL00050
A7ZRQ3sufI89.7999.790.0Cell division proteinABV16661
A0A380PIP1bipA89.7799.670.0Putative GTPaseCAL18716
Q8DYL6uvrB89.5999.850.0Excinuclease ABC, B subunitAE014259_2
D2TI55map89.3999.620.0Effector proteinCBG86951
D4HUC7pfkA89.0699.690.0ATP-dependent 6-phosphofructokinaseCBA19050
P19642pafP88.8799.810.0Transcription RegulatorAAA24098
A0A0F6B5R4STM14_RS1529088.6099.680.0Formate hydrogenlyase subunit 3ACY89858
P19786aroA88.5399.770.03-Phosphoshikimate 1-carboxyvinyltransferaseCAD05378
P09158speE88.4298.620.0Polyamine aminopropyltransferaseAAC73232
P30745moaA88.1599.700.0GTP 3',8-cyclaseAAC73868
D4HYW4asnB87.9199.640.0Asparagine synthase BCBA20089
D5AF41IMPDH87.6399.800.0Inosine-5'-monophosphate dehydrogenaseADE32434
P0C0B9bglB87.5499.330.0Putative phospho--glucosidaseAAK33487
C5BEV2glyA87.5399.760.0Serine h ydroxymethyltra nsferaseACR70340
Q97S30metF87.4198.960.0Methionine biosynthesis enzymesAAK74739
B5F8I0ArgD87.3899.510.0Acetylornithine/succinyldiaminopimelate aminotransferaseACH49836
A0A0D6I3U0envC87.2995.560.0Determinants for intrinsic CAMP resistanceALE64165
Q8ZPL7fumC87.2698.930.0Fumarate hydratase class IIAAL20389
P08331cpdB87.1799.850.02_,3_-Cyclic phosphodiesteraseAAA97109
D4HUF7metB86.9498.970.0Cystathionine gamma-synthaseCBA19080
C6DC70clpB86.9399.880.0Chaperone proteinACT14164
P0AB24efeO86.9399.730.0Iron uptake system componentAAC74103
Q66A26pykF86.6099.790.0Part of the pyruvate - tricarboxylic acid cycle nodeCAH21544
Q9ZFU7EutR86.5399.430.0HTH-type transcriptional regulatorAAC78127
Q8ZRE1phoR86.5199.540.0Histidine kinaseAAL19352
Q8ZMX2pat86.4899.210.0acetyltransferaseAAL21545
A4VWH9Eno86.4499.540.0EnolaseABP90468
D4ICB6nlpI86.0599.660.0Tetratricopeptide lipoproteinEAM_3066
P25535ubiI86.0099.750.0Aerobic ubiquinone-8 synthaseBAA14327
C5BDL7frdA85.9898.670.0Fumarate reductaseACR67633
P33221purT85.8395.170.0Formate-dependent phosphoribosylglycinamide formyltransferaseAAA23861
A4VYE0gidA85.2698.750.0tRNA uridine 5-carboxymethylaminomethyl modification enzymeABP91129
P0A452recA85.1998.460.0DNA recombination and repairAAL00560
A0A0F6B5S3STM14_RS1532584.9999.730.0Hydrogenase expression/formation proteinACY89867
B5TQV9PGM84.9499.480.0phosphoglucomutaseACH87041
D4I2T0pgi84.8599.820.0Glucose-6-phosphate isomeraseCBA23505
D4I0H1carA84.8297.450.0Carbamoyl-phosphate synthase small chainCBA22700
D0ZX10sssB84.81100.000.0Secreted effector proteinACY88258
D4HYF4purL84.7999.920.0Phosphoribosylformylglycinamidine synthaseCBA22070
P40120mdoD84.7399.640.0Glucans biosynthesis protein DAAC74506
Q54001MdsABC84.7299.190.0Multidrug transporter of SalmonellaTOLC_SALEN
P21169speC84.6799.860.0Constitutive ornithine decarboxylaseAAC76002
D4HUI1ilvA84.6399.810.0Threonine dehydrataseCBA19104
Q8ZNK8yeiE84.3299.650.0Putative LysR family transcriptional regulatorAAL21105
Q8ZJN0pgm84.2799.610.02,3-Bisphosphoglycerate-independent phosphoglycerate mutaseCAL18753
P13738nhaA84.2499.490.0Antiporter geneAAA23448
A0A2A7U510cadB84.2099.770.0Lysine-dependent acid resistance (LDAR) system membrane proteinPEH73496
D4HUY5rpoN84.0799.790.0Sigma factor, regulating essential virulence gene expressionCBA19258
A0A0F6B1M0ydcR84.0498.740.0Putative transcriptional regulatorACY88406
D4I2T4metA83.8299.680.0Homoserine O-succinyltransferaseCBA23513
Q7CQF1hnr83.6899.700.0Regulators of systemic infectionQ7CQF1_SALTY
D4I4L2glmS83.5899.840.0Glucosamine-fructose-6-phosphateaminotransferaseCBA24212
C6DI95PccS1_00144183.5599.360.0Transcriptional regulator, LysR family, MetRACT15089
P76142lsrB83.2896.480.0Autoinducer-2 ABC transporter periplasmic binding proteinAAC74589
Q8G8P0IroD83.0999.510.0Catecholate siderophore esterasesAAN76096AF449499_2
A0A0F6B5S4STM14_RS1533083.0499.700.0Formate hydrogenlyase transcriptional activatorACY89868
P31545efeB82.90100.470.0Deferrochelatase/peroxidaseAAC74104
A4VY17pdh82.7999.410.0Pyruvate dehydrogenaseABP91006
D0ZKI3bcsA82.7899.540.0cellulose synthesis regulationACY90746
P17750katG82.7699.720.0CatalaseAAL22946
A4VWD1mnmE82.6799.340.0Central tRNA-modifying GTPaseABP90420
D4HWM2cysI382.3999.300.0Sulfite reductaseCBA19698
C5BF98mdh82.3799.680.0Malate dehydrogenaseACR67684
P31554LptD82.3299.750.0LPS-assembly proteinBAA34130
Q8Z4H3iroC82.3098.930.0Putative ABC transporter proteinAAO70240
Q8Z445barA81.9999.460.0AAO70423
Q6KD45iucD81.4199.770.0aerobactinACJ63516
A0A0F6B5P9STM14_RS1523081.3199.690.0NorR family transcriptional regulatorACY89843
Q8Z4H1iroN80.9499.590.0TonB-dependent outer membrane siderophore receptor proteinAAO70243
P58662rcsC1180.7899.680.0Sensor proteinAAL21172
H9L460katE80.58100.000.0CatalaseAAL20243
Q8ZQE4MacB80.5699.690.0ABC-Type Efux PumpAAL19878
P26469rfaC80.1996.540.0heptosyl transferaseAAL22571
Q8XDQ1katN80.0099.335.59e-180Effector proteinBAB35075
A0A0F6B5R1STM14_RS1527592.1699.616.72e-179Formate hydrogenlyase complex iron-sulfur subunitACY89855
A0A0F6B5S8STM14_RS1534583.4590.851.53e-178Manganese/iron ABC transporter ATP-binding proteinACY89872
P0AA16ompR100.0099.581.54e-177Transcriptional regulatorAAC76430
P07014sdhB97.4899.581.98e-177Succinate dehydrogenase iron-sulfur subunitAAA23896
A0A0F6B5S1STM14_RS1531588.6299.668.71e-177Hydrogenase assembly chaperoneACY89865
A0A0F6B5P8STM14_RS1522590.6699.618.58e-176Arabinose 5-phosphate isomeraseACY89842
P0A9Q1arcA97.0699.589.33e-175Aerobic respiration control proteinAAA97297
D2TR63artP93.8099.594.49e-173Arginine ABC transporter, ATP-binding proteinCBG87650
U6ZHA8kdgR88.5999.625.92e-173virulence negative regulatorsERO57666
P39832znuB92.3499.622.66e-171Zn(2(+)) ABC transporter membrane subunitAAC74929
P45610tonB99.1899.592.48e-170siderophores synthesisCAA48498
A0A0M2J080sufC90.7399.602.31e-169Sulfur mobilizationAPF09033
A0A0F6B5T0STM14_RS1535587.4594.432.51e-169Iron ABC transporter permeaseACY89874
C6DEY6rsmA81.6299.272.28e-168Ribosomal RNA small subunit methyltransferase AACT14650
P0A9X1znuC90.4099.213.07e-167Zn(2(+)) ABC transporter ATP binding subunitAAC74928
A0A086ITU0fimC100.0099.552.44e-166Molecular chaperoneAUU95693
A0A0F6B5S9STM14_RS1535081.4898.547.58e-166Iron ABC transporter permeaseACY89873
A0A518VKX7kduD84.1999.619.96e-1652-Dehydro-3-deoxy-D-gluconate 5-dehydrogenaseQHP58461
P0A2F2cob84.9398.911.96e-163nicotinamide adenine dinucleotide (NAD + )-dependent deacetylaseAAC78722
W9B383dedA100.0099.551.72e-159DedA family inner membrane proteinARA47408
P0A2T6crp100.0099.532.78e-159Regulators of systemic infectionCRP_SALTY
Q7CPD5tatC84.9499.625.03e-159Sec-independent protein translocaseAAL22819
Q8Z8K9entA85.6699.603.48e-1572,3-Dihydro-2,3-dihydroxybenzoate dehydrogenaseAAO69872
Q8GM84rcsB99.5499.544.23e-157govern the expression of cps and of the loci implicated in lipid A remodelingAAL25250
P0A1D7ClpP99.0399.529.23e-156proteolytic componentBAA94668
C9Y236FkpA88.1294.204.33e-155virulence factorCBA34185
Q8GM81rmpA98.0999.531.42e-154Regulator of mucoid phenotypeAAL25252
F5ZP95phoP93.2799.115.57e-154Virulence transcriptional regulatory proteinAEF07105
D2TU76cpxR95.6999.571.67e-153Two-component response regulatorCBG90542
P96058sirA93.1299.541.79e-153AAO68606
W9BQ45leuD100.0099.501.11e-1523-Isopropylmalate dehydratase small subunitAIT01850
P0AF26narJ86.3899.168.00e-152Nitrate reductase molybdenum cofactor assembly chaperoneAAC74310
P08870pyrE93.9099.531.58e-149Orotate phosphoribosyltransferaseAAL22592
Q93MY4covR84.6899.583.41e-149Responder proteinAAK71319
P43019sodA95.1599.529.66e-149Cytoplasmic superoxide dismutaseAAC43331
P11350narI90.6299.123.14e-147Respiratory nitrate reductase 1 gamma chainAAC74311
Q66EI1pdhR86.3391.764.66e-147Part of the pyruvate - tricarboxylic acid cycle nodeCAH19952
G3FT04MrkA99.5099.515.67e-146Ferrous iron transporterAEO27492
A0A0H3NDI1tsaA95.0099.509.40e-146PeroxiredoxinCBW16497
A0A0F6B1X1pspA92.3499.556.36e-144Phage-shock proteinACY88508
A0A0S3FFR9fimA100.0099.482.18e-141Fimbrial proteinAUU95694
P0A251ahpC99.4799.473.21e-141PeroxiredoxinAAL19559
Q5KQZ9magA99.4899.486.54e-141Contributes to K1 capsular polysaccharide (CPS) biosynthesisBAD86762
P0AF32narV82.7499.566.78e-139Respiratory nitrate reductase 2 gamma chainBAA15102
P64036EF-P97.3499.478.94e-139Elongation factorAAL23157
Q8ZMF9pimt88.9499.522.38e-138Protein isoaspartate methyl transferaseAAL21806
P66796QseB85.8499.553.07e-137Two-component system response regulatorCAD03009
B3VA60CovR81.6699.564.42e-137serves to repress GAS virulence factor-encoding genesACE75886
P0A2F0rpoE96.8699.484.79e-137Regulators of systemic infectionRPOE_SALT
A1ABF3RstA80.7594.442.04e-134Part of a two component regulatory systemABJ00993
B0LF83fimI100.0099.441.96e-132Pilin (type 1 fimbria component protein)ABW24954
P0A2F4sodB91.1999.482.10e-132Cytoplasmic superoxide dismutaseAAL20353
P08179purN83.4199.066.05e-132Phosphoribosylglycinamide formyltransferaseAAA83899
A0A0D6I7L0ppiA92.6398.951.40e-130Peptidyl-prolyl cis-trans isomeraseALD83590
A6T684pagP99.4290.532.98e-128AcyltransferaseABR76105
P60317ProQ85.1599.131.08e-127RNA chaperoneAAL20761
W9BND0yfiR100.0094.942.48e-126Negative regulator of YfiBNR systemCDO12935
Q6D4B5eda85.9299.071.51e-1242-Keto-3-deoxy-6-phosphogluconate aldolaseCAG75378
A0A0F6B5R2STM14_RS1528090.0099.451.68e-123Formate hydrogenlyase subunit 5ACY89856
A1AEN2LuxS93.5799.428.33e-123controller in the Quorum sensingABJ02122
P0AFV4MepS86.2499.474.35e-122Peptidoglycan DD-endopeptidase/peptidoglycan LD-carboxypeptidaseAAC75236
P0ACR9MprA92.5798.876.82e-122Transcriptional repressor of an operon encoding the EmrAB efflux pump.CAA38090
A0A0F7DI09ppiB94.5199.391.67e-117Peptidyl-prolyl cis-trans isomeraseALD83591
D3VBH2lrp96.9599.394.11e-117Global Transcription FactorCBJ89611
A0A0F6B5Q6STM14_RS1525590.7595.051.44e-115Hypothetical proteinACY89850
A0A0H3NC59yeaB82.2999.481.15e-114RNA methyltransferaseCBW17849
P0AC98satP87.2399.471.10e-113Succinate-acetate/proton symporterAAC73121
P0A2G1smpB94.3899.383.27e-113Regulators of systemic infectionSSRP_SALTY
P0AB06ycbK91.2699.455.20e-113Peptidoglycan LD-endopeptidaseAAC74012
A0A0T5I632fimF90.7199.458.63e-113Putative fimbrial subunitSBY39291
P23484fecI89.0299.433.92e-112RNA polymerase sigma factorAAA23766
P64281greA94.3099.373.29e-111Transcription elongation factorAAL22169
P0A1G5DksA98.6799.347.64e-111Response RegulatorAAD01437
D2TNF0argR94.2399.362.26e-107Arginine repressorCBG91281
Q8ZLJ2greB91.0899.371.08e-106Transcription elongation factorAAL22365
Q7CQY3fur96.0099.341.34e-106Ferric uptake regulation proteinAAL19637
D4I230hcp-282.2199.391.29e-102T6SS Effector proteinCBA23273
Q7CQ10iscR93.2998.792.49e-98Fe-S cluster sensorAAL21438
P0A917OmpX81.9898.262.27e-97Outer membrane proteinAAA66329
A6TAK8hns100.0099.268.45e-97pleiotropic regulatorABR77629
Q665I9ptsN85.0695.654.46e-96Part of the pyruvate - tricarboxylic acid cycle nodeCAH22766
A0A0F6B5Q9STM14_RS1526588.3998.733.78e-92Formate hydrogenlyase maturation proteinACY89853
A0A0L9JQ40iscU97.6699.223.24e-91Fe-S cluster sensorAPQ81541
A1JQ74ybeY81.8297.471.32e-89EndoribonucleaseCAL13026
A0A0F6B5R0STM14_RS1527087.5099.271.89e-88NADH-quinone oxidoreductase subunitACY89854
U2W9V3SpxA291.6799.255.91e-88Transcriptional regulatorERL21461
A6TF94arnF100.0099.216.80e-86Hypothetical proteinABR79228
A0A0F7J4C9tomB91.1399.209.29e-86Hha toxicity attenuatorAKH06147
P40676slyA84.0399.311.34e-85Regulators of systemic infectionSLYA_SALTY
P69054sdhC93.0299.236.70e-85Succinate dehydrogenaseAAA23893
Q57PB8MarA92.7496.881.93e-84Transcriptional regulatorAAX65443
Q8XBU9ybdB82.4899.282.21e-84Proofreading thioesteraseAE005239_7
A0A1C1TY69mdtJ99.1799.175.23e-78Multidrug transporter subunitAUY17561
Q57RZ3ramA90.2799.123.70e-76Transcriptional regulatorAAX64518
A6TF95arnE100.0099.129.86e-76Hypothetical proteinABR79229
Q6CZA0metJ96.1999.064.44e-75Repressor of the methionine biosynthesis regulonCAG77150
P0AC44sdhD90.4499.147.76e-71Succinate dehydrogenaseAAA23894
B5XR94mdtI97.2599.099.14e-71Multidrug resistance proteinACI10803
C6DIJ6PccS1_00152397.9698.991.47e-67Transcriptional regulator, Fis family, FisACT11296
P64394himD98.9297.892.77e-66Regulators of systemic infectionIHFB_SALTY
P0A1R0hfq91.2698.061.16e-64Regulators of systemic infectionHFQ_SALTY
D4HX89yfiA80.1898.231.89e-64CBA19780
A0A0F7DJX4ppiC92.4798.943.17e-60Peptidyl-prolyl cis-trans isomeraseALD83589
D0Z9U0hupA95.5698.906.32e-58Nucleoid-associated protein, is a basic DNA-binding protein involved in gene regulationACY83030
Q8DQV4spr047985.4297.962.23e-57essential geneAAK99283
E0SMW8clpS82.9887.851.46e-56ATP-dependent Clp protease adapter proteinADM98238
D4HXP5ptsH96.4798.847.61e-56Phosphocarrier protein HPrCBA21825
A0A0F6B5S2STM14_RS1532090.0098.901.31e-55Hydrogenase formation proteinACY89866
D4HUY4yhbH80.0098.962.06e-54a novel ribosome-associated modulation proteinCBA19257
Q8DP67spr132792.9498.845.76e-54essential geneAAL00131
P0AA34yedF96.1098.721.60e-52Hypothetical transcription factorAAL20878
Q8CZ89spr017585.2398.881.36e-51pathogenitcity relatedAAK98979
Q8DRE1spr017783.1587.255.21e-50essential geneAAK98981
Q7CR17hha98.6198.638.84e-50Hemolysin expression-modulating proteinAAL19427
Q8ZQ03ycfR84.7198.848.90e-48Outer membrane proteinAAL20143
A0A0U1J4N7yqiC89.8779.001.83e-46Membrane fusogenic activityCNQ39570
P0A9Y9cspC100.0098.574.54e-46Cold shock proteinAAC06037
A0A0F6AYC2cspE97.1098.571.73e-45Cold shock proteinACY87244
A0A0F6B1X0pspB81.0898.671.70e-42Phage-shock proteinACY88507
P69913csrA100.0098.398.56e-40Post-transcriptional regulatorAAA71919
A0A6C7HPB2SEN153893.3398.361.16e-33Conserved hypothetical proteinCAR33117
Q48412RomA (VK055_1984)98.1179.704.66e-72Metallo-beta-lactamase superfamily proteinAIK80590
W9B5X1ykfE (VK055_1949)99.3284.091.40e-108inhibitor of vertebrate C-type lysozymeAIK80555
D4I4J9EaAdeP (EAMY 3685)84.2698.630.0Putative AzgA family transporterCBA24187
W9B570FepA (VK055_1934)99.3786.000.0TonB-dependent siderophore receptor family proteinAIK80540
W9BF24EntA (VK055_1922)99.6095.800.02,3-Dihydro-2,3-dihydroxybenzoate dehydrogenaseAIK80528
Q9I0J4nuoI (PA2644)82.9596.173.65e-108NADH-quinone oxidoreductaseAE004693_3
A1JLB7RcsB (YE1397)91.4397.226.14e-142Transcriptional regulatory proteinCAL11489
A0A0F6B0X0STM14_RS07735 (lppB)84.8197.502.12e-41Hypothetical proteinACY88148
A0A0F6B0X1STM14_RS07740 (lpp)97.4498.731.54e-49Murein lipoproteinACY88149
P0AA28thioredoxin 197.2599.097.65e-76Redox activityBAA00903
A0A0F6B5P4STM14_RS15205 (slrB)81.6799.171.35e-67PTS glucitol/sorbitol transporter subunit IIAACY89838
A0A0F6B0W8STM14_RS07725 (ynhA/sufE)80.4499.281.10e-82Cysteine desulfuration proteinACY88146
A0A0F6B5P2STM14_RS15195 (srlA)93.0599.472.48e-131PTS sorbitol transporter subunit IICACY89836
B5Y006BetI (VK055_1951)100.0099.491.10e-144Transcriptional repressorAIK80557
B5XZZ0EntD (VK055_1935)92.8299.522.26e-1434'-Phosphopantetheinyl transferase superfamily proteinAIK80541
D2TUX9dsbA (ROD_38991)87.9299.524.10e-141Thiol:disulfide interchange proteinCBG90603
Q56056RNase III96.4699.563.30e-164endoribonucleasesAAA92440
A0A0F6B0W5STM14_RS07710 (sufC)90.7399.602.31e-169Fe-S cluster assembly ATPaseACY88143
W9B5Y9FepC (VK055_1930)100.0099.620.0Ferric vibriobactin ABC transporter, ATP-binding proteinAIK80536
A0A0F6B5P5STM14_RS15210 (srlD)91.8999.622.80e-177Sorbitol-6-phosphate dehydrogenaseACY89839
Q8X6J9ovrB (Z0346)84.6999.660.0LysR-type transcriptional regulatorAE005205_3
W9BFU2lpxL1 (BN49_2155)99.6799.670.0Lipid A late acyltransferaseATM55433
W9B4X1lpxL2 (BN49_1538)99.6799.670.0Lipid A late acyltransferaseAIT02281
W9BNM7FepD (VK055_1928)99.7099.700.0Ferric enterobactin transport system permeaseAIK80534
W9B576FepG (VK055_1929)99.7099.700.0Ferric enterobactin transport system permeaseAIK80535
Q04M32ilvC (SPD_0406)97.3599.710.0Ketol-acid reductoisomerase (NADP(+))ABJ55451
A0A086IIR8YbdK (VK055_1976)100.0099.730.0Gamma-glutamyl cysteine ligaseAIK80582
A0A085DFX7EntC (VK055_1925)99.7499.740.0Isochorismate synthaseAIK80531
A0A0F6B0W7STM14_RS07720 (sufS)81.0399.750.0Cysteine desulfuraseACY88145
A0A0F6B0X2STM14_RS07745 (pykF)96.1799.790.0Pyruvate kinase IACY88150
W9B580entE (VK055_1924)99.2599.810.0(2,3-dihydroxybenzoyl)adenylate synthaseAIK80530
E0SMW9clpA (Dda3937_02363)89.8799.870.0ATP-dependent Clp protease ATP-binding subunitADM98239
A0A0F6B5P3STM14_RS15200 (srlE)87.12100.310.0PTS sorbitol transporter subunit IIBACY89837
D2TI49degP (ROD_01651)90.98100.640.0Periplasmic serine endoprotease DegP-likeCBG86945
D4I3E6trpB92.0566.500.0Tryptophan synthase beta chainCBA20869
A0A8E5JM30acrD90.4763.680.0Resistance-nodulation-cell division (RND) transporterQUZ94265
W8ZK20yegN87.3660.810.0Multidrug efflux system subunitCDN82752
B5XZY6EntF (VK055_1931)98.6060.590.0Amino acid adenylation domain proteinAIK80537

BLASTP v2.8.1+ (Database: PHI-base v4.14, Nov. 2022 release)

Plasmid


PlasmidFinder

Plasmid Identity Query / Template Accession no.
IncFIB(K)99.11560 / 560JN233704
IncFII(pKP91)90.95232 / 230CP000966

PlasmidFinder 2.0.1 (Database: plasmidfinder_db, Jan. 2023 release)

Prophage


Phigaro

Scaffold Begin End Transposable Taxonomy pVOGs
JUNV01000105.1334038521FalseSiphoviridaeVOG1539, VOG5277, VOG4662, VOG1509, VOG5084, VOG4000, VOG10933, VOG6971, VOG3477, VOG2473, VOG9325, VOG2471, VOG0697, VOG2469, VOG8535, VOG2468, VOG9541, VOG2467, VOG5296, VOG2466, VOG5027, VOG2464, VOG7068, VOG0796, VOG0632, VOG1520, VOG4565, VOG0765, VOG2096, VOG7615, VOG4693, VOG0618, VOG0293, VOG2339, VOG5837, VOG4755, VOG10912, VOG7516, VOG8996, VOG4571, VOG4788, VOG8249, VOG0355, VOG4566, VOG2338, VOG0248, VOG0827
JUNV01000257.1390728955FalseSiphoviridaeVOG1539, VOG5277, VOG5838, VOG4820, VOG4820, VOG4634, VOG0704, VOG9583, VOG4589, VOG0204, VOG4553, VOG4568, VOG4556, VOG4544, VOG4581, VOG9438, VOG6465, VOG2125, VOG2388, VOG2096, VOG0251, VOG4693, VOG4694, VOG4566, VOG2085, VOG2186, VOG10933

Phigaro v2.3.0 (Database: Aug. 2017 release)